KEGG   ENZYME: 2.3.1.26Help
Entry
EC 2.3.1.26                 Enzyme                                 

Name
sterol O-acyltransferase;
cholesterol acyltransferase;
sterol-ester synthase;
sterol-ester synthetase;
sterol-ester synthase;
acyl coenzyme A-cholesterol-O-acyltransferase;
acyl-CoA:cholesterol acyltransferase;
ACAT;
acylcoenzyme A:cholesterol O-acyltransferase;
cholesterol ester synthase;
cholesterol ester synthetase;
cholesteryl ester synthetase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:cholesterol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + cholesterol = CoA + cholesterol ester [RN:R01461]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
cholesterol [CPD:C00187]
Product
CoA [CPD:C00010];
cholesterol ester [CPD:C02530]
Comment
The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group.
History
EC 2.3.1.26 created 1972
Pathway
ec00100  Steroid biosynthesis
Orthology
K00637  sterol O-acyltransferase
Genes
HSA: 6646(SOAT1) 8435(SOAT2)
PTR: 457553(SOAT1) 737291(SOAT2)
PPS: 100990991(SOAT1) 100991938(SOAT2)
GGO: 101137508(SOAT1) 101143800(SOAT2)
PON: 100436698(SOAT1) 100443060(SOAT2)
NLE: 100590480(SOAT1) 100591122(SOAT2)
MCC: 701171(SOAT2) 716989(SOAT1)
MCF: 102121286(SOAT1) 102135925(SOAT2)
CSAB: 103230515(SOAT1) 103238380(SOAT2)
RRO: 104670609(SOAT2) 104672006(SOAT1)
RBB: 108521617(SOAT2) 108539887(SOAT1)
CJC: 100387443(SOAT1) 100412165(SOAT2)
SBQ: 101047229(SOAT1) 101052421(SOAT2)
MMU: 20652(Soat1) 223920(Soat2)
RNO: 266770(Soat2) 81782(Soat1)
CGE: 100689317(Soat1) 100752385(Soat2)
NGI: 103728004(Soat1) 103738463(Soat2)
HGL: 101718579(Soat2) 101725301(Soat1)
CCAN: 109684043(Soat2) 109693443(Soat1)
OCU: 100009537(SOAT1) 100349393(SOAT2)
TUP: 102485090(SOAT1) 102501974(SOAT2)
CFA: 486511(SOAT2) 490325(SOAT1)
AML: 100464310(SOAT1) 100466845(SOAT2)
UMR: 103668575(SOAT1) 103675666(SOAT2)
ORO: 101372404(SOAT2) 101377194(SOAT1)
FCA: 101081271(SOAT1) 101099223(SOAT2)
PTG: 102951570(SOAT2) 102951637(SOAT1)
AJU: 106977936(SOAT1) 106986455(SOAT2)
BTA: 504287(SOAT1) 513554(SOAT2)
BOM: 102266586(SOAT1) 102286882(SOAT2)
BIU: 109559050(SOAT2) 109570627(SOAT1)
PHD: 102325324(SOAT1) 102341784(SOAT2)
CHX: 102181472(SOAT2) 102186791(SOAT1)
OAS: 101107179(SOAT2) 101121363(SOAT1)
SSC: 100515544(SOAT2) 100628166(SOAT1)
CFR: 102509905(SOAT2) 102517625(SOAT1)
CDK: 105094576(SOAT2) 105099977(SOAT1)
BACU: 103005265(SOAT2) 103019063(SOAT1)
LVE: 103074467(SOAT1) 103078608(SOAT2)
OOR: 101283408(SOAT1) 101288997(SOAT2)
ECB: 100050551(SOAT1) 100146367(SOAT2)
EPZ: 103559415(SOAT2) 103566918(SOAT1)
EAI: 106833928(SOAT1) 106835276(SOAT2)
MYB: 102251864(SOAT1) 102258914(SOAT2)
MYD: 102752811(SOAT2) 102760492(SOAT1)
HAI: 109384905(SOAT1) 109391779(SOAT2)
RSS: 109443691(SOAT2) 109447265(SOAT1)
PALE: 102897908(SOAT1) 102897972(SOAT2)
LAV: 100666457(SOAT1) 100670395(SOAT2)
MDO: 100022219(SOAT1)
SHR: 100920315(SOAT1) 100933677(SOAT2)
OAA: 100081816 100085367(SOAT1)
GGA: 424424(SOAT1)
MGP: 100544187(SOAT1)
CJO: 107317265(SOAT1)
APLA: 101790922(SOAT1)
ACYG: 106042512(SOAT1)
TGU: 100223763(SOAT1)
GFR: 102041188(SOAT1)
FAB: 101815412(SOAT1)
PHI: 102102644(SOAT1)
PMAJ: 107208206(SOAT1)
CCW: 104693579(SOAT1)
FPG: 101919752(SOAT1)
FCH: 102060236(SOAT1)
CLV: 102098103(SOAT1)
EGZ: 104132041(SOAT1)
AAM: 106484966(SOAT1)
ASN: 102373020(SOAT1) 102378548 102379056(SOAT2)
AMJ: 102568578(SOAT1) 102573699
PSS: 102448344(SOAT1) 102450944(SOAT2)
CMY: 102934330(SOAT2) 102943858(SOAT1)
CPIC: 101940194(SOAT2) 101944538(SOAT1)
PVT: 110077048(SOAT1)
PBI: 103048435(SOAT2) 103064093(SOAT1)
GJA: 107107994 107122901(SOAT1)
XLA: 108708653 108714368(soat1.L) 446863(soat1.S) 779411(soat2.S)
XTR: 100145286(soat1) 100216296(soat2) 101730739
NPR: 108786819(SOAT2) 108800649(SOAT1)
DRE: 564424(soat1)
IPU: 108265920(soat1) 108272126
TRU: 101072139(soat2) 101077060 105417935(soat1)
LCO: 104919967(soat2) 104929343(soat1) 109138516
NCC: 104966663
MZE: 101475426 101487179(soat1)
OLA: 101162519 101164716(soat1)
XMA: 102229353(soat1) 102229837
PRET: 103464078(soat1) 103464407
NFU: 107385327 107393145(soat1)
LCF: 108881364(soat1) 108884835
HCQ: 109510620 109532427(soat1)
BPEC: 110154556 110160201(soat1)
SASA: 106566146 106613907(soat1)
ELS: 105007362 105026366(soat1)
SFM: 108919079(soat1) 108928332
LCM: 102351870(SOAT1) 102367356(SOAT2)
CMK: 103179969(soat1) 103189932(soat2)
SPU: 583194
APLC: 110974464
DSI: Dsimw501_GD18564(Dsim_GD18564)
AAG: 5572188
AME: 552313
BIM: 100740568
BTER: 100647632
PBAR: 105426039
HST: 105189309
PGC: 109860842
NVI: 100122384
DPA: 109542077
NVL: 108562027
BMOR: 101740142
PMAC: 106710838
PRAP: 110996350
PXY: 105387244
ZNE: 110828545
FCD: 110846328
TUT: 107364500
CEL: CELE_B0395.2(mboa-1)
CBR: CBG16409
TSP: Tsp_07565
CRG: 105344142
MYI: 110446400
OBI: 106877085
SHX: MS3_07855
EPA: 110232256
ADF: 107331943
SCE: YCR048W(ARE1) YNR019W(ARE2)
ERC: Ecym_2101
KMX: KLMA_30485(ARE2)
NCS: NCAS_0A04580(NCAS0A04580) NCAS_0D04420(NCAS0D04420)
NDI: NDAI_0I00520(NDAI0I00520) NDAI_0K01630(NDAI0K01630)
TPF: TPHA_0H02220(TPHA0H02220)
TBL: TBLA_0F04000(TBLA0F04000) TBLA_0I02260(TBLA0I02260)
TDL: TDEL_0A07320(TDEL0A07320)
KAF: KAFR_0F00800(KAFR0F00800) KAFR_0J02490(KAFR0J02490)
PIC: PICST_33115(ARE2)
CAL: CAALFM_C206940CA(ARE2)
CAUR: QG37_08236
SLB: AWJ20_1276(ARE2)
NTE: NEUTE1DRAFT127291(NEUTE1DRAFT_127291) NEUTE1DRAFT87893(NEUTE1DRAFT_87893)
MGR: MGG_06765
CMT: CCM_07840
ANI: AN4208.2
ANG: ANI_1_628164(An18g04660)
ABE: ARB_05568
TVE: TRV_06840
SPO: SPAC13G7.05(are1) SPCP1E11.05c(are2)
CNE: CNF01130
CNB: CNBF3580
ABP: AGABI1DRAFT105226(AGABI1DRAFT_105226)
ABV: AGABI2DRAFT185966(AGABI2DRAFT_185966)
MGL: MGL_2868
DFA: DFA_06257
 » show all
Taxonomy
Reference
1  [PMID:5439042]
  Authors
Sgoutas DS.
  Title
Effect of geometry and position of ethylenic bond upon acyl coenzyme A--cholesterol-O-acyltransferase.
  Journal
Biochemistry 9:1826-33 (1970)
Reference
2  [PMID:42927]
  Authors
Spector AA, Mathur SN, Kaduce TL.
  Title
Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism.
  Journal
Prog Lipid Res 18:31-53 (1979)
DOI:10.1016/0163-7827(79)90003-1
Reference
3  [PMID:389289]
  Authors
Taketani S, Nishino T, Katsuki H.
  Title
Characterization of sterol-ester synthetase in Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 575:148-55 (1979)
DOI:10.1016/0005-2760(79)90140-1
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.26
IUBMB Enzyme Nomenclature: 2.3.1.26
ExPASy - ENZYME nomenclature database: 2.3.1.26
BRENDA, the Enzyme Database: 2.3.1.26
CAS: 9027-63-8

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