KEGG   ENZYME: 2.3.1.245Help
Entry
EC 2.3.1.245                Enzyme                                 

Name
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase;
lsrF (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:glycerone phosphate C-acetyltransferase
Reaction(IUBMB)
glycerone phosphate + acetyl-CoA = 3-hydroxy-5-phosphooxypentane-2,4-dione + CoA [RN:R11182]
Reaction(KEGG)
Substrate
glycerone phosphate [CPD:C00111];
acetyl-CoA [CPD:C00024]
Product
3-hydroxy-5-phosphooxypentane-2,4-dione [CPD:C20960];
CoA [CPD:C00010]
Comment
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
History
EC 2.3.1.245 created 2015
Orthology
K08321  3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
Genes
ECO: b1517(lsrF)
ECJ: JW1510(lsrF)
ECD: ECDH10B_1648(lsrF)
EBW: BWG_1336(lsrF)
ECOK: ECMDS42_1228(lsrF)
ECE: Z2188(yneB)
ECS: ECs2124
ECF: ECH74115_2130(lsrF)
ETW: ECSP_2002(lsrF)
ELX: CDCO157_1964
EOI: ECO111_1913(lsrF)
EOH: ECO103_1647(lsrF)
ECOO: ECRM13514_1874(lsrF)
ECOH: ECRM13516_1882(lsrF)
EOK: G2583_1882(lsrF)
ESO: O3O_12740
ESM: O3M_12855
ESL: O3K_12895
ECW: EcE24377A_1717(lsrF)
ELH: ETEC_1587
ECX: EcHS_A1599(lsrF)
ECM: EcSMS35_1655(lsrF)
ECY: ECSE_1607
ECR: ECIAI1_1529(lsrF)
ECK: EC55989_1650(lsrF)
ECT: ECIAI39_1780(lsrF)
EOC: CE10_1706(lsrF)
EUM: ECUMN_1785(lsrF)
EBR: ECB_01474(yneB)
EBD: ECBD_2125
EKF: KO11_15580(lsrF)
EDJ: ECDH1ME8569_1460(lsrF)
ELW: ECW_m1646(lsrF)
ELL: WFL_08060(lsrF)
EBL: ECD_01474(lsrF)
EBE: B21_01485(lsrF)
EFE: EFER_1560(lsrF)
STY: STY3792(yneB)
STT: t3540(yneB)
STM: STM4078(yneB)
SEO: STM14_4903(yneB)
SEY: SL1344_4027(yneB)
SEJ: STMUK_4063(yneB)
SEB: STM474_4260(yneB)
SEF: UMN798_4421(yneB)
SENR: STMDT2_39411(yneB)
SEND: DT104_40871(yneB)
SENI: CY43_21325
SPT: SPA3921(yneB)
SEK: SSPA3649
SEI: SPC_4184(yneB)
SEC: SCH_3967(yneB)
SHB: SU5_0175
SENS: Q786_20020
SED: SeD_A4477
SEG: SG3342(yneB)
SEL: SPUL_3585(yneB)
SEGA: SPUCDC_3571(yneB)
SET: SEN3868(yneB)
SENA: AU38_19995
SENO: AU37_20010
SENV: AU39_20030
SENQ: AU40_22335
SENL: IY59_20490
SEEP: I137_17225
SENE: IA1_19840
SFL: SF1578
SFX: S1704
SFV: SFV_1574(yneB)
SFE: SFxv_1771(lsrF-1)
SFN: SFy_2263
SFS: SFyv_2318
SFT: NCTC1_01711(yneB)
SDY: SDY_1623(yneB)
ENC: ECL_04478
ECLX: LI66_19510
ECLY: LI62_21510
ECLZ: LI64_18650
EEC: EcWSU1_03894(lsrF)
KPN: KPN_03503(yneB)
KPU: KP1_4800
KPP: A79E_0614
KPE: KPK_0609(lsrF)
KPR: KPR_4707(lsrF)
KPJ: N559_0668
KPX: PMK1_01021(lsrF_1)
KPNU: LI86_03235
KPNK: BN49_0604(lsrF)
KVA: Kvar_0597
KOX: KOX_03290
KOE: A225_5106
EAE: EAE_03930
EAR: CCG33206
CAMA: F384_16545
CLAP: NCTC11466_04016(lsrF)
METY: MRY16398_06810(lsrF)
AHN: NCTC12129_00640(lsrF)
YPE: YPO0408
YPK: y3773
YPH: YPC_4195
YPA: YPA_3877
YPN: YPN_0278
YPM: YP_3773(fbaB)
YPZ: YPZ3_0400
YPD: YPD4_0353
YPX: YPD8_0354
YPW: CH59_1453
YPJ: CH55_2402
YPV: BZ15_3163
YPL: CH46_506
YPS: YPTB0548(yneB)
YPO: BZ17_2011
YPY: YPK_3654
YPB: YPTS_0572
YPQ: DJ40_1819
YPU: BZ21_3928
YPR: BZ20_1545
YPC: BZ23_28
YPF: BZ19_4055
YEN: YE0524
YEY: Y11_37581
YEW: CH47_2952
YET: CH48_1074
YAL: AT01_3042
YFR: AW19_3883
YIN: CH53_1164
YKR: CH54_1907
YRO: CH64_3157
RAA: Q7S_12855
SOD: Sant_3803(lsrF)
PLU: plu3147(lsrF)
PAY: PAU_01469(yneB)
XBO: XBJ1_4104(lsrF)
XBV: XBW1_0359(lsrF)
XNE: XNC1_4325(lsrF)
XNM: XNC2_4174(lsrF)
XDO: XDD1_3690(lsrF)
MMK: MU9_2077
HIA: H733_1679(lsrF)
HIC: NTHIC486_00206(lsrF)
HSO: HS_0055
HSM: HSM_1948
PMU: PM1278
PMP: Pmu_19390
PMUL: DR93_522
AAT: D11S_1392
AAN: D7S_00019
AACN: AANUM_1700
DOL: Dole_1897
SFU: Sfum_2464
RSU: NHU_00496
MGM: Mmc1_1606
ELM: ELI_1077
PFAC: PFJ30894_00534(lsrF)
MOO: BWL13_02435(lsrF)
NCA: Noca_0399
SRO: Sros_2413
TPYO: X956_00455
TBI: Tbis_1197
BCEL: BcellWH2_01197(lsrF)
PDI: BDI_0631
CTE: CT1773
CPC: Cpar_0433
CCH: Cag_1641
CLI: Clim_1971
PVI: Cvib_0463
PLT: Plut_0411
PAA: Paes_1802
PROC: Ptc2401_01899(lsrF)
NMR: Nmar_1078
NIN: NADRNF5_0857(lsrF)
NCT: NMSP_0543(aroA'_1)
NGA: Ngar_c22370(lsrF)
NVN: NVIE_008540(lsrF)
NEV: NTE_02180
TAA: NMY3_02387(lsrF)
NCV: NCAV_1110(lsrF)
NBV: T478_0889
LOKI: Lokiarch_24430(lsrF_1) Lokiarch_49990(lsrF_2)
 » show all
Taxonomy
Reference
1  [PMID:19714241]
  Authors
Diaz Z, Xavier KB, Miller ST
  Title
The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF.
  Journal
PLoS One 4:e6820 (2009)
DOI:10.1371/journal.pone.0006820
  Sequence
[eco:b1517]
Reference
2  [PMID:25225400]
  Authors
Marques JC, Oh IK, Ly DC, Lamosa P, Ventura MR, Miller ST, Xavier KB
  Title
LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing  the quorum sensing signal autoinducer-2.
  Journal
Proc Natl Acad Sci U S A 111:14235-40 (2014)
DOI:10.1073/pnas.1408691111
  Sequence
[eco:b1517]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.245
IUBMB Enzyme Nomenclature: 2.3.1.245
ExPASy - ENZYME nomenclature database: 2.3.1.245
BRENDA, the Enzyme Database: 2.3.1.245

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