KEGG   ENZYME: 2.3.1.303
Entry
EC 2.3.1.303                Enzyme                                 
Name
alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und 2IV-O-acetyltransferase;
rfbL (gene name);
wbaL (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:alpha-L-rhamnopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 2IV-O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und = CoA + 2-O-acetyl-alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und [RN:R12738]
Reaction(KEGG)
R12738(G)
Substrate
acetyl-CoA [CPD:C00024];
alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und
Product
CoA [CPD:C00010];
2-O-acetyl-alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und
Comment
The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.
History
EC 2.3.1.303 created 2021
Orthology
K25194  O-antigen biosynthesis O-acetyltransferase
Genes
SEESNSL254_A2268
SENNSN31241_31920
SENBBN855_21750
SAVIJYB87_13120
Reference
1  [PMID:1379320]
  Authors
Brown PK, Romana LK, Reeves PR.
  Title
Molecular analysis of the rfb gene cluster of Salmonella serovar muenchen (strain M67): the genetic basis of the polymorphism between groups C2 and B.
  Journal
Mol Microbiol 6:1385-94 (1992)
DOI:10.1111/j.1365-2958.1992.tb00859.x
  Sequence
Reference
2  [PMID:7541787]
  Authors
Liu D, Lindqvist L, Reeves PR
  Title
Transferases of O-antigen biosynthesis in Salmonella enterica: dideoxyhexosyltransferases of groups B and C2 and acetyltransferase of group C2.
  Journal
J Bacteriol 177:4084-8 (1995)
DOI:10.1128/JB.177.14.4084-4088.1995
  Sequence
Reference
3  [PMID:28929089]
  Authors
Zhao X, Dai Q, Jia R, Zhu D, Liu M, Wang M, Chen S, Sun K, Yang Q, Wu Y, Cheng A.
  Title
Two Novel Salmonella Bivalent Vaccines Confer Dual Protection against Two Salmonella Serovars in Mice.
  Journal
Front Cell Infect Microbiol 7:391 (2017)
DOI:10.3389/fcimb.2017.00391
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.303
IUBMB Enzyme Nomenclature: 2.3.1.303
ExPASy - ENZYME nomenclature database: 2.3.1.303
BRENDA, the Enzyme Database: 2.3.1.303

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