KEGG   ENZYME: 2.3.1.277
Entry
EC 2.3.1.277                Enzyme                                 
Name
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase;
afsA (gene name);
scbA (gene name);
barX (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
3-oxoacyl-[acyl-carrier protein]:glycerone phosphate 3-oxonacylltransferase
Reaction(IUBMB)
a medium-chain 3-oxoacyl-[acyl-carrier protein] + glycerone phosphate = 2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate + a holo-[acyl-carrier protein] [RN:R12289]
Reaction(KEGG)
R12289
Substrate
medium-chain 3-oxoacyl-[acyl-carrier protein] [CPD:C22064];
glycerone phosphate [CPD:C00111]
Product
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate [CPD:C22065];
holo-[acyl-carrier protein] [CPD:C00229]
Comment
The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
History
EC 2.3.1.277 created 2018
Orthology
K22463  2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase
Genes
YREHEC60_12875
AMAHDLM_1345
PBHAAW51_3063
MPAGC0J29_24015
MPAEK0O64_03280
MCROMI149_03875
MAICMAIC_49490
CSXCSING_09340
NCYNOCYR_1429
NBRO3I_009095 O3I_022440 O3I_026160
NNONONO_c59160
NSRNS506_05283
NTPCRH09_04845 CRH09_10155 CRH09_19790
NOZDMB37_02530 DMB37_29865
NODFOH10_10135
NAHF5544_11680
NWLNWFMUON74_54410
NIEKV110_09630 KV110_16520 KV110_22410
NHUH0264_14695
NYALTV02_03870 LTV02_18435
RHARHA1_ro04614
RERRER_54010
REYO5Y_25660
REBXU06_26000
RQIC1M55_27235
ROPROP_45600
ROAPd630_LPD01099 Pd630_LPD06644
REQREQ_44790
RHBNY08_569
RAVAAT18_22295
RFAA3L23_03815 A3L23_04925
RHSA3Q41_04426
RRZCS378_12125
RHQIM25_24585
RHODAOT96_07205
RRT4535765_02640
RTMG4H71_11170
RKOJWS14_25400
GPOGPOL_c20770 GPOL_c49040
SCOSCO6266(SCAH10.31) SCP1.243(mmfL)
SMASAVERM_2269(avaA)
SGRSGR_6889(afsA)
SGBWQO_00740
SCBSCAB_12081 SCAB_63031 SCAB_63111
SSXSACTE_3173 SACTE_6321
SVLStrvi_3600
SHYSHJG_4004 SHJG_7319 SHJG_8650
SHOSHJGH_3769 SHJGH_7079 SHJGH_8410
SRCM271_03790 M271_07485
SMALSMALA_6930 SMALA_7619
SSOII1A49_38425 I1A49_41870
SCTSCAT_0001 SCAT_2185(afsA) SCAT_5778 SCAT_p0948
SCYSCATT_21660 SCATT_57810 SCATT_p07910
SFASfla_3302 Sfla_6323
SBHSBI_08929
SVESVEN_4183 SVEN_5969
SDVBN159_2279 BN159_4440
SALSSLNWT_0249 SLNWT_2752 SLNWT_4679
STRPF750_0224(afsA) F750_3441(afsA)
SFISFUL_271
SALUDC74_5978 DC74_7047 DC74_7321 DC74_7607
SALLSAZ_30970 SAZ_36560 SAZ_37915 SAZ_39250
SLVSLIV_06815(afsA)
SGUSGLAU_25495
SVTSVTN_03085 SVTN_03460 SVTN_29875
STREGZL_00107 GZL_01281 GZL_01594 GZL_09306
SCWTU94_11455
SLDT261_0487 T261_2144
SLCSL103_20520 SL103_26350
SXISXIM_17800
STRMM444_36350 M444_36565 M444_38055
SAMBSAM23877_0232
SCZABE83_19750 ABE83_34265
SCXAS200_21945 AS200_24410 AS200_44220
SRWTUE45_05044 TUE45_pSRc_0609(TUE45_pSRTUE45c_0609)
SLEsle_45960(sle_45960)
SRNA4G23_05421
SPAVSpa2297_32650
STRTA8713_01240
SCLFBB341_16850 BB341_25515
SGSAVL59_00695
STSIA4E84_21260
SALWCP975_23005
SCADDN051_10570
SLSSLINC_5092 SLINC_6540
SNRSNOUR_05455 SNOUR_06740
SPLULK06_017405
STRDNI25_18850
SNWBBN63_07420 BBN63_21870 BBN63_24955
SAUOBV401_38280
SSIAA7J05_00415 A7J05_00570 A7J05_13280 A7J05_36165 A7J05_36320
SVUB1H20_00410 B1H20_15505
SPUNBFF78_11405
SGVB1H19_37530
SLAUSLA_3053
SALFSMD44_04059 SMD44_04421
SALJSMD11_3339 SMD11_6032
SLXSLAV_20865 SLAV_40300
STROSTRMOE7_29285 STRMOE7_35135
SFKKY5_6104c
SNZDC008_13210 DC008_27305
SGEDWG14_02015
SRJSRO_3382
SDXC4B68_08540 C4B68_08560
SGDELQ87_36110
SCYAEJ357_14630 EJ357_16305 EJ357_35240 EJ357_36165
SASTCD934_15305
SNQCP978_34585
STIRDDW44_16615 DDW44_31525
SKACP970_10415
SGZC0216_31320 C0216_31805
SNKCP967_04275 CP967_15135 CP967_17825 CP967_30545 CP967_30560 CP967_31560
SHAWCEB94_20765
SRKFGW37_31685
SFICEIZ62_19125 EIZ62_31530
SGALCP966_28410
SSPODDQ41_04315 DDQ41_08110 DDQ41_31065
SVRCP971_19130 CP971_26335
SPADDVK44_28100 DVK44_34195
SFYGFH48_20475 GFH48_38925
SAQUEJC51_22105 EJC51_25725 EJC51_43860
SGFHEP81_03594 HEP81_07959
SCAVCVT27_00255 CVT27_14835
SSEOD0Z67_22095
SBYH7H31_04615
SRIMCP984_08935 CP984_23685 CP984_38960
SSUBCP968_00750 CP968_02880 CP968_15830 CP968_33915
SPHVF9278_17975
SCINCP977_27350 CP977_28615
SPACB1H29_00920 B1H29_36145
STSUB7R87_00235 B7R87_00255
SCHACP983_09845 CP983_27850
SGXH4W23_30995
SCOECP976_22215 CP976_30025 CP976_32365
SBATG4Z16_00070
SNFJYK04_00153 JYK04_01859
SPLACP981_29465 CP981_30955 CP981_35585
STUIGCM10017668_35390(mmfL) GCM10017668_35620
SATAC5746_12505
SCHFIPT68_15530 IPT68_28530 IPT68_29305
SHUNDWB77_00550 DWB77_04718
SHARHUT13_05645
SCYGS1361_31310
SFEUIM697_07635 IM697_32675
SLIAHA039_01285 HA039_05325 HA039_14005 HA039_29945
SDWK7C20_10825 K7C20_28250 K7C20_34355
SCALI6J39_00530 I6J39_15520
SAUHSU9_026870 SU9_030680 SU9_031850 SU9_032980
SFBCP974_28860
SROIIAG44_08745 IAG44_35000
SXNIAG42_22440
SGJIAG43_25740 IAG43_33485
SHKJ2N69_15050 J2N69_24035
SANUK7396_00440 K7396_02020 K7396_07590 K7396_08770
STRYEQG64_15560
SDDD9753_06795 D9753_09135
SACTDMT42_11890 DMT42_14060 DMT42_19780 DMT42_29840
SMAOCAG99_00900
SINEKI385_40060
SDECL3078_43220
KSKKSE_01060t(ksbS2L) KSE_08560 KSE_22970(ksbS3) KSE_44600(ksbS4) KSE_58120 KSE_75680t(ksbS2R)
KABB7C62_00290
KAUB6264_02795 B6264_13770 B6264_20890
KITCFP65_3606 CFP65_4017
STRIC7M71_001450 C7M71_007220
RIAC7V51_14130
ASOIMTP13_02140
AGXAGREI_0437
ARRARUE_c35120
AAUAAur_3376
RDNHMPREF0733_10613
BCAUI6G59_16805
NDANdas_3370
NGVCDO52_02955
NEXNE857_20455
NGNLCN96_20855
FRAFrancci3_2120
BSDBLASA_0744
SACGFDZ84_25550
AMYCCU254_30050
AABA4R43_32240
AMYYYIM_46150
SSYIEKG83_10415
KALKALB_5811
AHMTL08_24095
STPStrop_4151
SAQSare_3017
MSAGGCM10017556_32740
ACTNL083_0231
PRYPrubr_43810
AEYCDG81_10645 CDG81_11415
 » show all
Reference
1  [PMID:2492509]
  Authors
Horinouchi S, Suzuki H, Nishiyama M, Beppu T
  Title
Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis.
  Journal
J Bacteriol 171:1206-10 (1989)
DOI:10.1128/JB.171.2.1206-1210.1989
  Sequence
[sgr:SGR_6889]
Reference
2  [PMID:17277085]
  Authors
Kato JY, Funa N, Watanabe H, Ohnishi Y, Horinouchi S
  Title
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
  Journal
Proc Natl Acad Sci U S A 104:2378-83 (2007)
DOI:10.1073/pnas.0607472104
Reference
3  [PMID:17464053]
  Authors
Hsiao NH, Soding J, Linke D, Lange C, Hertweck C, Wohlleben W, Takano E
  Title
ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and  is able to synthesize gamma-butyrolactones.
  Journal
Microbiology 153:1394-404 (2007)
DOI:10.1099/mic.0.2006/004432-0
  Sequence
[sco:SCO6266]
Reference
4  [PMID:19778967]
  Authors
Lee YJ, Kitani S, Nihira T
  Title
Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the {gamma}-butyrolactone autoregulator in Streptomyces virginiae.
  Journal
Microbiology 156:206-10 (2010)
DOI:10.1099/mic.0.032003-0
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.277
IUBMB Enzyme Nomenclature: 2.3.1.277
ExPASy - ENZYME nomenclature database: 2.3.1.277
BRENDA, the Enzyme Database: 2.3.1.277

DBGET integrated database retrieval system