KEGG   ENZYME: 2.3.1.268Help
Entry
EC 2.3.1.268                Enzyme                                 

Name
ethanol O-acetyltransferase;
eat1 (gene name);
ethanol acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:ethanol O-acetyltransferase
Reaction(IUBMB)
ethanol + acetyl-CoA = ethyl acetate + CoA [RN:R11957]
Reaction(KEGG)
Substrate
ethanol [CPD:C00469];
acetyl-CoA [CPD:C00024]
Product
ethyl acetate [CPD:C00849];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the yeast Wickerhamomyces anomalus, is responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts. It is only distantly related to enzymes classified as EC 2.3.1.84, alcohol O-acetyltransferase. The enzyme also possesses thioesterase and esterase activities, which are inhibited by high ethanol concentrations.
History
EC 2.3.1.268 created 2018
Orthology
K22586  ethanol O-acetyltransferase
Reference
1  [PMID:28356220]
  Authors
Kruis AJ, Levisson M, Mars AE, van der Ploeg M, Garces Daza F, Ellena V, Kengen SWM, van der Oost J, Weusthuis RA
  Title
Ethyl acetate production by the elusive alcohol acetyltransferase from yeast.
  Journal
Metab Eng 41:92-101 (2017)
DOI:10.1016/j.ymben.2017.03.004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.268
IUBMB Enzyme Nomenclature: 2.3.1.268
ExPASy - ENZYME nomenclature database: 2.3.1.268
BRENDA, the Enzyme Database: 2.3.1.268

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