Entry
Name
lipid IVA palmitoyltransferase;
PagP;
crcA (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine:lipid-IVA palmitoyltransferase
Reaction(IUBMB)
(1) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A [RN:
R11223 ];
(2) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = 2-acyl-sn-glycero-3-phosphocholine + lipid IIB [RN:
R12206 ];
(3) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA = 2-acyl-sn-glycero-3-phosphocholine + lipid IVB [RN:
R12187 ]
Reaction(KEGG)
Substrate
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine [CPD:
C03889 ];
hexa-acyl lipid A [CPD:
C21193 ];
lipid IIA [CPD:
C19884 ];
lipid IVA [CPD:
C04919 ]
Product
2-acyl-sn-glycero-3-phosphocholine [CPD:
C04233 ];
hepta-acyl lipid A [CPD:
C21194 ];
lipid IIB [CPD:
C22002 ];
lipid IVB [CPD:
C21982 ]
Comment
Isolated from the bacteria Escherichia coli and Salmonella typhimurium. The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position. There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds. The enzyme also acts on Kdo-(2->4)-Kdo-(2->6)-lipid IVA.
History
EC 2.3.1.251 created 2015
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K12973 lipid IVA palmitoyltransferase
Genes
ECD : ECDH10B_0582(crcA) ECDH10B_0690(crcA)
ECOO : ECRM13514_0646(pagP)
ECOH : ECRM13516_0591(pagP)
ELR : ECO55CA74_03855(pagP)
ECW : EcE24377A_0647(pagP)
EDJ : ECDH1ME8569_0591(pagP)
ECOI : ECOPMV1_00641(pagP)
SEM : STMDT12_C06900(pagP)
SETC : CFSAN001921_13895(pagP)
SEEN : SE451236_09165(pagP)
SENH : CFSAN002069_05705(pagP)
SEEH : SEEH1578_12570(pagP)
SENJ : CFSAN001992_08190(pagP)
SEEC : CFSAN002050_09750(pagP)
SEEB : SEEB0189_016145(pagP)
SENC : SEET0819_10105(pagP)
ENL : A3UG_06180(pagP) A3UG_14955
ECLG : EC036_11890 EC036_38500
ECLE : ECNIH2_06925(pagP) ECNIH2_14910
ECLI : ECNIH5_06015(pagP) ECNIH5_13820
ECLX : LI66_05890(pagP) LI66_14335
ECLY : LI62_06790(pagP) LI62_15690
EHM : AB284_11150 AB284_18975(pagP)
EXF : BFV63_06020(pagP) BFV63_14080
ECLA : ECNIH3_06030(pagP) ECNIH3_13885
ECLC : ECR091_06010(pagP) ECR091_13820
EAU : DI57_04820 DI57_12690(pagP)
ENO : ECENHK_06275(pagP) ECENHK_14430(pagP)
ECAN : CWI88_08080 CWI88_16225(pagP)
ECHG : FY206_07300 FY206_15985
EPT : HWQ17_06620(pagP) HWQ17_21485(pagP)
ENT : Ent638_1158 Ent638_2570
EAS : Entas_1138 Entas_3340
ENX : NI40_005685(pagP) NI40_014375
LNI : CWR52_06235 CWR52_20650
EBG : FAI37_00535 FAI37_14730
ENZ : G0034_06025 G0034_15030
ENS : HWQ15_14495(pagP) HWQ15_22545(pagP)
ENK : LOC22_02360(pagP) LOC22_16765(pagP)
EHU : D5067_0008625 D5067_0016670(pagp)
EMOR : L6Y89_05875(pagP) L6Y89_14020(pagP)
ENB : ELK40_06565 ELK40_14695
EQU : OM418_05790(pagP) OM418_14100(pagP)
EDY : F0320_05530(pagP) F0320_13905(pagP)
KPE : KPK_3918(pagP) KPK_A0097
KVD : KR75_15215 KR75_27110
KOX : KOX_14170(pagP) KOX_24295(pagP)
KOY : J415_13335(pagP) J415_23370(pagP)
KOM : HR38_12910 HR38_22630
KOK : KONIH1_08115 KONIH1_18945
KOC : AB185_02015 AB185_17310 AB185_28010
KLL : BJF97_08490 BJF97_18710
KLW : DA718_10465 DA718_20155
KGR : JJJ10_10200(pagP) JJJ10_20060(pagP)
KPAS : LUW96_14870(pagP) LUW96_24965(pagP)
KLC : K7H21_10150(pagP) K7H21_20085(pagP)
KLM : BWI76_07975 BWI76_18525
REE : electrica_01950(pagP_1) electrica_03676(pagP_2) electrica_05241(pagP_3)
KLP : GUC22_09365(pagP) GUC22_19315(pagP)
ROR : RORB6_03255(pagP) RORB6_11790(pagP)
RON : TE10_09090 TE10_18860
RPLN : B1209_09750 B1209_19495
RAO : DSD31_09705 DSD31_18325
RTG : NCTC13098_02444(pagP_1) NCTC13098_05374(pagP_2)
CLAP : NCTC11466_03319(pagP)
KIE : NCTC12125_00667(pagP)
KAS : KATP_32490(pagP_1) KATP_47230(pagP_2)
LAZ : A8A57_05595 A8A57_06120(pagP)
LEF : LJPFL01_1208 LJPFL01_2681
LEW : DAI21_13025 DAI21_20670(pagp)
AHN : NCTC12129_03574(pagP)
METY : MRY16398_36900(pagP)
MPHG : MPHASIOC01_003955(pagP)
YPG : YpAngola_A1664(pagP)
YPI : YpsIP31758_2380(pagP)
SMW : SMWW4_v1c09490(pagP)
SERS : SERRSCBI_04390(pagP)
SFW : WN53_13910 WN53_24440
SFG : AV650_09460 AV650_20065
SFJ : SAMEA4384070_1031(pagP)
SOF : NCTC11214_00489(pagP)
SSAR : SSARUM_000887(pagP)
RACE : JHW33_11315(pagP) JHW33_11320(pagP)
RVC : J9880_02835(pagP) J9880_21480(pagP)
RBON : QNM34_17580(pagP) QNM34_17585(pagP)
RIU : I2123_19010(pagP) I2123_19015(pagP)
PAQU : DMB82_0019500(pagP)
PARL : PEC302110_01120(pagP)
EBI : EbC_12320(pagP) EbC_27780
ETO : RIN69_06695(pagP) RIN69_11405(pagP)
PVA : Pvag_pPag30356(crcA1) Pvag_pPag30521(crcA3)
PAGG : AL522_01030 AL522_01755
PAO : Pat9b_1049 Pat9b_5533
PAGC : BEE12_20640 BEE12_21460
PANS : FCN45_05490 FCN45_20705
PALF : K6R05_19000(pagP) K6R05_20625(pagP)
PPHO : CTZ24_05420 CTZ24_22220
TPTY : NCTC11468_01149(pagP)
PHEI : NCTC12003_01779(pagP)
PRJ : NCTC6933_02143(pagP)
LRI : NCTC12151_01055(pagP)
LLG : 44548918_02710(pagP)
LJR : NCTC11533_02884(pagP)
LCJ : NCTC11976_00705(pagP)
LWA : SAMEA4504053_0027(pagP)
LSS : NCTC12082_02050(pagP)
LADL : NCTC12735_00196(pagP)
LANT : TUM19329_03200(pagP)
BTRM : SAMEA390648700533(pagP)
AXX : ERS451415_00823(pagP)
ADY : HLG70_01020 HLG70_17830(pagP)
ACHA : KYT87_03510(pagP) KYT87_24735(pagP)
FPHO : SHINM1_015250(pagP)
» show all
Taxonomy
Reference
Authors
Bishop RE, Gibbons HS, Guina T, Trent MS, Miller SI, Raetz CR
Title
Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria.
Journal
Sequence
Reference
Authors
Cuesta-Seijo JA, Neale C, Khan MA, Moktar J, Tran CD, Bishop RE, Pomes R, Prive GG
Title
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.251