EC                Enzyme                                 

sphingoid base N-palmitoyltransferase;
mammalian ceramide synthase 5;
CERS5 (gene name);
LASS5 (gene name)
Transferring groups other than aminoacyl groups
palmitoyl-CoA:sphingoid base N-palmitoyltransferase
palmitoyl-CoA + a sphingoid base = an N-(palmitoyl)-sphingoid base + CoA
(other) R01496 R06517
palmitoyl-CoA [CPD:C00154];
sphingoid base
N-(palmitoyl)-sphingoid base;
CoA [CPD:C00010]
Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
EC created 2019, modified 2019
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
K23727  sphingoid base N-palmitoyltransferase
HSA: 253782(CERS6) 91012(CERS5)
PTR: 451891(CERS5) 741293(CERS6)
PPS: 100980816(CERS5) 100985038(CERS6)
GGO: 101126713(CERS6) 101131185(CERS5)
PON: 100452162(CERS6) 100454836(CERS5)
NLE: 100580966(CERS5) 100606355(CERS6)
MCC: 704953(CERS6) 713449(CERS5)
MCF: 101926756(CERS6) 102116993(CERS5)
CSAB: 103217252(CERS6) 103238299(CERS5)
RRO: 104655030(CERS6) 104679692(CERS5)
RBB: 108520506(CERS6) 108543894(CERS5)
CJC: 100400191(CERS5) 100406593(CERS6)
SBQ: 101031310(CERS5) 101042109(CERS6)
MMU: 241447(Cers6) 71949(Cers5)
MCAL: 110285303(Cers6) 110310406(Cers5)
MPAH: 110318337(Cers6) 110334738(Cers5)
RNO: 366065(Cers6) 366984(Cers5)
MUN: 110547416(Cers5) 110547789(Cers6)
CGE: 100761613(Cers6) 100774213(Cers5)
NGI: 103737993(Cers6) 103746545(Cers5)
HGL: 101701089(Cers5) 101713278(Cers6)
CCAN: 109689215 109689224(Cers6) 109695422(Cers5)
OCU: 100339974(CERS5) 100344726(CERS6)
TUP: 102474397(CERS5) 102484493(CERS6)
CFA: 477611(CERS5) 488387(CERS6)
VVP: 112916440(CERS6) 112921132(CERS5)
AML: 100473865(CERS6) 100474398(CERS5)
UMR: 103659527(CERS6) 103675475(CERS5)
UAH: 113250813(CERS6) 113257628(CERS5)
ORO: 101373517(CERS6) 101384709(CERS5)
FCA: 101084386(CERS6) 101087243(CERS5)
PTG: 102948771(CERS6) 102961799(CERS5)
PPAD: 109249101(CERS5) 109272468(CERS6)
AJU: 106969231(CERS5) 106970310(CERS6)
BTA: 530776(CERS5) 616901(CERS6)
BOM: 102271413(CERS5) 102282095(CERS6)
BIU: 109559116(CERS5) 109575183(CERS6) 109575194
CHX: 102170388 102170747(CERS5) 102176466(CERS6)
OAS: 101117661(CERS5) 101122252(CERS6)
SSC: 100126279(CERS6) 110260661(CERS5)
CFR: 102507747(CERS5) 102509169(CERS6)
CDK: 105091057(CERS6) 105097208(CERS5)
BACU: 103007274(CERS5) 103008265(CERS6)
LVE: 103076535(CERS6) 103088889(CERS5)
OOR: 101282056(CERS6) 101282990(CERS5)
DLE: 111172828(CERS6) 111174012(CERS5)
PCAD: 102983287(CERS6) 112064695(CERS5)
ECB: 100052305(CERS6) 100059999(CERS5)
EPZ: 103546204(CERS5) 103567735(CERS6)
EAI: 106843426(CERS6) 106845048(CERS5)
MYB: 102246479(CERS6) 102262839(CERS5)
MYD: 102760303(CERS5) 102772688(CERS6)
MNA: 107527415(CERS6) 107528263(CERS5)
HAI: 109390309(CERS6) 109393272(CERS5)
DRO: 112318384(CERS5) 112322198(CERS6)
PALE: 102880099(CERS5) 102896376(CERS6)
RAY: 107514286(CERS5) 107521030(CERS6)
MJV: 108385188(CERS6) 108406540(CERS5)
LAV: 100660076(CERS6) 100674871(CERS5)
MDO: 100024030(CERS6)
SHR: 100924117(CERS6) 100929507(CERS5)
PCW: 110193982(CERS5) 110211536(CERS6)
OAA: 100083235(CERS6) 114814501(CERS5)
GGA: 426879(CERS5) 771503(CERS6)
MGP: 100544401(CERS6) 104913603(CERS5)
CJO: 107316742(CERS6) 107325704(CERS5)
NMEL: 110389242(CERS5) 110400020(CERS6)
APLA: 101789541(CERS5) 101804816(CERS6)
ACYG: 106029829(CERS6) 106047737(CERS5)
TGU: 100225623(CERS6) 100231332(CERS5)
LSR: 110472763(CERS6) 110478539(CERS5)
SCAN: 103814409(CERS6) 103823883(CERS5)
GFR: 102038365(CERS5) 102041033(CERS6)
FAB: 101816156(CERS5) 101818852(CERS6)
PHI: 102105774(CERS5) 102111990(CERS6)
PMAJ: 107207352(CERS6) 107215686(CERS5)
CCAE: 111932124(CERS6) 111940481(CERS5)
CCW: 104683743(CERS5) 104694173(CERS6)
ETL: 114069957(CERS5) 114073750(CERS6)
FPG: 101913508(CERS5) 101920423(CERS6)
FCH: 102052030(CERS5) 102052115(CERS6)
CLV: 102089975(CERS6) 102090443(CERS5)
EGZ: 104127999(CERS6) 104132784(CERS5)
NNI: 104010021(CERS6) 104011985(CERS5)
ACUN: 113482330(CERS6) 113491052(CERS5)
PADL: 103914717(CERS5) 103918187(CERS6)
AAM: 106499105(CERS6) 106499436(CERS5)
ASN: 102380256(CERS6) 102383725(CERS5)
AMJ: 102562554(CERS6) 102569929(CERS5)
PSS: 102452005(CERS5) 102460649(CERS6)
CMY: 102935736(CERS6) 102939527(CERS5)
CPIC: 101938783(CERS5) 101947382(CERS6)
ACS: 100552770(cers5) 100563712(cers6)
PVT: 110074286(CERS5) 110076893(CERS6)
PBI: 103050325(CERS5) 103062842(CERS6)
PMUR: 107287846(CERS6) 107302713(CERS5)
TSR: 106545288(CERS5) 106546629(CERS6)
PMUA: 114586906(CERS5) 114606000(CERS6)
GJA: 107115690 107119688(CERS6) 107122515(CERS5)
XLA: 108701361 108702983 399185(trh4) 495501(cers5.S)
XTR: 100101657(cers5) 100489264(cers6)
NPR: 108789979(CERS5) 108796981(CERS6)
DRE: 323020(cers5) 564867(cers6)
IPU: 108255109(cers5) 108266969(cers6)
PHYP: 113526149(cers6) 113537857(cers5)
AMEX: 103028461(cers6) 103035123(cers5)
EEE: 113577516(cers6) 113580588(cers5)
TRU: 101069548(cers5) 101069883(cers6) 105416273
LCO: 104924188(cers6) 104928376(cers5) 104935436
MZE: 101465150 101466824(cers6) 101466872(cers5)
ONL: 100693585 100695512(cers5) 100700285(cers6)
OLA: 101156449(cers6) 101166550 101175231(cers5)
XMA: 102228308(cers5) 102231596 102234372(cers6)
XCO: 114135628(cers5) 114143560 114148177(cers6)
PRET: 103461713(cers6) 103464664(cers5) 103467553
CVG: 107082007(cers6) 107097563 107101127(cers5)
KMR: 108231679(cers5) 108232041 108240800(cers6)
ALIM: 106512928(cers6) 106517657 106523186 106536835(cers5)
AOCE: 111572807(cers6) 111576050(cers5) 111588345
CSEM: 103385495 103386746(cers5) 103392228(cers6)
POV: 109631475(cers6) 109635146 109635609(cers5)
SDU: 111217339 111218344(cers6) 111233599(cers5)
SLAL: 111648435(cers5) 111654505(cers6) 111665353 111667195
HCQ: 109507970(cers5) 109526957(cers6) 109528680
BPEC: 110155830(cers5) 110158056 110163953(cers6)
ELS: 105016697(cers5) 105022463(cers6) 109614588
SFM: 108920298 108927896(cers6) 108931341(cers5)
PKI: 111835271(cers5) 111836391(cers6) 111852288
LCM: 102345762(CERS5) 102354959(CERS6)
CMK: 103172411 103176381(cers6) 103190303(cers5)
BFO: 118424561
CIN: 778662 778663(lag1-like1)
APLC: 110973426
SKO: 100373352
DME: Dmel_CG3576(schlank)
DER: 6551335
DSE: 6612295
DSI: Dsimw501_GD28007(Dsim_GD28007)
DAN: 26514187
DSR: 110181935
DPE: 6603077
DMN: 108164752
DWI: 6648628
DAZ: 108618444
DNV: 108655797
DHE: 111598102
DVI: 6634510
MDE: 101890389
LCQ: 111685485
AAG: 5571461
AALB: 109432412
AME: 727350
BIM: 100742830
BTER: 100650450
OBB: 114878598
MPHA: 105834422
AEC: 105147584
ACEP: 105623188
PBAR: 105429305
VEM: 105558072
HST: 105190345
DQU: 106748799
CFO: 105251260
LHU: 105679186
PGC: 109859190
OBO: 105276915
NVI: 100124217
CSOL: 105361245
MDL: 103573253
DPA: 109544248
ATD: 109604206
NVL: 108563163
PXY: 105391568
DNX: 107162818
AGS: 114120474
RMD: 113551978
CLEC: 106662291
ZNE: 110827521
TUT: 107361924
PTEP: 107453820
CEL: CELE_C09G4.1(hyl-1) CELE_K02G10.6(hyl-2)
CBR: CBG14524(Cbr-hyl-2) CBG15635(Cbr-hyl-1)
BMY: Bm1_06625
TSP: Tsp_02045
EGL: EGR_07006
ADF: 107356367
AMIL: 114965228
PDAM: 113665414
SPIS: 111326256
TPV: TP02_0395
SMIN: v1.2.016704.t1(symbB.v1.2.016704.t1) v1.2.016704.t2(symbB.v1.2.016704.t2) v1.2.031003.t1(symbB.v1.2.031003.t1)
 » show all
1  [PMID:16100120]
Lahiri S, Futerman AH
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.
J Biol Chem 280:33735-8 (2005)
2  [PMID:15772421]
Xu Z, Zhou J, McCoy DM, Mallampalli RK
LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia.
J Lipid Res 46:1229-38 (2005)
3  [PMID:15823095]
Mizutani Y, Kihara A, Igarashi Y
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
Biochem J 390:263-71 (2005)
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