KEGG   ENZYME: 2.3.1.24Help
Entry
EC 2.3.1.24                 Enzyme                                 

Name
sphingosine N-acyltransferase;
ceramide synthetase;
sphingosine acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:sphingosine N-acyltransferase
Reaction(IUBMB)
acyl-CoA + sphingosine = CoA + a ceramide [RN:R01496]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
sphingosine [CPD:C00319]
Product
CoA [CPD:C00010];
ceramide [CPD:C00195]
Comment
Acts on sphingosine or its 2-epimer.
History
EC 2.3.1.24 created 1972
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04709  Acyl-CoA-dependent ceramide synthase
K04710  ceramide synthetase
Genes
HSA: 10715(CERS1) 204219(CERS3) 253782(CERS6) 29956(CERS2) 79603(CERS4) 91012(CERS5)
PTR: 451891(CERS5) 453683(CERS3) 456435(CERS4) 468773(CERS1) 469482(CERS2) 741293(CERS6)
PPS: 100968130(CERS1) 100973710(CERS4) 100973768(CERS2) 100980816(CERS5) 100985038(CERS6) 100994802(CERS3)
GGO: 101126713(CERS6) 101128445(CERS3) 101131101(CERS4) 101131185(CERS5) 101148109(CERS2) 109024075(CERS1)
PON: 100174286(CERS2) 100437726(CERS4) 100447528(CERS1) 100451535(CERS3) 100452162(CERS6) 100454836(CERS5)
NLE: 100579482(CERS4) 100580966(CERS5) 100581669(CERS2) 100583004(CERS1) 100590821(CERS3) 100606355(CERS6)
MCC: 106994665(CERS1) 693696(CERS3) 704953(CERS6) 706728(CERS4) 713449(CERS5) 716180(CERS2)
MCF: 101926302(CERS4) 101926756(CERS6) 102116814(CERS2) 102116993(CERS5) 102143963(CERS3) 107128159(CERS1)
CSAB: 103217252(CERS6) 103231276(CERS3) 103234393(CERS1) 103238299(CERS5) 103247210(CERS2)
RRO: 104655030(CERS6) 104676807(CERS3) 104679692(CERS5) 104680635(CERS1) 104681063(CERS2) 104682288(CERS4)
RBB: 108512618(CERS3) 108515632(CERS1) 108520506(CERS6) 108533256(CERS2) 108534518(CERS4) 108543894(CERS5)
CJC: 100400191(CERS5) 100406591(CERS3) 100406593(CERS6) 100412093(CERS2) 100414013(CERS4) 103789832(CERS1)
SBQ: 101031310(CERS5) 101037762(CERS4) 101041201(CERS1) 101042109(CERS6) 101042956(CERS3) 101043514(CERS2)
MMU: 241447(Cers6) 545975(Cers3) 67260(Cers4) 71949(Cers5) 76893(Cers2) 93898(Cers1)
RNO: 290658(Cers1) 304208(Cers4) 310667(Cers2) 366065(Cers6) 366984(Cers5) 499174(Cers3)
CGE: 100758196(Cers4) 100761613(Cers6) 100765511(Cers1) 100765986(Cers2) 100770521(Cers3) 100774213(Cers5)
NGI: 103726528(Cers4) 103726856(Cers1) 103730090(Cers2) 103737993(Cers6) 103746545(Cers5) 103747188(Cers3)
HGL: 101701089(Cers5) 101702770(Cers3) 101705418(Cers1) 101713278(Cers6) 101715336(Cers4) 101716285(Cers2)
CCAN: 109681206(Cers2) 109684934(Cers1) 109689215 109689224(Cers6) 109695422(Cers5) 109698441(Cers4) 109700448(Cers3)
OCU: 100337851(CERS3) 100339974(CERS5) 100344726(CERS6) 100352973(CERS4)
TUP: 102474397(CERS5) 102475021(CERS3) 102475765(CERS1) 102484493(CERS6) 102495526(CERS4) 102502685(CERS2)
CFA: 477611(CERS5) 483187(CERS2) 485008(CERS4) 488387(CERS6) 607925(CERS3) 609789(CERS1)
AML: 100466254(CERS3) 100473865(CERS6) 100474398(CERS5) 100475918(CERS4) 100478537(CERS1) 100481999(CERS2)
UMR: 103659527(CERS6) 103659988(CERS3) 103667533(CERS2) 103675149(CERS1) 103675475(CERS5) 103681884(CERS4)
ORO: 101372787(CERS2) 101373517(CERS6) 101379762(CERS4) 101380694(CERS1) 101381953(CERS3) 101384709(CERS5)
FCA: 101084386(CERS6) 101087243(CERS5) 101089084(CERS1) 101093918(CERS4) 101094362(CERS2) 101099301(CERS3)
PTG: 102948771(CERS6) 102961418(CERS1) 102961799(CERS5) 102968533(CERS3) 102970444(CERS2) 102972870(CERS4)
AJU: 106969135(CERS1) 106969231(CERS5) 106970310(CERS6) 106970780(CERS4) 106972088(CERS3) 106979828(CERS2)
BTA: 505233(CERS4) 530776(CERS5) 539223(CERS2) 614354(CERS3) 615296(CERS1) 616901(CERS6)
BOM: 102264858(CERS2) 102269743(CERS1) 102271413(CERS5) 102275684(CERS4) 102282095(CERS6) 102282323(CERS3)
BIU: 109555312(CERS2) 109559116(CERS5) 109560813(CERS1) 109561659(CERS4) 109575125(CERS3) 109575183(CERS6) 109575194
PHD: 102318840(CERS4) 102324961(CERS5) 102325529(CERS6) 102330749(CERS2) 102334903(CERS1) 102345046(CERS3)
CHX: 102169911(CERS3) 102170388 102170747(CERS5) 102174737(CERS4) 102176466(CERS6) 102182556(CERS2) 102189571(CERS1)
OAS: 101101856 101102559(CERS4) 101107095(CERS1) 101109498(CERS2) 101110093(CERS3) 101117661(CERS5) 101122252(CERS6)
SSC: 100126279(CERS6) 100127167(CERS4) 100152265(CERS3) 100156737(CERS2) 100525450(CERS1) 110260661(CERS5)
CFR: 102505196(CERS3) 102507344(CERS1) 102507747(CERS5) 102509169(CERS6) 102511821(CERS2) 102519510(CERS4)
CDK: 105087579(CERS4) 105091057(CERS6) 105093450(CERS3) 105097208(CERS5) 105101886(CERS1) 105103195(CERS2)
BACU: 103003098(CERS1) 103007274(CERS5) 103008265(CERS6) 103009608(CERS2) 103009742(CERS4) 103016103(CERS3)
LVE: 103069846(CERS4) 103076535(CERS6) 103076923(CERS2) 103082414(CERS3) 103088889(CERS5) 103091398(CERS1)
OOR: 101271239(CERS2) 101273399(CERS1) 101282056(CERS6) 101282990(CERS5) 101287722(CERS3) 101289498(CERS4)
ECB: 100050135(CERS3) 100052305(CERS6) 100055037(CERS2) 100059999(CERS5) 100066949(CERS4) 100069594(CERS1)
EPZ: 103543133(CERS4) 103546204(CERS5) 103547641(CERS2) 103561069(CERS3) 103565074(CERS1) 103567735(CERS6)
EAI: 106839474(CERS3) 106843426(CERS6) 106844495(CERS4) 106845048(CERS5) 106846409(CERS1) 106846528(CERS2)
MYB: 102242969(CERS3) 102246479(CERS6) 102249252(CERS1) 102250642(CERS4) 102256999(CERS2) 102262839(CERS5)
MYD: 102759130(CERS3) 102760303(CERS5) 102767770(CERS4) 102769776(CERS1) 102772688(CERS6) 102772826(CERS2)
HAI: 109372275(CERS2) 109380354(CERS3) 109382399(CERS1) 109390309(CERS6) 109393272(CERS5) 109396095(CERS4)
RSS: 109434705(CERS4) 109442471 109443798(CERS5) 109444964(CERS3) 109445192(CERS6) 109450009(CERS1) 109451618(CERS2)
PALE: 102880099(CERS5) 102885878(CERS1) 102885951(CERS2) 102889613(CERS3) 102890907(CERS4) 102896376(CERS6)
LAV: 100660076(CERS6) 100667031(CERS1) 100671292(CERS3) 100673086(CERS2) 100674671(CERS4) 100674871(CERS5)
MDO: 100014952(CERS2) 100016686(CERS1) 100020588(CERS3) 100024030(CERS6) 100025505
SHR: 100917962(CERS2) 100919047(CERS4) 100919316 100919629(CERS3) 100924117(CERS6) 100929507(CERS5) 100932082 100934161
OAA: 100078502(CERS1) 100083235(CERS6) 100090289(CERS4) 100090484(CERS3)
GGA: 100859441(CERS2) 420050(CERS4) 420118(CERS1) 426879(CERS5) 428318(CERS4L) 771503(CERS6)
MGP: 100539644 100544401(CERS6) 100547857(CERS1) 100550977 104912889(CERS3) 104913603(CERS5) 104914444(CERS2)
CJO: 107316742(CERS6) 107318875(CERS3) 107324560(CERS2) 107325354(CERS1) 107325374 107325633 107325704(CERS5)
APLA: 101789541(CERS5) 101790332 101790516 101794409(CERS3) 101795233(CERS2) 101797400 101804779(CERS1) 101804816(CERS6)
ACYG: 106029829(CERS6) 106036468(CERS3) 106044958 106045005(CERS4) 106047737(CERS5) 106047960(CERS1) 106049279(CERS2)
TGU: 100217479(CERS4) 100224527(CERS3) 100225623(CERS6) 100228761(CERS2) 100230030(CERS1) 100231332(CERS5)
GFR: 102032032(CERS2) 102034358 102035945(CERS1) 102036650(CERS3) 102038365(CERS5) 102041033(CERS6) 102042316
FAB: 101809766(CERS1) 101812995(CERS4) 101816156(CERS5) 101818464(CERS3) 101818852(CERS6)
PHI: 102104999(CERS3) 102105767 102105774(CERS5) 102106078(CERS2) 102107684(CERS1) 102111990(CERS6) 102114515
PMAJ: 107199043(CERS1) 107207352(CERS6) 107209495(CERS3) 107214659(CERS2) 107215358 107215532 107215686(CERS5)
CCAE: 111932124(CERS6) 111934002(CERS3) 111939476(CERS2) 111940267(CERS1) 111940438(CERS4) 111940456 111940481(CERS5)
CCW: 104683743(CERS5) 104683905(CERS3) 104694173(CERS6) 104696921 104696922 104697388(CERS1)
FPG: 101913508(CERS5) 101915529(CERS3) 101919852(CERS2) 101920423(CERS6) 101922241 101923637(CERS1)
FCH: 102046386(CERS1) 102047202 102049480(CERS2) 102052030(CERS5) 102052115(CERS6) 102054381(CERS3)
CLV: 102084875 102089975(CERS6) 102090020(CERS3) 102090443(CERS5) 102098532(CERS1)
EGZ: 104122870(CERS3) 104126317(CERS4) 104127999(CERS6) 104129703(CERS2) 104129784(CERS1) 104132784(CERS5)
AAM: 106490998 106495414(CERS2) 106495821(CERS3) 106497727(CERS4) 106499105(CERS6) 106499436(CERS5)
ASN: 102368101 102380256(CERS6) 102383180(CERS2) 102383725(CERS5) 102384359(CERS1) 102388749(CERS3)
AMJ: 102562554(CERS6) 102563913(CERS1) 102569929(CERS5) 102575439(CERS3) 102575869(CERS2) 102576734(CERS4)
PSS: 102445918(CERS2) 102447507(CERS4) 102449546(CERS1) 102452005(CERS5) 102452581(CERS3) 102460649(CERS6)
CMY: 102929497(CERS2) 102935204(CERS1) 102935736(CERS6) 102939527(CERS5) 102939917(CERS3) 102942007
CPIC: 101932603(CERS2) 101938783(CERS5) 101945509 101945790 101947382(CERS6) 101947682(CERS3) 103305686(CERS1)
ACS: 100552770(cers5) 100554835(cers3) 100563712(cers6) 100565999(cers2)
PVT: 110072464(CERS4) 110072532(CERS1) 110072978(CERS3) 110074286(CERS5) 110076893(CERS6) 110081442(CERS2)
PBI: 103050325(CERS5) 103050368 103052023 103052910(CERS2) 103062842(CERS6) 103067220(CERS3) 103067620(CERS1)
XLA: 108699337 108700334 108701361 108702983 108703695(cers1.S) 108713514(cers1.L) 379135(cers3.L) 399185(trh4) 444162(cers3.S) 495501(cers5.S)
XTR: 100036728(cers2) 100101657(cers5) 100379773(cers4) 100485129(cers1) 100489264(cers6) 448139(cers3)
NPR: 108789800(CERS2) 108789979(CERS5) 108790075(CERS3) 108792262 108796582(CERS1) 108796981(CERS6)
DRE: 100330155(cers4b) 259251(cers2a) 323020(cers5) 564867(cers6) 568169(cers1)
IPU: 100304753 100528482(cers1) 108255109(cers5) 108264168 108266969(cers6) 108271085(cers3) 108271250(cers4) 108272661(cers2) 108280569
LCM: 102345762(CERS5) 102351990(CERS1) 102354959(CERS6) 102356427(CERS2) 102362821(CERS4) 102365974(CERS3)
CMK: 103172411 103176381(cers6) 103181964(cers1) 103183569(cers4) 103187682(cers3) 103190303(cers5)
CIN: 100101810(lag1-like3) 100184115 778663(lag1-like1)
DME: Dmel_CG3576(schlank)
DER: 6551335
DPE: 6603077
DSI: Dsimw501_GD28007(Dsim_GD28007)
DWI: 6648628
MDE: 101890389
AAG: 5571461
AME: 727350
BIM: 100742830
BTER: 100650450
AEC: 105147584
ACEP: 105623188
PBAR: 105429305
HST: 105190345
DQU: 106748799
CFO: 105251260
LHU: 105679186
PGC: 109859190
NVI: 100124217(Lag1)
MDL: 103573253
DPA: 109544248
NVL: 108563163
PXY: 105391568
DNX: 107162818
CLEC: 106662291
ZNE: 110827521
CEL: CELE_C09G4.1(hyl-1) CELE_K02G10.6(hyl-2) CELE_Y6B3B.10(lagr-1)
CBR: CBG13635(Cbr-lagr-1) CBG14524(Cbr-hyl-2) CBG15635(Cbr-hyl-1)
BMY: Bm1_06625
SHX: MS3_08053
GMX: 100780212
VRA: 106767204
VAR: 108343571
LJA: Lj0g3v0091289.3(Lj0g3v0091289.3) Lj0g3v0223069.1(Lj0g3v0223069.1) Lj2g3v1197780.1(Lj2g3v1197780.1) Lj2g3v1197780.2(Lj2g3v1197780.2) Lj4g3v0586760.1(Lj4g3v0586760.1)
PAVI: 110757744
CSV: 101216753
CMO: 103503576
CMAX: 111489698
CMOS: 111445656
CPEP: 111808002
RCU: 8264575
JCU: 105650613
SIND: 105161648
BVG: 104896289
OBR: 102701019
BDI: 100842490
ATS: 109746855(LOC109746855) 109758794(LOC109758794) 109763657(LOC109763657) 109770111(LOC109770111) 109780339(LOC109780339) 109787032(LOC109787032)
SBI: 8065380
ZMA: 100282996
SITA: 101782546
MIS: MICPUN_107343(LAG1)
SCE: YHL003C(LAG1) YKL008C(LAC1)
KMX: KLMA_30063(LAG1) KLMA_80123(lag1)
NCS: NCAS_0A05070(NCAS0A05070) NCAS_0F00970(NCAS0F00970)
NDI: NDAI_0H01460(NDAI0H01460) NDAI_0K02120(NDAI0K02120)
TPF: TPHA_0C04030(TPHA0C04030) TPHA_0G03260(TPHA0G03260)
TBL: TBLA_0B05480(TBLA0B05480) TBLA_0I00240(TBLA0I00240)
TDL: TDEL_0A02770(TDEL0A02770)
KAF: KAFR_0A01800(KAFR0A01800) KAFR_0D03370(KAFR0D03370)
PIC: PICST_32904(LAG1.1) PICST_41505(LAG1.2) PICST_45900(LAG1.3)
SLB: AWJ20_1430(LAG1) AWJ20_4551(LAG1)
NTE: NEUTE1DRAFT150581(NEUTE1DRAFT_150581) NEUTE1DRAFT81502(NEUTE1DRAFT_81502)
ANG: ANI_1_1620094(An11g00990) ANI_1_194184(An04g00600) ANI_1_2320184(An04g10300)
SPO: SPAC1A6.09c(lag1) SPBC3E7.15c(lac1)
ABP: AGABI1DRAFT106395(AGABI1DRAFT_106395) AGABI1DRAFT113528(AGABI1DRAFT_113528)
ABV: AGABI2DRAFT191824(AGABI2DRAFT_191824)
MGL: MGL_3614
DDI: DDB_G0282607(crsA)
DFA: DFA_08234(crsA)
PYO: PY17X_1040700(PY00812)
SMIN: v1.2.016704.t1(symbB.v1.2.016704.t1) v1.2.016704.t2(symbB.v1.2.016704.t2) v1.2.031003.t1(symbB.v1.2.031003.t1)
 » show all
Taxonomy
Reference
1  [PMID:5973195]
  Authors
Sribney M.
  Title
Enzymatic synthesis of ceramide.
  Journal
Biochim Biophys Acta 125:542-7 (1966)
DOI:10.1016/0005-2760(66)90042-7
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.24
IUBMB Enzyme Nomenclature: 2.3.1.24
ExPASy - ENZYME nomenclature database: 2.3.1.24
BRENDA, the Enzyme Database: 2.3.1.24
CAS: 37257-09-3

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