KEGG   ENZYME: 2.3.1.283
Entry
EC 2.3.1.283                Enzyme                                 
Name
2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase;
papA1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase]:2'-acyl-2-O-sulfo-alpha,alpha-trehalose 3'-(hydroxy)phthioceranyltransferase
Reaction(IUBMB)
a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose = a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-[(hydroxy)phthioceranic acid synthase]
Substrate
(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase];
2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose [CPD:C22096]
Product
3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose;
holo-[(hydroxy)phthioceranic acid synthase]
Comment
This mycobacterial enzyme catalyses the acylation of 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose at the 3' position by a (hydroxy)phthioceranoyl group during the biosynthesis of mycobacterial sulfolipids.
History
EC 2.3.1.283 created 2019
Orthology
K23415  2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
Genes
MTURv3824c(papA1)
MTVRVBD_3824c
MTCMT3932
MRAMRA_3864(papA1)
MTFTBFG_13858
MTBTBMG_03871
MTKTBSG_03894
MTZTBXG_003841
MTIMRGA423_24125
MTECCDC5079_3554
MTURCFBS_4054(papA1)
MTLCCDC5180_3503
MTOMTCTRI2_3903(papA1)
MTDUDA_3824c(papA1)
MTNERDMAN_4191(papA1)
MTJJ112_20560
MTUBMT7199_3893
MTUCJ113_26760
MTUEJ114_20435
MTXM943_19635
MTUHI917_26890
MTULTBHG_03762
MTUTHKBT1_4037(papA1)
MTUUHKBT2_4047(papA1)
MTQHKBS1_4050(papA1)
MBOBQ2027_MB3854C(papA1)
MBBBCG_3887c(papA1)
MBTJTY_3889(papA1)
MBMBCGMEX_3888c(papA1)
MBKK60_039680
MBXBCGT_3689
MAFMAF_38390(papA1)
MMICRN08_4222
MCEMCAN_38431(papA1)
MCQBN44_120234(papA)
MCVBN43_90341(papA)
MCXBN42_90352(papA)
MCZBN45_110186(papA)
MSEOMSEO_38250(papA1)
MMAMK3U93_10360
MSPGF6B93_09715 F6B93_09720
MPAAMKK62_13550
 » show all
Reference
1  [PMID:17259623]
  Authors
Bhatt K, Gurcha SS, Bhatt A, Besra GS, Jacobs WR Jr
  Title
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
  Journal
Microbiology 153:513-20 (2007)
DOI:10.1099/mic.0.2006/003103-0
  Sequence
[mtu:Rv3824c]
Reference
2  [PMID:17592143]
  Authors
Kumar P, Schelle MW, Jain M, Lin FL, Petzold CJ, Leavell MD, Leary JA, Cox JS, Bertozzi CR
  Title
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
  Journal
Proc Natl Acad Sci U S A 104:11221-6 (2007)
DOI:10.1073/pnas.0611649104
  Sequence
[mtu:Rv3824c]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.283
IUBMB Enzyme Nomenclature: 2.3.1.283
ExPASy - ENZYME nomenclature database: 2.3.1.283
BRENDA, the Enzyme Database: 2.3.1.283

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