KEGG   ENZYME: 2.3.1.26
Entry
EC 2.3.1.26                 Enzyme                                 
Name
sterol O-acyltransferase;
cholesterol acyltransferase;
sterol-ester synthase;
acyl coenzyme A-cholesterol-O-acyltransferase;
acyl-CoA:cholesterol acyltransferase;
ACAT;
acylcoenzyme A:cholesterol O-acyltransferase;
cholesterol ester synthase;
cholesterol ester synthetase;
cholesteryl ester synthetase;
SOAT1 (gene name);
SOAT2 (gene name);
ARE1 (gene name);
ARE2 (gene name);
acyl-CoA:cholesterol O-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
long-chain acyl-CoA:sterol O-acyltransferase
Reaction(IUBMB)
a long-chain acyl-CoA + a sterol = CoA + a long-chain 3-hydroxysterol ester [RN:R12496]
Reaction(KEGG)
R12496 > R01461
Substrate
long-chain acyl-CoA [CPD:C02843];
sterol [CPD:C00370]
Product
CoA [CPD:C00010];
long-chain 3-hydroxysterol ester [CPD:C22215]
Comment
The enzyme catalyses the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A. The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA. In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol. In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of `foam cells', a hallmark of early atherosclerotic lesions. In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell.
History
EC 2.3.1.26 created 1972, modified 2019
Pathway
ec00100  Steroid biosynthesis
Orthology
K00637  sterol O-acyltransferase
Genes
HSA: 6646(SOAT1) 8435(SOAT2)
PTR: 457553(SOAT1) 737291(SOAT2)
PPS: 100990991(SOAT1) 100991938(SOAT2)
GGO: 101137508(SOAT1) 101143800(SOAT2)
PON: 100436698(SOAT1) 100443060(SOAT2)
PPYG: 129010128(SOAT2) 129017243(SOAT1)
NLE: 100590480(SOAT1) 100591122(SOAT2)
HMH: 116473179(SOAT1) 116481019(SOAT2)
SSYN: 129466657(SOAT2) 129469258(SOAT1)
MCC: 701171(SOAT2) 716989(SOAT1)
MCF: 102121286(SOAT1) 102135925(SOAT2)
MTHB: 126931112 126940434
MNI: 105474290(SOAT2) 105484509(SOAT1)
CSAB: 103230515(SOAT1) 103238380(SOAT2)
CATY: 105580285(SOAT2) 105580775(SOAT1)
PANU: 100998458(SOAT1) 101012402(SOAT2)
TGE: 112627146(SOAT1) 112635341(SOAT2)
MLEU: 105530478(SOAT1) 105555056(SOAT2)
RRO: 104670609(SOAT2) 104672006(SOAT1)
RBB: 108521617(SOAT2) 108539887(SOAT1)
TFN: 117076693(SOAT1) 117090055(SOAT2)
PTEH: 111541702(SOAT2) 111555313(SOAT1)
CANG: 105503675(SOAT2) 105518253(SOAT1)
CJC: 100387443(SOAT1) 100412165(SOAT2)
SBQ: 101047229(SOAT1) 101052421(SOAT2)
CIMI: 108284861(SOAT2) 108301278(SOAT1)
ANAN: 105711559(SOAT1) 105715855(SOAT2)
CSYR: 103267545(SOAT1) 103269719(SOAT2)
MMUR: 105870615(SOAT2) 105875493(SOAT1)
LCAT: 123635256(SOAT1) 123639778(SOAT2)
PCOQ: 105812143(SOAT1) 105818570(SOAT2)
OGA: 100962874(SOAT2) 100965917(SOAT1)
MMU: 20652(Soat1) 223920(Soat2)
MCAL: 110301596(Soat1) 110310293(Soat2)
MPAH: 110321652(Soat1) 110335070(Soat2)
RNO: 266770(Soat2) 81782(Soat1)
MCOC: 116082223(Soat2) 116101816(Soat1)
ANU: 117702297 117716546(Soat1) 117718851(Soat2)
ASYL: 127667998(Soat2) 127697142(Soat1)
MUN: 110552319(Soat2) 110563339(Soat1)
CGE: 100689317(Soat1) 100752385(Soat2)
MAUA: 101835581(Soat1) 101839263(Soat2)
PROB: 127223438(Soat1) 127226139(Soat2)
PLEU: 114696635(Soat2)
MORG: 121444182(Soat2) 121455104(Soat1) 121459544
MFOT: 126493601 126497348
AAMP: 119822422(Soat2) 119827492(Soat1)
NGI: 103728004(Soat1) 103738463(Soat2)
HGL: 101718579(Soat2) 101725301(Soat1)
CPOC: 100716750(Soat1) 100728450(Soat2)
CCAN: 109684043(Soat2) 109693443(Soat1)
DORD: 105985111(Soat1) 105997917(Soat2)
DSP: 122103891(Soat1) 122124220(Soat2)
DMER: 138835800(Soat1) 138837020(Soat2)
PLOP: 125359533(Soat1) 125364195(Soat2)
NCAR: 124961744 124976730 124983098
MMMA: 107147338(Soat1) 107148797(Soat2)
ITI: 101975117(Soat2) 101977701(Soat1)
OCU: 100009537 100349393 127493699
OPI: 101522712(SOAT2) 101524678(SOAT1)
TUP: 102485090(SOAT1) 102501974(SOAT2)
GVR: 103592220(SOAT2) 103607560(SOAT1)
CFA: 486511(SOAT2) 490325(SOAT1)
CLUD: 112648530(SOAT1) 112667196(SOAT2)
VVP: 112921168(SOAT2) 112921836(SOAT1)
VLG: 121480399(SOAT2) 121494712(SOAT1)
NPO: 129505888(SOAT1) 129517309(SOAT2)
AML: 100464310(SOAT1) 100466845(SOAT2)
UMR: 103668575(SOAT1) 103675666(SOAT2)
UAH: 113262770(SOAT1)
UAR: 123794617(SOAT2) 123801346(SOAT1)
ELK: 111150910 111157987
LLV: 125085747 125107568
MPUF: 101687685(SOAT2) 101693044(SOAT1)
MNP: 132020716(SOAT2) 132025478(SOAT1)
MLK: 131812750 131814387(SOAT1) 131838708(SOAT2)
NVS: 122891626(SOAT2) 122918640(SOAT1)
ORO: 101372404(SOAT2) 101377194(SOAT1)
EJU: 114222870(SOAT1) 114225688(SOAT2)
ZCA: 113922052(SOAT2) 113931946(SOAT1)
MLX: 118008807(SOAT2) 118014416(SOAT1)
NSU: 110574128(SOAT1) 110577438(SOAT2)
LWW: 102743591(SOAT1) 102745995(SOAT2)
FCA: 101081271(SOAT1) 101099223(SOAT2)
PYU: 121011872(SOAT1) 121038507(SOAT2)
PCOO: 112857638(SOAT1) 112867347(SOAT2)
PBG: 122473464(SOAT2) 122476340(SOAT1)
PVIV: 125155223(SOAT1) 125170088(SOAT2)
LRUF: 124501744 124510178
LGF: 123585001(SOAT1) 123590418(SOAT2)
AJU: 106977936 106986455
PTG: 102951570(SOAT2) 102951637(SOAT1)
PPAD: 109249185(SOAT2) 109253480(SOAT1)
PUC: 125919109 125925196
PLEZ: 122211610(SOAT1) 122224602(SOAT2)
HHV: 120247273(SOAT2) 120247467(SOAT1)
BTA: 504287(SOAT1) 513554(SOAT2)
BOM: 102266586(SOAT1) 102286882(SOAT2)
BIU: 109559050(SOAT2) 109570627(SOAT1)
BBUB: 102395575(SOAT2) 102403392(SOAT1)
BBIS: 104996024(SOAT1) 105001568(SOAT2)
CHX: 102181472(SOAT2) 102186791(SOAT1)
OAS: 101107179(SOAT2) 101121363(SOAT1)
BTAX: 128048481(SOAT2) 128061846(SOAT1)
CSUM: 138078097(SOAT2) 138090196(SOAT1)
ODA: 120858285(SOAT2) 120880520(SOAT1)
CCAD: 122427255(SOAT2) 122452089(SOAT1)
MREE: 136166036(SOAT2) 136168534(SOAT1)
OVR: 110121573(SOAT1) 110138220(SOAT2)
MBEZ: 129536694(SOAT2) 129551328(SOAT1)
SSC: 100515544(SOAT2) 100628166(SOAT1)
CFR: 102509905(SOAT2) 102517625(SOAT1)
CBAI: 105068919(SOAT1) 105076275(SOAT2)
CDK: 105094576(SOAT2) 105099977(SOAT1)
VPC: 102525768(SOAT2) 102544460(SOAT1)
BACU: 103005265(SOAT2) 103019063(SOAT1)
BMUS: 118902710(SOAT2) 118903964(SOAT1)
LVE: 103074467(SOAT1) 103078608(SOAT2)
OOR: 101283408(SOAT1) 101288997(SOAT2)
LALB: 132510405(SOAT1) 132528795(SOAT2)
GMF: 115858699(SOAT2) 115862986(SOAT1)
DDP: 132433714(SOAT2) 132439894(SOAT1)
DLE: 111165675(SOAT1) 111173958(SOAT2)
PCAD: 102977521(SOAT2) 102985612(SOAT1)
PSIU: 116759682(SOAT1) 116761048(SOAT2)
PPHC: 136125465(SOAT1) 136130732(SOAT2)
NASI: 112394196(SOAT2) 112408926(SOAT1)
ECB: 100050551(SOAT1) 100146367(SOAT2)
EPZ: 103559415(SOAT2) 103566918(SOAT1)
EAI: 106833928(SOAT1) 106835276(SOAT2)
MYB: 102251864(SOAT1) 102258914(SOAT2)
MYD: 102752811(SOAT2) 102760492(SOAT1)
MMYO: 118651668(SOAT2) 118673106(SOAT1)
MLF: 102418054(SOAT2) 102428466(SOAT1) 102443306
MDT: 132220965(SOAT1) 132227654(SOAT2)
MYUM: 138995600(SOAT1) 139007096(SOAT2)
PKL: 118721361(SOAT1) 118730166(SOAT2)
EFUS: 103285336(SOAT2) 103290107(SOAT1)
MNA: 107528134(SOAT2) 107531050(SOAT1)
DRO: 112298110(SOAT1) 112318616(SOAT2)
SHON: 118979108(SOAT1)
AJM: 119043504(SOAT2) 119049583(SOAT1)
PDIC: 114511879(SOAT1) 114513415(SOAT2)
PHAS: 123813033(SOAT2) 123818366(SOAT1)
MMF: 118624235(SOAT2) 118637878(SOAT1)
PPAM: 129082004(SOAT1) 129084819(SOAT2)
HAI: 109384905(SOAT1) 109391779(SOAT2)
RFQ: 117014674(SOAT1) 117029355(SOAT2)
PALE: 102897908(SOAT1) 102897972(SOAT2)
PGIG: 120602128(SOAT2) 120617615(SOAT1)
PVP: 105292844(SOAT1) 105302667(SOAT2)
RAY: 107509023(SOAT1) 107509777(SOAT2)
MJV: 108391159(SOAT1) 108402966(SOAT2)
TOD: 119241232(SOAT1) 119247978(SOAT2)
SARA: 101547112(SOAT2) 101552737(SOAT1)
SFUM: 130016605(SOAT1) 130029057(SOAT2)
SETR: 126013412(SOAT1) 126022514(SOAT2)
LAV: 100666457(SOAT1) 100670395(SOAT2)
TMU: 101352609 101353901
ETF: 101639422(SOAT1) 101653803(SOAT2)
DNM: 101415761(SOAT2) 101424051 101439724(SOAT1) 101443584 101447432
MDO: 100022219(SOAT1)
GAS: 123247969(SOAT1) 123250227(SOAT2)
SHR: 100920315(SOAT1) 100933677(SOAT2)
AFZ: 127562851 127564116
PCW: 110194139(SOAT2) 110206808(SOAT1)
TVP: 118847809(SOAT1) 118850164 118852369(SOAT2)
PBRV: 138144174(SOAT1) 138171631(SOAT2)
MLAO: 141512840(SOAT1) 141514758(SOAT2)
OAA: 100081816(SOAT2) 100085367(SOAT1)
TACU: 119933245(SOAT2) 119937971(SOAT1)
GGA: 424424(SOAT1)
PCOC: 116230442(SOAT1)
MGP: 100544187(SOAT1)
CJO: 107317265(SOAT1)
TPAI: 128072355(SOAT1)
LMUT: 125692820(SOAT1)
NMEL: 110402509(SOAT1)
APLA: 101790922(SOAT1)
ACYG: 106042512(SOAT1)
CATA: 118243612(SOAT1)
AFUL: 116492028(SOAT1)
TGU: 100223763(SOAT1)
LSR: 110478939(SOAT1)
SCAN: 103814788(SOAT1)
PMOA: 120512224(SOAT1)
OTC: 121344266(SOAT1)
PRUF: 121359796(SOAT1)
ATRC: 139594158(SOAT1)
GFR: 102041188(SOAT1)
FAB: 101815412(SOAT1)
OMA: 130256262(SOAT1)
PHI: 102102644(SOAT1)
PMAJ: 107208206(SOAT1)
CCAE: 111932597(SOAT1)
CCW: 104693579(SOAT1)
CBRC: 103617772(SOAT1)
ACOE: 138113737(SOAT1)
ETL: 114062572(SOAT1)
ZAB: 102068817(SOAT1)
ZLE: 135451040(SOAT1)
ACHL: 103801132(SOAT1)
SVG: 106852277(SOAT1)
MMEA: 130578676(SOAT1)
HRT: 120756333(SOAT1)
SATI: 136364720(SOAT1)
CCIC: 134046758(SOAT1)
FPG: 101919752(SOAT1)
FCH: 102060236(SOAT1)
CCRI: 104161119(SOAT1)
NNT: 104404757(SOAT1)
SHAB: 115611920(SOAT1)
ACUN: 113483059(SOAT1)
TALA: 104359540(SOAT1)
ACHC: 115349189(SOAT1)
HALD: 104318542(SOAT1)
HLE: 104839987(SOAT1)
HHAR: 128148124(SOAT1)
GCL: 127018959
CSTI: 104555920(SOAT1)
LDI: 104340696(SOAT1)
MNB: 103771603(SOAT1)
DPUB: 104301527(SOAT1)
PPUS: 135177738(SOAT1)
AVIT: 104272519(SOAT1)
BRHI: 104500815(SOAT1)
EGZ: 104132041(SOAT1)
NNI: 104011338(SOAT1)
PCRI: 104027277
PCAO: 104050189(SOAT1)
PADL: 103914031(SOAT1)
AFOR: 103896098(SOAT1)
FGA: 104072630
GSTE: 104262334(SOAT1)
CBOY: 140654171(SOAT1)
CLV: 102098103(SOAT1)
CNIC: 135996761(SOAT1)
MUI: 104541724(SOAT1)
PGUU: 104464167(SOAT1)
PLET: 104626826(SOAT1)
EHS: 104503438(SOAT1)
CMAC: 104485418(SOAT1)
CUCA: 104058591(SOAT1)
TEO: 104376697(SOAT1)
BREG: 104639838(SOAT1)
OHA: 104334033(SOAT1)
ACAR: 104521592(SOAT1)
CPEA: 104386099(SOAT1)
CVF: 104293343(SOAT1)
RTD: 128914060(SOAT1)
CRID: 134519667(SOAT1)
AAM: 106484966(SOAT1)
AROW: 112975091(SOAT1)
NPD: 112947695(SOAT1)
TGT: 104569011(SOAT1)
DNE: 112983702(SOAT1)
SCAM: 104142656(SOAT1)
ASN: 102373020(SOAT1) 102378548 102379056
AMJ: 102568578(SOAT1) 102573699
CPOO: 109307171(SOAT1)
GGN: 109286970(SOAT1)
PSS: 102448344(SOAT1) 102450944(SOAT2)
CMY: 102934330(SOAT2) 102943858(SOAT1)
CCAY: 125629323(SOAT2) 125641194(SOAT1)
DCC: 119846053(SOAT2) 119860240(SOAT1)
CPIC: 101940194(SOAT2) 101944538(SOAT1)
TST: 117881322(SOAT1) 117889003(SOAT2)
CABI: 116828547(SOAT2) 116834217(SOAT1)
MRV: 120370550(SOAT1) 120391259(SOAT2)
ACS: 100556270(soat1) 100559804 100567184 100567378 107982384
ASAO: 132767693 132767703 132767704 132768150 132774375(SOAT1)
PVT: 110077048(SOAT1)
SUND: 121920463 121920466(SOAT2) 121928759(SOAT1)
PBI: 103048435 103064093(SOAT1)
PMUR: 107283372(SOAT1) 107288520 107288521 107288522 107288523 107288524 114922654
CTIG: 120302341 120302356 120302357 120305394(SOAT1) 120318140
TSR: 106544465(SOAT1) 106557336
PGUT: 117659869 117661157(SOAT1) 117666479(SOAT2)
PCAE: 139310743 139310744 139312832 139313789(SOAT1)
APRI: 131190602 131192136 131195380(SOAT1)
PTEX: 113438092(SOAT1) 113452036 113452083
NSS: 113413156(SOAT1) 113416199(SOAT2) 113428273
VKO: 123027911(SOAT1)
PMUA: 114586205(SOAT2) 114598569 114598570 114598594
PRAF: 128406219(SOAT2) 128415270 128415274 128415290
ZVI: 118076791(SOAT2) 118077703 118088264 118088449 118089157
HCG: 128322612(SOAT1)
STOW: 125432919(SOAT1)
EMC: 129329984(SOAT1)
XLA: 108708653 108714368(soat1.L) 446863(soat1.S) 779411(soat2.S)
XTR: 100145286(soat1) 100216296(soat2) 101730739
NPR: 108786819(SOAT2) 108800649(SOAT1)
RTEM: 120929304 120929305 120929306 120945640(SOAT1)
ACAT: 141103454(SOAT1) 141126554 141127282
BBUF: 120978476(SOAT1) 120993919 120993920 120996087(SOAT2)
BGAR: 122931422 122931423 122932620 122943182(SOAT1)
DTC: 141049601(SOAT2) 141085813(SOAT1)
PWL: 138292372(SOAT2) 138293093(SOAT1)
MUO: 115464627 115466732 115471620(SOAT1)
GSH: 117346573(SOAT1) 117358099(SOAT2)
DRE: 564424(soat1) 564868(soat2)
SRX: 107707573(soat1) 107734612 107758003
SANH: 107657858 107681296 107700347
SGH: 107549691 107566412(soat2) 107599004(soat1)
CCAR: 109059086 109059087 109072620(soat2)
CAUA: 113050186 113076346 113078370
CGIB: 127963506 128016063 128018858
PTET: 122334286(soat2) 122350872 122350873(soat1)
LROH: 127166972(soat2) 127169395(soat1)
GRF: 141286968(soat1)
OMC: 131541835(soat2) 131546155(soat1)
PPRM: 120464561(soat2) 120472593(soat1)
RKG: 130072475(soat2) 130091631(soat1)
MAMB: 125273400(soat2) 125279535(soat1)
CIDE: 127514526 127517048
CERY: 137011089(soat2) 137026923(soat1)
MASI: 127415313 127424471 127446012 127449568
TROS: 130556599(soat2) 130568637(soat1)
TDW: 130407317(soat1) 130424365(soat2)
MANU: 129413652(soat1) 129450319(soat2)
PDAB: 135730485(soat1) 135757743(soat2)
IPU: 108265920 108272126(soat2)
IFU: 128615077(soat2)
PHYP: 113535230(soat1) 113540941
SMEO: 124400361(soat1) 124402877(soat2)
TFD: 113642643(soat1) 113643245(soat2)
TVC: 132854010(soat1)
CGAR: 128526764(soat2) 128530314(soat1)
NGRA: 132893466(soat1)
TRN: 134316923(soat2)
AMEX: 103034708(soat2) 103042750(soat1)
CMAO: 118808481(soat2) 118813967(soat1)
EEE: 113571647
CHAR: 105898315(soat1) 105912296(soat2)
SPIL: 134092763(soat2) 134101941(soat1)
TRU: 101072139 101077060 105417935(soat1)
TFS: 130523855(soat2) 130528548(soat1)
TNG: GSTEN00013578G001 GSTEN00028839G001
LCO: 104919967 104929343(soat1)
NCC: 104966663
TBEN: 117487523 117487536 117489542(soat2)
CGOB: 115007559(soat1) 115007732
PGEO: 117446071(soat2)
GACU: 117534199(soat2) 117561314(soat1)
EMAC: 134869785(soat1) 134883068(soat2)
ELY: 117253487(soat1) 117257034(soat2)
EFO: 125894498(soat2) 125896259(soat1)
PLEP: 121941376(soat1) 121957287(soat2)
SLUC: 116051366(soat2) 116055456(soat1)
ECRA: 117942651(soat2) 117950136(soat1)
ESP: 116677754 116688603 116696008(soat1)
PFLV: 114554740 114562037(soat1)
GAT: 120823793(soat1) 120834696(soat2)
PPUG: 119216929(soat1) 119229555(soat2)
AFB: 129094276(soat1) 129106033(soat2)
CLUM: 117729764(soat1) 117730505(soat2)
PSWI: 130193926(soat1) 130207765(soat2)
CANA: 137794544(soat1) 137796733(soat2)
CVE: 137870256(soat1) 137873888(soat2)
MSAM: 119885539(soat2) 119900719(soat1)
SCHU: 122877963(soat1) 122885523(soat2)
CUD: 121507035(soat2) 121511848(soat1)
SPUL: 138606279(soat2) 138607327(soat1)
LMIX: 132959495(soat1) 132978149(soat2)
ALAT: 119021832(soat2) 119028077(soat1)
ASTR: 137595540(soat2) 137598460(soat1)
MZE: 101475426 101487179(soat1)
ONL: 100697439 100706988(soat1)
OAU: 116320715(soat2) 116323167(soat1)
OLA: 101162519 101164716(soat1)
OML: 112144903(soat2) 112150835(soat1)
CSAI: 133448306(soat2) 133458403(soat1)
XMA: 102229353(soat1) 102229837
XCO: 114136210 114150622(soat1)
XHE: 116711257(soat2) 116725326(soat1)
PRET: 103464078(soat1) 103464407
PFOR: 103135830(soat2) 103138480(soat1)
PLAI: 106951090(soat1) 106956632(soat2)
PMEI: 106906815(soat1) 106928441(soat2)
GAF: 122834468(soat2) 122838042(soat1)
PPRL: 129358277(soat2) 129375407(soat1)
CVG: 107100648(soat1) 107103130
CTUL: 119780837(soat1) 119790317(soat2)
GMU: 124856666(soat2) 124874467(soat1)
NFU: 107385327 107393145(soat1)
KMR: 108230591(soat1) 108231501(soat2)
ALIM: 106512175(soat1) 106514738(soat2)
NWH: 119407832(soat1) 119412417(soat2)
AOCE: 111563899(soat1) 111583785(soat2)
EJA: 138196634(soat2) 138198810(soat1)
BFRE: 138616557(soat2) 138621193(soat1)
MCEP: 125006149(soat2) 125009997(soat1)
CSEM: 103386401 103393235(soat1)
POV: 109625295(soat1) 109635497
SSEN: 122767836(soat2) 122781268(soat1)
SSOE: 131460291(soat2) 131466169(soat1)
HHIP: 117759962(soat1) 117762290(soat2)
HSP: 118105418(soat2) 118121497(soat1)
PPLT: 128448477(soat1) 128448599(soat2)
SMAU: 118309354(soat2) 118317947(soat1)
LCF: 108881364 108884835
SDU: 111223955 111231092(soat1)
SLAL: 111651858(soat1) 111659793
XGL: 120791280(soat1) 120806976(soat2)
HCQ: 109510620 109532427(soat1)
SSCV: 125968452(soat1) 125977466(soat2)
SBIA: 133503845(soat1)
PEE: 133406096(soat1) 133408754(soat2)
PTAO: 133480593(soat1) 133483969(soat2)
BPEC: 110154556 110160201(soat1)
ENY: 140354074(soat1) 140365339(soat2)
MALB: 109954616 109967403(soat1)
BSPL: 114853833 114853837(soat1) 114855010(soat2)
SJO: 128355969(soat2) 128361589(soat1)
SSCO: 133977557(soat2) 133985066(soat1)
GMH: 115555114(soat1) 115557510
SASA: 106566146 106613907(soat1)
STRU: 115158397 115207329
OTW: 112251021(soat1) 112262720(soat2)
OMY: 110494785(soat2) 110524440(soat1)
OGO: 123996939(soat1) 124003974(soat2)
ONE: 115108434
OKI: 109880336 109902629 116352802
OKE: 118377858(soat2) 118391189(soat1)
OMM: 135512904(soat1) 135540402(soat2)
OCLA: 139371430 139409274
SALP: 111975891(soat1) 112069696
SNH: 120054864(soat1) 120057880(soat2)
CCLU: 121533399(soat1) 121574796(soat2)
ELS: 105007362 105026366(soat1)
OEP: 134011262(soat1) 134028759(soat2)
SFM: 108919079(soat1) 108928332
PKI: 111835303(soat2) 111848971(soat1)
AANG: 118210915(soat2) 118226300(soat1)
AROT: 135238297(soat2) 135253699(soat1)
CCOG: 133109500(soat2) 133127741(soat1)
LOC: 102683439 102692222(soat1)
PSPA: 121308925 121330530(soat1)
ARUT: 117401130 117412248(soat1) 117967106
PSEX: 120524936 120538330(soat1)
LCM: 102351870(SOAT1) 102367356(SOAT2)
CMK: 103179969(soat1) 103189932(soat2)
RTP: 109927029(soat1)
CPLA: 122554481(soat1)
HOC: 132819027(soat1)
LERI: 129701149 129714745
HAKA: 140737125(soat1) 140741184
PMRN: 116938002 116947859(SOAT1)
LRJ: 133345154(SOAT1) 133346176
BFO: 118424040
BBEL: 109486598
SPU: 583194
LPIC: 129275263 129275264
AJJ: 139958949
APLC: 110974464
ARUN: 117300032
AAMU: 139948720
AFIL: 140148322
AJC: 117119475
PFLL: 139141041
DME: Dmel_CG8112(CG8112)
DER: 6552441
DSE: 6607223
DSI: Dsimw501_GD18564(Dsim_GD18564)
DYA: Dyak_GE25896
DAN: 6500959
DSR: 110188757
DPO: 4803005
DPE: 6594563
DMN: 108155015
DWI: 6647984
DGR: 6564030
DMO: Dmoj_GI24769
DAZ: 108621893
DNV: 108660378
DHE: 111601473
DVI: 6629264
CCAT: 101451980 110117796
BOD: 106626744 106626771
BDR: 105223844 105223866
RZE: 108360403 108373973
AOQ: 129245151 129246468
ALUD: 128867912 128868539
TDA: 119677573 119677574 119677575
MDE: 101888385 101888553 101888657 131801360 131806388
SCAC: 106088722 106090130
LCQ: 111677357
LSQ: 119613698
CVJ: 135961781
GFS: 119641400
ECOE: 129952566
CLON: 129614860
AGA: 1280474 1280475
ACOZ: 120958112 120958113
AARA: 120899616 120899617
AMER: 121600051 121600052
ASTE: 118506231 118506233
AMAP: 126568063 126568107
AFUN: 125768646 125768648 125768649
AMOU: 128310285
AMRS: 128706969 128718614
AALI: 118467967
ACOS: 131272310
AAG: 5572188
AALB: 109414895
ASUA: 134222396 134222407 134225915
CQU: CpipJ_CPIJ002958 CpipJ_CPIJ002959 CpipJ_CPIJ019799
CPII: 120415133 120415150 120418140
CBRI: 134826986
BCOO: 119072470
LLL: 129786032 129788154
PPAP: 129804892
AME: 552313
ACER: 107994543
ALAB: 122719619
ADR: 102682014
AFLR: 100867825
BIM: 100740568
BBIF: 117210741
BVK: 117231158
BVAN: 117166502
BHUN: 126864203
BTER: 100647632
BAFF: 126917486
BPYO: 122572532
BPAS: 132906621
FVI: 122537029
CCAL: 108625512
OBB: 114873905
OLG: 117602601
MGEN: 117225204
NMEA: 116425360
CGIG: 122397367
SOC: 105197438 105197445 105197466 105197475 105200298 105204780 113002721 113005162
MPHA: 105831194 105833666 105836642
AEC: 105150715 105150716 105150717 105151440
ACEP: 105621768 105621834
ACOC: 108684121 108684206
MZT: 108720837 108724915
CCOA: 108777084 108777093 108777094
PBAR: 105426039
VEM: 105561384
COBS: 139104453
TLN: 139821674
HST: 105189309
DQU: 106742888
CFO: 105249109 105258340 112639984 112639992
FEX: 115233029 115233030 115238810 115238828 115242059
PMEC: 138945200 138945201
LHU: 105672373 137001787
PGC: 109860842
OBO: 105279911
PCF: 106787777
PFUC: 122523461
VPS: 122629732
VCRB: 124423761
VVE: 124950227
NVI: 100122384
CSOL: 105364083
TPRE: 106651706
LHT: 122508158
LBD: 127283473
MDL: 103570127
CGLO: 123270202
CTYP: 141533608
FAS: 105265222 105265223
DAM: 107042461 107042462 107042470
VCAN: 122406801
CCIN: 107266592
DSM: 124408128
NPT: 124215918
NFB: 124179373
NLO: 107224311
NVG: 124301797
AROA: 105685071
TCA: 658068 658748
TMOL: 138125932 138126492 138132940 138132942 138132943 138133114 138133582
DPA: 109542077
ESIM: 136409862
EFOR: 136343404
SOY: 115878857
AGRG: 126742221
ATD: 109602527 109602539
CSET: 123313911 123314184
HAXR: 123680008 123680009 123680010
AGB: 108910891 108910892
LDC: 111513203 111515739
DVV: 126881300 126883280 126883375
NVL: 108562027
APLN: 108733598
PPYR: 116177681 116177682 116177749 116177750 116178333 116178705 116178872 116178989 116178991
OTU: 111414247 111414328 111414346 111414424
BMOR: 101740142
BMAN: 114250606
MSEX: 115443132
DPL: KGM_205051
BANY: 112053868
MJU: 123880906
NIQ: 126769886
VCD: 124533682
MCIX: 123653845
PMAC: 106710838
PPOT: 106109072
PXU: 106128493
BPHI: 137930264
PRAP: 110996350
PBX: 123710757
PNAP: 125053184
ZCE: 119835008
CCRC: 123691139
LSIN: 126970490
AAGE: 121731533
HAW: 110375674
HZE: 124630965
TNL: 113504657
SLIU: 111352082
OFU: 114355532
ONU: 135071756
ATRA: 106131919
GMW: 113517407
PGW: 126367539
LGLY: 125227927
CSTB: 134742474
CFUM: 141428215
CCRN: 123296336 123296346 123296589
PHU: Phum_PHUM045410
FOC: 113205675 113212022 113212023
TPAL: 117640334 117643334
ZNE: 110828545
CSEC: 111873548
PAME: 138701131
BROR: 134538978
IEL: 124154101 124158916
HAMR: 139686633 139691969
FCD: 110846328
DPX: DAPPUDRAFT_40502
DMK: 116925270
DPZ: 124334038
AFRA: 136031884
PVM: 113813586
PJA: 122250809
PCHN: 125026217
PMOO: 119580231
HAME: 121873321
PCLA: 123745246
CQD: 128700861
PTRU: 123508683
ESN: 126983518 126991418
MNZ: 135206057
MRJ: 136834243
PORN: 139757781
HAZT: 108682478
PPOI: 119096288 119096541
DSV: 119434536 119436658
RSAN: 119398639
RMP: 119161465
TUT: 107364500
DPTE: 113795447 113797138 113797938 113797945
DFR: 124493577 124493920 124493923 124498527
CSCU: 111627895 111641665
CVS: 136968418 136972895 136973331 136975298
PTEP: 107437856 107447646
ABRU: 129958417 129958421 129958430 129959909 129959912 129959937 129961994 129964000 129972034 129975596 129980591 129981367 129981390 129981398 129981620
UDV: 129221949 129229948
SDM: 118197968 118203916
LPOL: 106470327 106472059
PMEO: 129590407 129598651 129598664
CEL: CELE_B0395.2(mboa-1)
CBR: CBG_16409
CRQ: GCK72_023150
NAI: NECAME_05183
TSP: Tsp_07565
HRO: HELRODRAFT_114186
LGI: LOTGIDRAFT_172306
PVUL: 126807715
PCAN: 112563801
LSAX: 138982160
BGT: 106063279
GAE: 121380781
HRF: 124110534
HRJ: 124279265
HASI: 137255746
HCRA: 139470191
CRG: 105344142
CANU: 128164162
CVN: 111114616
OED: 125666778
MYI: 110446400
PMAX: 117343927
AIRR: 138313545 138314318
MCAF: 127730990
MMER: 123531201
RPHI: 132714013 132720951
DPOL: 127854875
MAEA: 128229585
OBI: 106877085
OSN: 115211603
LJP: 135477406
LAK: 106150577 106151044
SMM: Smp_134390
SHX: MS3_00002971(SOAT1)
OVI: T265_01192
EGL: EGR_03337
LLON: 135500093
NVE: 5521639
EPA: 110232256
ATEN: 116304971
ADF: 107331943
AMIL: 114961555
MCAZ: 138045390
MFOO: 138012787
PDAM: 113664737
SPIS: 111333509
DGT: 114516569
XEN: 124439814
HSY: 130621711
RES: 135682526
TAD: TRIADDRAFT_22890
AQU: 100639150 100639276 105312507
CME: CYME_CME100C
SCE: YCR048W(ARE1) YNR019W(ARE2)
SEUB: DI49_0798 DI49_4754
SPAO: SPAR_C01020 SPAR_N03210
AGO: AGOS_AAR065C
ERC: Ecym_2101
KLA: KLLA0_C09152g
KMX: KLMA_30485(ARE2)
LTH: KLTH0A06204g
VPO: Kpol_1027p14
ZRO: ZYRO0D08734g
CGR: 2886771(GVI51_C02761) 2891371(GVI51_M10549)
NCS: NCAS_0A04580(NCAS0A04580) NCAS_0D04420(NCAS0D04420)
NDI: NDAI_0I00520(NDAI0I00520) NDAI_0K01630(NDAI0K01630)
TPF: TPHA_0H02220(TPHA0H02220)
TBL: TBLA_0F04000(TBLA0F04000) TBLA_0I02260(TBLA0I02260)
TGB: HG536_0A08890
TDL: TDEL_0A07320(TDEL0A07320)
KAF: KAFR_0F00800(KAFR0F00800) KAFR_0J02490(KAFR0J02490)
KNG: KNAG_0D00500(KNAG0D00500) KNAG_0I02600(KNAG0I02600)
ZMK: HG535_0A07180
SLUD: SCDLUD_001216
DHA: DEHA2F24222g DEHA2F24244g
PIC: PICST_33115(ARE2)
PGU: PGUG_00464
SPAA: SPAPADRAFT_54917
LEL: PVL30_003276(ARE2)
LBG: 92208860(LODBEIA_P36640)
CAL: CAALFM_C206940CA(ARE2)
CTP: CTRG_01764 CTRG_01765
COT: CORT_0C06130
CDU: CD36_21230
CLU: CLUG_05837
CLUS: A9F13_05g01133
CAUR: CJI96_0000646
ASAU: 88173034(PUMCH_001969)
PPA: PAS_chr3_0467
PKZ: C5L36_0A02310
BNN: FOA43_003406
BBRX: BRETT_004256
OPA: HPODL_02962
YLI: 2908079(YALI2_F00129g)
SLB: AWJ20_1276(ARE2)
NCR: NCU03991 NCU04144
NTE: NEUTE1DRAFT127291(NEUTE1DRAFT_127291) NEUTE1DRAFT87893(NEUTE1DRAFT_87893)
SMP: 10801040(SMAC4_04443)
PAN: PODANSg8191 PODANSg903
PBEL: QC761_203980(ARE2_1) QC761_402360(ARE2_2)
PPSD: QC762_203980(ARE2_1) QC762_402360(ARE2_2)
PPSP: QC763_203980(ARE2_1) QC763_402360(ARE2_2)
PPSA: QC764_203980(ARE2_1) QC764_402360(ARE2_2)
TTT: THITE_2108121 THITE_2110877
MTM: MYCTH_2301957 MYCTH_2307471
CTHR: CTHT_0068350
RTHE: 98124350(VTJ83DRAFT_3339)
MGR: MGG_06765
PPEI: PpBr36_07254
PGRI: PgNI_05834
TMN: UCRPA7_2776 UCRPA7_8403
SSCK: SPSK_04973
FGR: FGSG_02016 FGSG_09863
FPU: FPSE_10216 FPSE_10942
FPOA: FPOAC1_002150 FPOAC1_002938
FVN: FVRRES_02392 FVRRES_03256
FVR: FVEG_02575 FVEG_07471
FOX: FOXG_04347 FOXG_05564
NHE: NECHADRAFT_41716 NECHADRAFT_85955
FFC: NCS54_00674000 NCS54_01249700
FKR: NCS57_00713800 NCS57_01260300
FMU: J7337_005499 J7337_010529
TRE: TRIREDRAFT_50607
TRR: M419DRAFT_102202
TATV: 25777632(TrAtP1_010879)
TASP: 36618659(TrAFT101_009212)
MAW: 19245112(ARE2_1) 19246264(are2)
MAJ: MAA_04727 MAA_08231
MBRN: 26242018(G6M90_00g045170) 26246515(ARE2)
PCHM: VFPPC_07473 VFPPC_14324
CMT: CCM_07840
AMUS: LMH87_000988 LMH87_002823
PLJ: 28885021(PLICBS_006198) 28891714(PLICBS_010242)
PTKZ: JDV02_002124(ARE2_1) JDV02_008365(ARE2_2)
VAL: VDBG_09403
VDA: VDAG_04641
CFJ: CFIO01_00425 CFIO01_08515
CLUP: CLUP02_09869 CLUP02_17284
CHIG: CH63R_09453 CH63R_13093
CDET: 87950653(CDEST_14153) 87951323(CDEST_14823)
SAPO: SAPIO_CDS0513 SAPIO_CDS8551
ELA: UCREL1_1079 UCREL1_758
PFY: PFICI_07207 PFICI_11190
SSL: SS1G_07371 SS1G_10590
BFU: BCIN_04g01080 BCIN_10g05780
MBE: MBM_00195 MBM_07979
PSCO: LY89DRAFT_610053 LY89DRAFT_749752
GLZ: GLAREA_04618 GLAREA_07902
ANI: ANIA_04208
AFM: AFUA_1G06040
ACT: ACLA_028560
NFI: NFIA_018690
AOR: AO090009000480
ANG: An18g04660
AFV: AFLA_010885
ALUC: AKAW2_31133A
ACHE: ACHE_11056S
APUU: APUU_60437A
PCS: N7525_000329
PDP: PDIP_69720
POU: POX_e06739 POX_f08155
TMF: EYB26_000873
TRG: TRUGW13939_03791
CIM: CIMG_03839
CPW: 9693949(D8B26_003318)
URE: UREG_02086
ABE: ARB_05568
TVE: TRV_06840
PBL: PAAG_01841
PBN: PADG_00520
AJE: HCAG_00155
BGH: BDBG_07403
PNO: SNOG_02790 SNOG_11748
PTE: PTT_18164 PTT_20058
PTRR: 6339839(PtrM4_025400) 6339947(PtrM4_003330)
BZE: COCCADRAFT_104696 COCCADRAFT_5418
BSC: COCSADRAFT_158622 COCSADRAFT_244117
BOR: COCMIDRAFT_23450 COCMIDRAFT_79731
AALT: CC77DRAFT_1017866 CC77DRAFT_370839
ADAC: 96087964(ACET3X_007642)
ARAB: EKO05_0000560 EKO05_0003480
ZTR: MYCGRDRAFT_41169 MYCGRDRAFT_44439(ARE1)
PFJ: MYCFIDRAFT_184454 MYCFIDRAFT_208180
FFU: CLAFUR5_01809 CLAFUR5_08804
CBET: CB0940_00670 CB0940_10727
BCOM: BAUCODRAFT_61588 BAUCODRAFT_71776
NPA: UCRNP2_3303 UCRNP2_4061
TML: GSTUM_00000025001 GSTUM_00001327001
SPO: 2538854(are2) 2542851(are1)
SOM: SOMG_02780(are1) SOMG_04121(are2)
CNE: CNF01130
CNB: CNBF3580
CNG: CNAG_05860
CGI: CGB_F5190W
CDEU: CNBG_1683
CDEC: 89990615(IAS62_003843)
CTEG: 91990748(I308_103892)
CBAS: 91983835(I312_103790)
CDEP: 91087238(L203_103027)
KMG: 30165744(I203_100197)
KNE: 92184204(IAR55_006946)
KDJ: 28971989(I303_106451)
KBI: 30204603(I302_101520)
KPIN: 30173934(I206_106889)
KSH: 87958363(IL334_006233)
KER: 91103834(V865_005033)
TMS: TREMEDRAFT_34263
CCAC: CcaHIS019_0409000(ARE2)
TVS: TRAVEDRAFT_148341
DSQ: DICSQDRAFT_153227
PCO: PHACADRAFT_178226
SHS: STEHIDRAFT_125940
HIR: HETIRDRAFT_387282
PSQ: PUNSTDRAFT_66632
ADL: AURDEDRAFT_61665
FME: FOMMEDRAFT_16175
GTR: GLOTRDRAFT_115574
RSX: RhiXN_05037
LBC: LACBIDRAFT_188091
CCI: CC1G_00886
ABP: AGABI1DRAFT105226(AGABI1DRAFT_105226)
ABV: AGABI2DRAFT185966(AGABI2DRAFT_185966)
PCUB: JR316_0007947
MRR: Moror_7033
MORE: E1B28_007332
SCM: SCHCO_02619284(SCHCODRAFT_02619284)
CPUT: CONPUDRAFT_59491
SLA: SERLADRAFT_350480
WSE: WALSEDRAFT_32831
UMA: UMAG_05355
PFP: PFL1_05361
SGRA: EX895_003094
MGL: MGL_2868
MRT: MRET_3462
PGR: PGTG_16235
PTRC: PtA15_2A594
PSTR: Pst134EA_019313
RIE: OCT59_029734
ACAN: ACA1_031610
TGO: TGME49_263710(ACAT1A)
BBES: BESB_000420
TET: TTHERM_00046980 TTHERM_00895740
PTM: GSPATT00019987001 GSPATT00022217001
PIF: PITG_12278
PSOJ: PHYSODRAFT_350290
 » show all
Reference
1  [PMID:42927]
  Authors
Spector AA, Mathur SN, Kaduce TL.
  Title
Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism.
  Journal
Prog Lipid Res 18:31-53 (1979)
DOI:10.1016/0163-7827(79)90003-1
Reference
2  [PMID:389289]
  Authors
Taketani S, Nishino T, Katsuki H.
  Title
Characterization of sterol-ester synthetase in Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 575:148-55 (1979)
DOI:10.1016/0005-2760(79)90140-1
Reference
3  [PMID:9717734]
  Authors
Lee O, Chang CC, Lee W, Chang TY
  Title
Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines.
  Journal
J Lipid Res 39:1722-7 (1998)
Reference
4  [PMID:9020103]
  Authors
Yang H, Cromley D, Wang H, Billheimer JT, Sturley SL
  Title
Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity.
  Journal
J Biol Chem 272:3980-5 (1997)
DOI:10.1074/jbc.272.7.3980
Reference
5  [PMID:9857049]
  Authors
Chang CC, Lee CY, Chang ET, Cruz JC, Levesque MC, Chang TY
  Title
Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner.
  Journal
J Biol Chem 273:35132-41 (1998)
DOI:10.1074/jbc.273.52.35132
Reference
6  [PMID:18480028]
  Authors
Das A, Davis MA, Rudel LL
  Title
Identification of putative active site residues of ACAT enzymes.
  Journal
J Lipid Res 49:1770-81 (2008)
DOI:10.1194/jlr.M800131-JLR200
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.26
IUBMB Enzyme Nomenclature: 2.3.1.26
ExPASy - ENZYME nomenclature database: 2.3.1.26
BRENDA, the Enzyme Database: 2.3.1.26
CAS: 9027-63-8

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