KEGG   ENZYME: 2.3.1.291Help
Entry
EC 2.3.1.291                Enzyme                                 

Name
sphingoid base N-palmitoyltransferase;
mammalian ceramide synthase 5;
CERS5 (gene name);
LASS5 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
palmitoyl-CoA:sphingoid base N-palmitoyltransferase
Reaction(IUBMB)
palmitoyl-CoA + a sphingoid base = a C16 ceramide + CoA
Reaction(KEGG)
(other) R01496 R06517
Show
Substrate
palmitoyl-CoA [CPD:C00154];
sphingoid base
Product
C16 ceramide;
CoA [CPD:C00010]
Comment
Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
History
EC 2.3.1.291 created 2019
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K23727  sphingoid base N-palmitoyltransferase
Genes
HSA: 253782(CERS6) 91012(CERS5)
PTR: 451891(CERS5) 741293(CERS6)
PPS: 100980816(CERS5) 100985038(CERS6)
GGO: 101126713(CERS6) 101131185(CERS5)
PON: 100452162(CERS6) 100454836(CERS5)
NLE: 100580966(CERS5) 100606355(CERS6)
MCC: 704953(CERS6) 713449(CERS5)
MCF: 101926756(CERS6) 102116993(CERS5)
CSAB: 103217252(CERS6) 103238299(CERS5)
RRO: 104655030(CERS6) 104679692(CERS5)
RBB: 108520506(CERS6) 108536981 108543894(CERS5)
CJC: 100400191(CERS5) 100406593(CERS6)
SBQ: 101031310(CERS5) 101042109(CERS6)
MMU: 241447(Cers6) 71949(Cers5)
MCAL: 110285303(Cers6) 110310406(Cers5)
MPAH: 110318337(Cers6) 110334738(Cers5)
RNO: 366065(Cers6) 366984(Cers5)
MUN: 110547416(Cers5) 110547789(Cers6)
CGE: 100761613(Cers6) 100774213(Cers5)
NGI: 103737993(Cers6) 103746545(Cers5)
HGL: 101701089(Cers5) 101713278(Cers6)
CCAN: 109689215 109689224(Cers6) 109695422(Cers5)
OCU: 100339974(CERS5) 100344726(CERS6)
TUP: 102474397(CERS5) 102484493(CERS6)
CFA: 477611(CERS5) 488387(CERS6)
VVP: 112916440(CERS6) 112921132(CERS5)
AML: 100473865(CERS6) 100474398(CERS5)
UMR: 103659527(CERS6) 103675475(CERS5)
UAH: 113250813(CERS6) 113257628(CERS5)
ORO: 101373517(CERS6) 101384709(CERS5)
FCA: 101084386(CERS6) 101087243(CERS5)
PTG: 102948771(CERS6) 102961799(CERS5)
PPAD: 109249101(CERS5) 109272468(CERS6)
AJU: 106969231(CERS5) 106970310(CERS6)
BTA: 530776(CERS5) 616901(CERS6)
BOM: 102271413(CERS5) 102282095(CERS6)
BIU: 109559116(CERS5) 109575183(CERS6) 109575194
CHX: 102170388 102170747(CERS5) 102176466(CERS6)
OAS: 101117661(CERS5) 101122252(CERS6)
SSC: 100126279(CERS6) 110260661(CERS5)
CFR: 102507747(CERS5) 102509169(CERS6)
CDK: 105091057(CERS6) 105097208(CERS5)
BACU: 103007274(CERS5) 103008265(CERS6)
LVE: 103076535(CERS6) 103088889(CERS5)
OOR: 101282056(CERS6) 101282990(CERS5)
DLE: 111172828(CERS6) 111174012(CERS5)
PCAD: 102983287(CERS6) 112064695(CERS5)
ECB: 100052305(CERS6) 100059999(CERS5)
EPZ: 103546204(CERS5) 103567735(CERS6)
EAI: 106843426(CERS6) 106845048(CERS5)
MYB: 102246479(CERS6) 102262839(CERS5)
MYD: 102760303(CERS5) 102772688(CERS6)
MNA: 107527415(CERS6) 107528263(CERS5)
HAI: 109390309(CERS6) 109393272(CERS5)
DRO: 112318384(CERS5) 112322198(CERS6)
PALE: 102880099(CERS5) 102896376(CERS6)
RAY: 107514286(CERS5) 107521030(CERS6)
MJV: 108385188(CERS6) 108406540(CERS5)
LAV: 100660076(CERS6) 100674871(CERS5)
MDO: 100024030(CERS6)
SHR: 100924117(CERS6) 100929507(CERS5)
PCW: 110193982(CERS5) 110211536(CERS6)
OAA: 100083235(CERS6) 114814501(CERS5)
GGA: 426879(CERS5) 771503(CERS6)
MGP: 100544401(CERS6) 104913603(CERS5)
CJO: 107316742(CERS6) 107325704(CERS5)
NMEL: 110389242(CERS5) 110400020(CERS6)
APLA: 101789541(CERS5) 101804816(CERS6)
ACYG: 106029829(CERS6) 106047737(CERS5)
TGU: 100225623(CERS6) 100231332(CERS5)
LSR: 110472763(CERS6) 110478539(CERS5)
SCAN: 103814409(CERS6) 103823883(CERS5)
GFR: 102038365(CERS5) 102041033(CERS6)
FAB: 101816156(CERS5) 101818852(CERS6)
PHI: 102105774(CERS5) 102111990(CERS6)
PMAJ: 107207352(CERS6) 107215686(CERS5)
CCAE: 111932124(CERS6) 111940481(CERS5)
CCW: 104683743(CERS5) 104694173(CERS6)
ETL: 114069957(CERS5) 114073750(CERS6)
FPG: 101913508(CERS5) 101920423(CERS6)
FCH: 102052030(CERS5) 102052115(CERS6)
CLV: 102089975(CERS6) 102090443(CERS5)
EGZ: 104127999(CERS6) 104132784(CERS5)
NNI: 104010021(CERS6) 104011985(CERS5)
ACUN: 113482330(CERS6) 113491052(CERS5)
PADL: 103914717(CERS5) 103918187(CERS6)
AAM: 106499105(CERS6) 106499436(CERS5)
ASN: 102380256(CERS6) 102383725(CERS5)
AMJ: 102562554(CERS6) 102569929(CERS5)
PSS: 102452005(CERS5) 102460649(CERS6)
CMY: 102935736(CERS6) 102939527(CERS5) 102942007
CPIC: 101938783(CERS5) 101947382(CERS6)
ACS: 100552770(cers5) 100563712(cers6)
PVT: 110074286(CERS5) 110076893(CERS6)
PBI: 103050325(CERS5) 103062842(CERS6)
PMUR: 107287846(CERS6) 107302713(CERS5)
TSR: 106545288(CERS5) 106546629(CERS6)
PMUA: 114586906(CERS5) 114606000(CERS6)
GJA: 107115690 107119688(CERS6) 107122515(CERS5)
XLA: 108701361 108702983 399185(trh4) 495501(cers5.S)
XTR: 100101657(cers5) 100489264(cers6)
NPR: 108789979(CERS5) 108796981(CERS6)
DRE: 323020(cers5) 564867(cers6)
IPU: 108255109(cers5) 108266969(cers6)
PHYP: 113526149(cers6) 113537857(cers5)
AMEX: 103028461(cers6) 103035123(cers5)
EEE: 113577516(cers6) 113580588(cers5)
TRU: 101069548(cers5) 101069883(cers6) 105416273
LCO: 104924188(cers6) 104928376(cers5) 104935436
MZE: 101465150 101466824(cers6) 101466872(cers5)
ONL: 100693585 100695512(cers5) 100700285(cers6)
OLA: 101156449(cers6) 101166550 101175231(cers5)
XMA: 102228308(cers5) 102231596 102234372(cers6)
XCO: 114135628(cers5) 114143560 114148177(cers6)
PRET: 103461713(cers6) 103464664(cers5) 103467553
CVG: 107082007(cers6) 107097563 107101127(cers5)
KMR: 108231679(cers5) 108232041 108240800(cers6)
ALIM: 106512928(cers6) 106517657 106523186 106536835(cers5)
AOCE: 111572807(cers6) 111576050(cers5) 111588345
CSEM: 103385495 103386746(cers5) 103392228(cers6) 103394577
POV: 109631475(cers6) 109635146 109635609(cers5)
SDU: 111217339 111218344(cers6) 111233599(cers5)
SLAL: 111648435(cers5) 111654505(cers6) 111665353 111667195
HCQ: 109507970(cers5) 109526957(cers6) 109528680
BPEC: 110155830(cers5) 110158056 110163953(cers6)
ELS: 105016697(cers5) 105022463(cers6) 109614588
SFM: 108920298 108927896(cers6) 108931341(cers5)
PKI: 111835271(cers5) 111836391(cers6) 111852288
LCM: 102345762(CERS5) 102354959(CERS6)
CMK: 103172411 103176381(cers6) 103190303(cers5)
CIN: 778663(lag1-like1)
SPU: 582683
APLC: 110973426
SKO: 100373352
DME: Dmel_CG3576(schlank)
DER: 6551335
DSI: Dsimw501_GD28007(Dsim_GD28007)
DSR: 110181935
DPE: 6603077
DMN: 108164752
DWI: 6648628
DAZ: 108618444
DNV: 108655797
DHE: 111598102
MDE: 101890389
AAG: 5571461
AALB: 109432412
AME: 727350
BIM: 100742830
BTER: 100650450
OBB: 114878598
MPHA: 105834422
AEC: 105147584
ACEP: 105623188
PBAR: 105429305
VEM: 105558072
HST: 105190345
DQU: 106748799
CFO: 105251260
LHU: 105679186
PGC: 109859190
OBO: 105276915
NVI: 100124217(Lag1)
CSOL: 105361245
MDL: 103573253
DPA: 109544248
ATD: 109604206
NVL: 108563163
PXY: 105391568
DNX: 107162818
AGS: 114120474
RMD: 113551978
CLEC: 106662291
ZNE: 110827521
TUT: 107361924
PTEP: 107453820
CEL: CELE_C09G4.1(hyl-1) CELE_K02G10.6(hyl-2)
CBR: CBG14524(Cbr-hyl-2) CBG15635(Cbr-hyl-1)
BMY: Bm1_06625
TSP: Tsp_02045
SHX: MS3_07792
EGL: EGR_07006
ADF: 107356367
AMIL: 114965228
PDAM: 113665414
SPIS: 111326256
HMG: 101237570
BOE: 106333514
CPAP: 110813806
CIT: 102630646
LJA: Lj0g3v0091289.1(Lj0g3v0091289.1) Lj0g3v0091289.2(Lj0g3v0091289.2) Lj0g3v0223069.1(Lj0g3v0223069.1) Lj2g3v1197780.1(Lj2g3v1197780.1) Lj2g3v1197780.2(Lj2g3v1197780.2) Lj4g3v0586760.1(Lj4g3v0586760.1)
FVE: 101294739
RCN: 112174438
PPER: 18792982
PAVI: 110757744
CSV: 101205881
CMO: 103495235
CMAX: 111486095
CMOS: 111434695
CPEP: 111792771
MESC: 110615785
PEU: 105123414
JRE: 108979065
VVI: 100251278
NSY: 104217896
CCAV: 112500607
DCR: 108200958
SOE: 110798070
CQI: 110686029
DOSA: Os02t0581300-01(Os02g0581300) Os02t0728300-00(Os02g0728300) Os03t0264000-01(Os03g0264000)
ATS: 109746855(LOC109746855) 109758794(LOC109758794) 109763657(LOC109763657) 109780339(LOC109780339) 109783456(LOC109783456) 109787032(LOC109787032)
MIS: MICPUN_107343(LAG1)
DFA: DFA_08234(crsA)
PYO: PY17X_1040700(PY00812)
SMIN: v1.2.016704.t1(symbB.v1.2.016704.t1) v1.2.016704.t2(symbB.v1.2.016704.t2) v1.2.031003.t1(symbB.v1.2.031003.t1)
 » show all
Taxonomy
Reference
1  [PMID:16100120]
  Authors
Lahiri S, Futerman AH
  Title
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.
  Journal
J Biol Chem 280:33735-8 (2005)
  Sequence
[hsa:91012]
Reference
2  [PMID:15772421]
  Authors
Xu Z, Zhou J, McCoy DM, Mallampalli RK
  Title
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia.
  Journal
J Lipid Res 46:1229-38 (2005)
  Sequence
[mmu:71949]
Reference
3  [PMID:15823095]
  Authors
Mizutani Y, Kihara A, Igarashi Y
  Title
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
  Journal
Biochem J 390:263-71 (2005)
DOI:10.1042/BJ20050291
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.291
IUBMB Enzyme Nomenclature: 2.3.1.291
ExPASy - ENZYME nomenclature database: 2.3.1.291
BRENDA, the Enzyme Database: 2.3.1.291

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