KEGG   ENZYME: 2.3.1.255Help
Entry
EC 2.3.1.255                Enzyme                                 

Name
N-terminal amino-acid Nalpha-acetyltransferase NatA;
NAA10 (gene name);
NAA15 (gene name);
ARD1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:N-terminal-Gly/Ala/Ser/Val/Cys/Thr-[protein] Nalpha-acetyltransferase
Reaction(IUBMB)
(1) acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA;
(2) acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA;
(3) acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA;
(4) acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA;
(5) acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA;
(6) acetyl-CoA + an N-terminal-L-threonyl-[protein] = an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
Substrate
acetyl-CoA [CPD:C00024];
N-terminal-glycyl-[protein] [CPD:C02038];
N-terminal-L-alanyl-[protein];
N-terminal-L-seryl-[protein];
N-terminal-L-valyl-[protein];
N-terminal-L-cysteinyl-[protein];
N-terminal-L-threonyl-[protein]
Product
N-terminal-Nalpha-acetyl-glycyl-[protein];
CoA [CPD:C00010];
N-terminal-Nalpha-acetyl-L-alanyl-[protein];
N-terminal-Nalpha-acetyl-L-seryl-[protein];
N-terminal-Nalpha-acetyl-L-valyl-[protein];
N-terminal-Nalpha-acetyl-L-cysteinyl-[protein];
N-terminal-Nalpha-acetyl-L-threonyl-[protein]
Comment
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. The NatA complex is found in all eukaryotic organisms, and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val residues, that became available after removal of the initiator methionine.
History
EC 2.3.1.255 created 1989 as EC 2.3.1.88, part transferred 2016 to EC 2.3.1.255
Orthology
K20791  N-alpha-acetyltransferase 10/11
Genes
HSA: 8260(NAA10) 84779(NAA11)
PTR: 471192(NAA11) 741472(NAA10)
PPS: 100969659(NAA10) 100983536(NAA11)
GGO: 101130546(NAA10) 101133969(NAA11)
PON: 100442643(NAA10) 100461593(NAA11)
NLE: 100580726(NAA11) 100597851(NAA10)
MCC: 106995370(NAA10) 696758(NAA11)
MCF: 102115250(NAA11) 102131779(NAA10)
CSAB: 103232808(NAA10) 103235862(NAA11)
RRO: 104659724(NAA11) 104661168(NAA10)
RBB: 108532511(NAA11) 108535067(NAA10)
CJC: 100406061(NAA11) 100895278(NAA10)
SBQ: 101030072(NAA11) 101035451(NAA10) 104653085
MMU: 56292(Naa10) 97243(Naa11)
RNO: 100909833 289482(Naa11) 363518(Naa10) 498890(RGD1560212)
CGE: 100770650(Naa11) 100774782(Naa10) 103158544
HGL: 101703587(Naa11) 101726555(Naa10)
CCAN: 109674513 109701912(Naa10)
OCU: 100328748(NAA10) 100357154(NAA11)
TUP: 102475091 102495862(NAA11)
CFA: 608326(NAA11) 610872(NAA10)
AML: 100469394(NAA11) 105241829(NAA10)
UMR: 103665344(NAA11) 103679669(NAA10)
ORO: 101380907(NAA10) 101384076(NAA11)
FCA: 101089502(NAA10) 101094415(NAA11)
PTG: 102951149(NAA11) 102969109(NAA10)
AJU: 106976908(NAA11) 106989722(NAA10)
BTA: 528769(NAA11) 613636(NAA10)
BOM: 102265827(NAA11) 102274922(NAA10)
BIU: 109560181(NAA11)
PHD: 102320644(NAA11) 102321658(NAA10)
CHX: 102170405(NAA11) 102173381(NAA10)
OAS: 101106920(NAA10) 101112570(NAA11)
SSC: 100514972(NAA11) 106507058(NAA10)
CFR: 102520946(NAA11) 102523521(NAA10)
CDK: 105091743(NAA11) 105098712(NAA10)
BACU: 103010983(NAA11)
LVE: 103070464(NAA10) 103071336(NAA11) 103072829
OOR: 101279489 101279786(NAA10) 101282928(NAA11)
ECB: 100051638(NAA11) 100058039(NAA10)
EPZ: 103545083 103564768(NAA11)
EAI: 106825627(NAA10) 106828060(NAA11)
MYB: 102259298(NAA10) 102261118(NAA11)
MYD: 102758473(NAA10) 102769289(NAA11)
HAI: 109383259 109394348(NAA10) 109395483(NAA11)
RSS: 109439689(NAA11) 109443034 109460090(NAA10)
PALE: 102888427(NAA10) 102896925(NAA11)
LAV: 100658025(NAA11) 104847082(NAA10)
MDO: 100016066(NAA10)
SHR: 105751065(NAA10)
OAA: 100082522(NAA10)
GGA: 107049486(NAA10L)
PHI: 102108725(NAA10)
FPG: 101919022(NAA10)
FCH: 102046001(NAA10)
AAM: 106497490
ASN: 102385303(NAA10)
AMJ: 102568475(NAA10)
PSS: 102445247
CPIC: 101940107
ACS: 100552905(naa10)
PVT: 110078643(NAA10)
PBI: 103066638(NAA10)
PMUR: 107284223(NAA10)
GJA: 107122921(NAA10)
XLA: 108698289(naa10.L) 380183(naa10.S)
XTR: 493223(naa10)
NPR: 108790461(NAA10)
DRE: 406643(naa10)
IPU: 100528897(naa10)
PHYP: 113530311(naa10)
AMEX: 103038013(naa10)
TRU: 101064008(naa10)
LCO: 104932839(naa10)
NCC: 104967524(naa10)
MZE: 101474430(naa10)
OLA: 101165304(naa10)
XMA: 102237921(naa10)
PRET: 103467318(naa10)
NFU: 107390853(naa10)
KMR: 108244572(naa10)
CSEM: 103384586(naa10)
LCF: 108876576(naa10)
SDU: 111219066(naa10)
HCQ: 109528436(naa10)
BPEC: 110164694(naa10)
MALB: 109969819(naa10)
SASA: 106567016(ARD1B) 106572706(ARD1H) 106598483
ELS: 105013520(naa10)
SFM: 108939176(naa10)
LCM: 102363792(NAA10)
CMK: 103191282
CIN: 100186199
SPU: 580091
APLC: 110984911
SKO: 100368039
DME: Dmel_CG11989(vnc)
DER: 6546098
DPE: 6600245
DSI: Dsimw501_GD14230(Dsim_GD14230)
DWI: 6639597
MDE: 101897153
AAG: 5568308
AME: 726609
BIM: 100740913
BTER: 100651130
SOC: 105195496
MPHA: 105832276
AEC: 105143593
PBAR: 105430528
HST: 105188927
DQU: 106749919
CFO: 105248968
LHU: 105676499
PGC: 109859283
OBO: 105288243
PCF: 106786854
NVI: 100115808
MDL: 103579661
TCA: 658076
DPA: 109536171
NVL: 108565805
BMOR: 101746540
PMAC: 106719112
PRAP: 110998070
HAW: 110378073
TNL: 113501257
PXY: 105393984
API: 100161244
DNX: 107173754
CLEC: 106673398
TUT: 107359272
DPTE: 113797484
CEL: CELE_K07H8.3(daf-31)
CBR: CBG01585
TSP: Tsp_08387
CRG: 105347645
MYI: 110443139
OBI: 106880538
LAK: 106174282
SHX: MS3_01754
EGL: EGR_00204
EPA: 110242115
PDAM: 113686507
SPIS: 111341156
HMG: 100202225
AQU: 100633369
ATH: AT5G13780
CRB: 17882405
CPAP: 110809285
CIT: 102607662
TCC: 18614584
GRA: 105803264
GAB: 108489505
EGR: 104421888
CCAJ: 109804770
CAM: 101504041
LJA: Lj3g3v0824660.1(Lj3g3v0824660.1) Lj3g3v0824670.1(Lj3g3v0824670.1)
ADU: 107462819
FVE: 101292225
PPER: 18787673
PMUM: 103330713
PAVI: 110746174
CSV: 101210984
CMO: 103499957
MCHA: 111013957
RCU: 8259257
JCU: 105628752
POP: 7467350
VVI: 100265457
SLY: 101259670
SPEN: 107008492
SOT: 102600123
CANN: 107839724
CCAV: 112499647
BVG: 104907557
SOE: 110803890
OSA: 4337136
DOSA: Os04t0635800-01(Os04g0635800)
OBR: 102722485
BDI: 100841191
ATS: 109748107(LOC109748107)
SBI: 8068442
ZMA: 100272537(GNAT42) 541935(sgb101)
SITA: 101775211
PDA: 103703942
DCT: 110097276
PEQ: 110031883
AOF: 109851434
ATR: 18428408
CRE: CHLREDRAFT_95444(NAT1)
APRO: F751_2925
SCE: YHR013C(ARD1)
ERC: Ecym_4533
KMX: KLMA_20561(ARD1)
NCS: NCAS_0G00900(NCAS0G00900)
NDI: NDAI_0F01040(NDAI0F01040)
TPF: TPHA_0K00170(TPHA0K00170)
TBL: TBLA_0E02720(TBLA0E02720)
TDL: TDEL_0A04660(TDEL0A04660)
KAF: KAFR_0C05780(KAFR0C05780)
PIC: PICST_34722(ARD1)
CAL: CAALFM_CR10400WA(CaO19.7617)
CAUR: QG37_03290
SLB: AWJ20_1336(ARD1)
NCR: NCU08944
NTE: NEUTE1DRAFT143671(NEUTE1DRAFT_143671)
MGR: MGG_07496
SSCK: SPSK_06418
MAW: MAC_07535
MAJ: MAA_03140
CMT: CCM_03638
BFU: BCIN_04g04090(Bcard1)
MBE: MBM_08105
ANI: AN1328.2
ANG: ANI_1_180074(An08g01190)
ABE: ARB_08044
TVE: TRV_04359
PNO: SNOG_05059(SNOG_05058)
PTE: PTT_14887
SPO: SPAC15E1.08(naa10)
CNE: CNE05130
CNB: CNBE5130
ABP: AGABI1DRAFT113278(AGABI1DRAFT_113278) AGABI1DRAFT80054(AGABI1DRAFT_80054)
ABV: AGABI2DRAFT187118(AGABI2DRAFT_187118) AGABI2DRAFT192079(AGABI2DRAFT_192079)
MGL: MGL_2095
DDI: DDB_G0275449(natA)
DFA: DFA_01817(natA)
EHI: EHI_005070(103.t00022) EHI_186730(294.t00008)
PYO: PY17X_1204800(PY00941)
PCB: PCHAS_120240(PC000314.00.0)
TAN: TA09345
TPV: TP04_0161
BBO: BBOV_II004010(18.m06331)
CPV: cgd5_3090
SMIN: v1.2.002004.t1(symbB.v1.2.002004.t1) v1.2.007550.t1(symbB.v1.2.007550.t1)
SPAR: SPRG_07128
ARM: ART_0999
 » show all
Taxonomy
Reference
1  [PMID:2551674]
  Authors
Mullen JR, Kayne PS, Moerschell RP, Tsunasawa S, Gribskov M, Colavito-Shepanski M, Grunstein M, Sherman F, Sternglanz R
  Title
Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast.
  Journal
EMBO J 8:2067-75 (1989)
  Sequence
Reference
2  [PMID:1600941]
  Authors
Park EC, Szostak JW
  Title
ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity.
  Journal
EMBO J 11:2087-93 (1992)
Reference
3  [PMID:12888564]
  Authors
Sugiura N, Adams SM, Corriveau RA
  Title
An evolutionarily conserved N-terminal acetyltransferase complex associated with  neuronal development.
  Journal
J Biol Chem 278:40113-20 (2003)
DOI:10.1074/jbc.M301218200
  Sequence
[mmu:74838 56292]
Reference
4  [PMID:14517307]
  Authors
Gautschi M, Just S, Mun A, Ross S, Rucknagel P, Dubaquie Y, Ehrenhofer-Murray A, Rospert S
  Title
The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides.
  Journal
Mol Cell Biol 23:7403-14 (2003)
DOI:10.1128/MCB.23.20.7403-7414.2003
Reference
5  [PMID:25966763]
  Authors
Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X
  Title
Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis.
  Journal
Plant Cell 27:1547-62 (2015)
DOI:10.1105/tpc.15.00173
  Sequence
Reference
6  [PMID:25987439]
  Authors
Dorfel MJ, Lyon GJ
  Title
The biological functions of Naa10 - From amino-terminal acetylation to human disease.
  Journal
Gene 567:103-31 (2015)
DOI:10.1016/j.gene.2015.04.085
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.255
IUBMB Enzyme Nomenclature: 2.3.1.255
ExPASy - ENZYME nomenclature database: 2.3.1.255
BRENDA, the Enzyme Database: 2.3.1.255

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