KEGG   ENZYME: 2.3.1.259Help
Entry
EC 2.3.1.259                Enzyme                                 

Name
N-terminal methionine Nalpha-acetyltransferase NatF;
NAA60 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:N-terminal-Met-Lys/Ser/Val/Leu/Gln/Ile/Tyr/Thr-[transmembrane protein] Met-Nalpha-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-Nalpha-acetyl-L-methionyl-[transmembrane protein] + CoA
Substrate
acetyl-CoA [CPD:C00024];
N-terminal-L-methionyl-[transmembrane protein]
Product
N-terminal-Nalpha-acetyl-L-methionyl-[transmembrane protein];
CoA [CPD:C00010]
Comment
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis. NatF is found only in higher eukaryotes, and is absent from yeast. Unlike other Nat systems the enzyme is located in the Golgi apparatus. It faces the cytosolic side of intracellular membranes, and specifically acetylates transmembrane proteins whose N termini face the cytosol. NatF targets N-terminal L-methionine residues attached to Lys, Ser, Val, Leu, Gln, Ile, Tyr and Thr residues.
History
EC 2.3.1.259 created 1989 as EC 2.3.1.88, part transferred 2016 to EC 2.3.1.259
Orthology
K21121  N-alpha-acetyltransferase 60
Genes
HSA: 79903(NAA60)
PPS: 100976892(NAA60)
GGO: 101128451 101140622 109023050(NAA60) 109025256
PON: 100442711(NAA60)
NLE: 100594954(NAA60)
MCC: 703207(NAA60)
MCF: 101867007(NAA60)
CSAB: 103227510(NAA60)
RRO: 104672297(NAA60)
RBB: 108538286(NAA60)
CJC: 100388736(NAA60)
SBQ: 101047996(NAA60)
MMU: 74763(Naa60)
MCAL: 110311719(Naa60)
MPAH: 110329609(Naa60)
RNO: 363545(Naa60)
MUN: 110545966(Naa60)
CGE: 100765069(Naa60)
NGI: 103744342(Naa60)
HGL: 101705001(Naa60)
CCAN: 109681688(Naa60) 109702239
OCU: 100339358(NAA60)
TUP: 102496365(NAA60)
CFA: 609456(NAA60)
VVP: 112923257(NAA60)
AML: 100475085(NAA60)
UMR: 103668540(NAA60)
UAH: 113270868(NAA60)
ORO: 101368928(NAA60)
FCA: 101097199(NAA60)
PTG: 102956593(NAA60)
AJU: 106978800(NAA60)
BTA: 514154(NAA60)
BOM: 102284251(NAA60)
BIU: 109578595(NAA60)
BBUB: 102400094(NAA60)
PHD: 102325201(NAA60)
CHX: 102187019(NAA60)
OAS: 101120793(NAA60)
SSC: 100739355(NAA60)
CFR: 102506796(NAA60)
CDK: 105099669(NAA60)
BACU: 103018945(NAA60)
LVE: 103073215(NAA60)
OOR: 101283656(NAA60)
DLE: 111185242(NAA60)
ECB: 100065966(NAA60)
EPZ: 103553021(NAA60)
EAI: 106826055(NAA60)
MYB: 102239764 102262291(NAA60)
MNA: 107535788(NAA60)
HAI: 109376774(NAA60)
RSS: 109436344(NAA60)
DRO: 112298350(NAA60)
PALE: 102888501(NAA60)
LAV: 100664578(NAA60)
TMU: 101342825
MDO: 100016396(NAA60)
SHR: 100927065(NAA60)
PCW: 110214533(NAA60)
OAA: 100091367(NAA60)
GGA: 416659(NAA60)
MGP: 100541164(NAA60)
CJO: 107320974(NAA60)
APLA: 101801604(NAA60)
ACYG: 106033570(NAA60)
TGU: 100232229(NAA60)
LSR: 110481459(NAA60)
SCAN: 103817756(NAA60)
GFR: 102033337(NAA60)
FAB: 101815151(NAA60)
PHI: 102105859(NAA60)
PMAJ: 107211293(NAA60)
CCAE: 111935891(NAA60)
CCW: 104684674(NAA60)
ETL: 114057013(NAA60)
FPG: 101923095(NAA60)
FCH: 102055540(NAA60)
CLV: 102084596(NAA60)
EGZ: 104121962(NAA60)
NNI: 104023458(NAA60)
ACUN: 113485696(NAA60)
AAM: 106482333(NAA60)
ASN: 102380292(NAA60)
AMJ: 102565984(NAA60)
PSS: 102444632(NAA60)
CMY: 102943802
CPIC: 101951671(NAA60)
ACS: 100559165(naa60)
PVT: 110089105(NAA60)
PBI: 103053152(NAA60)
PMUR: 107283982(NAA60)
GJA: 107109325(NAA60)
XLA: 108701639(naa60.L) 108703194
XTR: 100127619(naa60)
NPR: 108791085(NAA60)
DRE: 570640(nat15)
IPU: 108255159(naa60)
PHYP: 113546957(naa60)
AMEX: 103022043(naa60)
EEE: 113572845(naa60)
TRU: 101074253(naa60)
LCO: 104926826(naa60)
MZE: 101487939(naa60)
OLA: 101169610(naa60)
XMA: 102217265(naa60)
XCO: 114148394(naa60)
PRET: 103468313(naa60)
NFU: 107376190(naa60)
KMR: 108249598(naa60)
CSEM: 103393634(naa60)
SDU: 111223769(naa60)
HCQ: 109530002(naa60)
BPEC: 110171429(naa60)
MALB: 109967557(naa60)
OTW: 112246363(naa60)
SALP: 112078584(naa60)
ELS: 105013475(naa60)
SFM: 108935797(naa60)
PKI: 111849109(naa60)
LCM: 102354212(NAA60)
CMK: 103171941(naa60)
CIN: 100185125
SPU: 594473
APLC: 110976163
SKO: 100371949
DME: Dmel_CG18177(Naa60)
DER: 6543971
DPE: 6602778
DSI: Dsimw501_GD14213(Dsim_GD14213)
DWI: 6645291
DAZ: 108613067
DNV: 108651276
DHE: 111598677
MDE: 101893918
AME: 552443
BIM: 100749452
BTER: 100642384
SOC: 105207988
MPHA: 105830440
AEC: 105154632
ACEP: 105619513
PBAR: 105423977
HST: 105191015
DQU: 106741867
CFO: 105249139
LHU: 105677576
PGC: 109857933
OBO: 105286510
PCF: 106784002
NVI: 100123019
MDL: 103568252
TCA: 660507
DPA: 109540036
NVL: 108563781
BMOR: 101739089
PMAC: 106719159
PRAP: 111003750
HAW: 110379620
TNL: 113501357
PXY: 105386420
API: 100167289
DNX: 107167488
AGS: 114120025
CLEC: 106663058
ZNE: 110838665
FCD: 110848454
TUT: 107360104
DPTE: 113791029
CEL: CELE_F30F8.10(F30F8.10)
CBR: CBG23731
BMY: Bm1_47710
PCAN: 112567066
CRG: 105340306
MYI: 110466956
OBI: 106883587
LAK: 106158510
SHX: MS3_05166
EGL: EGR_06272
EPA: 110242945
ADF: 107341446
PDAM: 113679321
SPIS: 111321648
HMG: 105846977
AQU: 100634882
 » show all
Taxonomy
Reference
1  [PMID:21750686]
  Authors
Van Damme P, Hole K, Pimenta-Marques A, Helsens K, Vandekerckhove J, Martinho RG, Gevaert K, Arnesen T
  Title
NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation.
  Journal
PLoS Genet 7:e1002169 (2011)
DOI:10.1371/journal.pgen.1002169
  Sequence
[hsa:79903] [dme:Dmel_CG18177]
Reference
2  [PMID:25732826]
  Authors
Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, Stove SI, Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S, Ziegler M, Niere M, Gevaert K, Arnesen T
  Title
An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of  transmembrane proteins and maintains Golgi integrity.
  Journal
Cell Rep 10:1362-74 (2015)
DOI:10.1016/j.celrep.2015.01.053
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.259
IUBMB Enzyme Nomenclature: 2.3.1.259
ExPASy - ENZYME nomenclature database: 2.3.1.259
BRENDA, the Enzyme Database: 2.3.1.259

DBGET integrated database retrieval system