KEGG   ENZYME: 2.3.1.285Help
Entry
EC 2.3.1.285                Enzyme                                 

Name
(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase;
AT1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:(13S,14R)-1,13-dihydroxy-N-methylcanadine O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + (13S,14R)-1,13-dihydroxy-N-methylcanadine = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA [RN:R11689]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
(13S,14R)-1,13-dihydroxy-N-methylcanadine [CPD:C21587]
Product
(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine;
CoA [CPD:C00010]
Comment
The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.
History
EC 2.3.1.285 created 2019
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22095  (13S,14R)-1,13-dihydroxy-N-methylcandine 13-O-acetyltransferase
Genes
PSOM: 113322791
Taxonomy
Reference
1  [PMID:25485687]
  Authors
Dang TT, Chen X, Facchini PJ.
  Title
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.
  Journal
Nat Chem Biol 11:104-6 (2015)
DOI:10.1038/nchembio.1717
Reference
2  [PMID:29610307]
  Authors
Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD
  Title
Complete biosynthesis of noscapine and halogenated alkaloids in yeast.
  Journal
Proc Natl Acad Sci U S A 115:E3922-E3931 (2018)
DOI:10.1073/pnas.1721469115
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.285
IUBMB Enzyme Nomenclature: 2.3.1.285
ExPASy - ENZYME nomenclature database: 2.3.1.285
BRENDA, the Enzyme Database: 2.3.1.285

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