KEGG   ENZYME: 2.3.1.250
Entry
EC 2.3.1.250                Enzyme                                 
Name
[Wnt protein] O-palmitoleoyl transferase;
porcupine;
PORCN (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
(9Z)-hexadec-9-enoyl-CoA:[Wnt]-L-serine O-hexadecenoyltransferase
Reaction(IUBMB)
(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine = CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine [RN:R11201]
Reaction(KEGG)
R11201
Substrate
(9Z)-hexadec-9-enoyl-CoA [CPD:C21072];
[Wnt]-L-serine [CPD:C21172]
Product
CoA [CPD:C00010];
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine [CPD:C21171]
Comment
The enzyme, found in animals, modifies a specific serine residue in Wnt proteins, e.g. Ser209 in human Wnt3a and Ser224 in chicken WNT1 [2,3]. The enzyme can accept C13 to C16 fatty acids in vitro, but only (9Z)-hexadecenoate modification is observed in vivo [1]. cf. EC 3.1.1.98, [Wnt protein]-O-palmitoleoyl-L-serine hydrolase.
History
EC 2.3.1.250 created 2015
Orthology
K00181  O-palmitoleoyl transferase
Genes
HSA64840(PORCN)
PTR465615(PORCN)
PPS100975031(PORCN)
GGO101153520(PORCN)
PON100447682(PORCN)
NLE100594546(PORCN)
HMH116811655
MCC710426(PORCN)
MCF102125855(PORCN)
MTHB126945573
MNI105493894(PORCN)
CSAB103231923(PORCN)
CATY105590475(PORCN)
PANU101004687(PORCN)
TGE112615052(PORCN)
MLEU105547730(PORCN)
RRO104660667(PORCN)
RBB108517458(PORCN)
TFN117077372(PORCN)
PTEH111534356(PORCN)
CANG105515021(PORCN)
CJC100398110(PORCN)
SBQ101049119(PORCN)
CIMI108300886(PORCN)
CSYR103250459(PORCN)
MMUR105856379(PORCN)
LCAT123628352(PORCN)
PCOQ105816785(PORCN)
OGA100953924(PORCN)
MMU53627(Porcn)
MCAL110286489(Porcn)
MPAH110313314(Porcn)
RNO317368(Porcn)
MCOC116068943(Porcn)
ANU117694367(Porcn)
MUN110565607(Porcn)
CGE100765928(Porcn)
MAUA101841408(Porcn)
PLEU114701312(Porcn)
MORG121442545 121442652
MFOT126512874
AAMP119804796(Porcn)
NGI103741637(Porcn)
HGL101700667(Porcn)
CPOC100729593(Porcn)
CCAN109698114(Porcn)
DORD105997850(Porcn)
DSP122098788(Porcn)
PLOP125344006(Porcn)
NCAR124971849
MMMA107159837(Porcn)
OCU100342483
OPI101531355(PORCN)
TUP102474936(PORCN)
GVR103589460(PORCN)
CFA480903(PORCN)
CLUD112673145(PORCN)
VVP112907223(PORCN)
VLG121482331(PORCN)
NPO129518886(PORCN)
AML100473692(PORCN)
UMR103669346(PORCN)
UAH113265915(PORCN)
UAR123787597(PORCN)
ELK111150334
LLV125091652
MPUF101669917(PORCN)
MNP132006883(PORCN)
MLK131821668(PORCN)
NVS122897028(PORCN)
ORO101377277(PORCN)
EJU114216825(PORCN)
ZCA113930376(PORCN)
MLX118009997(PORCN)
NSU110570946(PORCN)
LWW102730963(PORCN)
FCA101093667(PORCN)
PYU121026162(PORCN)
PCOO112870881(PORCN)
PBG122477960(PORCN)
LRUF124509703
PTG102967780(PORCN)
PPAD109248062(PORCN)
PUC125931653
AJU106989470
HHV120221002(PORCN)
BTA540373(PORCN)
BOM102273839(PORCN)
BIU109555475(PORCN)
BBUB102389940 102394073(PORCN)
BBIS104996719(PORCN)
CHX102177509(PORCN)
OAS101112290(PORCN) 105606369
BTAX128062889 128069966(PORCN)
ODA120872776 120882086(PORCN)
CCAD122420292 122434506(PORCN)
MBEZ129535085(PORCN) 129547028
SSC100627921(PORCN)
CFR102519750(PORCN)
CBAI105079386(PORCN)
CDK105103314(PORCN)
VPC102531973(PORCN)
BACU103004140(PORCN)
LVE103071172(PORCN)
OOR101269503(PORCN)
DLE111169492(PORCN) 111179658(CBFB)
PCAD102976114 102990752
PSIU116743988(CBFB) 116747922(PORCN)
NASI112391528(CBFB) 112416012(PORCN)
ECB100051598(PORCN)
EAI106827434(PORCN)
MYB102240738(PORCN)
MYD102761947(PORCN)
MMYO118653961(PORCN)
MLF102423004(PORCN)
MNA107541398(PORCN)
PKL118731770(PORCN)
EFUS103301279(PORCN)
HAI109374803(PORCN)
DRO112322444(PORCN)
SHON118998309(PORCN)
AJM119059940(PORCN)
PDIC114505219(PORCN)
PHAS123832748(PORCN)
MMF118635768(PORCN)
RFQ117021673(PORCN)
PPAM129065130(PORCN)
PALE102890685(PORCN)
PGIG120587108(PORCN)
PVP105310018(PORCN)
RAY107515035(PORCN)
MJV108404728(PORCN)
TOD119246179(PORCN)
SARA101553356(PORCN)
LAV100654628(PORCN)
TMU101349448
ETF101644616(PORCN)
DNM101435131(PORCN)
MDO100018836(PORCN)
GAS123254636(PORCN)
SHR100930661(PORCN)
AFZ127542453
PCW110201002(PORCN)
OAA100090726(PORCN)
GGA107050792(PORCN)
PCOC116241283
MGP104915865(PORCN)
CJO107307404(PORCN)
TGU115492077(PORCN)
LSR110483405(PORCN)
PMOA120504132(PORCN)
OTC121337227(PORCN)
FAB101819915(PORCN)
OMA130266121(PORCN)
PHI102113345(PORCN)
PMAJ107198878(PORCN)
CCW120412223(PORCN)
CLV102093109(PORCN)
AGEN126035191
SHAB115602869(PORCN)
ASN102382175(PORCN)
AMJ102566547(PORCN)
PSS102461420(PORCN)
CMY102938717(PORCN)
CCAY125628233(PORCN)
DCC119846991(PORCN)
CPIC101949555(PORCN)
TST117888851(PORCN)
CABI116818876(PORCN)
MRV120388535(PORCN)
ACS100567937(porcn)
ASAO132767797(PORCN)
PVT110081188(PORCN)
SUND121924116(PORCN)
PBI103053075(PORCN)
PMUR107291924(PORCN)
CTIG120306623(PORCN)
TSR106543185 106546205(PORCN)
PGUT117675425(PORCN)
APRI131189918(PORCN)
PTEX113443417(PORCN)
NSS113417778(PORCN)
VKO123024033(PORCN)
PMUA114587580(PORCN)
PRAF128405042(PORCN)
ZVI118075227(PORCN)
HCG128346328(PORCN)
GJA107120739(PORCN)
STOW125429737(PORCN)
EMC129346152(PORCN)
XLA397828(porcn.L)
XTR394996(porcn)
NPR108789209(PORCN)
RTEM120913901(PORCN)
BBUF120977468(PORCN)
BGAR122946336(PORCN)
MUO115462000 115463453(PORCN)
GSH117349751(PORCN)
DRE100006275(porcn) 333999(porcnl)
SRX107731151 107731263 107745789 107745836
SANH107668005 107668076 107695217 107695296
SGH107549961 107550497 107585894
CCAR109061989 109065659 109095160 109105327
CAUA113073436 113076434 113102075 113107221
CGIB127963081 127963229 128018710 128018738 128019149
PTET122350048(porcnl) 122350760(porcn)
LROH127169199(porcn) 127170288(porcnl)
OMC131545698(porcnl) 131545732(porcn)
PPRM120469045(porcnl) 120483061(porcn)
RKG130086196(porcn) 130094689(porcnl)
MAMB125279358(porcn) 125279607(porcnl)
CIDE127517565 127518169
MASI127414821 127423791 127424656
TROS130567714(porcnl) 130568256(porcn)
TDW130406879(porcn) 130440144(porcnl)
MANU129414052(porcnl) 129414202(porcn)
IPU108265120(porcn) 108265978(porcnl)
IFU128607848(porcnl) 128607956(porcn)
PHYP113536477 113542874
SMEO124399422(porcn) 124400532(porcnl)
TFD113655896(porcnl) 113655968(porcn)
TVC132853639(porcn) 132854086(porcnl)
AMEX103028991(porcn)
CMAO118812954(porcn) 118813162(porcnl)
EEE113581100 113589826
CHAR105893660 105898967(porcnl)
TRU101068343 101075803(porcn) 115249167
TFS130529442 130529943
TNGGSTEN00008492G001 GSTEN00023528G001
LCO104932129(porcn) 104932803
NCC104941482(porcn)
TBEN117481496
CGOB115010825(porcn) 115021090
PGEO117442369 117449932
GACU117535475 117546296
ELY117258359 117258980
EFO125891611 125892011
PLEP121946928 121947330
SLUC116043570 116050880
ECRA117947578(porcn) 117948144
ESP116692801(porcn) 116693086
PFLV114558454 114558943(porcn)
GAT120829223 120829918
PPUG119222140 119222177 119223717
AFB129099465 129099777
CLUM117733550 117733641
MSAM119904975
SCHU122882377 122882472
CUD121516963 121518143
ALAT119022821 119023139
MZE101468644(porcn) 101476019
ONL100693496 100702239(porcn)
OAU116311432 116319534
OLA101155172 101170431(porcn)
OML112140019 112159828
XMA102217940 102227294(porcn)
XCO114142172 114149109(porcn)
XHE116721237 116737533(porcn)
PRET103466972 103467706(porcn)
PFOR103139050(porcn) 103154223
PLAI106954495(porcn) 106957133
PMEI106915880(porcn) 106928340
GAF122832196 122837021
CVG107091005 107091484(porcn)
CTUL119784972 119786837
GMU124870195 124870306
NFU107390509(porcn) 107390546
KMR108231910 108231935
ALIM106519341(porcn) 106527381
NWH119416866 119417554
AOCE111588285 111588352(porcn)
MCEP125015774
CSEM103384848 103385376(porcn)
POV109630854 109635080(porcn)
SSEN122776625
HHIP117764921 117765142
HSP118110452 118111054
LCF108900495
SDU111219005 111235086(porcn)
SLAL111654166(porcn) 111670805
XGL120804160 120804186
HCQ109513006(porcn) 109528448
SSCV125988018 125988189
SBIA133511818
PEE133399582 133408183
BPEC110156024 110164851(porcn)
MALB109966788(porcn)
BSPL114859240 114859378
SJO128357218 128357919
SASA106566826 106567241 106572297 106572375
STRU115165745 115168081 115168256
OTW112216182 112221910 112222061
OMY110492277 110492779 110532482
OGO124032098 124045064 124045924
ONE115102223 115102364 115132332
OKI109869570 109869636 109908160
OKE118359741 118359884 118360844
SALP111966642 111977065 111977229
SNH120058875 120058959 120060691 120060727
CCLU121538206 121538520 121545530
ELS105013829 105022369(porcn)
SFM108934774(porcn)
PKI111847825(porcn)
AANG118210576
LOC102684972(porcn)
PSPA121328230
ARUT117404205
PSEX120542054
LCM102364055(PORCN)
RTP109925909(porcn)
HOC132809909
PMRN116949361(PORCN)
LRJ133342631(PORCN)
BFO118415732
BBEL109477032
CIN100184764
SCLV120347325
SPU577959
LPIC129256802
APLC110988533
AJC117107839
SKO100313706
DMEDmel_CG6205(por)
DER6550117
DSE6614853
DSIDsimw501_GD15644(Dsim_GD15644)
DYADyak_GE15535
DSR110175931
DPO4814399
DPE6601754
DMN108162839
DWI6641106
DGR6569466
DMODmoj_GI15128
DAZ108620003
DNV115563932
DHE111593036
CCAT101448453
BDR105228235
TDA119671846
MDE101890144
SCAC106091266
LCQ111682962
LSQ119603600
GFS119637440
ECOE129944727
AGA1277989
ACOZ120959036
AARA120904138
AMER121597630
ASTE118513906
AFUN125766244
AMOU128303936
AALI118458605
AAG5564741
AALB109414987 109415134
CQUCpipJ_CPIJ000099
CPII120418850
CNS116345220
BCOO119067887
AME726113
ACER108003503
ALAB122720734
ADR102674318
AFLR100871834
BIM100740785
BBIF117211587
BVK117240251
BVAN117157118
BTER100648194
BAFF126919252
BPYO122570759
BPAS132910495
FVI122529402
OBB114879801
MGEN117229105
NMEA116433156
CGIG122399864
SOC105193582
MPHA105838828
AEC105152828
ACEP105624957
PBAR105424498
VEM105566978
HST105184742
DQU106747608
CFO105248892
FEX115232774
LHU105679336
PGC109858919
OBO105279498
PCF106786776
PFUC122522876
VPS122630265
VCRB124425463
NVI100122410
CSOL105362089
TPRE106659297
LHT122510294
LBD127283514
MDL103574188
CGLO123269822
FAS105271265
DAM107045049
AGIF122851534
VCAN122414173
CCIN107267335
DSM124410849
NPT124219607
NFB124184095
NLO107217269
NVG124304519
TCA659497
DPA109541125
SOY115882280
AGRG126748831
ATD109601042
CSET123321148
AGB108907390
LDC111515703
NVL108568744 108568786
APLN108739361
PPYR116160529
OTU111425421 111425422
BMOR101737359
BMAN114245528
MSEX115452376
BANY112055417
MJU123864139
NIQ126775983
VCD124539274
MCIX123665635
PMAC106719603
PPOT106107998
PXU106117026
PRAP111004230
ZCE119829995
LSIN126971745
HAW110374464
HZE124640324
TNL113492516
SLIU111354862
OFU114364665
PXY105385137
PGW126381926
CCRN123302959
API100570269
DNX107170409
AGS114130312
RMD113557205
ACOO126844941
BTAB109032519
DCI103514751 103520657
CLEC106670556
HHAL106678206
NLU111048266
HVI124369176
PHUPhum_PHUM569150
FOC113212043
TPAL117651741
ZNE110831158
CSEC111863242
SGRE126298607
IEL124170835
FCD110856733
DPXDAPPUDRAFT_303185
DMK116924256
DPZ124335031
PVM113818886
PJA122254583
PCHN125028524
PMOO119578899
HAME121861550
PCLA123753984
CQD128701575
PTRU123504854
ESN126996621
HAZT108672941
EAF111701569
LSM121127842
PPOI119112996 119113011
DSV119461453
RSAN119396184
RMP119174396
VDE111250436
VJA111258745
TUT107363051
DPTE113791185
DFR124498311
CSCU111616324
PTEP107439356
UDV129220815 129221351
SDM118193395
PMEO129581884
CELCELE_T07H6.2(mom-1)
CBRCBG_05032(Cbr-mom-1)
CRQGCK72_024553
BMYBM_BM5662(Bma-mom-1)
LOALOAG_07740
HROHELRODRAFT_98326
LGILOTGIDRAFT_234449
PVUL126828146
PCAN112572215
BGT106051375
GAE121369168
HRF124144239
HRJ124252948
CRG105321139
CVN111106534
CANU128158895
OED125654022
MYI110447646
PMAX117331615
MCAF127728009
MMER128547864
RPHI132737663 132747490
DPOL127832279
OBI106871820
OSN115226104
LAK106179299
SMMSmp_133180.1
SHXMS3_00006239
EGLEGR_05657
NVE5512182
EPA110249538
ATEN116297591
AMIL114969569
PDAM113684790
SPIS111327926
DGT114531920
XEN124445468
HMG105848083
HSY130655944
TADTRIADDRAFT_56916
AQU100642144
 » show all
Reference
1  [PMID:17141155]
  Authors
Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S
  Title
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.
  Journal
Dev Cell 11:791-801 (2006)
DOI:10.1016/j.devcel.2006.10.003
  Sequence
[mmu:53627]
Reference
2  [PMID:24292069]
  Authors
Gao X, Hannoush RN
  Title
Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine.
  Journal
Nat Chem Biol 10:61-8 (2014)
DOI:10.1038/nchembio.1392
  Sequence
[hsa:64840]
Reference
3  [PMID:25451226]
  Authors
Miranda M, Galli LM, Enriquez M, Szabo LA, Gao X, Hannoush RN, Burrus LW
  Title
Identification of the WNT1 residues required for palmitoylation by Porcupine.
  Journal
FEBS Lett 588:4815-24 (2014)
DOI:10.1016/j.febslet.2014.11.016
  Sequence
[hsa:64840]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.250
IUBMB Enzyme Nomenclature: 2.3.1.250
ExPASy - ENZYME nomenclature database: 2.3.1.250
BRENDA, the Enzyme Database: 2.3.1.250

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