KEGG   ENZYME: 2.3.1.251Help
Entry
EC 2.3.1.251                Enzyme                                 

Name
lipid IVA palmitoyltransferase;
PagP;
crcA (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine:lipid-IVA palmitoyltransferase
Reaction(IUBMB)
(1) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A [RN:R11223];
(2) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = 2-acyl-sn-glycero-3-phosphocholine + lipid IIB;
(3) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA = 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
Reaction(KEGG)
Substrate
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine [CPD:C03889];
hexa-acyl lipid A [CPD:C21193];
lipid IIA [CPD:C19884];
lipid IVA [CPD:C04919]
Product
2-acyl-sn-glycero-3-phosphocholine [CPD:C04233];
hepta-acyl lipid A [CPD:C21194];
lipid IIB;
lipid IVB
Comment
Isolated from the bacteria Escherichia coli and Salmonella typhimurium. The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position. There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds. The enzyme also acts on Kdo-(2->4)-Kdo-(2->6)-lipid IVA.
History
EC 2.3.1.251 created 2015
Orthology
K12973  lipid IVA palmitoyltransferase
Genes
ECO: b0622(pagP)
ECJ: JW0617(crcA)
ECD: ECDH10B_0582(crcA) ECDH10B_0690(crcA)
EBW: BWG_0495(pagP)
ECOK: ECMDS42_0483(crcA)
ECE: Z0767(crcA)
ECS: ECs0661(pagP)
ECF: ECH74115_0711(pagP)
ETW: ECSP_0676(crcA)
ELX: CDCO157_0648(pagP)
EOJ: ECO26_0697(crcA)
EOI: ECO111_0653(crcA)
EOH: ECO103_0630(crcA)
ECOO: ECRM13514_0646(pagP)
ECOH: ECRM13516_0591(pagP)
ECG: E2348C_0523(pagP)
EOK: G2583_0786(pagP)
ELR: ECO55CA74_03855(pagP)
ESO: O3O_06815(pagP)
ESM: O3M_18460(pagP)
ESL: O3K_18480(pagP)
ECW: EcE24377A_0647(pagP)
ELH: ETEC_0651
EUN: UMNK88_658(crcA)
ECC: c0713(crcA)
ECP: ECP_0653
ECI: UTI89_C0626(crcA)
ECV: APECO1_1430(crcA)
ECX: EcHS_A0674(pagP)
ECY: ECSE_0690
ECR: ECIAI1_0606(crcA)
ECQ: ECED1_0619(crcA)
ECK: EC55989_0615(crcA)
ECT: ECIAI39_0598(pagP)
EOC: CE10_0621(pagP)
EUM: ECUMN_0715(crcA)
ECZ: ECS88_0664(crcA)
ELO: EC042_0658(pagP)
ELN: NRG857_02830(pagP)
ESE: ECSF_0562
EBR: ECB_00592(crcA)
EBD: ECBD_3028
EKF: KO11_20555(pagP)
EDJ: ECDH1ME8569_0591(pagP)
EIH: ECOK1_0633(pagP)
ELU: UM146_14400(pagP)
ELW: ECW_m0677(pagP)
ELL: WFL_03365(pagP)
ELC: i14_0681(pagP)
ELD: i02_0681(pagP)
ELP: P12B_c0606(pagP)
EBL: ECD_00592(pagP)
EBE: B21_00581(pagP)
ELF: LF82_1590(pagP)
ECOL: LY180_03370(pagP)
ECOI: ECOPMV1_00641(pagP)
ECOJ: P423_03055(pagP)
ECOS: EC958_0741(crcA)
EFE: EFER_2481
EAL: EAKF1_ch0839c(pagP)
STY: STY0677(pagP)
STT: t2239(pagP)
SENT: TY21A_11355(pagP)
STM: STM0628(pagP)
SEO: STM14_0731(pagP)
SEY: SL1344_0616(pagP)
SEM: STMDT12_C06900(pagP)
SEJ: STMUK_0633(pagP)
SEB: STM474_0649(pagP)
SEF: UMN798_0679(pagP)
SETU: STU288_11235(pagP)
SETC: CFSAN001921_13895(pagP)
SENR: STMDT2_06191(pagP)
SEND: DT104_06571(pagP)
SENI: CY43_03425(pagP)
SEEN: SE451236_09165(pagP)
SPT: SPA2106(pagP)
SEK: SSPA1958
SEI: SPC_0643(pagP)
SEH: SeHA_C0743(pagP)
SHB: SU5_01318
SENH: CFSAN002069_05705(pagP)
SEEH: SEEH1578_12570(pagP)
SEE: SNSL254_A0683(pagP)
SEW: SeSA_A0787(pagP)
SEA: SeAg_B0669(pagP)
SENS: Q786_03070(pagP)
SED: SeD_A0729(pagP)
SEG: SG0632(pagP)
SEL: SPUL_2334(pagP)
SEGA: SPUCDC_2320(pagP)
SET: SEN0597(pagP)
SENA: AU38_03055(pagP)
SENO: AU37_03050(pagP)
SENV: AU39_03055(pagP)
SENQ: AU40_03360(pagP)
SENL: IY59_03105(pagP)
SENJ: CFSAN001992_08190(pagP)
SEEC: CFSAN002050_09750(pagP)
SEEB: SEEB0189_016145(pagP)
SEEP: I137_10650(pagP)
SENB: BN855_6210(pagP)
SENE: IA1_03290(pagP)
SENC: SEET0819_10105(pagP)
SBG: SBG_0536(pagP)
SBZ: A464_604
SBV: N643_02665(pagP)
SFL: SF0658(pagP)
SFX: S0681(crcA)
SFV: SFV_0703(crcA)
SFE: SFxv_0725(pagP)
SFN: SFy_0895
SFS: SFyv_0933
SFT: NCTC1_00707(pagP)
SSN: SSON_0576(crcA)
SBO: SBO_0487(crcA)
SDY: SDY_0545(pagP)
SHQ: A0259_06800(pagP)
ENO: ECENHK_06275(pagP) ECENHK_14430(pagP)
ECLO: ENC_41620
EEC: EcWSU1_01206(crcA)
ECLN: ECNIH4_16430(pagP)
ECLX: LI66_05890(pagP) LI66_14335
ECLY: LI62_06790(pagP) LI62_15690
ECLZ: LI64_06360(pagP)
EKB: BFV64_05910(pagP)
ELG: BH714_02125(pagP)
ECLS: LI67_006935(pagP)
ERN: BFV67_05675(pagP)
ENR: H650_21950(pagP)
ENF: AKI40_2109(pagP)
ESA: ESA_02705
CSK: ES15_2776(pagP)
CSZ: CSSP291_12755(pagP)
CTU: CTU_12560(crcA)
KPN: KPN_00655(crcA)
KPU: KP1_1610(crcA)
KPP: A79E_3584
KPE: KPK_3918(pagP) KPK_A0097
KPO: KPN2242_06150(pagP)
KPR: KPR_3920(crcA)
KPJ: N559_3668
KPI: D364_03440(pagP)
KPX: PMK1_02989(pagP)
KPNU: LI86_18820
KPNK: BN49_1714(crcA)
KOX: KOX_14170(pagP) KOX_24295(pagP)
KOY: J415_13335(pagP) J415_23370(pagP)
KMI: VW41_05645(pagP)
EAE: EAE_13800(pagP)
EAR: CCG31211
CKO: CKO_02535
CRO: ROD_06371(pagP)
CFD: CFNIH1_13280(pagP)
CBRA: A6J81_09955(pagp)
CWE: CO701_15660(pagP)
CYO: CD187_17110(pagP)
CAMA: F384_02760(pagP)
CAF: AL524_19530(pagp)
CIF: AL515_07770(pagp)
CFAR: CI104_07470(pagP)
CIR: C2U53_16675(pagp)
CIE: AN232_23205(pagp)
EBT: EBL_c27410(crcA)
ROR: RORB6_03255(pagP) RORB6_11790(pagP)
CNT: JT31_06595(pagP)
CEM: LH23_11330(pagP)
CEN: LH86_10760(pagP)
PGE: LG71_21810(pagP)
KSA: C813_08515(pagP)
KOR: AWR26_17950(pagP)
KRD: A3780_06305(pagP)
KCO: BWI95_12025(pagP)
LAX: APT61_16475(pagP)
LEI: C2U54_10985(pagP)
LEH: C3F35_05485(pagP)
EBF: D782_3218
PSTS: E05_07370
YPE: YPO1744(pagP)
YPK: y2563(crcA)
YPH: YPC_2537
YPA: YPA_1118
YPN: YPN_2378
YPM: YP_1485(crcA)
YPG: YpAngola_A1664(pagP)
YPZ: YPZ3_1969
YPT: A1122_17145(pagP)
YPD: YPD4_1547
YPX: YPD8_2007(crcA)
YPW: CH59_3421
YPJ: CH55_933
YPV: BZ15_1803
YPL: CH46_3377
YPS: YPTB1622
YPO: BZ17_880
YPI: YpsIP31758_2380(pagP)
YPY: YPK_2476
YPB: YPTS_1744
YPQ: DJ40_601
YPU: BZ21_972
YPR: BZ20_353
YPC: BZ23_1250
YPF: BZ19_1049
YEN: YE1762(pagP)
YEY: Y11_06171
YEW: CH47_1162
YET: CH48_4060
YAL: AT01_819
YFR: AW19_1512
YIN: CH53_4365
YKR: CH54_151
YRO: CH64_859
YRU: BD65_583
SPE: Spro_0993
SRL: SOD_c08470(pagP)
SPLY: Q5A_004510(pagP)
SMAF: D781_0938
SMW: SMWW4_v1c09490(pagP)
SMAR: SM39_0311
SERF: L085_23805(pagP)
SERS: SERRSCBI_04390(pagP)
RAA: Q7S_17220(pagP) Q7S_17225(pagP)
ECA: ECA0175(pagP)
PATR: EV46_00910
PATO: GZ59_01860(pagP)
PCT: PC1_4079
PEC: W5S_4511
SGL: SG1577
SOD: Sant_1379(pagP)
DDD: Dda3937_02050(crcA)
DDQ: DDI_4497
ETA: ETA_23630(pagP)
EPY: EpC_24980(pagP)
EPR: EPYR_02703(crcA)
EAM: EAMY_1108(crcA)
EAY: EAM_1115(pagP)
EBI: EbC_12320(pagP) EbC_27780
ERJ: EJP617_22300(pagP)
PAM: PANA_1113(crcA)
PLF: PANA5342_3176(crcA)
PAJ: PAJ_0434(crcA)
PVA: Pvag_pPag30356(crcA1) Pvag_pPag30521(crcA3)
PSTW: DSJ_07960
TPTY: NCTC11468_01149(pagP)
PLU: plu2784
PAY: PAU_01754(crcA)
PMR: PMI1595(pagP)
PMIB: BB2000_1684(pagP)
XBV: XBW1_2437
PSI: S70_01305(pagP)
PRG: RB151_024850(pagP)
PHEI: NCTC12003_01779(pagP)
MMK: MU9_2523
ETR: ETAE_2687(crcA)
ETD: ETAF_2422(pagP)
ETE: ETEE_0789(pagP)
ETC: ETAC_12895(pagP)
LRI: NCTC12151_01055(pagP)
PPUD: DW66_5829
LPN: lpg0025(pagP)
LPH: LPV_0029(rcp)
LPO: LPO_0026(rcp)
LPM: LP6_0026(pagP)
LPF: lpl0026(rcp)
LPP: lpp0025(rcp)
LPC: LPC_0026
LPA: lpa_00034
LPE: lp12_0025
LLO: LLO_0052
LFA: LFA_0031
LHA: LHA_0032
LOK: Loa_02891(pagP)
LCD: clem_14745(pagP)
LLG: 44548918_02710(pagP)
TMC: LMI_0024
SLIM: SCL_2150
SVA: SVA_3780
LHK: LHK_03209
PSE: NH8B_3870
BYI: BYI23_A008150(pagP)
BUE: BRPE67_ACDS08120(pagP)
PPNO: DA70_08970
PPNM: LV28_21840
PPUL: RO07_16230
PSPU: NA29_20930
PAPI: SG18_00070
BPE: BP3006(pagP)
BPC: BPTD_2973(pagP)
BPER: BN118_3128
BPET: B1917_0828(pagP)
BPEU: Q425_23490(pagP)
BPA: BPP3735
BPAR: BN117_0949
BBR: BB4181
BBX: BBS798_3959(pagP)
BAV: BAV2864(pagP)
BHO: D560_0675
BHM: D558_0661
BHZ: ACR54_03924(pagP)
BTRM: SAMEA390648700533(pagP)
AXY: AXYL_00807(pagP)
AXX: ERS451415_00823(pagP)
ODI: ODI_R2313
CFU: CFU_0622(crcA)
CARE: LT85_0683
TIN: Tint_2427
THI: THI_2818
MMB: Mmol_1609
MEH: M301_0969
BPRC: D521_2046(pagP)
CAVI: CAV_1180
 » show all
Taxonomy
Reference
1  [PMID:11013210]
  Authors
Bishop RE, Gibbons HS, Guina T, Trent MS, Miller SI, Raetz CR
  Title
Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria.
  Journal
EMBO J 19:5071-80 (2000)
DOI:10.1093/emboj/19.19.5071
  Sequence
[eco:b0622]
Reference
2  [PMID:20826347]
  Authors
Cuesta-Seijo JA, Neale C, Khan MA, Moktar J, Tran CD, Bishop RE, Pomes R, Prive GG
  Title
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.
  Journal
Structure 18:1210-9 (2010)
DOI:10.1016/j.str.2010.06.014
  Sequence
[eco:b0622]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.251
IUBMB Enzyme Nomenclature: 2.3.1.251
ExPASy - ENZYME nomenclature database: 2.3.1.251
BRENDA, the Enzyme Database: 2.3.1.251

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