KEGG ENZYME: 2.3.1.242

ENZYME: 2.3.1.242

Entry

EC 2.3.1.242                Enzyme

Name

Kdo2-lipid IVA palmitoleoyltransferase;
LpxP;
palmitoleoyl-acyl carrier protein-dependent acyltransferase;
cold-induced palmitoleoyl transferase;
palmitoleoyl-[acyl-carrier protein]:Kdo2-lipid IVA O-palmitoleoyltransferase;
(Kdo)2-lipid IVA palmitoleoyltransferase;
alpha-Kdo-(2->4)-alpha-(2->6)-lipid IVA palmitoleoyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

(9Z)-hexadec-9-enoyl-[acyl-carrier protein]:Kdo2-lipid IVA O-palmitoleoyltransferase

Reaction(IUBMB)

a (9Z)-hexadec-9-enoyl-[acyl-carrier protein] + Kdo2-lipid IVA = (9Z)-hexadec-9-enoyl-Kdo2-lipid IVA + an [acyl-carrier protein] [RN:R10906]

Reaction(KEGG)

R10906

Substrate

(9Z)-hexadec-9-enoyl-[acyl-carrier protein] [CPD:C16520];
Kdo2-lipid IVA [CPD:C06025]

Product

(9Z)-hexadec-9-enoyl-Kdo2-lipid IVA [CPD:C20933];
[acyl-carrier protein] [CPD:C00229]

Comment

The enzyme, characterized from the bacterium Escherichia coli, is induced upon cold shock and is involved in the formation of a cold-adapted variant of the outer membrane glycolipid lipid A.

History

EC 2.3.1.242 created 2014

Pathway

ec00540

Lipopolysaccharide biosynthesis

Orthology

K12974

KDO2-lipid IV(A) palmitoleoyltransferase

Genes

ECO:	b2378(lpxP)

ECJ:	JW2375(ddg)

ECD:	ECDH10B_2543(lpxP)

EBW:	BWG_2146(lpxP)

ECOK:

ECMDS42_1935(ddg)

ECOC:

C3026_13225

ECE:	Z3643(ddg)

ECS:	ECs_3258(lpxP)

ECF:	ECH74115_3609

ETW:	ECSP_3327(lpxP)

ELX:	CDCO157_3022

EOI:	ECO111_3114(ddg)

EOJ:	ECO26_3438(ddg)

EOH:	ECO103_2903(ddg)

ECOO:

ECRM13514_3202(ddg)

ECOH:

ECRM13516_3064(ddg)

ESL:

O3K_07480

ESO:

O3O_18155

ESM:

O3M_07530

ECK:	EC55989_2674(ddg)

ECG:	E2348C_2571(lpxP)

EOK:	G2583_2911(lpxP)

ELR:	ECO55CA74_14440

ELH:

ETEC_2497

ECW:	EcE24377A_2666

EUN:	UMNK88_2976

ECP:

ECP_2404

ENA:	ECNA114_2459(ddg)

ECOS:

EC958_4999

ECV:	APECO1_4159(ddg)

ECOA:

APECO78_15645

ECX:	EcHS_A2514

ECM:	EcSMS35_2529

ECY:

ECSE_2675

ECR:	ECIAI1_2444(ddg)

ECQ:	ECED1_2825(ddg)

EUM:	ECUMN_2708(ddg)

ECT:	ECIAI39_2522(ddg)

EOC:	CE10_2755(lpxP)

EBR:	ECB_02288(ddg)

ECOB:

C3029_16010

EBL:	ECD_02288(lpxP)

EBE:	B21_02249(lpxP)

EBD:

ECBD_1294

ECI:	UTI89_C2710(ddg)

EIH:	ECOK1_2694

ECZ:	ECS88_2573(ddg)

ECC:	c2915(ddg)

ELO:	EC042_2597(lpxP)

ELN:	NRG857_11950

ESE:

ECSF_2248

ECL:	EcolC_1291

EKO:	EKO11_1340

EKF:	KO11_10870(lpxP)

EAB:	ECABU_c26980

EDH:	EcDH1_1279

EDJ:	ECDH1ME8569_2317(ddg)

ELU:	UM146_04710

ELW:	ECW_m2611(lpxP)

ELL:	WFL_12810(lpxP)

ELC:	i14_2712(ddg)

ELD:	i02_2712(ddg)

ELP:	P12B_c2496

ELF:	LF82_1232(lpxP)

ECOL:

LY180_12260

ECOI:

ECOPMV1_02582(htrB_2)

ECOJ:

P423_13220

EFE:	EFER_0790(ddg)

EAL:	EAKF1_ch3621c

EMA:	C1192_23570

ESZ:	FEM44_01935(lpxP)

ERUY:

OSH18_19555(lpxP)

STY:

STY2639

STT:

t0457

SEX:	STBHUCCB_4920

SENT:

TY21A_02330

STM:	STM2401(ddg)

SEO:	STM14_2953(ddg)

SEV:	STMMW_24241

SEY:	SL1344_2369(lpxP)

SEM:	STMDT12_C24240

SEJ:	STMUK_2432(ddg)

SEB:	STM474_2501(ddg)

SEF:	UMN798_2592

SETU:

STU288_08395

SETC:

CFSAN001921_04770

SENR:

STMDT2_23691

SEND:

DT104_24581

SENI:

CY43_12850

SEEN:

SE451236_18220

SPT:	SPA0459(ddg)

SEK:

SSPA0426

SPQ:	SPAB_00561

SEI:	SPC_1256(ddg)

SEC:	SCH_2402(ddg)

SENH:

CFSAN002069_19770

SEEH:

SEEH1578_21340

SENN:

SN31241_35100

SENS:

Q786_11860

SEG:	SG2437(ddg)

SEL:	SPUL_0478(ddg)

SEGA:

SPUCDC_0478(ddg)

SET:	SEN2387(ddg)

SENA:

AU38_12080

SENO:

AU37_12095

SENV:

AU39_12095

SENQ:

AU40_13540

SENL:

IY59_12415

SENJ:

CFSAN001992_21580

SEEC:

CFSAN002050_18945

SEEB:

SEEB0189_007560

SEEP:

I137_02185

SENB:

BN855_24890

SENE:

IA1_11985

SENC:

SEET0819_19450

SES:	SARI_00489

SBG:

SBG_2203

SBZ:

A464_2528

SBV:	N643_10670

SALZ:

EOS98_07000

SFL:	SF2444(ddg)

SFX:	S2582(ddg)

SFV:	SFV_2436(ddg)

SFE:	SFxv_2690(lpxP)

SFN:

SFy_3466

SFS:

SFyv_3541

SFT:	NCTC1_02681(ddg)

SSN:	SSON_2469(ddg)

SBO:	SBO_2404(ddg)

SBC:	SbBS512_E2746

SDY:	SDY_2576(ddg)

SDZ:	Asd1617_03471

SHQ:	A0259_15645

ENC:

ECL_03721

ENL:	A3UG_16330

ECLG:

EC036_31780

ECLE:

ECNIH2_16305

ECLN:

ECNIH4_06850

ECLI:

ECNIH5_15240

ECLX:

LI66_15645

ECLY:

LI62_17145

ECLZ:

LI64_15075

EHM:	AB284_09775

EXF:	BFV63_15465

ECLA:

ECNIH3_15335

ECLC:

ECR091_15270

EAU:	DI57_03325

EKB:	BFV64_16010

ENO:	ECENHK_15900

EEC:	EcWSU1_03221(lpxP)

ELG:	BH714_12245 BH714_17305

ECAN:

CWI88_06455

ERN:	BFV67_15785

ECLS:

LI67_017170

ECHG:

FY206_17635(lpxP)

ESH:	C1N69_16155

EPT:	HWQ17_01755(lpxP) HWQ17_20080(lpxP)

ENT:	Ent638_2917

EAS:	Entas_3123

ENR:	H650_04190

ENX:	NI40_009845 NI40_015920

ENF:	AKI40_2835

LNI:	CWR52_19125

EBG:	FAI37_13170(lpxP)

END:	A4308_20560

ENZ:	G0034_16510(lpxP)

ENS:	HWQ15_01225(lpxP)

ENK:	LOC22_03785(lpxP)

EHU:	D5067_0006845(lpxP)

EMOR:

L6Y89_15465(lpxP)

ENB:	ELK40_16305

EQU:	OM418_15770(lpxP)

EPU:	QVH39_16545(lpxP)

EDY:	F0320_15435(lpxP)

ESA:

ESA_02951

CSK:	ES15_3030(lpxP)

CSZ:	CSSP291_14045

CSJ:	CSK29544_04229

CCON:

AFK62_04695

CDM:	AFK67_04645

CSI:	P262_04376

CMJ:	AFK66_015090

CUI:	AFK65_04615

CMW:	AFK63_13990

CTU:	CTU_09250(ddg)

KPN:

KPN_01167

KPU:

KP1_2185

KPM:	KPHS_20470

KPP:

A79E_3023

KPH:	KPNIH24_18350

KPZ:	KPNIH27_10030

KPV:	KPNIH29_10540

KPW:	KPNIH30_10725

KPY:	KPNIH31_10155

KPG:	KPNIH32_10565

KPC:	KPNIH10_10180

KPQ:	KPR0928_10350

KPT:	VK055_1295(lpxL)

KPO:	KPN2242_08945

KPR:	KPR_2210 KPR_2211

KPJ:

N559_3127

KPI:	D364_06060

KPA:	KPNJ1_03359

KPS:	KPNJ2_03351

KPX:	PMK1_03505(htrB_3)

KPB:	FH42_01645

KPNE:

KU54_015935

KPNU:

LI86_16245

KPNK:

BN49_2301

KVA:

Kvar_3191

KPE:	KPK_3319 KPK_4958(lpxL)

KPK:	A593_20375 A593_25930

KVD:	KR75_18225 KR75_27095

KVQ:	SP68_24685

KQU:	AVR78_15160

KQV:	B8P98_16545

KOX:	KOX_02260 KOX_17880

KOE:

A225_2433

KOY:	J415_19915

KOM:	HR38_16170

KMI:	VW41_04510

KOK:	KONIH1_11675

KOC:	AB185_24520

EAE:	EAE_20940 EAE_21810

EAR:

CCG29572

KLL:	BJF97_12270

KLW:	DA718_16845

KAR:	LGL98_15365(lpxP)

KGR:	JJJ10_16855(lpxP)

KPAS:

LUW96_18250(lpxP)

KLC:	K7H21_06570(lpxP) K7H21_16610(lpxP)

KLM:	BWI76_10115 BWI76_11405

REE:	electrica_03052(htrB_1)

KLP:	GUC22_15855(lpxP)

ROR:	RORB6_08800

RON:	TE10_11765

RPLN:

B1209_16180

RAO:	DSD31_15385

RTG:	NCTC13098_04341(htrB_1)

CRO:	ROD_27921(lpxP)

CKO:

CKO_00422

CFD:	CFNIH1_23325

CBRA:

A6J81_24460

CWE:	CO701_05975

CYO:	CD187_07375 CD187_18990

CPOT:

FOB25_18540(lpxP)

CFQ:	C2U38_17625

CSED:

JY391_07110(lpxP)

CAMA:

F384_13225

CAF:	AL524_10215

CIF:	AL515_16195

CFAR:

CI104_17940

CIR:	C2U53_28170

CIE:	AN232_11825

CPAR:

CUC49_12255

CTEL:

GBC03_12085(lpxP) GBC03_19165(lpxP)

CITZ:

E4Z61_00660(lpxP)

CARS:

E1B03_18840(lpxP)

CIX:	M4I31_07235(lpxP)

CIB:	HF677_007135(lpxP)

CENS:

P2W74_07020(lpxP)

CITR:

GUC46_07135(lpxP)

EBT:	EBL_c23630

CNT:	JT31_07790

CEM:	LH23_09930

CEN:	LH86_09990

CLAP:

NCTC11466_03588(htrB_2)

PGE:	LG71_15375

ESC:	Entcl_2116

KLE:	AO703_11605

KSA:	C813_04810

KOR:	AWR26_13805(lpxP) AWR26_14285(lpxP)

KRD:	A3780_09615 A3780_10085

KCO:	BWI95_15280 BWI95_22145

KOT:	EH164_12710

KPSE:

IP581_10025(lpxP)

KOB:	HF650_10385(lpxP)

KOO:	O9K67_14020(lpxP)

KOU:	C0557_10400

KCA:	AAEY27_12585(lpxP)

KIE:	NCTC12125_00960(htrB_1)

KAS:	KATP_17780(lpxP)

KLU:	K7B04_19570(lpxP)

KCY:	RIN60_09235(lpxP)

LAX:	APT61_06500

LEI:	C2U54_21535

LEH:	C3F35_18490

LEE:	DVA44_06615

LER:	GNG29_16145(lpxP)

LEA:	GNG26_15990(lpxP)

LPNU:

KQ929_05665(lpxP)

LEY:	DVA43_01345

LAZ:	A8A57_15025

LEF:	LJPFL01_2962

LEW:	DAI21_11630

BUF:	D8682_10695

BAGE:

BADSM9389_32830

BFT:	MNO13_19360(lpxP)

BSEL:

RHD99_19305(lpxP)

SYM:	K6K13_10925(lpxP)

AHN:	NCTC12129_02526(ddg)

ASUB:

NLZ15_10825(lpxP)

YRE:	HEC60_07835(lpxP)

SGOE:

A8O29_010270(lpxP)

KIN:	AB182_10360

PDZ:	HHA33_12995(lpxP)

METY:

MRY16398_23250(lpxP)

IZH:	FEM41_10605(lpxP)

PSGC:

G163CM_08290(lpxP)

SCOL:

KFZ77_11180(lpxP)

PVJ:	LMA04_03535(lpxP)

SUPE:

P0H77_11900(lpxP)

TOE:	QMG90_12795(lpxP)

MPHG:

MPHASIOC01_002886(lpxP) MPHASIOC01_003061(lpxP)

EBF:

D782_1803

EBC:	C2U52_20950

EBU:	CUC76_05125

EBB:

F652_2355

PSTS:

E05_06240

YPE:	YPO3632(ddg)

YPK:	y0236(ddg)

YPH:

YPC_4380

YPA:

YPA_3645

YPN:

YPN_3538

YPM:	YP_3915(ddg)

YPP:	YPDSF_0239

YPG:	YpAngola_A1232(htrB2)

YPZ:

YPZ3_3121

YPT:	A1122_07575

YPD:

YPD4_3109

YPX:

YPD8_3216

YPW:	CH59_2387(lpxL)

YPJ:	CH55_2569(lpxL)

YPV:	BZ15_4076(lpxL)

YPL:	CH46_1427(lpxL)

YPS:	YPTB3597(ddg)

YPO:	BZ17_3003(lpxL)

YPI:	YpsIP31758_0361(htrB2)

YPY:

YPK_0430

YPB:

YPTS_3787

YPQ:	DJ40_2816(lpxL)

YPU:	BZ21_2925(lpxL)

YPR:	BZ20_2517(lpxL)

YPC:	BZ23_3197(lpxL)

YPF:	BZ19_3062(lpxL)

YEN:	YE3829(ddg)

YEP:	YE105_C3546

YEY:

Y11_27341

YEW:	CH47_3967(lpxL)

YET:	CH48_2072(lpxL)

YEF:	FORC2_0357

YEE:	YE5303_01031(ddg)

YSI:	BF17_05605

YAL:	AT01_2110(lpxL)

YFR:	AW19_2837(lpxL)

YIN:	CH53_2176(lpxL)

YKR:	CH54_2951(lpxL)

YRO:	CH64_2252(lpxL)

YRU:	BD65_1562(lpxL)

YRB:	UGYR_08345

YAK:	ACZ76_07110

YMA:	DA391_01705

YHI:	D5F51_20275

YEL:	LC20_00553

YCA:	F0T03_19730(lpxP)

YMO:	HRD69_03355(lpxP)

YAS:	N0H69_05035(lpxP)

YKI:	HRD70_02395(lpxP)

YEG:	PL78_10795

SMAR:

SM39_3882(lpxP)

SMAC:

SMDB11_3678(lpxP)

SMW:	SMWW4_v1c43920(lpxP)

SPE:

Spro_4425

SRR:	SerAS9_4529

SRL:	SOD_c42360(lpxP)

SRY:	M621_23130

SPLY:

Q5A_023075(lpxP)

SRS:	SerAS12_4530

SRA:	SerAS13_4530

SMAF:

D781_4156

SLQ:	M495_22290

SERF:

L085_06260

SERS:

SERRSCBI_21205

SFW:	WN53_05280

SFG:	AV650_00640 AV650_27480

SRZ:	AXX16_0993

SERM:

CLM71_21365

SQU:	E4343_18655(lpxP)

SFJ:	SAMEA4384070_4388(htrB_2)

SOF:	NCTC11214_02250(htrB_2)

SSUR:

ATE40_018470

SURI:

J0X03_02160(lpxP)

SRHZ:

FO014_12260(lpxP)

SENP:

KHA73_21415(lpxP)

SNEM:

NLX84_02345(lpxP) NLX84_22485(lpxP)

SNEV:

OI978_08900(lpxP)

SGRI:

SGBXF1_04370(htrB_2)

SSAR:

SSARUM_004291(lpxP)

SERB:

QEP77_00285(lpxP)

SFO:	Z042_09485

RAH:	Rahaq_4028

RACE:

JHW33_14465(lpxP)

RAQ:	Rahaq2_4132

RAA:

Q7S_20470

ROX:	BV494_18830

RVC:	J9880_05605(lpxP)

RBON:

QNM34_20480(lpxP)

RIU:	I2123_21750(lpxP)

GQU:	AWC35_13855 AWC35_16440

EAME:

GXP68_18825(lpxP)

RBAD:

H2866_09930(lpxP)

RCB:	O1V66_15435(lpxP)

CARU:

P0E69_18015(lpxP)

NIG:	C1N62_15570

SERA:

Ser39006_021495

SERQ:

CWC46_21505

PROD:

PCO85_03960(lpxP)

ECA:	ECA0781(ddg)

PATR:

EV46_03425

PATO:

GZ59_06870(ddg)

PCT:

PC1_0655

PCC:	PCC21_006860

PCV:	BCS7_03340 BCS7_13145

PWA:	Pecwa_0886

PPAR:

A8F97_14495

PEC:

W5S_0778

PWS:	A7983_11860

PPOA:

BJK05_20325

PBRA:

B5S52_18270

PPUJ:

E2566_03825(lpxP)

PARI:

I2D83_18380(lpxP)

PAQU:

DMB82_0003970(lpxP) DMB82_0007970(lpxL)

PVZ:	OA04_07680(lpxP) OA04_16160(htrB)

PPAV:

LOZ86_04190(lpxP)

PQU:	IG609_003390(lpxP) IG609_007375(lpxL)

PPOO:

LW347_03670(lpxP)

PCAC:

OI450_15840(lpxP)

PACB:

M9782_05920(lpxP) M9782_16060(lpxP)

PARL:

PEC302110_06950(lpxP)

PPEU:

DUT67_18460(lpxP)

DDD:	Dda3937_02265(ddg)

DZE:	Dd1591_3380

DDC:	Dd586_0679

DZC:	W909_03580

DSO:	A4U42_12655

CED:	LH89_08750

DFN:	CVE23_03980

DDQ:

DDI_0536

DAQ:	DAQ1742_00767(lpxP)

DIC:	Dpoa569_003258(lpxP)

DLC:	O1Q98_08130(lpxP)

DDA:	Dd703_2121

BGJ:	AWC36_03655 AWC36_14830

BRB:	EH207_02725 EH207_09780(lpxL)

BNG:	EH206_07420(lpxL) EH206_18385

BIZ:	HC231_07655(lpxL) HC231_19725(lpxP)

LBQ:	CKQ53_08380 CKQ53_11750

LPOP:

I6N93_10045(lpxL) I6N93_13480(lpxP)

SGL:

SG0784

SOD:	Sant_2836(lpxP)

PES:	SOPEG_1130(lpxP)

SLIG:

GTU79_07280(lpxP)

EAM:	EAMY_0267(ddg)

EAY:	EAM_3150(lpxP)

ETA:	ETA_02550(ddg)

EPY:	EpC_02750(ddg)

EPR:	EPYR_00286(ddg)

EBI:	EbC_40850(ddg)

ERJ:	EJP617_14400(ddg)

EPE:	CI789_20740

EHD:	ERCIPSTX3056_445(lpxP)

ERWI:

GN242_02040(lpxP)

ETP:	LU633_03230(lpxP)

ERP:	LJN55_02295(lpxP)

EPI:	Q3V30_02280(lpxP)

ETO:	RIN69_02195(lpxP)

EGE:	EM595_0412(lpxP)

PAM:	PANA_3932(ddg)

PLF:	PANA5342_0120(ddg)

PAJ:	PAJ_3135(ddg)

PAQ:	PAGR_g0116

PVA:	Pvag_3205(ddg)

PAGG:

AL522_04160

PAO:	Pat9b_3918

KLN:	LH22_02680

PANT:

PSNIH1_05520

PANP:

PSNIH2_16235

PAGC:

BEE12_06490

PALH:

B1H58_05410

PANS:

FCN45_19180(lpxP)

PEY:	EE896_00555(lpxP)

PDIS:

D8B20_17085

PER:	LAC65_15715(lpxP)

PJI:	KTJ90_00530(lpxP)

PANO:

OJ965_03075(lpxP)

KPIE:

N5580_17990(lpxP)

PALF:

K6R05_00550(lpxP)

PPHO:

CTZ24_19925

PDIP:

KFZ74_19700(lpxP)

PGZ:	C2E15_02330

PCD:	C2E16_02390

MINT:

C7M51_03962(lpxP)

MTHI:

C7M52_03071(lpxP)

MHAN:

K6958_02245(lpxP)

TCI:	A7K98_02265

TPTY:

NCTC11468_00494(htrB_2)

TATU:

EFZ10_13825

PMAK:

PMPD1_0430

PMR:	PMI0808(ddg)

PMIB:

BB2000_0876(ddg)

PVL:	AOB99_06475

PVG:	CRN77_15535

PHAU:

PH4a_13370

PROT:

BTA34_05135

PCOL:

F1325_06750(lpxL)

PCIB:

F9282_06500(lpxL)

PPEE:

I6G31_03155(lpxL)

PAPP:

QQS39_06645(lpxL) QQS39_08275(lpxP)

PSI:

S70_04395

PSX:	DR96_55(lpxL)

PSTA:

BGK56_07600

PTHA:

OI982_19080(lpxL)

PRG:	RB151_026350(htrB_2)

PRQ:	CYG50_02890(lpxL)

PVC:	G3341_09120(lpxL)

PHAG:

PZ638_08360(lpxL)

MMK:	MU9_1856 MU9_2673

ANS:	ArsFIN_45070(lpxP_2) ArsFIN_46420(lpxP_3)

MWI:	MNY66_09615(lpxL)

EIC:	NT01EI_3298

ETD:

ETAF_2652

ETE:

ETEE_1146

ETR:

ETAE_2920

ETC:	ETAC_14060

EDW:	QY76_05725

EDL:	AAZ33_15520(lpxL)

EHO:	A9798_02615

HAV:	AT03_16890

HPAR:

AL518_09765

OPO:	DSM2777_08335

EAZ:	JHT90_00040(lpxL)

ALTO:

AltI4_31880(lpxP)

MATH:

THO17_00300

UBR:	RHO15_03730(lpxL)

SADE:

GFK82_00143(lpxP)

AKA:	TKWG_01530

AMIM:

MIM_c02530

» show all

Reference

1 [PMID:10092655]

Authors

Carty SM, Sreekumar KR, Raetz CR

Title

Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein.

Journal

J Biol Chem 274:9677-85 (1999)
DOI:10.1074/jbc.274.14.9677

Sequence

[eco:b2378]

Reference

2 [PMID:11830594]

Authors

Vorachek-Warren MK, Carty SM, Lin S, Cotter RJ, Raetz CR

Title

An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C.

Journal

J Biol Chem 277:14186-93 (2002)
DOI:10.1074/jbc.M200408200

Sequence

[eco:b2378]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.242

IUBMB Enzyme Nomenclature:

2.3.1.242

ExPASy - ENZYME nomenclature database:

2.3.1.242

BRENDA, the Enzyme Database:

2.3.1.242

DBGET integrated database retrieval system