KEGG   ENZYME: 2.3.1.26
Entry
EC 2.3.1.26                 Enzyme                                 
Name
sterol O-acyltransferase;
cholesterol acyltransferase;
sterol-ester synthase;
acyl coenzyme A-cholesterol-O-acyltransferase;
acyl-CoA:cholesterol acyltransferase;
ACAT;
acylcoenzyme A:cholesterol O-acyltransferase;
cholesterol ester synthase;
cholesterol ester synthetase;
cholesteryl ester synthetase;
SOAT1 (gene name);
SOAT2 (gene name);
ARE1 (gene name);
ARE2 (gene name);
acyl-CoA:cholesterol O-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
long-chain acyl-CoA:sterol O-acyltransferase
Reaction(IUBMB)
a long-chain acyl-CoA + a sterol = CoA + a long-chain 3-hydroxysterol ester [RN:R12496]
Reaction(KEGG)
R12496 > R01461
Substrate
long-chain acyl-CoA [CPD:C02843];
sterol [CPD:C00370]
Product
CoA [CPD:C00010];
long-chain 3-hydroxysterol ester [CPD:C22215]
Comment
The enzyme catalyses the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A. The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA. In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol. In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of `foam cells', a hallmark of early atherosclerotic lesions. In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell.
History
EC 2.3.1.26 created 1972, modified 2019
Pathway
ec00100  Steroid biosynthesis
Orthology
K00637  sterol O-acyltransferase
Genes
HSA: 6646(SOAT1) 8435(SOAT2)
PTR: 457553(SOAT1) 737291(SOAT2)
PPS: 100990991(SOAT1) 100991938(SOAT2)
GGO: 101137508(SOAT1) 101143800(SOAT2)
PON: 100436698(SOAT1) 100443060(SOAT2)
NLE: 100590480(SOAT1) 100591122(SOAT2)
MCC: 701171(SOAT2) 716989(SOAT1)
MCF: 102121286(SOAT1) 102135925(SOAT2)
MTHB: 126931112 126940434
CSAB: 103230515(SOAT1) 103238380(SOAT2)
CATY: 105580285(SOAT2) 105580775(SOAT1)
PANU: 100998458(SOAT1) 101012402(SOAT2)
TGE: 112627146(SOAT1) 112635341(SOAT2)
RRO: 104670609(SOAT2) 104672006(SOAT1)
RBB: 108521617(SOAT2) 108539887(SOAT1)
TFN: 117076693(SOAT1) 117090055(SOAT2)
PTEH: 111541702(SOAT2) 111555313(SOAT1)
CANG: 105503675(SOAT2) 105518253(SOAT1)
CJC: 100387443(SOAT1) 100412165(SOAT2)
SBQ: 101047229(SOAT1) 101052421(SOAT2)
CSYR: 103267545(SOAT1) 103269719(SOAT2)
MMUR: 105870615(SOAT2) 105875493(SOAT1)
LCAT: 123635256(SOAT1) 123639778(SOAT2)
PCOQ: 105812143(SOAT1) 105818570(SOAT2)
OGA: 100962874(SOAT2) 100965917(SOAT1)
MMU: 20652(Soat1) 223920(Soat2)
MCAL: 110301596(Soat1) 110310293(Soat2)
MPAH: 110321652(Soat1) 110335070(Soat2)
RNO: 266770(Soat2) 81782(Soat1)
MCOC: 116082223(Soat2) 116101816(Soat1)
MUN: 110552319(Soat2) 110563339(Soat1)
CGE: 100689317(Soat1) 100752385(Soat2)
MAUA: 101835581(Soat1) 101839263(Soat2)
PLEU: 114696635(Soat2)
MORG: 121444182(Soat2) 121455104(Soat1) 121459544
MFOT: 126493601 126497348
AAMP: 119822422(Soat2) 119827492(Soat1)
NGI: 103728004(Soat1) 103738463(Soat2)
HGL: 101718579(Soat2) 101725301(Soat1)
CPOC: 100716750(Soat1) 100728450(Soat2)
CCAN: 109684043(Soat2) 109693443(Soat1)
DORD: 105985111(Soat1) 105997917(Soat2)
DSP: 122103891(Soat1) 122124220(Soat2)
NCAR: 124961744 124976730 124983098
OCU: 100009537 100349393
OPI: 101522712(SOAT2) 101524678(SOAT1)
TUP: 102485090(SOAT1) 102501974(SOAT2)
GVR: 103592220(SOAT2) 103607560(SOAT1)
CFA: 486511(SOAT2) 490325(SOAT1)
CLUD: 112648530(SOAT1) 112667196(SOAT2)
VVP: 112921168(SOAT2) 112921836(SOAT1)
VLG: 121480399(SOAT2) 121494712(SOAT1)
AML: 100464310(SOAT1) 100466845(SOAT2)
UMR: 103668575(SOAT1) 103675666(SOAT2)
UAH: 113257567(SOAT2) 113262770(SOAT1)
UAR: 123794617(SOAT2) 123801346(SOAT1)
ELK: 111150910 111157987
LLV: 125085747 125107568
MPUF: 101687685(SOAT2) 101693044(SOAT1)
ORO: 101372404(SOAT2) 101377194(SOAT1)
EJU: 114222870(SOAT1) 114225688(SOAT2)
ZCA: 113922052(SOAT2) 113931946(SOAT1)
MLX: 118008807(SOAT2) 118014416(SOAT1)
NSU: 110574128(SOAT1) 110577438(SOAT2)
LWW: 102743591(SOAT1) 102745995(SOAT2)
FCA: 101081271(SOAT1) 101099223(SOAT2)
PYU: 121011872(SOAT1) 121038507(SOAT2)
PBG: 122473464(SOAT2) 122476340(SOAT1)
LRUF: 124501744 124510178
PTG: 102951570(SOAT2) 102951637(SOAT1)
PPAD: 109249185(SOAT2) 109253480(SOAT1)
AJU: 106977936(SOAT1) 106986455(SOAT2)
HHV: 120247273(SOAT2) 120247467(SOAT1)
BTA: 504287(SOAT1) 513554(SOAT2)
BOM: 102266586(SOAT1) 102286882(SOAT2)
BIU: 109559050(SOAT2) 109570627(SOAT1)
BBUB: 102395575(SOAT2) 102403392(SOAT1)
BBIS: 104996024(SOAT1) 105001568(SOAT2)
CHX: 102181472(SOAT2) 102186791(SOAT1)
OAS: 101107179(SOAT2) 101121363(SOAT1)
ODA: 120858285(SOAT2) 120880520(SOAT1)
CCAD: 122427255(SOAT2) 122452089(SOAT1)
SSC: 100515544(SOAT2) 100628166(SOAT1)
CFR: 102509905(SOAT2) 102517625(SOAT1)
CBAI: 105068919(SOAT1) 105076275(SOAT2)
CDK: 105094576(SOAT2) 105099977(SOAT1)
VPC: 102525768(SOAT2) 102544460(SOAT1)
BACU: 103005265(SOAT2) 103019063(SOAT1)
LVE: 103074467(SOAT1) 103078608(SOAT2)
OOR: 101283408(SOAT1) 101288997(SOAT2)
DLE: 111165675(SOAT1) 111173958(SOAT2)
PCAD: 102977521(SOAT2) 102985612(SOAT1)
PSIU: 116759682(SOAT1) 116761048(SOAT2)
ECB: 100050551(SOAT1) 100146367(SOAT2)
EPZ: 103559415(SOAT2) 103566918(SOAT1)
EAI: 106833928(SOAT1) 106835276(SOAT2)
MYB: 102251864(SOAT1) 102258914(SOAT2)
MYD: 102752811(SOAT2) 102760492(SOAT1)
MMYO: 118651668(SOAT2) 118673106(SOAT1)
MLF: 102418054(SOAT2) 102428466(SOAT1) 102443306
MNA: 107528134(SOAT2) 107531050(SOAT1)
PKL: 118721361(SOAT1) 118730166(SOAT2)
HAI: 109384905(SOAT1) 109391779(SOAT2)
DRO: 112298110(SOAT1) 112318616(SOAT2)
SHON: 118979108(SOAT1)
AJM: 119043504(SOAT2) 119049583(SOAT1)
PDIC: 114511879(SOAT1) 114513415(SOAT2)
PHAS: 123813033(SOAT2) 123818366(SOAT1)
MMF: 118624235(SOAT2) 118637878(SOAT1)
RFQ: 117014674(SOAT1) 117029355(SOAT2)
PALE: 102897908(SOAT1) 102897972(SOAT2)
PGIG: 120602128(SOAT2) 120617615(SOAT1)
PVP: 105292844(SOAT1) 105302667(SOAT2)
RAY: 107509023(SOAT1) 107509777(SOAT2)
MJV: 108391159(SOAT1) 108402966(SOAT2)
TOD: 119241232(SOAT1) 119247978(SOAT2)
SARA: 101547112(SOAT2) 101552737(SOAT1)
LAV: 100666457(SOAT1) 100670395(SOAT2)
TMU: 101352609 101353901
ETF: 101639422(SOAT1) 101653803(SOAT2)
DNM: 101415761(SOAT2) 101424051 101439724(SOAT1) 101443584 101447432
MDO: 100022219(SOAT1)
GAS: 123247969(SOAT1) 123250227(SOAT2)
SHR: 100920315(SOAT1) 100933677(SOAT2)
PCW: 110194139(SOAT2) 110206808(SOAT1)
OAA: 100081816(SOAT2) 100085367(SOAT1)
GGA: 424424(SOAT1)
PCOC: 116230442(SOAT1)
MGP: 100544187(SOAT1)
CJO: 107317265(SOAT1)
NMEL: 110402509(SOAT1)
APLA: 101790922(SOAT1)
ACYG: 106042512(SOAT1)
AFUL: 116492028(SOAT1)
TGU: 100223763(SOAT1)
LSR: 110478939(SOAT1)
SCAN: 103814788(SOAT1)
PMOA: 120512224(SOAT1)
OTC: 121344266(SOAT1)
PRUF: 121359796(SOAT1)
GFR: 102041188(SOAT1)
FAB: 101815412(SOAT1)
PHI: 102102644(SOAT1)
PMAJ: 107208206(SOAT1)
CCAE: 111932597(SOAT1)
CCW: 104693579(SOAT1)
CBRC: 103617772(SOAT1)
ETL: 114062572(SOAT1)
ZAB: 102068817(SOAT1)
ACHL: 103801132(SOAT1)
FPG: 101919752(SOAT1)
FCH: 102060236(SOAT1)
CLV: 102098103(SOAT1)
EGZ: 104132041(SOAT1)
NNI: 104011338(SOAT1)
PLET: 104626826(SOAT1)
PCRI: 104027277
PCAO: 104050189(SOAT1)
ACUN: 113483059(SOAT1)
TALA: 104359540(SOAT1)
PADL: 103914031(SOAT1)
AFOR: 103896098(SOAT1)
ACHC: 115349189(SOAT1)
HALD: 104318542(SOAT1)
HLE: 104839987(SOAT1)
GCL: 127018959
CCRI: 104161119(SOAT1)
CSTI: 104555920(SOAT1)
EHS: 104503438(SOAT1)
CMAC: 104485418(SOAT1)
MUI: 104541724(SOAT1)
FGA: 104072630
GSTE: 104262334(SOAT1)
LDI: 104340696(SOAT1)
MNB: 103771603(SOAT1)
OHA: 104334033(SOAT1)
NNT: 104404757(SOAT1)
DPUB: 104301527(SOAT1)
PGUU: 104464167(SOAT1)
ACAR: 104521592(SOAT1)
CPEA: 104386099(SOAT1)
AVIT: 104272519(SOAT1)
CVF: 104293343(SOAT1)
CUCA: 104058591(SOAT1)
TEO: 104376697(SOAT1)
BRHI: 104500815(SOAT1)
AAM: 106484966(SOAT1)
AROW: 112975091(SOAT1)
NPD: 112947695(SOAT1)
TGT: 104569011(SOAT1)
DNE: 112983702(SOAT1)
SCAM: 104142656(SOAT1)
ASN: 102373020(SOAT1) 102378548 102379056
AMJ: 102568578(SOAT1) 102573699
CPOO: 109307171(SOAT1)
GGN: 109286970(SOAT1)
PSS: 102448344(SOAT1) 102450944(SOAT2)
CMY: 102934330(SOAT2) 102943858(SOAT1)
CPIC: 101940194(SOAT2) 101944538(SOAT1)
TST: 117881322(SOAT1) 117889003(SOAT2)
CABI: 116828547(SOAT2) 116834217(SOAT1)
MRV: 120370550(SOAT1) 120391259(SOAT2)
ACS: 100556270(soat1) 100559804 100567184 100567378 107982384
PVT: 110077048(SOAT1)
SUND: 121920463 121920466(SOAT2) 121928759(SOAT1)
PBI: 103048435 103064093(SOAT1)
PMUR: 107283372(SOAT1) 107288520 107288521 107288522 107288523 107288524 114922654
CTIG: 120302341 120302356 120302357 120305394(SOAT1) 120318140
TSR: 106544465(SOAT1) 106557336
PGUT: 117661157(SOAT1) 117666479
VKO: 123027911(SOAT1)
PMUA: 114586205(SOAT2) 114598569 114598570 114598594
ZVI: 118076791(SOAT2) 118077703 118088264 118088449 118089157
STOW: 125432919(SOAT1)
XLA: 108708653 108714368(soat1.L) 446863(soat1.S) 779411(soat2.S)
XTR: 100145286(soat1) 100216296(soat2) 101730739
NPR: 108786819(SOAT2) 108800649(SOAT1)
RTEM: 120929304 120929305 120929306 120945640(SOAT1)
BBUF: 120978476(SOAT1) 120993919 120993920 120996087(SOAT2)
BGAR: 122931422 122931423 122932620 122943182(SOAT1)
DRE: 564424(soat1) 564868(soat2)
SRX: 107707573(soat1) 107734612 107758003
SANH: 107657858 107681296 107700347
SGH: 107549691 107566412(soat2) 107599004(soat1)
CCAR: 109059086 109059087 109072620
CAUA: 113050186 113076346 113078370
PPRM: 120464561(soat2) 120472593(soat1)
MAMB: 125273400(soat2) 125279535(soat1)
IPU: 108265920(soat1) 108272126(soat2)
PHYP: 113535230(soat1) 113540941
SMEO: 124400361(soat1) 124402877(soat2)
TFD: 113642643(soat1) 113643245(soat2)
AMEX: 103034708 103042750 111197020
EEE: 113571647
TRU: 101072139 101077060 105417935(soat1)
TNG: GSTEN00013578G001 GSTEN00028839G001
LCO: 104919967 104929343(soat1)
NCC: 104966663
CGOB: 115007559(soat1) 115007732
ELY: 117253487(soat1) 117257034(soat2)
EFO: 125894498(soat2) 125896259(soat1)
PLEP: 121941376(soat1) 121957287(soat2)
SLUC: 116051366(soat2) 116055456(soat1)
ECRA: 117942651(soat2) 117950136(soat1)
ESP: 116677754 116688603 116696008(soat1)
PFLV: 114554740 114562037(soat1)
GAT: 120823793(soat1) 120834696(soat2)
PPUG: 119216929(soat1) 119229555(soat2)
MSAM: 119885539(soat2) 119900719(soat1)
CUD: 121507035(soat2) 121511848(soat1)
ALAT: 119021832(soat2) 119028077(soat1)
MZE: 101475426 101487179(soat1)
ONL: 100697439 100706988(soat1)
OAU: 116320715(soat2) 116323167(soat1)
OLA: 101162519 101164716(soat1)
OML: 112144903(soat2) 112150835(soat1)
XMA: 102229353(soat1) 102229837
XCO: 114136210 114150622(soat1)
XHE: 116711257(soat2) 116725326(soat1)
PRET: 103464078(soat1) 103464407
PFOR: 103135830(soat2) 103138480(soat1)
PLAI: 106951090(soat1) 106956632(soat2)
PMEI: 106906815(soat1) 106928441(soat2)
GAF: 122834468(soat2) 122838042(soat1)
CVG: 107100648(soat1) 107103130
CTUL: 119780837(soat1) 119790317(soat2)
GMU: 124856666(soat2) 124874467(soat1)
NFU: 107385327 107393145(soat1)
KMR: 108230591(soat1) 108231501(soat2)
ALIM: 106512175(soat1) 106514738(soat2)
NWH: 119407832(soat1) 119412417(soat2)
AOCE: 111563899(soat1) 111583785
MCEP: 125006149(soat2) 125009997(soat1)
CSEM: 103386401 103393235(soat1)
POV: 109625295(soat1) 109635497
SSEN: 122767836(soat2) 122781268(soat1)
HHIP: 117759962(soat1) 117762290(soat2)
HSP: 118105418(soat2) 118121497(soat1)
LCF: 108881364 108884835
SDU: 111223955 111231092(soat1)
SLAL: 111651858(soat1) 111659793
XGL: 120791280(soat1) 120806976(soat2)
HCQ: 109510620 109532427(soat1)
BPEC: 110154556 110160201(soat1)
MALB: 109954616 109967403(soat1)
BSPL: 114853833 114853837(soat1) 114855010(soat2)
SASA: 106566146 106613907(soat1)
STRU: 115158397 115207329
OTW: 112251021(soat1) 112262720(soat2)
OMY: 110494785(soat2) 110524440(soat1)
OGO: 123996939(soat1) 124003974(soat2)
ONE: 115108434
SALP: 111975891(soat1) 112069696
SNH: 120054864(soat1) 120057880(soat2)
CCLU: 121533399(soat1) 121574796(soat2)
ELS: 105007362 105026366(soat1)
SFM: 108919079(soat1) 108928332
PKI: 111835303(soat2) 111848971(soat1)
AANG: 118210915(soat2) 118226300(soat1)
LOC: 102683439 102692222(soat1)
PSPA: 121308925 121330530(soat1)
ARUT: 117401130 117412248(soat1) 117967106
PSEX: 120524936 120538330(soat1)
LCM: 102351870(SOAT1) 102367356(SOAT2)
CMK: 103179969(soat1) 103189932(soat2)
RTP: 109927029(soat1)
BFO: 118424040
BBEL: 109486598
SPU: 583194
APLC: 110974464
AJC: 117119475
DME: Dmel_CG8112(CG8112)
DER: 6552441
DSE: 6607223
DSI: Dsimw501_GD18564(Dsim_GD18564)
DYA: Dyak_GE25896
DAN: 6500959
DSR: 110188757
DPO: 4803005
DPE: 6594563
DMN: 108155015
DWI: 6647984
DGR: 6564030
DMO: Dmoj_GI24769
DAZ: 108621893
DNV: 108660378
DHE: 111601473
DVI: 6629264
CCAT: 101451980 110117796
BOD: 106626744 106626771
RZE: 108360403 108373973
MDE: 101888385 101888553 101888657
SCAC: 106088722 106090130
LCQ: 111677357
LSQ: 119613698
AGA: AgaP_AGAP012216 AgaP_AGAP012217
ACOZ: 120958112 120958113
AARA: 120899616 120899617
ASTE: 118506231 118506233
AAG: 5572188
AALB: 109414895
CQU: CpipJ_CPIJ002958 CpipJ_CPIJ002959 CpipJ_CPIJ019799
CPII: 120415133 120415150 120418140
BCOO: 119072470
AME: 552313
ACER: 107994543
ALAB: 122719619
BIM: 100740568
BBIF: 117210741
BVK: 117231158
BVAN: 117166502
BTER: 100647632
BPYO: 122572532
CCAL: 108625512
OBB: 114873905
MGEN: 117225204
NMEA: 116425360
CGIG: 122397367
SOC: 105197438 105197445 105197466 105197475 105200298 105204780
MPHA: 105831194 105833666 105836642
AEC: 105150715 105150716 105150717 105151440
ACEP: 105621768 105621834
PBAR: 105426039
VEM: 105561384
HST: 105189309
DQU: 106742888
CFO: 105249109 105258340 112639984 112639992
FEX: 115233029 115233030 115238810 115238828 115242059
LHU: 105673784
PGC: 109860842
OBO: 105279911
PCF: 106787777
PFUC: 122523461
VPS: 122629732
NVI: 100122384
CSOL: 105364083
TPRE: 106651706
MDL: 103570127
CGLO: 123270202
FAS: 105265222 105265223
DAM: 107042461 107042462 107042470
CCIN: 107266592
TCA: 658068 658748
DPA: 109542077
SOY: 115878857
ATD: 109602527 109602539
CSET: 123313911 123314184
AGB: 108910891 108910892
LDC: 111513203 111515739
NVL: 108562027
APLN: 108733598
PPYR: 116177681 116177682 116177749 116177750 116178333 116178705 116178872 116178989 116178991
OTU: 111414247 111414328 111414346 111414424
BMOR: 101740142
BMAN: 114250606
MSEX: 115443132
DPL: KGM_205051
BANY: 112053868
NIQ: 126769886
PMAC: 106710838
PPOT: 106109072
PXU: 106128493
PRAP: 110996350
PBX: 123710757
ZCE: 119835008
CCRC: 123691139
HAW: 110375674
HZE: 124630965
TNL: 113504657
SLIU: 111352082
OFU: 114355532
PHU: Phum_PHUM045410
FOC: 113205675 113212022 113212023
TPAL: 117640334 117643334
ZNE: 110828545
CSEC: 111873548
FCD: 110846328
DPX: DAPPUDRAFT_40502
DMK: 116925270
DPZ: 124334038
PVM: 113813586
PJA: 122250809
PCHN: 125026217
HAME: 121873321
PCLA: 123745246
PTRU: 123508683
HAZT: 108682478
PPOI: 119096288 119096541
ISC: IscW_ISCW007924
DSV: 119434536 119436658
RSAN: 119398639
RMP: 119161465
TUT: 107364500
DPTE: 113795447 113797138 113797938 113797945
DFR: 124493577 124493920 124493923 124498527
CSCU: 111627895 111641665
PTEP: 107437856 107447646
SDM: 118197968 118203916
CEL: CELE_B0395.2(mboa-1)
CBR: CBG_16409
NAI: NECAME_05183
TSP: Tsp_07565
HRO: HELRODRAFT_114186
LGI: LOTGIDRAFT_172306
PCAN: 112563801
BGT: 106063279
GAE: 121380781
HRF: 124110534
HRJ: 124279265
CRG: 105344142
MYI: 110446400
PMAX: 117343927
MMER: 123531201
OBI: 106877085
OSN: 115211603
LAK: 106150577 106151044
SMM: Smp_134390
SHX: MS3_00002971(SOAT1)
OVI: T265_01192
EGL: EGR_03337
NVE: 5521639
EPA: 110232256
ATEN: 116304971
ADF: 107331943
AMIL: 114961555
PDAM: 113664737
SPIS: 111333509
DGT: 114516569
XEN: 124439814
TAD: TRIADDRAFT_22890
AQU: 100639150 100639276 105312507
QSU: 111983552 111991223 112020324 112020675
CME: CYME_CME100C
SCE: YCR048W(ARE1) YNR019W(ARE2)
SEUB: DI49_0798 DI49_4754
SPAO: SPAR_C01020 SPAR_N03210
AGO: AGOS_AAR065C
ERC: Ecym_2101
KLA: KLLA0_C09152g
KMX: KLMA_30485(ARE2)
LTH: KLTH0A06204g
VPO: Kpol_1027p14
ZRO: ZYRO0D08734g
CGR: CAGL0C02981g CAGL0M10571g
NCS: NCAS_0A04580(NCAS0A04580) NCAS_0D04420(NCAS0D04420)
NDI: NDAI_0I00520(NDAI0I00520) NDAI_0K01630(NDAI0K01630)
TPF: TPHA_0H02220(TPHA0H02220)
TBL: TBLA_0F04000(TBLA0F04000) TBLA_0I02260(TBLA0I02260)
TGB: HG536_0A08890
TDL: TDEL_0A07320(TDEL0A07320)
KAF: KAFR_0F00800(KAFR0F00800) KAFR_0J02490(KAFR0J02490)
KNG: KNAG_0D00500(KNAG0D00500) KNAG_0I02600(KNAG0I02600)
ZMK: HG535_0A07180
PPA: PAS_chr3_0467
DHA: DEHA2F24222g DEHA2F24244g
PIC: PICST_33115(ARE2)
PGU: PGUG_00464
SPAA: SPAPADRAFT_54917
LEL: LELG_02432
CAL: CAALFM_C206940CA(ARE2)
CTP: CTRG_01764 CTRG_01765
COT: CORT_0C06130
CDU: CD36_21230
CTEN: CANTEDRAFT_113635
YLI: YALI0F06578g
CLU: CLUG_05837
CLUS: A9F13_05g01133
CAUR: CJI97_002862
SLB: AWJ20_1276(ARE2)
PKZ: C5L36_0A02310
BNN: FOA43_003406
BBRX: BRETT_004256
OPA: HPODL_02962
SLUD: SCDLUD_001216
NCR: NCU03991 NCU04144
NTE: NEUTE1DRAFT127291(NEUTE1DRAFT_127291) NEUTE1DRAFT87893(NEUTE1DRAFT_87893)
SMP: SMAC_04443 SMAC_06169
PAN: PODANSg8191 PODANSg903
TTT: THITE_2108121 THITE_2110877
MTM: MYCTH_2301957 MYCTH_2307471
CTHR: CTHT_0068350
MGR: MGG_06765
PPEI: PpBr36_07254
TMN: UCRPA7_2776 UCRPA7_8403
SSCK: SPSK_04973
FGR: FGSG_02016 FGSG_09863
FPU: FPSE_10216 FPSE_10942
FVR: FVEG_02575 FVEG_07471
FOX: FOXG_04347 FOXG_05564
NHE: NECHADRAFT_41716 NECHADRAFT_85955
TRE: TRIREDRAFT_50607
TRR: M419DRAFT_102202
MAW: MAC_00801 MAC_01953
MAJ: MAA_04727 MAA_08231
CMT: CCM_07840
PLJ: VFPFJ_09596
VAL: VDBG_09403
VDA: VDAG_04641
CFJ: CFIO01_00425 CFIO01_08515
CLUP: CLUP02_09869 CLUP02_17284
CHIG: CH63R_09453 CH63R_13093
SAPO: SAPIO_CDS0513 SAPIO_CDS8551
ELA: UCREL1_1079 UCREL1_758
PFY: PFICI_07207 PFICI_11190
SSL: SS1G_07371 SS1G_10590
BFU: BCIN_04g01080 BCIN_10g05780
MBE: MBM_00195 MBM_07979
PSCO: LY89DRAFT_610053 LY89DRAFT_749752
GLZ: GLAREA_04618 GLAREA_07902
ANI: AN4208.2
AFM: AFUA_1G06040
ACT: ACLA_028560
NFI: NFIA_018690
AOR: AO090009000480
ANG: ANI_1_628164(An18g04660)
AFV: AFLA_010885
ALUC: AKAW2_31133A
ACHE: ACHE_11056S
APUU: APUU_60437A
PCS: Pc13g01800 Pc13g05460
PDP: PDIP_69720
TMF: PMAA_024150
TRG: TRUGW13939_03791
CIM: CIMG_03839
CPW: CPC735_004930
URE: UREG_02086
PBL: PAAG_01841
PBN: PADG_00520
ABE: ARB_05568
TVE: TRV_06840
AJE: HCAG_00155
BGH: BDBG_07403
PNO: SNOG_02790 SNOG_11748
PTE: PTT_18164 PTT_20058
BZE: COCCADRAFT_104696 COCCADRAFT_5418
BSC: COCSADRAFT_158622 COCSADRAFT_244117
BOR: COCMIDRAFT_23450 COCMIDRAFT_79731
AALT: CC77DRAFT_1017866 CC77DRAFT_370839
ZTR: MYCGRDRAFT_41169 MYCGRDRAFT_44439(ARE1)
PFJ: MYCFIDRAFT_184454 MYCFIDRAFT_208180
FFU: CLAFUR5_01809 CLAFUR5_08804
BCOM: BAUCODRAFT_61588 BAUCODRAFT_71776
NPA: UCRNP2_3303 UCRNP2_4061
TML: GSTUM_00000025001 GSTUM_00001327001
SPO: SPAC13G7.05(are1) SPCP1E11.05c(are2)
CNE: CNF01130
CNB: CNBF3580
CNG: CNAG_05860
CGI: CGB_F5190W
TMS: TREMEDRAFT_34263
TVS: TRAVEDRAFT_148341
DSQ: DICSQDRAFT_153227
PCO: PHACADRAFT_178226
SHS: STEHIDRAFT_125940
HIR: HETIRDRAFT_387282
PSQ: PUNSTDRAFT_66632
ADL: AURDEDRAFT_61665
FME: FOMMEDRAFT_16175
GTR: GLOTRDRAFT_115574
LBC: LACBIDRAFT_188091
CCI: CC1G_00886
ABP: AGABI1DRAFT105226(AGABI1DRAFT_105226)
ABV: AGABI2DRAFT185966(AGABI2DRAFT_185966)
PCUB: JR316_0007947
MRR: Moror_7033
MORE: E1B28_007332
SCM: SCHCO_02619284(SCHCODRAFT_02619284)
CPUT: CONPUDRAFT_59491
SLA: SERLADRAFT_350480
WSE: WALSEDRAFT_32831
UMA: UMAG_05355
PFP: PFL1_05361
MGL: MGL_2868
MRT: MRET_3462
PGR: PGTG_16235
ACAN: ACA1_031610
TGO: TGME49_263710(ACAT1A)
TET: TTHERM_00046980 TTHERM_00895740
PTM: GSPATT00019987001 GSPATT00022217001
PIF: PITG_12278
PSOJ: PHYSODRAFT_350290
 » show all
Reference
1  [PMID:42927]
  Authors
Spector AA, Mathur SN, Kaduce TL.
  Title
Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism.
  Journal
Prog Lipid Res 18:31-53 (1979)
DOI:10.1016/0163-7827(79)90003-1
Reference
2  [PMID:389289]
  Authors
Taketani S, Nishino T, Katsuki H.
  Title
Characterization of sterol-ester synthetase in Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 575:148-55 (1979)
DOI:10.1016/0005-2760(79)90140-1
Reference
3  [PMID:9717734]
  Authors
Lee O, Chang CC, Lee W, Chang TY
  Title
Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines.
  Journal
J Lipid Res 39:1722-7 (1998)
Reference
4  [PMID:9020103]
  Authors
Yang H, Cromley D, Wang H, Billheimer JT, Sturley SL
  Title
Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity.
  Journal
J Biol Chem 272:3980-5 (1997)
DOI:10.1074/jbc.272.7.3980
Reference
5  [PMID:9857049]
  Authors
Chang CC, Lee CY, Chang ET, Cruz JC, Levesque MC, Chang TY
  Title
Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner.
  Journal
J Biol Chem 273:35132-41 (1998)
DOI:10.1074/jbc.273.52.35132
Reference
6  [PMID:18480028]
  Authors
Das A, Davis MA, Rudel LL
  Title
Identification of putative active site residues of ACAT enzymes.
  Journal
J Lipid Res 49:1770-81 (2008)
DOI:10.1194/jlr.M800131-JLR200
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.26
IUBMB Enzyme Nomenclature: 2.3.1.26
ExPASy - ENZYME nomenclature database: 2.3.1.26
BRENDA, the Enzyme Database: 2.3.1.26
CAS: 9027-63-8

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