KEGG   ENZYME: 2.3.1.257
Entry
EC 2.3.1.257                Enzyme                                 
Name
N-terminal L-serine Nalpha-acetyltransferase NatD;
NAA40 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:N-terminal-L-seryl-[histone 4/2A] L-serine Nalpha-acetyltransferase
Reaction(IUBMB)
(1) acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA;
(2) acetyl-CoA + an N-terminal-L-seryl-[histone H2A] = an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
Substrate
acetyl-CoA [CPD:C00024];
N-terminal-L-seryl-[histone H4];
N-terminal-L-seryl-[histone H2A]
Product
N-terminal-Nalpha-acetyl-L-seryl-[histone H4];
CoA [CPD:C00010];
N-terminal-Nalpha-acetyl-L-seryl-[histone H2A]
Comment
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. NatD is found in all eukaryotic organisms, and acetylates solely the serine residue at the N-terminus of histones H2A or H4. Efficient recognition and acetylation by NatD requires at least the first 30 to 50 highly conserved amino acid residues of the histone N terminus.
History
EC 2.3.1.257 created 1989 as EC 2.3.1.88, part transferred 2016 to EC 2.3.1.257
Orthology
K20794  N-alpha-acetyltransferase 40
Genes
HSA79829(NAA40)
PTR466645(NAA40)
PPS100981949(NAA40)
GGO101143531(NAA40)
PON100172762(NAA40)
NLE100597032(NAA40)
MCC722126(NAA40)
MCF102132995 102140277(NAA40)
MTHB126935594 126941197
CSAB103233535(NAA40)
CATY105577510(NAA40)
PANU101020857(NAA40)
TGE112607084(NAA40)
RRO104672944(NAA40)
RBB108536146(NAA40)
TFN117080291(NAA40)
PTEH111522370(NAA40)
CJC100407232(NAA40)
SBQ101044119(NAA40)
CSYR103252370(NAA40)
MMUR105878459(NAA40)
LCAT123641448(NAA40)
OGA100962198(NAA40)
MMU70999(Naa40)
MCAL110285764(Naa40)
MPAH110317122(Naa40)
RNO361718(Naa40)
MCOC116103483(Naa40)
MUN110551613(Naa40)
CGE100754917(Naa40)
MAUA101831978(Naa40)
PLEU114680681(Naa40)
MORG121454313(Naa40)
MFOT126498339
AAMP119816421(Naa40)
NGI103735065(Naa40)
HGL101707230(Naa40)
CPOC100735089(Naa40)
CCAN109683256(Naa40)
DORD105989204(Naa40)
DSP122105331(Naa40)
NCAR124959871
OCU100357175
OPI101522836(NAA40)
TUP102488940(NAA40)
GVR103586217(NAA40)
CFA476041(NAA40)
CLUD112659364(NAA40)
VVP112924329(NAA40)
VLG121472105(NAA40)
AML100466974(NAA40)
UMR103679416(NAA40)
UAH113244193(NAA40)
UAR123778435(NAA40)
ELK111150012
LLV125078674
MPUF101670794(NAA40)
ORO101381023(NAA40)
EJU114220442(NAA40)
ZCA113915058(NAA40)
MLX118015980(NAA40)
NSU110575930(NAA40)
LWW102746424(NAA40)
FCA101096166(NAA40)
PYU121023995(NAA40)
PBG122483937(NAA40)
LRUF124505827
PTG102960376(NAA40)
PPAD109246639(NAA40)
AJU106981748(NAA40)
HHV120249210(NAA40)
BTA517933(NAA40)
BOM102279641(NAA40)
BIU109554585(NAA40)
BBUB102390933(NAA40)
BBIS104987179(NAA40)
CHX102178517(NAA40)
OAS101121556(NAA40)
ODA120874619(NAA40)
CCAD122431122(NAA40)
SSC100525678(NAA40)
CFR102520489(NAA40)
CBAI105070620(NAA40)
CDK105101532(NAA40)
VPC102535375(NAA40)
BACU103011139(NAA40)
LVE103088039(NAA40)
OOR101269925(NAA40)
DLE111183827(NAA40)
PCAD102995130(NAA40)
PSIU116758648(NAA40)
ECB100054687(NAA40)
EPZ103565283(NAA40)
EAI106833644(NAA40)
MYB102256277(NAA40)
MYD102751829(NAA40)
MMYO118665380(NAA40)
MLF102440355(NAA40)
MNA107539791(NAA40)
PKL118707293(NAA40)
HAI109384310(NAA40)
DRO112317279(NAA40)
SHON118991655(NAA40)
AJM119045461(NAA40)
PDIC114500669(NAA40)
PHAS123829577(NAA40)
MMF118628893(NAA40)
RFQ117030625(NAA40)
PALE102882302(NAA40)
PGIG120600602(NAA40)
PVP105297834(NAA40)
RAY107497079(NAA40)
MJV108385873(NAA40)
TOD119250096(NAA40)
SARA101547449(NAA40)
LAV100665545(NAA40)
TMU101355467
ETF101656941(NAA40)
DNM101435329(NAA40)
MDO100014638(NAA40)
GAS123251248(NAA40)
SHR100914155(NAA40)
PCW110195518(NAA40)
OAA114810348(NAA40)
GGA430563(NAA40)
PCOC116239479(NAA40)
MGP104915945(NAA40)
CJO107307431(NAA40)
NMEL110391372(NAA40)
TGU100226136(NAA40)
LSR110478822(NAA40)
SCAN108964188(NAA40)
GFR102039633(NAA40)
FAB101806023(NAA40)
PHI102107203(NAA40)
PMAJ107199372(NAA40)
CBRC103624397(NAA40)
FPG101920518(NAA40)
FCH102055361
AFOR103895617(NAA40)
ACHC115337567 115338459
HLE104834087(NAA40)
AGEN126033868
CCRI104161191(NAA40)
MUI104540466(NAA40)
LDI104340133(NAA40)
NNT104399376(NAA40)
ACAR104525526(NAA40)
CVF104295810(NAA40)
CUCA104059228(NAA40)
AAM106496829(NAA40)
AROW112964592(NAA40)
NPD112957329(NAA40)
ASN102374858(NAA40)
AMJ102560163(NAA40)
PSS102463007(NAA40)
CMY102936163(NAA40)
CPIC101947534(NAA40)
TST117879894(NAA40)
CABI116838763(NAA40)
MRV120409567(NAA40)
ACS100567361(naa40)
PVT110084988(NAA40)
SUND121915180(NAA40)
PBI103066331(NAA40)
PMUR107296909(NAA40)
CTIG120317133(NAA40)
TSR106541617(NAA40)
PGUT117670765(NAA40)
VKO123032697(NAA40)
PMUA114587229(NAA40)
ZVI118076281(NAA40)
GJA107118258(NAA40)
STOW125441462(NAA40)
XLA108715148(naa40.S) 414673(naa40.L)
XTR100145481(naa40)
NPR108794126(NAA40)
RTEM120917616(NAA40)
BBUF120980935(NAA40)
BGAR122920469(NAA40)
DRE101882407 550325(naa40)
SRX107749810 107750594
SANH107668433 107691908
SGH107562113(naa40) 107588221
CCAR109093058 109093074
CAUA113052096 113105837
PPRM120470475(naa40)
MAMB125264564(naa40)
IPU108268037(naa40)
PHYP113540510(naa40)
SMEO124387454(naa40)
TFD113635142(naa40)
AMEX103028030(naa40)
EEE113579801(naa40)
TRU101071547(naa40)
TNGGSTEN00025863G001
LCO104918113(naa40)
NCC104960744(naa40)
CGOB115023848(naa40)
ELY117246234(naa40)
EFO125884032(naa40)
PLEP121962224(naa40)
SLUC116042335(naa40)
ECRA117934659(naa40)
ESP116707129(naa40)
PFLV114546033(naa40)
GAT120822267(naa40)
PPUG119222707(naa40)
MSAM119912363(naa40)
CUD121504765(naa40)
ALAT119027140(naa40)
MZE101480401(naa40)
ONL100707835(naa40)
OAU116317869(naa40)
OLA101172283(naa40)
OML112156163(naa40)
XMA102216975(naa40)
XCO114157308(naa40)
XHE116733048(naa40)
PRET103480761(naa40)
PFOR103153607(naa40)
PLAI106948296(naa40)
PMEI106916893(naa40)
GAF122820552(naa40)
CVG107098314(naa40)
CTUL119786645(naa40)
GMU124880892(naa40)
NFU107377136(naa40)
KMR108242857(naa40)
ALIM106524985(naa40)
NWH119416884(naa40)
AOCE111568559 111583096(naa40)
MCEP125014965(naa40)
CSEM103384103(naa40)
POV109634840(naa40)
SSEN122766530(naa40)
HHIP117751787(naa40)
HSP118102625(naa40)
LCF108888768
SDU111231345(naa40)
SLAL111666432(naa40)
XGL120797326(naa40)
HCQ109515069(naa40)
BPEC110156250(naa40)
MALB109965807(naa40)
BSPL114846713(naa40)
SASA106578099(naa40) 106609028
STRU115194695 115198622
OTW112265773(naa40)
OMY110531394(naa40)
OGO124008273(naa40) 124013586
ONE115120596 115133832
SALP111951742 112071458
SNH120036528(naa40) 120049828
CCLU121554363(naa40) 121571244
ELS105005686(naa40)
SFM108920268(naa40) 108925397
PKI111835116(naa40)
AANG118223371(naa40) 118236359
LOC102690106(naa40)
PSPA121306257(naa40)
ARUT117398635 117969044
PSEX120539225(naa40)
LCM102365289(NAA40)
RTP109917440(naa40)
BFO118411483
BBEL109479116
CIN100185371
SPU577667
APLC110983990
AJC117105773
SKO100366932
DMEDmel_CG7593(Naa40)
DER6554540
DSE6612728
DSIDsimw501_GD17683(Dsim_GD17683)
DYADyak_GE10433
DAN6505521
DSR110186543
DPO4800505
DPE6595134
DMN108156106
DWI6647618
DGR6569628
DMODmoj_GI22333
DAZ108616216
DNV108659136
DHE111592703
DVI6632220
CCAT101460057
BOD106617820
RZE108363927
MDE101899623
SCAC106089209
LCQ111690536
LSQ119601076
HIS119652627
AGAAgaP_AGAP008428 AgaP_AGAP009686
ACOZ120954828 120959915
AARA120902230 120902522
ASTE118510012 118512617
AAG5576484
AALB109422944 115260596
CQUCpipJ_CPIJ006713
CPII120416251
CNS116338508
BCOO119068698
AME725628
ACER107994423
ALAB122714933
BIM100749722
BBIF117205098
BVK117231100
BVAN117157628
BTER100647060
BPYO122567782
CCAL108623661
OBB114880572
MGEN117224147
NMEA116423943
CGIG122398870
SOC105197102
MPHA105837509
AEC105154408
ACEP105623776
PBAR105423366
VEM105565778
HST105190975
DQU106750370
CFO105253606
FEX115237694
LHU105674567
PGC109851680
OBO105274665
PCF106789843
PFUC122513267
VPS122636857
NVI100116532
CSOL105364668
TPRE106650774
MDL103579009
CGLO123274905
FAS105270281
DAM107036080
AGIF122854621
CINS118073821
LHT122504439
CCIN107264517
TCA655482
DPA109546564
SOY115884957
ATD109597411
CSET123306741
AGB108914822
LDC111518114
NVL108566624
APLN108739447
PPYR116170734
OTU111418827
BMOR101746457
BMAN114244896
MSEX115450213 119191565
DPLKGM_214586 KGM_214587
BANY112047203
NIQ126776020
PMAC106721691
PPOT106103875
PXU106120260
PRAP110993088
PBX123716708
PNAP125052408
ZCE119828672
CCRC123699633
HAW110378602
HZE124640362
TNL113498728
SLIU111350599
OFU114365862
PXY105392246
API100162771
DNX107170201
AGS114129180
RMD113550953
BTAB109036776
DCI103511724
CLEC106670944
HHAL106688014
NLU111048051
PHUPhum_PHUM220190
FOC113203152
TPAL117650575
ZNE110830382
CSEC111869674
SGRE126354468
FCD110844419
DPXDAPPUDRAFT_300985
DMK116925045
DPZ124342451
PVM113812763
PJA122260965
PCHN125047534
HAME121868224
PCLA123771881
PTRU123498521
HAZT108671821
EAF111695096 111700859 111714048
LSM121124498
PPOI119089406 119089660 119114892
ISCIscW_ISCW015392
DSV119450702
RSAN119383924
RMP119170877
VDE111247158
VJA111269756
TUT107367944
DPTE113793965
DFR124492274
CSCU111641081
PTEP107456196
SDM118202757
CELCELE_Y38A10A.7(Y38A10A.7)
CBRCBG_09255
BMYBM_BM6414(Bm6414)
LOALOAG_06868
NAINECAME_00363
TSPTsp_04479
LGILOTGIDRAFT_56489
PCAN112569747
BGT106057215
GAE121372383
HRF124146676
HRJ124267123
CRG105346166
MYI110450220
PMAX117323849 117323850
MMER123541317
OBI106880900
OSN115217455
LAK106171082
SMMSmp_115340
SHXMS3_00005837(NAA40)
OVIT265_12729
EGLEGR_02878
NVE5503400
EPA110250229
ATEN116308522
AMIL114966702
PDAM113672338
SPIS111331912
DGT114520079
XEN124442425
HMG100208571
TADTRIADDRAFT_26664
AQU105313075
ATHAT1G18335
ALY9329058
CRB17898054
CSAT104756168
EUSEUTSA_v10008624mg
BRP103835910
BNA106362002 106385286 111210416
BOE106311958
RSZ108820829
THJ104812177
CPAP110823418
CIT102624643
CICCICLE_v10026363mg
PVY116139621
MINC123196878
TCC18604455
GRA105804306
GHI107890192 107922610
GAB108479612
DZI111316911
EGR104456376
GMX100500318
GSJ114366820
PVUPHAVU_004G146400g
VRA106765752
VAR108345008
VUN114181581
CCAJ109819199
APRC113867864
MTR11414065
CAM101502345
PSAT127133682
LJALj2g3v0635690.1(Lj2g3v0635690.1) Lj2g3v0635690.2(Lj2g3v0635690.2)
ADU107490586
AIP107644090
AHF112750871 112802399
LANG109343081
FVE101297932
RCN112176219
PPER18776082
PMUM103338906
PAVI110746559
PDUL117628715
MDM103438267 103455655
PXB103946893 103950532
ZJU107419482
MNT21387796
CSV101209918
CMO103489882
BHJ120083294
MCHA111008819
CMAX111492936
CMOS111452455
CPEP111788947
RCU8287866
JCU105640981
HBR110643080
MESC110630997
POP7485183
PEU105108207
PALZ118044319
JRE109012095 109012103
QSU111991427 112020332 112039692
QLO115959148
TWL119981119 119987428
VVI100257550
VRI117934419
SLY101267815
SPEN107021749
SOT102589877
SSTN125875041
CANN107875825
NTA107766384 107794622
NSY104228690
NTO104110267
NAU109226995
INI109183860
ITR116017414
SIND105158197
OEU111410836
EGT105975827
SSPL121748014 121786299
APAN127262734
HAN110865566
ECAD122603858
LSV111882672
CCAV112522385
DCR108210927
CSIN114272833 114315925
BVG104903568
SOE110782172
CQI110714252 110731648
NNU104607249
MING122061532
TSS122646359
PSOM113316807 113323159 113328403
OSA4330878 4338664
DOSAOs02t0772300-01(Os02g0772300) Os05t0387800-01(Os05g0387800)
OBR102703935
BDI100826552
ATS109772484
TDC119318025 119325964
TAES123128521 123138389 123145642
TUA125514790
LPER127306509
SBI8075214 8075215
ZMA100283323
SITA101759511
SVS117865531
PVIR120643423 120657329
PHAI112901445
PDA103719257
EGU105032761
MUS103977592 103998032
ZOF122041555 122046068
DCT110100032
PEQ110034003
AOF109822607
NCOL116261872
ATR18439216
SMOSELMODRAFT_116063 SELMODRAFT_86274
PPP112294901
VCNVOLCADRAFT_104565
CSLCOCSUDRAFT_63875
CVRCHLNCDRAFT_24426
OLUOSTLU_31107
OTAOT_ostta04g01780
BPGBathy06g03850
MISMICPUN_100333 MICPUN_60060 MICPUN_72973
MPPMICPUCDRAFT_46969 MICPUCDRAFT_7366
GSLGasu_39340
CCPCHC_T00005602001
SCEYMR069W(NAT4)
SEUBDI49_4158
SPAOSPAR_M01880
AGOAGOS_AGL071CA
ERCEcym_7256
KLAKLLA0_E18569g
KMXKLMA_60333
LTHKLTH0D06820g
VPOKpol_1018p34
ZROZYRO0B01980g
CGRCAGL0K02981g
NCSNCAS_0D02640(NCAS0D02640)
NDINDAI_0I02270(NDAI0I02270)
TPFTPHA_0C04180(TPHA0C04180)
TBLTBLA_0G02220(TBLA0G02220)
TGBHG536_0A04600
TDLTDEL_0A03060(TDEL0A03060)
KAFKAFR_0A01850(KAFR0A01850)
KNGKNAG_0C05820(KNAG0C05820)
ZMKHG535_0D03940
PPAPAS_chr2-1_0251
DHADEHA2B02816g
PICPICST_28557(NAT4)
PGUPGUG_02569
SPAASPAPADRAFT_56765
LELLELG_04562
CALCAALFM_C401250WA(NAT4)
CTPCTRG_00028
COTCORT_0E03940
CDUCD36_41240
CTENCANTEDRAFT_111433
YLIYALI0B00638g
CLUCLUG_04342
CLUSA9F13_04g01672
CAURCJI97_000704
SLBAWJ20_190
PKZC5L36_0E03480
BBRXBRETT_001088
OPAHPODL_05138
NCRNCU06037
NTENEUTE1DRAFT102894(NEUTE1DRAFT_102894)
SMPSMAC_07429
PANPODANSg2340
TTTTHITE_2116945
MTMMYCTH_2067021
MGRMGG_07226
PPEIPpBr36_01871
TMNUCRPA7_2094
SSCKSPSK_06531
FGRFGSG_11846
FPUFPSE_11636
FVRFVEG_00616
FOXFOXG_00821
NHENECHADRAFT_75282
TRETRIREDRAFT_64676
TRRM419DRAFT_82674
MAWMAC_06201
MAJMAA_00719
CMTCCM_05417
PLJVFPFJ_09121
VALVDBG_03919
VDAVDAG_01148
CFJCFIO01_09709
CLUPCLUP02_14181
CHIGCH63R_06190
SAPOSAPIO_CDS7644
ELAUCREL1_11489
PFYPFICI_13214
SSLSS1G_04033
BFUBCIN_01g02360
MBEMBM_00933
PSCOLY89DRAFT_571810
GLZGLAREA_04519
ANIAN3825.2
AFMAFUA_4G08210
ACTACLA_047570
NFINFIA_107970
ANGANI_1_1674184(An04g02660)
ALUCAKAW2_51294A
APUUAPUU_40567A
PCSPc13g07930
PDPPDIP_88050
TMFPMAA_089660
TRGTRUGW13939_01548
CIMCIMG_08817
CPWCPC735_063390
UREUREG_02746
PBLPAAG_03171
PBNPADG_03051
ABEARB_00221
TVETRV_05214
AJEHCAG_06250
BGHBDBG_02414
PNOSNOG_03413
PTEPTT_12560
BZECOCCADRAFT_82713
BSCCOCSADRAFT_95475
BORCOCMIDRAFT_100858
AALTCC77DRAFT_949967
ZTRMYCGRDRAFT_109414
PFJMYCFIDRAFT_27838
FFUCLAFUR5_01551
BCOMBAUCODRAFT_45698
NPAUCRNP2_4133
SPOSPCC825.04c(naa40)
CNECND03645
CNBCNBD2680
CNGCNAG_01247
CGICGB_D6350C
TASAA1Q1_01262
TVSTRAVEDRAFT_109407
DSQDICSQDRAFT_176732
PCOPHACADRAFT_134503
SHSSTEHIDRAFT_107334
HIRHETIRDRAFT_305325
ADLAURDEDRAFT_94587
FMEFOMMEDRAFT_146015
GTRGLOTRDRAFT_135380
LBCLACBIDRAFT_300721
CCICC1G_06759
ABVAGABI2DRAFT239526(AGABI2DRAFT_239526)
MRRMoror_15247
CPUTCONPUDRAFT_148722
SLASERLADRAFT_437354
WSEWALSEDRAFT_60481
WICJ056_002958
UMAUMAG_10085
PFPPFL1_00553
MGLMGL_1944
MRTMRET_1868
PGRPGTG_15000
MLRMELLADRAFT_105094
MBRMONBRDRAFT_29960
SREPTSG_03167
EHIEHI_061000
EDIEDI_072810
EIVEIN_054500
PFAPF3D7_1323300
PFHPFHG_00956
PREIPRSY57_1322300
PGABPGSY75_1323300
PYOPY17X_1343200
PCBPCHAS_1343100
PBEPBANKA_1338500
PVVPVVCY_1304110
PKNPKNH_1205500
PVXPVX_116705
PCYPCYB_123950
TANTA17725
TPVTP03_0684
TOTTOT_030000189
BEQBEWA_053010
BBOBBOV_III001570
BMICBmR1_04g05330
BBIGBBBOND_0302920
CPVcgd6_1800
CHOChro.60217
TGOTGME49_230060
PTIPHATRDRAFT_11358
FCYFRACYDRAFT_163037
TPSTHAPSDRAFT_21598
PIFPITG_06396
PSOJPHYSODRAFT_318403
SPARSPRG_07131
EHXEMIHUDRAFT_124867 EMIHUDRAFT_207283 EMIHUDRAFT_436794
GTTGUITHDRAFT_101053 GUITHDRAFT_118263 GUITHDRAFT_136122
TVATVAG_2v0254480 TVAG_2v0488670 TVAG_2v0864310 TVAG_2v0899830 TVAG_2v0983850
 » show all
Reference
1  [PMID:12915400]
  Authors
Song OK, Wang X, Waterborg JH, Sternglanz R
  Title
An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A.
  Journal
J Biol Chem 278:38109-12 (2003)
DOI:10.1074/jbc.C300355200
  Sequence
[sce:YMR069W]
Reference
2  [PMID:19332560]
  Authors
Polevoda B, Hoskins J, Sherman F
  Title
Properties of Nat4, an N(alpha)-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4.
  Journal
Mol Cell Biol 29:2913-24 (2009)
DOI:10.1128/MCB.00147-08
Reference
3  [PMID:25619998]
  Authors
Magin RS, Liszczak GP, Marmorstein R
  Title
The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD.
  Journal
Structure 23:332-41 (2015)
DOI:10.1016/j.str.2014.10.025
  Sequence
[hsa:79829] [spo:SPCC825.04c]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.257
IUBMB Enzyme Nomenclature: 2.3.1.257
ExPASy - ENZYME nomenclature database: 2.3.1.257
BRENDA, the Enzyme Database: 2.3.1.257

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