KEGG   ENZYME: 2.3.1.24Help
Entry
EC 2.3.1.24                 Enzyme                                 

Name
sphingosine N-acyltransferase;
ceramide synthetase;
sphingosine acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:sphingosine N-acyltransferase
Reaction(IUBMB)
acyl-CoA + sphingosine = CoA + a ceramide [RN:R01496]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
sphingosine [CPD:C00319]
Product
CoA [CPD:C00010];
ceramide [CPD:C00195]
Comment
Acts on sphingosine or its 2-epimer.
History
EC 2.3.1.24 created 1972
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04709  Acyl-CoA-dependent ceramide synthase
K04710  ceramide synthetase
Genes
HSA: 10715(CERS1) 204219(CERS3) 29956(CERS2) 79603(CERS4)
PTR: 453683(CERS3) 456435(CERS4) 468773(CERS1) 469482(CERS2)
PPS: 100968130(CERS1) 100973710(CERS4) 100973768(CERS2) 100994802(CERS3)
GGO: 101128445(CERS3) 101148109(CERS2) 109024075(CERS1)
PON: 100174286(CERS2) 100437726(CERS4) 100447528(CERS1) 100451535(CERS3)
NLE: 100579482(CERS4) 100581669(CERS2) 100583004(GDF1) 100590821(CERS3)
MCC: 106994665(CERS1) 693696(CERS3) 706728(CERS4) 716180(CERS2)
MCF: 101926302(CERS4) 102116814(CERS2) 102143963(CERS3) 107128159(CERS1)
CSAB: 103231276(CERS3) 103234393(CERS1) 103247210(CERS2)
RRO: 104676807(CERS3) 104680635(CERS1) 104681063(CERS2) 104682288(CERS4)
RBB: 108512618(CERS3) 108515632(CERS1) 108533256(CERS2) 108534518(CERS4)
CJC: 100406591(CERS3) 100412093(CERS2) 100414013(CERS4) 103789832(CERS1)
SBQ: 101037762(CERS4) 101041201(CERS1) 101042956(CERS3) 101043514(CERS2)
MMU: 545975(Cers3) 67260(Cers4) 76893(Cers2) 93898(Cers1)
MCAL: 110291523(Cers2) 110299355(Cers3) 110299631(Cers1) 110299943(Cers4)
MPAH: 110320738(Cers2) 110333640(Cers3) 110336399(Cers4) 110336871(Cers1)
RNO: 290658(Cers1) 304208(Cers4) 310667(Cers2) 499174(Cers3)
MUN: 110546438(Cers3) 110549168(Cers1) 110560786(Cers2)
CGE: 100758196(Cers4) 100765511(Cers1) 100765986(Cers2) 100770521(Cers3)
NGI: 103726528(Cers4) 103726856(Cers1) 103730090(Cers2) 103747188(Cers3)
HGL: 101702770(Cers3) 101705418(Cers1) 101715336(Cers4) 101716285(Cers2)
CCAN: 109681206(Cers2) 109684934(Cers1) 109698441(Cers4) 109700448(Cers3)
OCU: 100337851(CERS3) 100352973(CERS4)
TUP: 102475021(CERS3) 102475765(CERS1) 102495526(CERS4) 102502685(CERS2)
CFA: 483187(CERS2) 485008(CERS4) 607925(CERS3) 609789(CERS1)
VVP: 112907770(CERS2) 112909651(CERS4) 112913073(CERS1) 112923446(CERS3)
AML: 100466254(CERS3) 100475918(CERS4) 100478537(CERS1) 100481999(CERS2)
UMR: 103659988(CERS3) 103667533(CERS2) 103675149(CERS1) 103681884(CERS4)
UAH: 113242908(CERS4) 113246156(CERS2) 113256735(CERS1) 113263637(CERS3)
ORO: 101372787(CERS2) 101379762(CERS4) 101380694(CERS1) 101381953(CERS3)
FCA: 101089084(CERS1) 101093918(CERS4) 101094362(CERS2) 101099301(CERS3)
PTG: 102961418(CERS1) 102968533(CERS3) 102970444(CERS2) 102972870(CERS4)
PPAD: 109247644(CERS1) 109254210(CERS4) 109257029(CERS2) 109273347(CERS3)
AJU: 106969135(CERS1) 106970780(CERS4) 106972088(CERS3) 106979828(CERS2)
BTA: 505233(CERS4) 539223(CERS2) 614354(CERS3) 615296(CERS1)
BOM: 102264858(CERS2) 102269743(CERS1) 102275684(CERS4) 102282323(CERS3)
BIU: 109555312(CERS2) 109560813(CERS1) 109561659(CERS4) 109575125(CERS3)
BBUB: 102400914(CERS4) 102401086(CERS1) 102405478(CERS3) 102409179(CERS2)
CHX: 102169911(CERS3) 102174737(CERS4) 102182556(CERS2) 102189571(CERS1)
OAS: 101102559(CERS4) 101107095(CERS1) 101109498(CERS2) 101110093(CERS3)
SSC: 100127167(CERS4) 100152265(CERS3) 100156737(CERS2) 100525450(CERS1)
CFR: 102505196(CERS3) 102507344(CERS1) 102511821(CERS2) 102519510(CERS4)
CDK: 105087579(CERS4) 105093450(CERS3) 105101886(CERS1) 105103195(CERS2)
BACU: 103003098(CERS1) 103009608(CERS2) 103009742(CERS4) 103016103(CERS3)
LVE: 103069846(CERS4) 103076923(CERS2) 103082414(CERS3) 103091398(CERS1)
OOR: 101271239(CERS2) 101273399(CERS1) 101287722(CERS3) 101289498(CERS4)
DLE: 111165990(CERS4) 111166519(CERS1) 111169745(CERS2) 111187344(CERS3)
PCAD: 102975484(CERS3) 102977839(CERS1) 102982142(CERS2) 102991761(CERS4)
ECB: 100050135(CERS3) 100055037(CERS2) 100066949(CERS4) 100069594(CERS1)
EPZ: 103543133(CERS4) 103547641(CERS2) 103561069(CERS3) 103565074(CERS1)
EAI: 106839474(CERS3) 106844495(CERS4) 106846409(CERS1) 106846528(CERS2)
MYB: 102242969(CERS3) 102249252(CERS1) 102250642(CERS4) 102256999(CERS2)
MYD: 102759130(CERS3) 102767770(CERS4) 102769776(CERS1) 102772826(CERS2)
MNA: 107527642(CERS3) 107529900(CERS4) 107535343(CERS1) 107539131(CERS2)
HAI: 109372275(CERS2) 109380354(CERS3) 109382399(CERS1) 109396095(CERS4)
DRO: 112305215(CERS1) 112305258(CERS4) 112306075(CERS3) 112313815(CERS2)
PALE: 102885878(CERS1) 102885951(CERS2) 102889613(CERS3) 102890907(CERS4)
RAY: 107499037(CERS2) 107503723(CERS1) 107515791(CERS3) 107519920(CERS4)
MJV: 108386501(CERS3) 108387090(CERS4) 108406026(CERS1) 108409468(CERS2)
LAV: 100667031(CERS1) 100671292(CERS3) 100673086(CERS2) 100674671(CERS4)
MDO: 100014952(CERS2) 100016686(CERS1) 100020588(CERS3) 100025505
OAA: 100078502(CERS1) 100090289(CERS4) 100090484(CERS3) 100091312(CERS2)
GGA: 100859441(CERS2) 420050(CERS4) 420118(CERS1) 428318(CERS4L)
MGP: 100539644 100547857(CERS1) 100550977 104912889(CERS3) 104914444(CERS2)
CJO: 107318875(CERS3) 107324560(CERS2) 107325354(CERS1) 107325374 107325633
NMEL: 110388870(CERS1) 110388988 110389062 110403582(CERS3)
APLA: 101790332 101790516 101794409(CERS3) 101795233(CERS2) 101804779(CERS1)
ACYG: 106036468(CERS3) 106044958 106045005(CERS4) 106047960(CERS1) 106049279(CERS2)
TGU: 100217479(CERS4) 100223140(CERS3) 100228761(CERS2) 100230030(CERS1)
LSR: 110469450(CERS4) 110476809(CERS2) 110478333(CERS1) 110482993(CERS3)
GFR: 102032032(CERS2) 102034358 102035945(CERS1) 102036650(CERS3) 102042316
FAB: 101809766(CERS1) 101812995(CERS4) 101818464(CERS3)
PHI: 102104999(CERS3) 102105767 102106078(CERS2) 102107684(CERS1) 102114515
PMAJ: 107199043(CERS1) 107209495(CERS3) 107214659(CERS2) 107215358 107215532
CCAE: 111934002(CERS3) 111939476(CERS2) 111940267(CERS1) 111940438(CERS4) 111940456
FPG: 101915529(CERS3) 101919852(CERS2) 101922241 101923637(CERS1)
FCH: 102046386(CERS1) 102047202 102049480(CERS2) 102054381(CERS3)
CLV: 102084875 102090020(CERS3) 102098532(CERS1)
EGZ: 104122870(CERS3) 104126317(CERS4) 104129703(CERS2) 104129784(CERS1)
NNI: 104013688(CERS1) 104014462(CERS2) 104017067(CERS3) 104022916(CERS4)
ACUN: 113484146(CERS3) 113489365(CERS1) 113489464 113489465
PADL: 103914771(CERS3) 103916058 103916087 103923274(CERS1)
AAM: 106490998 106495414(CERS2) 106495821(CERS3) 106497727(CERS4)
ASN: 102368101 102383180(CERS2) 102384359(CERS1) 102388749(CERS3)
AMJ: 102563913(CERS1) 102575439(CERS3) 102575869(CERS2) 102576734(CERS4)
PSS: 102445918(CERS2) 102447507(CERS4) 102449546(CERS1) 102452581(CERS3)
CMY: 102929497(CERS2) 102935204(CERS1) 102939917(CERS3)
CPIC: 101932603(CERS2) 101945509 101945790 101947682(CERS3) 103305686(CERS1)
ACS: 100554835(cers3) 100565999(cers2)
PVT: 110072464(CERS4) 110072532(CERS1) 110072978(CERS3) 110081442(CERS2)
PBI: 103050368 103052910(CERS2) 103067220(CERS3) 103067620(CERS1)
PMUR: 107282886(CERS1) 107283879(CERS3) 107291598 107292912(CERS2) 107302088
TSR: 106543865(CERS1) 106544882
PMUA: 114584561 114586234(CERS2) 114588341(CERS4) 114588648(CERS1)
XLA: 108699337 108700334 108703695(cers1.S) 108713514(cers1.L) 379135(cers3.L) 444162(cers3.S)
XTR: 100036728(cers2) 100379773(cers4) 100485129(cers1) 448139(cers3)
NPR: 108789800(CERS2) 108790075(CERS3) 108792262 108796582(CERS1)
DRE: 100330155(cers4b) 259251(cers2a) 568169(cers1)
CSEM: 103378927(cers3) 103388281 103393467(cers1) 103393881
LCM: 102351990(CERS1) 102356427(CERS2) 102362821(CERS4) 102365974(CERS3)
CMK: 103181964(cers1) 103183569(cers4) 103187682(cers3)
CIN: 100101810(lag1-like3) 100184115
SPU: 592336
TUT: 107366570
CSCU: 111612809
CEL: CELE_Y6B3B.10(lagr-1)
CBR: CBG13635(Cbr-lagr-1)
TSP: Tsp_14433
LAK: 106174562
SHX: MS3_08053
EPA: 110240089
ADF: 107340796
AMIL: 114966382
DGT: 114522828
HMG: 100215789
SCE: YHL003C(LAG1) YKL008C(LAC1)
KMX: KLMA_30063(LAG1) KLMA_80123(lag1)
NCS: NCAS_0A05070(NCAS0A05070) NCAS_0F00970(NCAS0F00970)
NDI: NDAI_0H01460(NDAI0H01460) NDAI_0K02120(NDAI0K02120)
TPF: TPHA_0C04030(TPHA0C04030) TPHA_0G03260(TPHA0G03260)
TBL: TBLA_0B05480(TBLA0B05480) TBLA_0I00240(TBLA0I00240)
TDL: TDEL_0A02770(TDEL0A02770)
KAF: KAFR_0A01800(KAFR0A01800) KAFR_0D03370(KAFR0D03370)
PIC: PICST_32904(LAG1.1) PICST_41505(LAG1.2) PICST_45900(LAG1.3)
SLB: AWJ20_1430(LAG1) AWJ20_4551(LAG1)
NTE: NEUTE1DRAFT150581(NEUTE1DRAFT_150581) NEUTE1DRAFT81502(NEUTE1DRAFT_81502)
ANG: ANI_1_1620094(An11g00990) ANI_1_194184(An04g00600) ANI_1_2320184(An04g10300)
SPO: SPAC1A6.09c(lag1) SPBC3E7.15c(lac1)
ABP: AGABI1DRAFT106395(AGABI1DRAFT_106395) AGABI1DRAFT113528(AGABI1DRAFT_113528)
ABV: AGABI2DRAFT191824(AGABI2DRAFT_191824)
MGL: MGL_3614
 » show all
Taxonomy
Reference
1  [PMID:5973195]
  Authors
Sribney M.
  Title
Enzymatic synthesis of ceramide.
  Journal
Biochim Biophys Acta 125:542-7 (1966)
DOI:10.1016/0005-2760(66)90042-7
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.24
IUBMB Enzyme Nomenclature: 2.3.1.24
ExPASy - ENZYME nomenclature database: 2.3.1.24
BRENDA, the Enzyme Database: 2.3.1.24
CAS: 37257-09-3

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