Entry
Name
[Wnt protein] O-palmitoleoyl transferase;
porcupine;
PORCN (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
(9Z)-hexadec-9-enoyl-CoA:[Wnt]-L-serine O-hexadecenoyltransferase
Reaction(IUBMB)
(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine = CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine [RN:
R11201 ]
Reaction(KEGG)
Substrate
(9Z)-hexadec-9-enoyl-CoA [CPD:
C21072 ];
[Wnt]-L-serine [CPD:
C21172 ]
Product
CoA [CPD:
C00010 ];
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine [CPD:
C21171 ]
Comment
The enzyme, found in animals, modifies a specific serine residue in Wnt proteins, e.g. Ser209 in human Wnt3a and Ser224 in chicken WNT1 [2,3]. The enzyme can accept C13 to C16 fatty acids in vitro, but only (9Z)-hexadecenoate modification is observed in vivo [1]. cf. EC
3.1.1.98 , [Wnt protein]-O-palmitoleoyl-L-serine hydrolase.
History
EC 2.3.1.250 created 2015
Orthology
K00181 O-palmitoleoyl transferase
Genes
MORG : 121442545 121442652
BBUB : 102389940 102394073(PORCN)
OAS : 101112290(PORCN) 105606369
ODA : 120872776 120882086(PORCN)
CCAD : 122420292 122434506(PORCN)
DLE : 111169492(PORCN) 111179658(CBFB)
PCAD : 102976114 102990752(PORCN)
PSIU : 116743988(CBFB) 116747922(PORCN)
NASI : 112391528(CBFB) 112416012(PORCN)
TSR : 106543185 106546205(PORCN)
DRE : 100006275(porcn) 333999(porcnl)
SRX : 107731151 107731263 107745789 107745836
SANH : 107668005 107668076 107695217 107695296
SGH : 107549961 107550497 107585894
CCAR : 109061989 109065659 109095160 109105327
CAUA : 113073436 113076434 113102075 113107221
CGIB : 127963081 127963229 128018710 128018738 128019149
PPRM : 120469045(porcnl) 120483061(porcn)
MAMB : 125279358(porcn) 125279607(porcnl)
CIDE : 127517565 127518169
MASI : 127414821 127423791 127424656
IPU : 108265120(porcn) 108265978(porcnl)
PHYP : 113536477 113542874
SMEO : 124399422(porcn) 124400532(porcnl)
TFD : 113655896(porcnl) 113655968(porcn)
TRU : 101068343 101075803(porcn) 115249167
TNG : GSTEN00008492G001 GSTEN00023528G001
LCO : 104932129(porcn) 104932803
CGOB : 115010825(porcn) 115021090
PLEP : 121946928 121947330
SLUC : 116043570 116050880
ECRA : 117947578(porcn) 117948144
ESP : 116692801(porcn) 116693086
PFLV : 114558454 114558943(porcn)
PPUG : 119222140 119222177 119223717
ALAT : 119022821 119023139
MZE : 101468644(porcn) 101476019
ONL : 100693496 100702239(porcn)
OLA : 101155172 101170431(porcn)
XMA : 102217940 102227294(porcn)
XCO : 114142172 114149109(porcn)
XHE : 116721237 116737533(porcn)
PRET : 103466972 103467706(porcn)
PFOR : 103139050(porcn) 103154223
PLAI : 106954495(porcn) 106957133
PMEI : 106915880(porcn) 106928340
CVG : 107091005 107091484(porcn)
CTUL : 119784972 119786837
NFU : 107390509(porcn) 107390546
ALIM : 106519341(porcn) 106527381
AOCE : 111588285 111588352(porcn)
CSEM : 103384848 103385376(porcn)
POV : 109630854 109635080(porcn)
HHIP : 117764921 117765142
SDU : 111219005 111235086(porcn)
SLAL : 111654166(porcn) 111670805
HCQ : 109513006(porcn) 109528448
SSCV : 125988018 125988189
BPEC : 110156024 110164851(porcn)
BSPL : 114859240 114859378
SASA : 106566826 106567241 106572297 106572375
STRU : 115165745 115168081 115168256
OTW : 112216182 112221910 112222061
OMY : 110492277 110492779 110532482
OGO : 124032098 124045064 124045924
ONE : 115102223 115102364 115132332
SALP : 111966642 111977065 111977229
SNH : 120058875 120058959 120060691 120060727
CCLU : 121538206 121538520 121545530
ELS : 105013829 105022369(porcn)
DSI : Dsimw501_GD15644(Dsim_GD15644)
AGA : AgaP_AGAP007962(PORCN_ANOGA)
AALB : 109414987 109415134
PPOI : 119112996 119113011
CBR : CBG_05032(Cbr-mom-1)
BMY : BM_BM5662(Bma-mom-1)
» show all
Taxonomy
Reference
Authors
Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S
Title
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.
Journal
Sequence
Reference
Authors
Gao X, Hannoush RN
Title
Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine.
Journal
Sequence
Reference
Authors
Miranda M, Galli LM, Enriquez M, Szabo LA, Gao X, Hannoush RN, Burrus LW
Title
Identification of the WNT1 residues required for palmitoylation by Porcupine.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.250