KEGG   ENZYME: 2.3.1.291
Entry
EC 2.3.1.291                Enzyme                                 

Name
sphingoid base N-palmitoyltransferase;
mammalian ceramide synthase 5;
CERS5 (gene name);
LASS5 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
palmitoyl-CoA:sphingoid base N-palmitoyltransferase
Reaction(IUBMB)
palmitoyl-CoA + a sphingoid base = an N-(palmitoyl)-sphingoid base + CoA
Reaction(KEGG)
(other) R01496 R06517
Substrate
palmitoyl-CoA [CPD:C00154];
sphingoid base
Product
N-(palmitoyl)-sphingoid base;
CoA [CPD:C00010]
Comment
Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
History
EC 2.3.1.291 created 2019, modified 2019
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K23727  sphingoid base N-palmitoyltransferase
Genes
HSA: 253782(CERS6) 91012(CERS5)
PTR: 451891(CERS5) 741293(CERS6)
PPS: 100980816(CERS5) 100985038(CERS6)
GGO: 101126713(CERS6) 101131185(CERS5)
PON: 100452162(CERS6) 100454836(CERS5)
NLE: 100580966(CERS5) 100606355(CERS6)
MCC: 704953(CERS6) 713449(CERS5)
MCF: 101926756(CERS6) 102116993(CERS5)
CSAB: 103217252(CERS6) 103238299(CERS5)
RRO: 104655030(CERS6) 104679692(CERS5)
RBB: 108520506(CERS6) 108543894(CERS5)
CJC: 100400191(CERS5) 100406593(CERS6)
SBQ: 101031310(CERS5) 101042109(CERS6)
MMU: 241447(Cers6) 71949(Cers5)
MCAL: 110285303(Cers6) 110310406(Cers5)
MPAH: 110318337(Cers6) 110334738(Cers5)
RNO: 366065(Cers6) 366984(Cers5)
MUN: 110547416(Cers5) 110547789(Cers6)
CGE: 100761613(Cers6) 100774213(Cers5)
NGI: 103737993(Cers6) 103746545(Cers5)
HGL: 101701089(Cers5) 101713278(Cers6)
CCAN: 109689215 109689224(Cers6) 109695422(Cers5)
OCU: 100339974(CERS5) 100344726(CERS6)
TUP: 102474397(CERS5) 102484493(CERS6)
CFA: 477611(CERS5) 488387(CERS6)
VVP: 112916440(CERS6) 112921132(CERS5)
AML: 100473865(CERS6) 100474398(CERS5)
UMR: 103659527(CERS6) 103675475(CERS5)
UAH: 113250813(CERS6) 113257628(CERS5)
ORO: 101373517(CERS6) 101384709(CERS5)
FCA: 101084386(CERS6) 101087243(CERS5)
PTG: 102948771(CERS6) 102961799(CERS5)
PPAD: 109249101(CERS5) 109272468(CERS6)
AJU: 106969231(CERS5) 106970310(CERS6)
BTA: 530776(CERS5) 616901(CERS6)
BOM: 102271413(CERS5) 102282095(CERS6)
BIU: 109559116(CERS5) 109575183(CERS6) 109575194
CHX: 102170388 102170747(CERS5) 102176466(CERS6)
OAS: 101117661(CERS5) 101122252(CERS6)
SSC: 100126279(CERS6) 110260661(CERS5)
CFR: 102507747(CERS5) 102509169(CERS6)
CDK: 105091057(CERS6) 105097208(CERS5)
BACU: 103007274(CERS5) 103008265(CERS6)
LVE: 103076535(CERS6) 103088889(CERS5)
OOR: 101282056(CERS6) 101282990(CERS5)
DLE: 111172828(CERS6) 111174012(CERS5)
PCAD: 102983287(CERS6) 112064695(CERS5)
ECB: 100052305(CERS6) 100059999(CERS5)
EPZ: 103546204(CERS5) 103567735(CERS6)
EAI: 106843426(CERS6) 106845048(CERS5)
MYB: 102246479(CERS6) 102262839(CERS5)
MYD: 102760303(CERS5) 102772688(CERS6)
MNA: 107527415(CERS6) 107528263(CERS5)
HAI: 109390309(CERS6) 109393272(CERS5)
DRO: 112318384(CERS5) 112322198(CERS6)
PALE: 102880099(CERS5) 102896376(CERS6)
RAY: 107514286(CERS5) 107521030(CERS6)
MJV: 108385188(CERS6) 108406540(CERS5)
LAV: 100660076(CERS6) 100674871(CERS5)
MDO: 100024030(CERS6)
SHR: 100924117(CERS6) 100929507(CERS5)
PCW: 110193982(CERS5) 110211536(CERS6)
OAA: 100083235(CERS6) 114814501(CERS5)
GGA: 426879(CERS5) 771503(CERS6)
MGP: 100544401(CERS6) 104913603(CERS5)
CJO: 107316742(CERS6) 107325704(CERS5)
NMEL: 110389242(CERS5) 110400020(CERS6)
APLA: 101789541(CERS5) 101804816(CERS6)
ACYG: 106029829(CERS6) 106047737(CERS5)
TGU: 100225623(CERS6) 100231332(CERS5)
LSR: 110472763(CERS6) 110478539(CERS5)
SCAN: 103814409(CERS6) 103823883(CERS5)
GFR: 102038365(CERS5) 102041033(CERS6)
FAB: 101816156(CERS5) 101818852(CERS6)
PHI: 102105774(CERS5) 102111990(CERS6)
PMAJ: 107207352(CERS6) 107215686(CERS5)
CCAE: 111932124(CERS6) 111940481(CERS5)
CCW: 104683743(CERS5) 104694173(CERS6)
ETL: 114069957(CERS5) 114073750(CERS6)
FPG: 101913508(CERS5) 101920423(CERS6)
FCH: 102052030(CERS5) 102052115(CERS6)
CLV: 102089975(CERS6) 102090443(CERS5)
EGZ: 104127999(CERS6) 104132784(CERS5)
NNI: 104010021(CERS6) 104011985(CERS5)
ACUN: 113482330(CERS6) 113491052(CERS5)
PADL: 103914717(CERS5) 103918187(CERS6)
AAM: 106499105(CERS6) 106499436(CERS5)
ASN: 102380256(CERS6) 102383725(CERS5)
AMJ: 102562554(CERS6) 102569929(CERS5)
PSS: 102452005(CERS5) 102460649(CERS6)
CMY: 102935736(CERS6) 102939527(CERS5)
CPIC: 101938783(CERS5) 101947382(CERS6)
ACS: 100552770(cers5) 100563712(cers6)
PVT: 110074286(CERS5) 110076893(CERS6)
PBI: 103050325(CERS5) 103062842(CERS6)
PMUR: 107287846(CERS6) 107302713(CERS5)
TSR: 106545288(CERS5) 106546629(CERS6)
PMUA: 114586906(CERS5) 114606000(CERS6)
GJA: 107115690 107119688(CERS6) 107122515(CERS5)
XLA: 108701361 108702983 399185(trh4) 495501(cers5.S)
XTR: 100101657(cers5) 100489264(cers6)
NPR: 108789979(CERS5) 108796981(CERS6)
DRE: 323020(cers5) 564867(cers6)
IPU: 108255109(cers5) 108266969(cers6)
PHYP: 113526149(cers6) 113537857(cers5)
AMEX: 103028461(cers6) 103035123(cers5)
EEE: 113577516(cers6) 113580588(cers5)
TRU: 101069548(cers5) 101069883(cers6) 105416273
LCO: 104924188(cers6) 104928376(cers5) 104935436
MZE: 101465150 101466824(cers6) 101466872(cers5)
ONL: 100693585 100695512(cers5) 100700285(cers6)
OLA: 101156449(cers6) 101166550 101175231(cers5)
XMA: 102228308(cers5) 102231596 102234372(cers6)
XCO: 114135628(cers5) 114143560 114148177(cers6)
PRET: 103461713(cers6) 103464664(cers5) 103467553
CVG: 107082007(cers6) 107097563 107101127(cers5)
KMR: 108231679(cers5) 108232041 108240800(cers6)
ALIM: 106512928(cers6) 106517657 106523186 106536835(cers5)
AOCE: 111572807(cers6) 111576050(cers5) 111588345
CSEM: 103385495 103386746(cers5) 103392228(cers6)
POV: 109631475(cers6) 109635146 109635609(cers5)
SDU: 111217339 111218344(cers6) 111233599(cers5)
SLAL: 111648435(cers5) 111654505(cers6) 111665353 111667195
HCQ: 109507970(cers5) 109526957(cers6) 109528680
BPEC: 110155830(cers5) 110158056 110163953(cers6)
ELS: 105016697(cers5) 105022463(cers6) 109614588
SFM: 108920298 108927896(cers6) 108931341(cers5)
PKI: 111835271(cers5) 111836391(cers6) 111852288
LCM: 102345762(CERS5) 102354959(CERS6)
CMK: 103172411 103176381(cers6) 103190303(cers5)
BFO: 118424561
CIN: 778662 778663(lag1-like1)
APLC: 110973426
SKO: 100373352
DME: Dmel_CG3576(schlank)
DER: 6551335
DSE: 6612295
DSI: Dsimw501_GD28007(Dsim_GD28007)
DAN: 26514187
DSR: 110181935
DPE: 6603077
DMN: 108164752
DWI: 6648628
DAZ: 108618444
DNV: 108655797
DHE: 111598102
DVI: 6634510
MDE: 101890389
LCQ: 111685485
AAG: 5571461
AALB: 109432412
AME: 727350
BIM: 100742830
BTER: 100650450
OBB: 114878598
MPHA: 105834422
AEC: 105147584
ACEP: 105623188
PBAR: 105429305
VEM: 105558072
HST: 105190345
DQU: 106748799
CFO: 105251260
LHU: 105679186
PGC: 109859190
OBO: 105276915
NVI: 100124217
CSOL: 105361245
MDL: 103573253
DPA: 109544248
ATD: 109604206
NVL: 108563163
PXY: 105391568
DNX: 107162818
AGS: 114120474
RMD: 113551978
CLEC: 106662291
ZNE: 110827521
TUT: 107361924
PTEP: 107453820
CEL: CELE_C09G4.1(hyl-1) CELE_K02G10.6(hyl-2)
CBR: CBG14524(Cbr-hyl-2) CBG15635(Cbr-hyl-1)
BMY: Bm1_06625
TSP: Tsp_02045
EGL: EGR_07006
ADF: 107356367
AMIL: 114965228
PDAM: 113665414
SPIS: 111326256
TPV: TP02_0395
SMIN: v1.2.016704.t1(symbB.v1.2.016704.t1) v1.2.016704.t2(symbB.v1.2.016704.t2) v1.2.031003.t1(symbB.v1.2.031003.t1)
 » show all
Reference
1  [PMID:16100120]
  Authors
Lahiri S, Futerman AH
  Title
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.
  Journal
J Biol Chem 280:33735-8 (2005)
DOI:10.1074/jbc.M506485200
  Sequence
[hsa:91012]
Reference
2  [PMID:15772421]
  Authors
Xu Z, Zhou J, McCoy DM, Mallampalli RK
  Title
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia.
  Journal
J Lipid Res 46:1229-38 (2005)
DOI:10.1194/jlr.M500001-JLR200
  Sequence
[mmu:71949]
Reference
3  [PMID:15823095]
  Authors
Mizutani Y, Kihara A, Igarashi Y
  Title
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
  Journal
Biochem J 390:263-71 (2005)
DOI:10.1042/BJ20050291
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.291
IUBMB Enzyme Nomenclature: 2.3.1.291
ExPASy - ENZYME nomenclature database: 2.3.1.291
BRENDA, the Enzyme Database: 2.3.1.291

DBGET integrated database retrieval system