papA1 (gene name)
Transferring groups other than aminoacyl groups
(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase]:2'-acyl-2-O-sulfo-alpha,alpha-trehalose 3'-(hydroxy)phthioceranyltransferase
a (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose = a 3'-(hydroxy)phthioceranyl-2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose + holo-[(hydroxy)phthioceranic acid synthase]
(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase];
holo-[(hydroxy)phthioceranic acid synthase]
This mycobacterial enzyme catalyses the acylation of 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose at the 3' position by a (hydroxy)phthioceranoyl group during the biosynthesis of mycobacterial sulfolipids.
EC 126.96.36.1993 created 2019
K23415 2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
MSPG: F6B93_09715 F6B93_09720 » show all
Bhatt K, Gurcha SS, Bhatt A, Besra GS, Jacobs WR Jr
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
Kumar P, Schelle MW, Jain M, Lin FL, Petzold CJ, Leavell MD, Leary JA, Cox JS, Bertozzi CR
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
ExPASy - ENZYME nomenclature database: 188.8.131.523