KEGG   ENZYME: 2.3.1.236Help
Entry
EC 2.3.1.236                Enzyme                                 

Name
5-methylnaphthoic acid synthase;
AziB
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:acetyl-CoA malonyltransferase (5-methyl-1-naphthoic acid forming)
Reaction(IUBMB)
acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ = 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+ [RN:R11124]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
5-methyl-1-naphthoate [CPD:C20803];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001];
NADP+ [CPD:C00006]
Comment
A multi-domain polyketide synthase involved in the synthesis of azinomycin B in the bacterium Streptomyces griseofuscus.
History
EC 2.3.1.236 created 2014
Orthology
K21381  5-methylnaphthoic acid synthase
Reference
1  [PMID:18635006]
  Authors
Zhao Q, He Q, Ding W, Tang M, Kang Q, Yu Y, Deng W, Zhang Q, Fang J, Tang G, Liu W
  Title
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.
  Journal
Chem Biol 15:693-705 (2008)
DOI:10.1016/j.chembiol.2008.05.021
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.236
IUBMB Enzyme Nomenclature: 2.3.1.236
ExPASy - ENZYME nomenclature database: 2.3.1.236
BRENDA, the Enzyme Database: 2.3.1.236

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