KEGG   ENZYME: 2.3.1.265Help
Entry
EC 2.3.1.265                Enzyme                                 

Name
phosphatidylinositol dimannoside acyltransferase;
PIM2 acyltransferase;
ptfP1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol acyltransferase
Reaction(IUBMB)
(1) an acyl-CoA + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [RN:R11781 R12042];
(2) an acyl-CoA + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol [RN:R11782 R12039]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [CPD:C21607];
2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol
Product
CoA [CPD:C00010];
2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [CPD:C21608];
2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol [CPD:C21609]
Comment
The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs).
History
EC 2.3.1.265 created 2017
Pathway
ec00571  Lipoarabinomannan (LAM) biosynthesis
ec01100  Metabolic pathways
Orthology
K22311  phosphatidylinositol dimannoside acyltransferase
Genes
BUJ: BurJV3_2147
DGG: DGI_0096
MAMO: A6B35_08050
MAQU: Maq22A_c19640
MEE: DA075_05465
PMS: KNP414_02928
PMQ: PM3016_3168
PMW: B2K_16020
MTU: Rv2611c
MTV: RVBD_2611c
MTC: MT2686
MRA: MRA_2639
MTUR: CFBS_2763
MTD: UDA_2611c
MTUC: J113_18225
MTUH: I917_18425
MTUL: TBHG_02549
MTUT: HKBT1_2754
MTUU: HKBT2_2757
MBB: BCG_2636c
MBT: JTY_2630
MBX: BCGT_2457
MAF: MAF_26290
MMIC: RN08_2892
MLE: ML0453
MLB: MLBr00453
MPA: MAP_2713c
MAO: MAP4_1103
MAVI: RC58_05480
MAVU: RE97_05475
MAV: MAV_3487
MIT: OCO_33250
MIA: OCU_33150
MID: MIP_05002
MYO: OEM_33380
MIR: OCQ_34390
MLP: MLM_1610
MUL: MUL_3253
MMC: Mmcs_2245
MKM: Mkms_2292
MJL: Mjls_2284
MMI: MMAR_2091
MMM: W7S_16650
MHAD: B586_14005
MSHG: MSG_01936
MVA: Mvan_2561
MGI: Mflv_3835
MVQ: MYVA_2454
MHAS: MHAS_02273
MAB: MAB_2895c
MABB: MASS_2836
MCHE: BB28_14490
MSTE: MSTE_02858
ASD: AS9A_1807
CGL: NCgl1604(Cgl1668)
CGB: cg1877
CGU: WA5_1604
CGT: cgR_1713
CGM: cgp_1877
CGJ: AR0_08835
CEF: CE1782
CDI: DIP1385
CJK: jk1063
CUR: cu0928
COP: Cp31_1195
CPSE: CPTA_01759
CPSU: CPTB_02004
CPSF: CPTC_01750
CRD: CRES_1145
CVA: CVAR_1556
CTER: A606_06175
COA: DR71_2130
CSP: WM42_2556
CPHO: CPHO_05405
CAQU: CAQU_07120
CAMG: CAMM_06230
NSR: NS506_03887(lpxL)
RER: RER_29060
REY: O5Y_13245
ROP: ROP_68600
RHB: NY08_1182
GBR: Gbro_2290
GOR: KTR9_2207
TPR: Tpau_1922
SRT: Srot_1805
SCO: SCO1526(SCL2.16c)
SALB: XNR_5327
SMA: SAVERM_6827(plsC5)
SGR: SGR_6009
SGB: WQO_05355
SCT: SCAT_5297
SFA: Sfla_5338
SBH: SBI_02404
SHY: SHJG_2950
SVE: SVEN_1126
SALS: SLNWT_6408
STRP: F750_1284
SFI: SFUL_1037
SALU: DC74_1982
SALL: SAZ_10495
STRE: GZL_07169
SLD: T261_6731
STRM: M444_07970
SPRI: SPRI_6037
SLE: sle_55850(sle_55850)
STRD: NI25_31585
SMAL: SMALA_6492
SLAU: SLA_1023
SALF: SMD44_01566(htrB)
SALJ: SMD11_5508(htrB)
SFK: KY5_1310c
KSK: KSE_14520
BCV: Bcav_1982
JDE: Jden_1375
LMOI: VV02_15085
XCE: Xcel_1659
IDO: I598_0527
CFL: Cfla_1786
CFI: Celf_2039
PFRE: RM25_0950
MPH: MLP_23760
KFL: Kfla_3367
TFU: Tfu_2102
NDA: Ndas_0820
NAL: B005_3736
TCU: Tcur_2101
SRO: Sros_6125
FAL: FRAAL2133
ACE: Acel_1354
NML: Namu_3419
GOB: Gobs_3185
MMAR: MODMU_3365
KRA: Krad_3063
AMD: AMED_5323(htrB)
AMN: RAM_27115
AMM: AMES_5260(htrB)
AMZ: B737_5260(htrB)
AOI: AORI_4445(htrB)
AMQ: AMETH_2862(htrB)
PDX: Psed_3610
PSEH: XF36_11810
AMI: Amir_2093
SESP: BN6_30320
KAL: KALB_2450
ACTI: UA75_10855
ACAD: UA74_10770
ALO: CRK58134
SAQ: Sare_1774
MIL: ML5_2368
ASE: ACPL_6546
ACTN: L083_6075
AFS: AFR_31110
ACTS: ACWT_6415
CAI: Caci_2344
SNA: Snas_2406
AHE: Arch_0815
TPYO: X956_06000
BLA: BLA_1346
BBB: BIF_00294
BBC: BLC1_0789
BLV: BalV_0796
BLW: W7Y_0827
BLS: W91_0847
BANI: Bl12_0772
BANL: BLAC_04225
BANM: EN10_04180
BDE: BDP_1180
BDN: BBDE_1126
BAST: BAST_0797
BTP: D805_1058
BCOR: BCOR_0683
BPSP: AH67_04450
SIJ: SCIP_0671
PDO: PSDT_0810
TBI: Tbis_2073
AFO: Afer_1224
DFO: Dform_00687(lpxL|htrB) Dform_01755(lpxL|htrB)
STI: Sthe_1718
PBOR: BSF38_01250(lpxL_2)
 » show all
Taxonomy
Reference
1  [PMID:24810911]
  Authors
Svetlikova Z, Barath P, Jackson M, Kordulakova J, Mikusova K
  Title
Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid--monoacylated phosphatidylinositol dimannoside.
  Journal
Protein Expr Purif 100:33-9 (2014)
DOI:10.1016/j.pep.2014.04.014
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.265
IUBMB Enzyme Nomenclature: 2.3.1.265
ExPASy - ENZYME nomenclature database: 2.3.1.265
BRENDA, the Enzyme Database: 2.3.1.265

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