KEGG   ENZYME: 2.3.1.26Help
Entry
EC 2.3.1.26                 Enzyme                                 

Name
sterol O-acyltransferase;
cholesterol acyltransferase;
sterol-ester synthase;
sterol-ester synthetase;
sterol-ester synthase;
acyl coenzyme A-cholesterol-O-acyltransferase;
acyl-CoA:cholesterol acyltransferase;
ACAT;
acylcoenzyme A:cholesterol O-acyltransferase;
cholesterol ester synthase;
cholesterol ester synthetase;
cholesteryl ester synthetase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:cholesterol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + cholesterol = CoA + cholesterol ester [RN:R01461]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
cholesterol [CPD:C00187]
Product
CoA [CPD:C00010];
cholesterol ester [CPD:C02530]
Comment
The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group.
History
EC 2.3.1.26 created 1972
Pathway
ec00100  Steroid biosynthesis
Orthology
K00637  sterol O-acyltransferase
Genes
HSA: 6646(SOAT1) 8435(SOAT2)
PTR: 457553(SOAT1) 737291(SOAT2)
PPS: 100990991(SOAT1) 100991938(SOAT2)
GGO: 101137508(SOAT1) 101143800(SOAT2)
PON: 100436698(SOAT1) 100443060(SOAT2)
NLE: 100590480(SOAT1) 100591122(SOAT2)
MCC: 701171(SOAT2) 716989(SOAT1)
MCF: 102121286(SOAT1) 102135925(SOAT2)
CSAB: 103230515(SOAT1) 103238380(SOAT2)
RRO: 104670609(SOAT2) 104672006(SOAT1)
RBB: 108521617(SOAT2) 108539887(SOAT1)
CJC: 100387443(SOAT1) 100412165(SOAT2)
SBQ: 101047229(SOAT1) 101052421(SOAT2)
MMU: 20652(Soat1) 223920(Soat2)
RNO: 266770(Soat2) 81782(Soat1)
CGE: 100689317(Soat1) 100752385(Soat2)
NGI: 103728004(Soat1) 103738463(Soat2)
HGL: 101718579(Soat2) 101725301(Soat1)
CCAN: 109684043(Soat2) 109693443(Soat1)
OCU: 100009537(SOAT1) 100349393(SOAT2)
TUP: 102485090(SOAT1) 102501974(SOAT2)
CFA: 486511(SOAT2) 490325(SOAT1)
AML: 100464310(SOAT1) 100466845(SOAT2)
UMR: 103668575(SOAT1) 103675666(SOAT2)
ORO: 101372404(SOAT2) 101377194(SOAT1)
FCA: 101081271(SOAT1) 101099223(SOAT2)
PTG: 102951570(SOAT2) 102951637(SOAT1)
AJU: 106977936(SOAT1) 106986455(SOAT2)
BTA: 504287(SOAT1) 513554(SOAT2)
BOM: 102266586(SOAT1) 102286882(SOAT2)
BIU: 109559050(SOAT2) 109570627(SOAT1)
PHD: 102325324(SOAT1) 102341784(SOAT2)
CHX: 102181472(SOAT2) 102186791(SOAT1)
OAS: 101107179(SOAT2) 101121363(SOAT1)
SSC: 100515544(SOAT2) 100628166(SOAT1)
CFR: 102509905(SOAT2) 102517625(SOAT1)
CDK: 105094576(SOAT2) 105099977(SOAT1)
BACU: 103005265(SOAT2) 103019063(SOAT1)
LVE: 103074467(SOAT1) 103078608(SOAT2)
OOR: 101283408(SOAT1) 101288997(SOAT2)
ECB: 100050551(SOAT1) 100146367(SOAT2)
EPZ: 103559415(SOAT2) 103566918(SOAT1)
EAI: 106833928(SOAT1) 106835276(SOAT2)
MYB: 102251864(SOAT1) 102258914(SOAT2)
MYD: 102752811(SOAT2) 102760492(SOAT1)
HAI: 109384905(SOAT1) 109391779(SOAT2)
RSS: 109443691(SOAT2) 109447265(SOAT1)
PALE: 102897908(SOAT1) 102897972(SOAT2)
LAV: 100666457(SOAT1) 100670395(SOAT2)
TMU: 101352609 101353901
MDO: 100022219(SOAT1)
SHR: 100920315(SOAT1) 100933677(SOAT2)
OAA: 100081816 100085367(SOAT1)
GGA: 424424(SOAT1)
MGP: 100544187(SOAT1)
CJO: 107317265(SOAT1)
APLA: 101790922(SOAT1)
ACYG: 106042512(SOAT1)
TGU: 100223763(SOAT1)
GFR: 102041188(SOAT1)
FAB: 101815412(SOAT1)
PHI: 102102644(SOAT1)
PMAJ: 107208206(SOAT1)
CCAE: 111932597(SOAT1)
CCW: 104693579(SOAT1)
FPG: 101919752(SOAT1)
FCH: 102060236(SOAT1)
CLV: 102098103(SOAT1)
EGZ: 104132041(SOAT1)
AAM: 106484966(SOAT1)
ASN: 102373020(SOAT1) 102378548 102379056
AMJ: 102568578(SOAT1) 102573699
PSS: 102448344(SOAT1) 102450944(SOAT2)
CMY: 102934330(SOAT2) 102943858(SOAT1)
CPIC: 101940194(SOAT2) 101944538(SOAT1)
ACS: 100556270(soat1) 100559804 100567184 100567378 103282757 107982384
PVT: 110077048(SOAT1)
PBI: 103048435 103064093(SOAT1)
GJA: 107107994 107122901(SOAT1)
XLA: 108708653 108714368(soat1.L) 446863(soat1.S) 779411(soat2.S)
XTR: 100145286(soat1) 100216296(soat2) 101730739
NPR: 108786819(SOAT2) 108800649(SOAT1)
DRE: 564424(soat1)
SRX: 107707573(soat1) 107734612 107758003
SANH: 107657858 107681296 107700347
SGH: 107549691 107566412(soat2) 107580110 107580756 107599004(soat1)
CCAR: 109059086 109059087 109072620 109080481
IPU: 108265920(soat1) 108272126
AMEX: 103034708 103042750 111197020
TRU: 101072139(soat2) 101077060 105417935(soat1)
TNG: GSTEN00013578G001 GSTEN00028839G001
LCO: 104919967 104929343(soat1)
NCC: 104966663
MZE: 101475426 101487179(soat1)
OLA: 101162519 101164716(soat1)
XMA: 102229353(soat1) 102229837
PRET: 103464078(soat1) 103464407
NFU: 107385327 107393145(soat1)
KMR: 108230591(soat1) 108231501
CSEM: 103386400 103386401 103393235(soat1)
LCF: 108881364(soat1) 108884835
SDU: 111223955 111231092(soat1)
HCQ: 109510620 109532427(soat1)
BPEC: 110154556 110160201(soat1)
MALB: 109954616 109967403(soat1)
SASA: 106566146 106613907(soat1)
OTW: 112251021(soat1) 112262720 112263222
ELS: 105007362 105026366(soat1)
SFM: 108919079(soat1) 108928332
LCM: 102351870(SOAT1) 102367356(SOAT2)
CMK: 103179969(soat1) 103189932(soat2)
BFO: BRAFLDRAFT_115379
SPU: 583194
APLC: 110974464
DME: Dmel_CG8112(CG8112)
DPO: Dpse_GA20833
DAN: Dana_GF18181
DER: 6552441
DPE: 6594563
DSE: Dsec_GM23753
DSI: Dsimw501_GD18564(Dsim_GD18564)
DWI: 6647984
DYA: Dyak_GE25896
DGR: Dgri_GH18571
DMO: Dmoj_GI24769
DVI: Dvir_GJ22674
MDE: 101888385 101888553 101888657
AGA: AgaP_AGAP012216 AgaP_AGAP012217
AAG: 5572188
CQU: CpipJ_CPIJ002959
AME: 552313
BIM: 100740568
BTER: 100647632
SOC: 105197438 105197445 105197466 105197475 105200298 105204780 105206685 113005162
AEC: 105150715 105150716 105150717 105150735 105151440 105153905
ACEP: 105621768 105621834
PBAR: 105426039
HST: 105189309
DQU: 106742888
CFO: 105249109 105258340 112639984 112639992
LHU: 105672373 105673784
PGC: 109860842
PCF: 106787777
NVI: 100122384
MDL: 103570127
TCA: 658068 658748
DPA: 109542077
NVL: 108562027
BMOR: 101740142
DPL: KGM_205051
PMAC: 106710838
PRAP: 110996350
HAW: 110375674
PXY: 105387244
PHU: Phum_PHUM045410
ZNE: 110828545
FCD: 110846328
DPX: DAPPUDRAFT_40502
ISC: IscW_ISCW007924
TUT: 107364500
CEL: CELE_B0395.2(mboa-1)
CBR: CBG16409
NAI: NECAME_05183
LOA: LOAG_10851
TSP: Tsp_07565
HRO: HELRODRAFT_114186
LGI: LOTGIDRAFT_172306
CRG: 105344142
MYI: 110446400
OBI: 106877085
LAK: 106150577 106151044
SMM: Smp_134390
SHX: MS3_07855
OVI: T265_01192
EGL: EGR_03337
NVE: NEMVE_v1g80875
EPA: 110232256
ADF: 107331943
TAD: TRIADDRAFT_22890
AQU: 100639150 100639276 105312507
CME: CYME_CME100C
GSL: Gasu_00890 Gasu_51320
SCE: YCR048W(ARE1) YNR019W(ARE2)
AGO: AGOS_AAR065C
ERC: Ecym_2101
KLA: KLLA0_C09152g
KMX: KLMA_30485(ARE2)
LTH: KLTH0A06204g
VPO: Kpol_1027p14
ZRO: ZYRO0D08734g
CGR: CAGL0C02981g CAGL0M10571g
NCS: NCAS_0A04580(NCAS0A04580) NCAS_0D04420(NCAS0D04420)
NDI: NDAI_0I00520(NDAI0I00520) NDAI_0K01630(NDAI0K01630)
TPF: TPHA_0H02220(TPHA0H02220)
TBL: TBLA_0F04000(TBLA0F04000) TBLA_0I02260(TBLA0I02260)
TDL: TDEL_0A07320(TDEL0A07320)
KAF: KAFR_0F00800(KAFR0F00800) KAFR_0J02490(KAFR0J02490)
PPA: PAS_chr3_0467
DHA: DEHA2F24222g
PIC: PICST_33115(ARE2)
PGU: PGUG_00464
SPAA: SPAPADRAFT_54917
LEL: LELG_02432
CAL: CAALFM_C206940CA(ARE2)
CTP: CTRG_01764 CTRG_01765
COT: CORT_0C06130
CDU: CD36_21230
CTEN: CANTEDRAFT_113635
YLI: YALI0F06578g
CLU: CLUG_05837
CLUS: A9F13_05g01133
CAUR: QG37_08236
SLB: AWJ20_1276(ARE2)
NCR: NCU03991 NCU04144
NTE: NEUTE1DRAFT127291(NEUTE1DRAFT_127291) NEUTE1DRAFT87893(NEUTE1DRAFT_87893)
SMP: SMAC_04443 SMAC_06169
PAN: PODANSg8191 PODANSg903
TTT: THITE_2108121 THITE_2110877
MTM: MYCTH_2301957 MYCTH_2307471
CTHR: CTHT_0068350
MGR: MGG_06765
TMN: UCRPA7_2776 UCRPA7_8403
SSCK: SPSK_04973
FGR: FGSG_02016 FGSG_09863
FPU: FPSE_10216 FPSE_10942
FVR: FVEG_02575 FVEG_07471
FOX: FOXG_04347 FOXG_05564
NHE: NECHADRAFT_41716 NECHADRAFT_85955
TRE: TRIREDRAFT_50607
MAW: MAC_00801 MAC_01953
MAJ: MAA_04727 MAA_08231
CMT: CCM_07840
PLJ: VFPFJ_02889 VFPFJ_09596
VAL: VDBG_09403
VDA: VDAG_04641
CFJ: CFIO01_00425 CFIO01_08515
ELA: UCREL1_1079 UCREL1_758
PFY: PFICI_07207 PFICI_11190
SSL: SS1G_07371 SS1G_10590
MBE: MBM_00195 MBM_07979
PSCO: LY89DRAFT_610053 LY89DRAFT_749752
GLZ: GLAREA_04618 GLAREA_07902
ANI: AN4208.2
AFM: AFUA_1G06040
AOR: AO090009000480
ANG: ANI_1_628164(An18g04660)
AFV: AFLA_050060
ACT: ACLA_028560
NFI: NFIA_018690
PCS: Pc13g01800 Pc13g05460
PDP: PDIP_69720
CIM: CIMG_03839
CPW: CPC735_004930
PBL: PAAG_01841
PBN: PADG_00520
URE: UREG_02086
ABE: ARB_05568
TVE: TRV_06840
AJE: HCAG_00155
PNO: SNOG_02790 SNOG_11748
PTE: PTT_18164 PTT_20058
BZE: COCCADRAFT_104696 COCCADRAFT_5418
BSC: COCSADRAFT_158622 COCSADRAFT_244117
BOR: COCMIDRAFT_23450 COCMIDRAFT_79731
AALT: CC77DRAFT_1017866 CC77DRAFT_370839
ZTR: MYCGRDRAFT_41169 MYCGRDRAFT_44439(ARE1)
PFJ: MYCFIDRAFT_184454 MYCFIDRAFT_208180
BCOM: BAUCODRAFT_61588 BAUCODRAFT_71776
NPA: UCRNP2_3303 UCRNP2_4061
TML: GSTUM_00000025001 GSTUM_00001327001
SPO: SPAC13G7.05(are1) SPCP1E11.05c(are2)
CNE: CNF01130
CNB: CNBF3580
CGI: CGB_F5190W
TMS: TREMEDRAFT_34263
TVS: TRAVEDRAFT_148341
DSQ: DICSQDRAFT_153227
PCO: PHACADRAFT_178226
SHS: STEHIDRAFT_125940
HIR: HETIRDRAFT_387282
PSQ: PUNSTDRAFT_66632
ADL: AURDEDRAFT_61665
FME: FOMMEDRAFT_16175
GTR: GLOTRDRAFT_115574
LBC: LACBIDRAFT_188091
MRR: Moror_7033
CCI: CC1G_00886
SCM: SCHCODRAFT_53724
ABP: AGABI1DRAFT105226(AGABI1DRAFT_105226)
ABV: AGABI2DRAFT185966(AGABI2DRAFT_185966)
CPUT: CONPUDRAFT_59491
SLA: SERLADRAFT_350480
WSE: WALSEDRAFT_32831
UMA: UMAG_05355
PFP: PFL1_05361
MGL: MGL_2868
PGR: PGTG_16235
ACAN: ACA1_031610
TET: TTHERM_00046980 TTHERM_00895740
PTM: GSPATT00019987001 GSPATT00022217001
PIF: PITG_12278
PSOJ: PHYSODRAFT_350290
 » show all
Taxonomy
Reference
1  [PMID:5439042]
  Authors
Sgoutas DS.
  Title
Effect of geometry and position of ethylenic bond upon acyl coenzyme A--cholesterol-O-acyltransferase.
  Journal
Biochemistry 9:1826-33 (1970)
Reference
2  [PMID:42927]
  Authors
Spector AA, Mathur SN, Kaduce TL.
  Title
Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism.
  Journal
Prog Lipid Res 18:31-53 (1979)
DOI:10.1016/0163-7827(79)90003-1
Reference
3  [PMID:389289]
  Authors
Taketani S, Nishino T, Katsuki H.
  Title
Characterization of sterol-ester synthetase in Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 575:148-55 (1979)
DOI:10.1016/0005-2760(79)90140-1
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.26
IUBMB Enzyme Nomenclature: 2.3.1.26
ExPASy - ENZYME nomenclature database: 2.3.1.26
BRENDA, the Enzyme Database: 2.3.1.26
CAS: 9027-63-8

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (1402)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (480)   
   KEGG MGENES (200)   
   RefGene (706)   
   EGENES (15)   
Protein sequence (97)   
   UniProt (38)   
   SWISS-PROT (17)   
   RefSeq(pep) (41)   
   PMD (1)   
DNA sequence (105)   
   RefSeq(nuc) (62)   
   GenBank (26)   
   EMBL (17)   
Protein domain (1)   
   InterPro (1)   
All databases (1614)   

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