KEGG   ENZYME: 2.3.1.306
Entry
EC 2.3.1.306                Enzyme                                 
Name
acetyl-CoA:lysine N6-acetyltransferase;
LYC1 (gene name);
lysine N6-acetyltransferase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + L-lysine = CoA + N6-acetyl-L-lysine [RN:R00454]
Reaction(KEGG)
R00454
Substrate
acetyl-CoA [CPD:C00024];
L-lysine [CPD:C00047]
Product
CoA [CPD:C00010];
N6-acetyl-L-lysine [CPD:C02727]
Comment
The enzyme catalyses the first step of an L-lysine degradation pathway found in many fungal species. The enzyme is specific for acetyl-CoA as the acetyl donor. cf. EC 2.3.1.32, lysine N-acetyltransferase.
History
EC 2.3.1.306 created 2021
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18854  acetyl-CoA:lysine N6-acetyltransferase
Genes
YLI: 2911519(YALI2_E00122g)
Reference
1
  Authors
Schmidt H, Bode R, Birnbaum  D.
  Title
Lysine degradation in Candida maltosa: occurrence of a novel enzyme, acetyl-CoA: L-lysine N-acetyltransferase.
  Journal
Arch Microbiol 150:215-218 (1988)
Reference
2  [PMID:1682209]
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Reference
3  [PMID:8257283]
  Authors
Bode R, Thurau AM, Schmidt H.
  Title
Characterization of acetyl-CoA: L-lysine N6-acetyltransferase, which catalyses the first step of carbon catabolism from lysine in Saccharomyces cerevisiae.
  Journal
Arch Microbiol 160:397-400 (1993)
DOI:10.1007/BF00252227
Reference
4  [PMID:8082161]
  Authors
Beckerich JM, Lambert M, Gaillardin C
  Title
LYC1 is the structural gene for lysine N-6-acetyl transferase in yeast.
  Journal
Curr Genet 25:24-9 (1994)
DOI:10.1007/BF00712962
  Sequence
[yli:2911519]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.306
IUBMB Enzyme Nomenclature: 2.3.1.306
ExPASy - ENZYME nomenclature database: 2.3.1.306
BRENDA, the Enzyme Database: 2.3.1.306

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (18)   

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