KEGG   ENZYME: 2.3.1.256Help
Entry
EC 2.3.1.256                Enzyme                                 

Name
N-terminal methionine Nalpha-acetyltransferase NatC;
NAA30 (gene name);
NAA35 (gene name);
NAA38 (gene name);
MAK3 (gene name);
MAK10 (gene name);
MAK31 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:N-terminal-Met-Leu/Ile/Phe/Trp/Tyr-[protein] Met Nalpha-acetyltransferase
Reaction(IUBMB)
(1) acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA;
(2) acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA;
(3) acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA;
(4) acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA;
(5) acetyl-CoA + an N-terminal-L-methionyl-L-tyrosyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA
Substrate
acetyl-CoA [CPD:C00024];
N-terminal-L-methionyl-L-leucyl-[protein];
N-terminal-L-methionyl-L-isoleucyl-[protein];
N-terminal-L-methionyl-L-phenylalanyl-[protein];
N-terminal-L-methionyl-L-tryptophyl-[protein];
N-terminal-L-methionyl-L-tyrosyl-[protein]
Product
N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein];
CoA [CPD:C00010];
N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein];
N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein];
N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein];
N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein]
Comment
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues.
History
EC 2.3.1.256 created 1989 as EC 2.3.1.88, part transferred 2016 to EC 2.3.1.256
Orthology
K00670  N-alpha-acetyltransferase 30
Genes
HSA: 122830(NAA30)
PTR: 452931(NAA30)
PPS: 100981531(NAA30)
GGO: 109025345(NAA30)
PON: 100459700(NAA30)
NLE: 100597553(NAA30)
MCC: 699379(NAA30)
MCF: 102128074(NAA30)
CSAB: 103229063(NAA30)
RRO: 104656404(NAA30)
RBB: 108529710(NAA30)
CJC: 100415265(NAA30)
SBQ: 101032681 101036544(NAA30)
MMU: 70646(Naa30)
RNO: 498489(Naa30)
CGE: 100754621(Naa30)
NGI: 103739208(Naa30)
HGL: 101698630(Naa30)
CCAN: 109698791(Naa30)
OCU: 100351689(NAA30)
TUP: 102483447(NAA30)
CFA: 612880(NAA30)
AML: 100476028(NAA30)
UMR: 103674641(NAA30)
ORO: 101365515(NAA30)
FCA: 101097155(NAA30)
PTG: 102958560(NAA30)
AJU: 106983043(NAA30)
BTA: 533922(NAA30)
BOM: 102275143(NAA30)
BIU: 109564395(NAA30)
PHD: 102327811(NAA30)
CHX: 102173940(NAA30)
OAS: 101115036(NAA30)
SSC: 100152018(NAA30)
CFR: 102510523(NAA30)
CDK: 105091458(NAA30)
BACU: 102997859(NAA30)
LVE: 103073727(NAA30)
OOR: 101270817(NAA30)
ECB: 100058576(NAA30)
EPZ: 103558590(NAA30)
MYB: 102252365(NAA30)
MYD: 102753320(NAA30)
HAI: 109383973(NAA30)
RSS: 109444399(NAA30)
PALE: 102895957(NAA30)
LAV: 100666916(NAA30)
TMU: 101361489
MDO: 100020946(NAA30)
SHR: 100930137(NAA30)
OAA: 100086561(NAA30)
GGA: 423547(NAA30)
MGP: 100548140(NAA30)
CJO: 107315459(NAA30)
APLA: 101794680(NAA30)
ACYG: 106044007(NAA30)
TGU: 100229597(NAA30)
GFR: 102042942(NAA30)
FAB: 101811146(NAA30)
PHI: 102107068(NAA30)
PMAJ: 107206083(NAA30)
CCW: 104688983(NAA30)
FPG: 101910833(NAA30)
FCH: 102049348(NAA30)
CLV: 102097090(NAA30)
EGZ: 104129273(NAA30)
AAM: 106495892(NAA30)
ASN: 102371277(NAA30)
AMJ: 102568606(NAA30)
PSS: 102443373(NAA30)
CMY: 102935482(NAA30)
CPIC: 101944740(NAA30)
ACS: 100563427(naa30)
PVT: 110091012(NAA30)
PBI: 103057970(NAA30)
GJA: 107106715(NAA30)
XLA: 108698888(naa30.L) 779222(naa30.S)
XTR: 100379895(naa30)
NPR: 108791605(NAA30)
DRE: 100192212(naa30)
AMEX: 103045260(naa30)
TRU: 101062419(naa30)
LCO: 104919829(naa30)
NCC: 104960581(naa30)
MZE: 101479287(naa30)
OLA: 101167506(naa30)
XMA: 102225725(naa30)
PRET: 103457900(naa30)
NFU: 107378091(naa30)
CSEM: 103381024(naa30)
LCF: 108896902(naa30)
HCQ: 109523405(naa30)
BPEC: 110168290(naa30)
ELS: 105017543(naa30)
SFM: 108930802 108941457(naa30)
LCM: 102351004(NAA30)
CMK: 103178505(naa30)
CIN: 100184253
SPU: 582991
APLC: 110975182
SKO: 100370016
DME: Dmel_CG11412(CG11412) Dmel_CG32319(CG32319)
DSI: Dsimw501_GD13476(Dsim_GD13476) Dsimw501_GD24712(Dsim_GD24712)
MDE: 101888685
AAG: 5576262
AME: 552341(GB17389)
BIM: 100747752
BTER: 100648442
SOC: 105199616
AEC: 105151635
ACEP: 105617455
PBAR: 105428421
HST: 105189450
CFO: 105252346
LHU: 105677861
PGC: 109854433
NVI: 100116800
TCA: 664218
NVL: 108560806
BMOR: 101735969
PMAC: 106710971
PRAP: 110991344
PXY: 105388248
API: 100159183
DNX: 107173756
ZNE: 110828079
FCD: 110859247
TUT: 107366774
CEL: CELE_B0238.10(natc-2)
CBR: CBG06776
BMY: Bm1_25890
TSP: Tsp_01913
CRG: 105326736
MYI: 110446492
OBI: 106878892
SHX: MS3_07896
EPA: 110238824
ADF: 107346595
HMG: 100203012
AQU: 100637513
ATH: AT2G38130(ATMAK3)
CRB: 17888874
BRP: 103867135
BOE: 106339586
THJ: 104802366
CPAP: 110812967
CIT: 102624373
TCC: 18601134
GRA: 105770121
EGR: 104453523
GMX: 100806790
VRA: 106759578
VAR: 108328156
CCAJ: 109818974
CAM: 101510883
LJA: Lj1g3v3904440.1(Lj1g3v3904440.1) Lj1g3v3904440.2(Lj1g3v3904440.2)
LANG: 109333677
FVE: 101304691
PPER: 18782461
PMUM: 103330431
PAVI: 110764340
ZJU: 107427971
CSV: 101215795
CMO: 103501348
MCHA: 111011949
RCU: 8273096
JCU: 105630215
JRE: 109001288
VVI: 100261668
SLY: 101266164
SPEN: 107029228
SOT: 102603162
CANN: 107852172
NSY: 104230388
NTO: 104087121
INI: 109174898
OEU: 111388712
HAN: 110926172
LSV: 111917017
DCR: 108216487
BVG: 104897662
SOE: 110804914
NNU: 104592748
OSA: 4350619
DOSA: Os11t0525800-01(Os11g0525800)
OBR: 102717584
BDI: 100824497
ATS: 109761642(LOC109761642)
SBI: 8064790
SITA: 101752797
PDA: 103708043
EGU: 105051096
DCT: 110098937
AOF: 109823631
ATR: 18434331
MNG: MNEG_0916
APRO: F751_5973
SCE: YPR051W(MAK3)
ERC: Ecym_7457
KMX: KLMA_70335(MAK3)
NCS: NCAS_0A11000(NCAS0A11000)
NDI: NDAI_0A05300(NDAI0A05300)
TPF: TPHA_0A03750(TPHA0A03750)
TBL: TBLA_0B02570(TBLA0B02570)
TDL: TDEL_0C04730(TDEL0C04730)
KAF: KAFR_0H01050(KAFR0H01050)
PIC: PICST_52756(MAK3)
CAL: CAALFM_C401760WA(CaO19.4617)
CAUR: QG37_01472
NCR: NCU02417
NTE: NEUTE1DRAFT123929(NEUTE1DRAFT_123929)
MGR: MGG_03561
MAW: MAC_04717
MAJ: MAA_04509
CMT: CCM_01241
BFU: BCIN_02g05220(Bcmak3)
MBE: MBM_06752
ANI: AN4993.2
ANG: ANI_1_1658144(An16g03630)
ABE: ARB_01215
TVE: TRV_01293
SPO: SPBC15D4.06(naa30)
CNE: CNJ00870
CNB: CNBJ2640
ABP: AGABI1DRAFT45308(AGABI1DRAFT_45308)
ABV: AGABI2DRAFT76783(AGABI2DRAFT_76783)
MGL: MGL_2338
DFA: DFA_02509
EHI: EHI_123240(241.t00008)
PYO: PY17X_1228400(PY05005)
FCY: FRACYDRAFT_269632(NAT1_1)
SPAR: SPRG_02910
PSAB: PSAB_11350
 » show all
Taxonomy
Reference
1  [PMID:11274203]
  Authors
Polevoda B, Sherman F
  Title
NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p.
  Journal
J Biol Chem 276:20154-9 (2001)
DOI:10.1074/jbc.M011440200
Reference
2  [PMID:12890471]
  Authors
Polevoda B, Sherman F
  Title
Composition and function of the eukaryotic N-terminal acetyltransferase subunits.
  Journal
Biochem Biophys Res Commun 308:1-11 (2003)
DOI:10.1016/S0006-291X(03)01316-0
Reference
3  [PMID:12897255]
  Authors
Pesaresi P, Gardner NA, Masiero S, Dietzmann A, Eichacker L, Wickner R, Salamini F, Leister D
  Title
Cytoplasmic N-terminal protein acetylation is required for efficient photosynthesis in Arabidopsis.
  Journal
Plant Cell 15:1817-32 (2003)
DOI:10.1105/tpc.012377
  Sequence
[ath:AT2G38130]
Reference
4  [PMID:16484612]
  Authors
Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC
  Title
Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development.
  Journal
Circ Res 98:846-55 (2006)
DOI:10.1161/01.RES.0000214539.86593.7a
Reference
5  [PMID:19398576]
  Authors
Starheim KK, Gromyko D, Evjenth R, Ryningen A, Varhaug JE, Lillehaug JR, Arnesen T
  Title
Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.
  Journal
Mol Cell Biol 29:3569-81 (2009)
DOI:10.1128/MCB.01909-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.256
IUBMB Enzyme Nomenclature: 2.3.1.256
ExPASy - ENZYME nomenclature database: 2.3.1.256
BRENDA, the Enzyme Database: 2.3.1.256

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