KEGG   ENZYME: 2.3.1.283
Entry
EC 2.3.1.283                Enzyme                                 
Name
2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase;
papA1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase]:2'-acyl-2-O-sulfo-alpha,alpha-trehalose 3'-(hydroxy)phthioceranyltransferase
Reaction(IUBMB)
a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose = a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-[(hydroxy)phthioceranic acid synthase]
Substrate
(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase];
2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose [CPD:C22096]
Product
3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose;
holo-[(hydroxy)phthioceranic acid synthase]
Comment
This mycobacterial enzyme catalyses the acylation of 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose at the 3' position by a (hydroxy)phthioceranoyl group during the biosynthesis of mycobacterial sulfolipids.
History
EC 2.3.1.283 created 2019
Orthology
K23415  2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
Genes
MTU: Rv3824c(papA1)
MTV: RVBD_3824c
MTC: MT3932
MRA: MRA_3864(papA1)
MTF: TBFG_13858
MTB: TBMG_03871
MTK: TBSG_03894
MTZ: TBXG_003841
MTI: MRGA423_24125
MTE: CCDC5079_3554
MTUR: CFBS_4054(papA1)
MTL: CCDC5180_3503
MTO: MTCTRI2_3903(papA1)
MTD: UDA_3824c(papA1)
MTN: ERDMAN_4191(papA1)
MTJ: J112_20560
MTUB: MT7199_3893
MTUC: J113_26760
MTUE: J114_20435
MTX: M943_19635
MTUH: I917_26890
MTUL: TBHG_03762
MTUT: HKBT1_4037(papA1)
MTUU: HKBT2_4047(papA1)
MTQ: HKBS1_4050(papA1)
MBO: BQ2027_MB3854C(papA1)
MBB: BCG_3887c(papA1)
MBT: JTY_3889(papA1)
MBM: BCGMEX_3888c(papA1)
MBK: K60_039680
MBX: BCGT_3689
MAF: MAF_38390(papA1)
MMIC: RN08_4222
MCE: MCAN_38431(papA1)
MCQ: BN44_120234(papA)
MCV: BN43_90341(papA)
MCX: BN42_90352(papA)
MCZ: BN45_110186(papA)
MSEO: MSEO_38250(papA1)
MSPG: F6B93_09715 F6B93_09720
MKY: IWGMT90018_34280(papA3)
 » show all
Reference
1  [PMID:17259623]
  Authors
Bhatt K, Gurcha SS, Bhatt A, Besra GS, Jacobs WR Jr
  Title
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
  Journal
Microbiology 153:513-20 (2007)
DOI:10.1099/mic.0.2006/003103-0
  Sequence
[mtu:Rv3824c]
Reference
2  [PMID:17592143]
  Authors
Kumar P, Schelle MW, Jain M, Lin FL, Petzold CJ, Leavell MD, Leary JA, Cox JS, Bertozzi CR
  Title
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
  Journal
Proc Natl Acad Sci U S A 104:11221-6 (2007)
DOI:10.1073/pnas.0611649104
  Sequence
[mtu:Rv3824c]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.283
IUBMB Enzyme Nomenclature: 2.3.1.283
ExPASy - ENZYME nomenclature database: 2.3.1.283
BRENDA, the Enzyme Database: 2.3.1.283

  All links  
Gene (43)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (42)   
Protein sequence (10)   
   UniProt (5)   
   SWISS-PROT (5)   
DNA sequence (3)   
   GenBank (2)   
   EMBL (1)   
Protein domain (2)   
   InterPro (2)   
All databases (58)   

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