Entry
Name
3-keto-5-aminohexanoate cleavage enzyme;
kce (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase
Reaction(IUBMB)
(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate [RN:
R10564 ]
Reaction(KEGG)
Substrate
(5S)-5-amino-3-oxohexanoate;
acetyl-CoA [CPD:
C00024 ]
Product
L-3-aminobutanoyl-CoA [CPD:
C05231 ];
acetoacetate [CPD:
C00164 ]
Comment
Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, is involved in the anaerobic fermentation of lysine.
History
EC 2.3.1.247 created 2015
Pathway
Orthology
K18013 3-keto-5-aminohexanoate cleavage enzyme
Genes
THIP : N838_20450 N838_28815 N838_29140
GAI : IMCC3135_13280(kce_2) IMCC3135_15615(kce_3)
HPIZ : GYM47_15570 GYM47_16345
REH : H16_A1969(h16_A1969)
CNC : CNE_1c19390 CNE_2c18160 CNE_BB2p00910
REU : Reut_A1631 Reut_B3957 Reut_B5036
CBW : RR42_s0553 RR42_s2140 RR42_s2452
COX : E0W60_02185 E0W60_32225
BYI : BYI23_B006700 BYI23_D002050
BUE : BRPE67_BCDS09040 BRPE67_DCDS03800
BUZ : AYM40_11895 AYM40_12070 AYM40_26010 AYM40_28240 AYM40_28280
PHS : C2L64_08435 C2L64_12790 C2L64_23695
PTER : C2L65_07895 C2L65_26875 C2L65_27710
PACS : FAZ98_16245 FAZ98_29810
PAPI : SG18_14785 SG18_20720
PTX : ABW99_05960 ABW99_15955
PFIB : PI93_014870 PI93_021105 PI93_021110
AXY : AXYL_00249 AXYL_02458
AXO : NH44784_028411 NH44784_040761
AXN : AX27061_2263 AX27061_5475
AXX : ERS451415_02260 ERS451415_05501
ADT : APT56_11080 APT56_25150
AIS : BUW96_02570 BUW96_27005
ASW : CVS48_09975 CVS48_15775
ACHR : C2U31_23410 C2U31_30050
ACHB : DVB37_09670 DVB37_24805
ADY : HLG70_11410 HLG70_24950
ACHO : H4P35_09845 H4P35_23645
AMUI : PE062_06595 PE062_20425
ACK : C380_03345 C380_20510
ACRA : BSY15_2088 BSY15_860
CTT : CtCNB1_0216 CtCNB1_1723 CtCNB1_3917
CTES : O987_10865 O987_23565
DOE : DENOEST_0755 DENOEST_0851 DENOEST_1136
RBS : RHODOSMS8_00063(kce)
RHI : NGR_c06390 NGR_c06430
RGA : RGR602_PA00077 RGR602_PC00300
BARH : WN72_04025 WN72_30225
BOS : BSY19_2040 BSY19_4186
BVV : BHK69_11435 BHK69_28305
BOI : BLM15_10035 BLM15_28360
BOF : FQV39_13465 FQV39_25640
STAR : G3545_12725 G3545_16095
MEA : Mex_1p1042 Mex_1p1154 Mex_1p5135
MDI : METDI1843 METDI2003 METDI5740
MEX : Mext_1257 Mext_1354 Mext_4686
MCH : Mchl_1418 Mchl_1554 Mchl_5151
MZA : B2G69_05410 B2G69_13565 B2G69_14240
MRD : Mrad2831_4735 Mrad2831_5318
MET : M446_1332 M446_1737 M446_2423 M446_4653
MNO : Mnod_2085 Mnod_2376 Mnod_3440 Mnod_6459
META : Y590_05335 Y590_19170 Y590_23975
MAQU : Maq22A_c00780 Maq22A_c03910 Maq22A_c08500 Maq22A_c22455
MEE : DA075_03125 DA075_12485 DA075_16035
METD : C0214_05395 C0214_25705
MTEA : DK419_01265 DK419_07270 DK419_09485 DK419_20340
MIND : mvi_14970 mvi_39240 mvi_43550
MOC : BB934_00365 BB934_02185 BB934_22170 BB934_41915
LAP : ACP90_06225 ACP90_27140
LABT : FIU93_04910(kce2) FIU93_11865(kce5)
LAGG : B0E33_09765 B0E33_11200 B0E33_17780
RPON : G3256_03720 G3256_08615
PPIC : PhaeoP14_00173 PhaeoP14_02545
OAR : OA238_160p0810 OA238_160p0980
LEJ : ETW24_15385 ETW24_15995
LEV : ETW23_02855 ETW23_14710
SULD : B5M07_03430 B5M07_17075 B5M07_19205
SINL : DSM14862_03964(kce_5)
SFAV : PL335_13155 PL335_15835
SPSE : SULPSESMR1_00567(kce)
RMM : ROSMUCSMR3_03759(kce)
OCD : FHY55_04805 FHY55_16105
PCON : B0A89_06430 B0A89_14355
PZH : CX676_12425 CX676_15690
PSAN : HGN31_00310 HGN31_07345
THW : BMG03_07565 BMG03_13025
HML : HmaOT1_17455 HmaOT1_18410
LIT : FPZ52_05190 FPZ52_09070
PAED : G5B38_10040 G5B38_12430
POZ : I0K15_17980 I0K15_18240
THAS : C6Y53_00460 C6Y53_07000
CMAG : CBW24_06465 CBW24_12415
SPHD : HY78_16735 HY78_22010
RDI : CMV14_03860 CMV14_16595
SULN : FJR47_06265 FJR47_08260
PACE : A6070_00030 A6070_14755
AGE : AA314_04550 AA314_06943
SCU : SCE1572_11095 SCE1572_37295
PAUU : E8A73_023760 E8A73_028225
MRM : A7982_06888 A7982_13257
LLU : AKJ09_00844 AKJ09_10303
BSED : DN745_10915 DN745_13060
PCAY : FRD00_14095 FRD00_15175
CLS : CXIVA_02410 CXIVA_06660 CXIVA_07070 CXIVA_10680
CACE : CACET_c04310(kce) CACET_c30610
GFE : Gferi_09730 Gferi_10185 Gferi_11065 Gferi_11195
CPRF : K7H06_00150 K7H06_00255
CRAS : KVH43_03060 KVH43_03185
FPLA : A4U99_00635 A4U99_02450 A4U99_02930 A4U99_06985 A4U99_11325 A4U99_13675 A4U99_15495 A4U99_15680 A4U99_15875
VFA : MM35RIKEN_07360(kce)
VCOP : MM50RIKEN_12230(kce_1) MM50RIKEN_22420(kce_2)
CCT : CC1_10470 CC1_15150 CC1_27090 CC1_30820
CBOL : CGC65_03065 CGC65_09965
CST : CLOST_0198 CLOST_1384(kce)
IBU : IB211_00294 IB211_00977 IB211_02342c IB211_02425c IB211_02981c IB211_03192c IB211_03205
AMIJ : EQM06_00105 EQM06_04540 EQM06_05495 EQM06_10715 EQM06_12635
ABUT : Ami103574_00410 Ami103574_00875 Ami103574_04915 Ami103574_06350 Ami103574_07060 Ami103574_08060
ETM : CE91St48_04090(kce_1) CE91St48_09320(kce_2) CE91St48_13780(kce_3) CE91St48_34180(kce_4)
NTH : Nther_1884 Nther_1903
HALS : D7D81_01265 D7D81_18045
KME : H0A61_00948(kce_1) H0A61_01605(kce_2) H0A61_01689(kce_3)
AMEI : LV469_06375 LV469_08580
STED : SPTER_15940(kce_2) SPTER_16000(kce_3) SPTER_25770(kce_4) SPTER_40640(kce_6) SPTER_46160(kce_7)
MPAG : C0J29_07375 C0J29_14335
MBAI : MB901379_02355(kce)
MPHL : MPHLCCUG_04683(kce_2)
MGO : AFA91_08685 AFA91_08710 AFA91_23040
RHOD : AOT96_05775 AOT96_05800
SALS : SLNWT_0159 SLNWT_0164
NAQU : ENKNEFLB_00763(kce)
AGRA : AGRA3207_003561 AGRA3207_005241
PAUT : Pdca_13570 Pdca_50810
PBRO : HOP40_21330 HOP40_24710 HOP40_31065
MSAG : GCM10017556_19540(kce)
ACTR : Asp14428_52490(kce)
FVA : FV113G1_04320 FV113G1_13760 FV113G1_17250 FV113G1_29960
FUL : C4N20_04210 C4N20_08870 C4N20_13625 C4N20_15465
PSOE : CE91St14_15600(kce)
HLU : LT972_00540 LT972_06520
HALJ : G9465_01310 G9465_10725 G9465_13925 G9465_24225
NHO : HWV23_00435 HWV23_15080 HWV23_15145
NSAL : HWV07_02080 HWV07_02130
HALI : BV210_00545 BV210_19060
HSN : DV733_03480 DV733_08465
HALN : B4589_001425 B4589_004885
HALU : HUG12_08300 HUG12_20315
NAS : GCU68_19320 GCU68_20075
LOKI : Lokiarch_21000(kce_1) Lokiarch_49350(kce_2)
» show all
Taxonomy
Reference
Authors
Barker HA, Kahn JM, Hedrick L
Title
Pathway of lysine degradation in Fusobacterium nucleatum.
Journal
J Bacteriol 152:201-7 (1982)
Reference
Authors
Kreimeyer A, Perret A, Lechaplais C, Vallenet D, Medigue C, Salanoubat M, Weissenbach J
Title
Identification of the last unknown genes in the fermentation pathway of lysine.
Journal
Sequence
Reference
Authors
Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM.
Title
3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.247