| Entry |
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| Name |
N-terminal methionine Nalpha-acetyltransferase NatC;
NAA30 (gene name);
NAA35 (gene name);
NAA38 (gene name);
MAK3 (gene name);
MAK10 (gene name);
MAK31 (gene name)
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-CoA:N-terminal-Met-Leu/Ile/Phe/Trp/Tyr-[protein] Met Nalpha-acetyltransferase
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| Reaction(IUBMB) |
(1) acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA;
(2) acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA;
(3) acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA;
(4) acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA;
(5) acetyl-CoA + an N-terminal-L-methionyl-L-tyrosyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA
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| Substrate |
acetyl-CoA [CPD: C00024];
N-terminal-L-methionyl-L-leucyl-[protein];
N-terminal-L-methionyl-L-isoleucyl-[protein];
N-terminal-L-methionyl-L-phenylalanyl-[protein];
N-terminal-L-methionyl-L-tryptophyl-[protein];
N-terminal-L-methionyl-L-tyrosyl-[protein]
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| Product |
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein];
CoA [CPD: C00010];
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein];
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein];
N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein];
N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein]
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| Comment |
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues.
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| History |
EC 2.3.1.256 created 1989 as EC 2.3.1.88, part transferred 2016 to EC 2.3.1.256
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| Orthology |
| K00670 | N-alpha-acetyltransferase 30 |
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| Genes |
» show all
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| Reference |
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| Authors |
Polevoda B, Sherman F |
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| Title |
NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. |
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| Journal |
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| Reference |
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| Authors |
Polevoda B, Sherman F |
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| Title |
Composition and function of the eukaryotic N-terminal acetyltransferase subunits. |
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| Journal |
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| Reference |
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| Authors |
Pesaresi P, Gardner NA, Masiero S, Dietzmann A, Eichacker L, Wickner R, Salamini F, Leister D |
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| Title |
Cytoplasmic N-terminal protein acetylation is required for efficient photosynthesis in Arabidopsis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC |
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| Title |
Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. |
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| Journal |
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| Reference |
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| Authors |
Starheim KK, Gromyko D, Evjenth R, Ryningen A, Varhaug JE, Lillehaug JR, Arnesen T |
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| Title |
Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.256 |
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