KEGG   ENZYME: 2.3.1.296
Entry
EC 2.3.1.296                Enzyme                                 

Name
omega-hydroxyceramide transacylase;
PNPLA1 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
triacyl-sn-glycerol:ultra-long-chain omega-hydroxyceramide omega-O-linoleoyltransferase
Reaction(IUBMB)
a linoleate-containing triacyl-sn-glycerol + an ultra-long-chain omega-hydroxyceramide = a diacyl-sn-glycerol + a linoleate-esterified acylceramide
Substrate
linoleate-containing triacyl-sn-glycerol;
ultra-long-chain omega-hydroxyceramide
Product
diacyl-sn-glycerol;
linoleate-esterified acylceramide
Comment
The enzyme participates in the production of acylceramides in the stratum corneum, the outermost layer of the epidermis. Acylceramides are crucial components of the skin permeability barrier.
History
EC 2.3.1.296 created 2019
Orthology
K16813  omega-hydroxyceramide transacylase
Genes
HSA: 285848(PNPLA1)
PTR: 471991(PNPLA1)
PPS: 100981874(PNPLA1)
GGO: 101149146(PNPLA1)
PON: 100450832(PNPLA1)
NLE: 100596271(PNPLA1)
MCC: 100426523(PNPLA1)
MCF: 102142984(PNPLA1)
CSAB: 103221593(PNPLA1)
RRO: 104682872(PNPLA1)
RBB: 108528307(PNPLA1)
CJC: 100415082(PNPLA1)
SBQ: 101044461(PNPLA1)
MMU: 433091(Pnpla1)
MCAL: 110283928(Pnpla1)
MPAH: 110338533(Pnpla1)
RNO: 361812(Pnpla1)
MUN: 110546583(Pnpla1)
CGE: 100763234(Pnpla1)
NGI: 103739726(Pnpla1)
HGL: 101713574(Pnpla1)
CCAN: 109689861(Pnpla1)
OCU: 100339908(PNPLA1)
TUP: 102494197(PNPLA1)
CFA: 481763(PNPLA1)
VVP: 112913935(PNPLA1)
AML: 100464720(PNPLA1)
UMR: 103665449(PNPLA1)
UAH: 113243858(PNPLA1)
ORO: 101376548(PNPLA1)
ELK: 111152378
FCA: 101091788(PNPLA1)
PTG: 102966751(PNPLA1)
PPAD: 109271519(PNPLA1)
AJU: 106972772(PNPLA1)
BTA: 786888(PNPLA1)
BOM: 102270258(PNPLA1)
BIU: 109577451(PNPLA1)
BBUB: 102398763(PNPLA1)
CHX: 102189446(PNPLA1)
OAS: 101120362(PNPLA1)
SSC: 100154642(PNPLA1)
CFR: 102512995(PNPLA1)
CDK: 105101336(PNPLA1)
BACU: 103007961(PNPLA1)
LVE: 103087327(PNPLA1)
OOR: 101285071(PNPLA1)
DLE: 111178608(PNPLA1)
PCAD: 102990565(PNPLA1)
ECB: 100063661(PNPLA1)
EPZ: 103563196(PNPLA1)
EAI: 106824602(PNPLA1)
MYB: 102247326(PNPLA1)
MYD: 102756555(PNPLA1)
MNA: 107545587(PNPLA1)
HAI: 109395975(PNPLA1)
DRO: 112302420(PNPLA1)
PALE: 102898567(PNPLA1)
RAY: 107514707(PNPLA1)
MJV: 108390133(PNPLA1)
LAV: 100672854(PNPLA1)
TMU: 101340560
MDO: 100028911(PNPLA1)
SHR: 100927942(PNPLA1)
PCW: 110217314(PNPLA1)
OAA: 114813289(PNPLA1)
GGA: 428259(PNPLA1)
MGP: 100542403 100542559(PNPLA1)
CJO: 107324687(PNPLA1) 107324688
NMEL: 110388084 110388095(PNPLA1)
ACYG: 106048433(PNPLA1)
TGU: 100225038(PNPLA1) 115498565
LSR: 110473035(PNPLA1)
SCAN: 103822414(PNPLA1) 108963115
GFR: 102032738 102041930(PNPLA1)
FAB: 101809281(PNPLA1) 101817044
PHI: 102109501 102113209(PNPLA1)
PMAJ: 107214760 107215020(PNPLA1)
CCAE: 111939875(PNPLA1) 111939878
CCW: 104692425(PNPLA1) 109145293
ETL: 114064790(PNPLA1)
FPG: 101920072(PNPLA1)
CLV: 102097663(PNPLA1) 110364654
EGZ: 104131423(PNPLA1)
ACUN: 113489012(PNPLA1)
PADL: 103925952 103925953(PNPLA1)
PVT: 110085293
PMUA: 114599195
GJA: 107110977(PNPLA1)
XTR: 100497390(pnpla1)
NPR: 108800152
SGH: 107559157
CCAR: 109062467
NCC: 104941548
ALIM: 106522640
LCF: 108877866
MALB: 109968666
SALP: 111957907
 » show all
Reference
1  [PMID:28248318]
  Authors
Ohno Y, Kamiyama N, Nakamichi S, Kihara A
  Title
PNPLA1 is a transacylase essential for the generation of the skin barrier lipid omega-O-acylceramide.
  Journal
Nat Commun 8:14610 (2017)
DOI:10.1038/ncomms14610
  Sequence
[hsa:285848]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.296
IUBMB Enzyme Nomenclature: 2.3.1.296
ExPASy - ENZYME nomenclature database: 2.3.1.296
BRENDA, the Enzyme Database: 2.3.1.296

DBGET integrated database retrieval system