KEGG   ENZYME: 2.3.1.284
Entry
EC 2.3.1.284                Enzyme                                 

Name
3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase;
chp1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose:3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose 6,6'-di(hydroxy)phthioceranyltransferase
Reaction(IUBMB)
3 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose = 3,6,6'-tris-(hydroxy)phthioceranyl-2-palmitoyl(stearoyl)-2'-sulfo-alpha-alpha-trehalose + 2 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose [RN:R12348]
Reaction(KEGG)
R12348
Substrate
3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-alpha,alpha-trehalose [CPD:C22094]
Product
3,6,6'-tris-(hydroxy)phthioceranyl-2-palmitoyl(stearoyl)-2'-sulfo-alpha-alpha-trehalose;
2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose [CPD:C22096]
Comment
The enzyme, present in mycobacteria, catalyses the ultimate step in the biosynthesis of mycobacterial sulfolipids. It catalyses two successive transfers of a (hydroxy)phthioceranyl group from two diacylated intermediates to third diacylated intermediate, generating the tetraacylated sulfolipid.
History
EC 2.3.1.284 created 2019
Orthology
K23416  3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase
Genes
AEX: Astex_3003
MTU: Rv3822
MTV: RVBD_3822
MTC: MT3930
MRA: MRA_3862
MTF: TBFG_13856
MTB: TBMG_03869
MTK: TBSG_03892
MTZ: TBXG_003839
MTG: MRGA327_23530
MTUR: CFBS_4052
MTD: UDA_3822
MTUC: J113_26750
MTUE: J114_20425
MTUH: I917_26880
MTUL: TBHG_03760
MTUT: HKBT1_4035
MTUU: HKBT2_4045
MBX: BCGT_3687
MAF: MAF_38370
MMIC: RN08_4219
MMC: Mmcs_0415
MKM: Mkms_0424
MJL: Mjls_0403
MVA: Mvan_1838
GOR: KTR9_2569
 » show all
Reference
1  [PMID:22194604]
  Authors
Seeliger JC, Holsclaw CM, Schelle MW, Botyanszki Z, Gilmore SA, Tully SE, Niederweis M, Cravatt BF, Leary JA, Bertozzi CR
  Title
Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
  Journal
J Biol Chem 287:7990-8000 (2012)
DOI:10.1074/jbc.M111.315473
  Sequence
[mtu:Rv3822]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.284
IUBMB Enzyme Nomenclature: 2.3.1.284
ExPASy - ENZYME nomenclature database: 2.3.1.284
BRENDA, the Enzyme Database: 2.3.1.284

DBGET integrated database retrieval system