KEGG   ENZYME: 2.3.1.277
Entry
EC 2.3.1.277                Enzyme                                 

Name
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase;
afsA (gene name);
scbA (gene name);
barX (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
3-oxoacyl-[acyl-carrier protein]:glycerone phosphate 3-oxonacylltransferase
Reaction(IUBMB)
a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate = 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein] [RN:R12289]
Reaction(KEGG)
R12289
Substrate
medium-chain 3-oxoacyl-[acyl-carrier protein] [CPD:C22064];
glycerone phosphate [CPD:C00111]
Product
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate [CPD:C22065];
holo-[acyl-carrier protein] [CPD:C00229]
Comment
The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
History
EC 2.3.1.277 created 2018
Orthology
K22463  2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase
Genes
YRE: HEC60_12875
AMAH: DLM_1345
PBH: AAW51_3063
MPAG: C0J29_24015
MAIC: MAIC_49490
CSX: CSING_09340
NCY: NOCYR_1429
NBR: O3I_009095 O3I_022440 O3I_026160
NNO: NONO_c59160
NSR: NS506_05283
RER: RER_54010
REY: O5Y_25660
ROP: ROP_45600
REQ: REQ_44790
RHB: NY08_569
SCO: SCO6266(SCAH10.31) SCP1.243(mmfL)
SMA: SAVERM_2269(avaA)
SGR: SGR_6889(afsA)
SGB: WQO_00740
SBH: SBI_08929
STRP: F750_0224(afsA) F750_3441(afsA)
SFI: SFUL_271
SLV: SLIV_06815(afsA)
SRW: TUE45_05044 TUE45_pSRc_0609(TUE45_pSRTUE45c_0609)
SLE: sle_45960(sle_45960)
STRD: NI25_18850
SLAU: SLA_3053
SFK: KY5_6104c
SRJ: SRO_3382
KSK: KSE_01060t(ksbS2L) KSE_08560 KSE_22970(ksbS3) KSE_44600(ksbS4) KSE_58120 KSE_75680t(ksbS2R)
AAU: AAur_3376
NDA: Ndas_3370
AMYY: YIM_46150
KAL: KALB_5811
SAQ: Sare_3017
ACTN: L083_0231
 » show all
Reference
1  [PMID:2492509]
  Authors
Horinouchi S, Suzuki H, Nishiyama M, Beppu T
  Title
Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis.
  Journal
J Bacteriol 171:1206-10 (1989)
DOI:10.1128/JB.171.2.1206-1210.1989
  Sequence
[sgr:SGR_6889]
Reference
2  [PMID:17277085]
  Authors
Kato JY, Funa N, Watanabe H, Ohnishi Y, Horinouchi S
  Title
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
  Journal
Proc Natl Acad Sci U S A 104:2378-83 (2007)
DOI:10.1073/pnas.0607472104
Reference
3  [PMID:17464053]
  Authors
Hsiao NH, Soding J, Linke D, Lange C, Hertweck C, Wohlleben W, Takano E
  Title
ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and  is able to synthesize gamma-butyrolactones.
  Journal
Microbiology 153:1394-404 (2007)
DOI:10.1099/mic.0.2006/004432-0
  Sequence
[sco:SCO6266]
Reference
4  [PMID:19778967]
  Authors
Lee YJ, Kitani S, Nihira T
  Title
Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the {gamma}-butyrolactone autoregulator in Streptomyces virginiae.
  Journal
Microbiology 156:206-10 (2010)
DOI:10.1099/mic.0.032003-0
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.277
IUBMB Enzyme Nomenclature: 2.3.1.277
ExPASy - ENZYME nomenclature database: 2.3.1.277
BRENDA, the Enzyme Database: 2.3.1.277

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