KEGG   ENZYME: 2.3.1.278Help
Entry
EC 2.3.1.278                Enzyme                                 

Name
mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase;
papA3 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
mycolipenoyl-CoA:2-(long-chain-fatty acyl)-trehalose 3-mycolipenoyltransferase
Reaction(IUBMB)
a mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose = a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA [RN:R12288]
Reaction(KEGG)
Substrate
mycolipenoyl-CoA [CPD:C22062];
2-(long-chain-fatty acyl)-trehalose [CPD:C22061]
Product
2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose [CPD:C22063];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA---trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3.
History
EC 2.3.1.278 created 2018
Orthology
K23156  mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase / long-chain-acyl-CoA---trehalose acyltransferase
Genes
BSYM: CIT39_22775
MTU: Rv1182(papA3)
MTV: RVBD_1182
MTC: MT1219
MRA: MRA_1192(papA3)
MTF: TBFG_11206
MTB: TBMG_02800
MTK: TBSG_02814
MTZ: TBXG_002780
MTG: MRGA327_07450
MTUR: CFBS_1260(papA3)
MTO: MTCTRI2_1213(papA3)
MTD: UDA_1182(papA3)
MTN: ERDMAN_1324(papA3)
MTUC: J113_08295
MTUE: J114_06385
MTUH: I917_08405
MTUL: TBHG_01165
MTUT: HKBT1_1258(papA3)
MTUU: HKBT2_1264(papA3)
MTQ: HKBS1_1262(papA3)
MBO: BQ2027_MB1214(papA3)
MBB: BCG_1244(papA3)
MBT: JTY_1217(papA3)
MBM: BCGMEX_1216(papA3)
MBX: BCGT_1013
MAF: MAF_12010(papA3)
MMIC: RN08_1326
MCE: MCAN_11931(papA3)
MCQ: BN44_11321(papA)
MCV: BN43_30249(papA)
MCX: BN42_21047(papA)
MCZ: BN45_30244(papA)
MLE: ML1230(papA3)
MLB: MLBr01230(papA3)
MPA: MAP_2231(papA3) MAP_3721 MAP_3763c(papA3)
MLP: MLM_2749
MUL: MUL_1531(papA3)
MMI: MMAR_2343 MMAR_2355(papA3)
MLI: MULP_03269(papA3)
MSHG: MSG_03264 MSG_03826(papA3)
MSG: MSMEI_0399(papA3) MSMEI_4611
MVA: Mvan_0270
MGI: Mflv_0404
MPHL: MPHLCCUG_00973(papA3_1) MPHLCCUG_04852(papA3_2)
MVQ: MYVA_0272
MTHN: 4412656_01985(papA1)
MSAL: DSM43276_00716(papA2) DSM43276_00773(papA3_1) DSM43276_02932(papA3_2)
 » show all
Taxonomy
Reference
1  [PMID:19276083]
  Authors
Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, Bertozzi CR
  Title
PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.
  Journal
J Biol Chem 284:12745-51 (2009)
DOI:10.1074/jbc.M809088200
  Sequence
[mtu:Rv1182]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.278
IUBMB Enzyme Nomenclature: 2.3.1.278
ExPASy - ENZYME nomenclature database: 2.3.1.278
BRENDA, the Enzyme Database: 2.3.1.278

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