KEGG   ENZYME: 2.3.1.263Help
Entry
EC 2.3.1.263                Enzyme                                 

Name
2-amino-4-oxopentanoate thiolase;
AKPT;
AKP thiolase;
2-amino-4-ketopentanoate thiolase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:D-alanine acetyltransferase
Reaction(IUBMB)
acetyl-CoA + D-alanine = CoA + (2R)-2-amino-4-oxopentanoate [RN:R00399]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
D-alanine [CPD:C00133]
Product
CoA [CPD:C00010];
(2R)-2-amino-4-oxopentanoate [CPD:C03341]
Comment
A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the bacterium Clostridium sticklandii, is part of a degradation pathway of ornithine. It is specific for acetyl-CoA and D-alanine.
History
EC 2.3.1.263 created 2017
Orthology
K21399  2-amino-4-ketopentanoate thiolase alpha subunit
K21400  2-amino-4-ketopentanoate thiolase beta subunit
Genes
CEH: CEW89_15605 CEW89_15610
BACI: B1NLA3E_09765 B1NLA3E_09770
OCN: CUC15_16345 CUC15_16350
EAV: EH197_05055 EH197_05060
CSQ: CSCA_0121 CSCA_0122
CACE: CACET_c17490 CACET_c17500
CEU: A7L45_16585 A7L45_16590
CFM: BJL90_14520 BJL90_14525
CARG: RSJ17_08680 RSJ17_08685
CDRK: B9W14_17930 B9W14_17935
CDF: CD630_04430(ortA) CD630_04440(ortB)
PDC: CDIF630_00571(ortA) CDIF630_00572(ortB)
CST: CLOST_1292(ortB) CLOST_1293(ortA)
TTE: TTE1235 TTE1236(ThrC)
MBJ: KQ51_00245(trpB_1) KQ51_00246
 » show all
Taxonomy
Reference
1  [PMID:4407783]
  Authors
Jeng IM, Somack R, Barker HA
  Title
Ornithine degradation in Clostridium sticklandii; pyridoxal phosphate and coenzyme A dependent thiolytic cleavage of 2-amino-4-ketopentanoate to alanine and acetyl coenzyme A.
  Journal
Biochemistry 13:2898-903 (1974)
DOI:10.1021/bi00711a019
Reference
2  [PMID:19251850]
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M.
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.263
IUBMB Enzyme Nomenclature: 2.3.1.263
ExPASy - ENZYME nomenclature database: 2.3.1.263
BRENDA, the Enzyme Database: 2.3.1.263

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