KEGG ENZYME: 2.3.1.308

ENZYME: 2.3.1.308

Entry

EC 2.3.1.308                Enzyme

Name

tubulin N-terminal N-acetyltransferase NAT9;
NAT9 (gene name);
microtubule-associated N-acetyltransferase NAT9

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:N-terminal-Met-[tubulin] Met-Nalpha-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + an N-terminal-L-methionyl-[tubulin] = an N-terminal-Nalpha-acetyl-L-methionyl-[tubulin] + CoA [RN:R12978]

Reaction(KEGG)

R12978

Substrate

acetyl-CoA [CPD:C00024];
N-terminal-L-methionyl-[tubulin] [CPD:C22490]

Product

N-terminal-Nalpha-acetyl-L-methionyl-[tubulin] [CPD:C22491];
CoA [CPD:C00010]

Comment

The enzyme, characterized from the fruit fly (Drosophila melanogaster), acetylates the N-terminal of both alpha- and beta-tubulin. The enzyme acts cotranslationally, and can't act on a preformed tubulin alpha/beta heterodimer.

History

EC 2.3.1.308 created 2022

Orthology

K25762

tubulin N-terminal N-acetyltransferase

Genes

HSA:	26151(NAT9)

PTR:	454866(NAT9)

PPS:	100978775(NAT9)

GGO:	101146152(NAT9)

PON:	100436102(NAT9)

NLE:	100603978(NAT9)

HMH:	116483463(NAT9)

MCC:	699085(NAT9)

MCF:	102133875(NAT9)

MTHB:

126939244

MNI:	105469135(NAT9)

CSAB:

103243075(NAT9)

CATY:

105577761(NAT9)

PANU:

101019954(NAT9)

TGE:	112610090(NAT9)

MLEU:

105535395(NAT9)

RRO:	104681335(NAT9)

RBB:	108537347(NAT9)

TFN:	117066648(NAT9)

PTEH:

111542448(NAT9)

CANG:

105509948(NAT9)

CJC:	100387118(NAT9)

SBQ:	101047378(NAT9)

CIMI:

108309382(NAT9)

CSYR:

103259735(NAT9)

MMUR:

105878910(NAT9)

LCAT:

123650761(NAT9)

PCOQ:

105824766(NAT9)

OGA:	100955741(NAT9)

MMU:	66176(Nat9)

MCAL:

110304383(Nat9)

MPAH:

110332132(Nat9)

RNO:	303669(Nat9)

MCOC:

116076836(Nat9)

ANU:	117710657(Nat9)

MUN:	110547599(Nat9)

CGE:	100774051(Nat9)

MAUA:

101826874(Nat9)

PROB:

127219000(Nat9)

PLEU:

114707094(Nat9)

MORG:

121436212(Nat9)

MFOT:

126500359

AAMP:

119811820(Nat9)

NGI:	103732758(Nat9)

HGL:	101696817(Nat9)

CPOC:

100722236(Nat9)

CCAN:

109683598(Nat9)

DORD:

106002922(Nat9)

DSP:	122094973(Nat9)

NCAR:

124980879

OCU:

100356850

OPI:	101516449(NAT9)

TUP:	102468825(NAT9)

GVR:	103603692(NAT9)

CFA:	100856771(NAT9)

CLUD:

112672770(NAT9)

VVP:	112920773(NAT9)

VLG:	121473331(NAT9)

AML:	100475320(NAT9)

UMR:	103665716(NAT9)

UAH:	113244665(NAT9)

UAR:	123802928(NAT9)

ELK:

111160320

LLV:

125086655

MPUF:

101673928(NAT9)

NVS:	122906013(NAT9)

ORO:	101370571(NAT9)

EJU:	114216202(NAT9)

ZCA:	113939577(NAT9)

MLX:	118024298(NAT9)

NSU:	110583376(NAT9)

LWW:	102736416(NAT9)

FCA:	101091487(NAT9)

PYU:	121017881(NAT9)

PCOO:

112864647(NAT9)

PBG:	122485869(NAT9)

LRUF:

124513447

PTG:	102965049(NAT9)

PPAD:

109276969

PUC:

125926400

AJU:	106987800(NAT9)

HHV:	120228215(NAT9)

BTA:	514377(NAT9)

BOM:	102280628(NAT9)

BIU:	109573958(NAT9)

BBUB:

102411645(NAT9)

BBIS:

105000326(NAT9)

CHX:	102174595(NAT9)

OAS:	101103166(NAT9)

ODA:	120866710(NAT9)

CCAD:

122434883(NAT9)

SSC:	100359356(NAT9)

CFR:	102515497(NAT9)

CBAI:

105065680(NAT9)

CDK:	105104616(NAT9)

VPC:	102527701(NAT9)

BACU:

103000111(NAT9)

LVE:	103087003(NAT9)

OOR:	101285958(NAT9)

DLE:	111182863(NAT9)

PCAD:

102974632(NAT9)

PSIU:

116746439(NAT9)

NASI:

112410354(NAT9)

ECB:	100060418(NAT9)

EPZ:	103546548(NAT9)

EAI:	106830268(NAT9)

MYB:	102248025(NAT9)

MYD:	102765557(NAT9)

MMYO:

118671174(NAT9)

MLF:	102440681(NAT9)

MNA:	107542930(NAT9)

PKL:	118704611(NAT9)

HAI:	109383707(NAT9)

DRO:	112298788(NAT9)

SHON:

119000950(NAT9)

AJM:	119065286(NAT9)

PDIC:

114503367(NAT9)

PHAS:

123817351(NAT9)

MMF:	118634261(NAT9)

RFQ:	117013476(NAT9)

PALE:

102884405(NAT9)

PGIG:

120600243(NAT9)

PVP:	105293333(NAT9)

RAY:	107498097 107503800(NAT9)

MJV:	108386096(NAT9)

TOD:	119230704(NAT9)

SARA:

101541728(NAT9)

LAV:	100656812(NAT9)

TMU:

101340539

ETF:	101638799(NAT9)

DNM:	101441473(NAT9)

MDO:	100028058(NAT9)

GAS:	123244439(NAT9)

SHR:	100931763(NAT9)

AFZ:

127560502

PCW:	110219269(NAT9)

OAA:	100083113(NAT9)

GGA:	422109(NAT9)

PCOC:

116232380(NAT9)

MGP:	100539937(NAT9)

CJO:	107322367(NAT9)

NMEL:

110407192(NAT9)

APLA:

101795120(NAT9)

ACYG:

106034834(NAT9)

AFUL:

116496536(NAT9)

TGU:	100224642(NAT9)

LSR:	110484343(NAT9)

SCAN:

103819829(NAT9)

PMOA:

120505698(NAT9)

OTC:	121338336(NAT9)

PRUF:

121363837(NAT9)

GFR:	102040669(NAT9)

FAB:	101818008(NAT9)

PHI:	102113071(NAT9)

PMAJ:

107212573(NAT9)

CCAE:

111937338(NAT9)

CCW:	104694296(NAT9)

CBRC:

103621746(NAT9)

ETL:	114070600(NAT9)

ZAB:	102070393(NAT9)

ACHL:

103801929(NAT9)

SVG:	106854314(NAT9)

FPG:	101916729(NAT9)

FCH:	102054881(NAT9)

CLV:	102086034(NAT9)

EGZ:	104125412(NAT9)

NNI:	104020681(NAT9)

PLET:

104623751(NAT9)

PCRI:

104036731(NAT9)

PCAO:

104042291(NAT9)

ACUN:

113486824(NAT9)

TALA:

104356869(NAT9)

PADL:

103916693(NAT9)

AFOR:

103899231(NAT9)

ACHC:

115341002(NAT9)

HALD:

104318976(NAT9)

HLE:	104839153(NAT9)

AGEN:

126043916

GCL:

127024041

CCRI:

104157834(NAT9)

CSTI:

104563777(NAT9)

EHS:	104512131(NAT9)

CMAC:

104475011(NAT9)

MUI:	104543793(NAT9)

FGA:	104082805(NAT9)

GSTE:

104261408(NAT9)

LDI:	104342247(NAT9)

MNB:	103768328(NAT9)

OHA:	104337041(NAT9)

NNT:	104404244(NAT9)

SHAB:

115616652(NAT9)

DPUB:

104302377(NAT9)

PGUU:

104469713(NAT9)

ACAR:

104519049(NAT9)

CPEA:

104393193(NAT9)

AVIT:

104271952(NAT9)

CVF:	104281586(NAT9)

CUCA:

104061939(NAT9)

TEO:	104375060(NAT9)

BRHI:

104489061(NAT9)

AAM:	106500034(NAT9)

AROW:

112977728(NAT9)

NPD:	112953679(NAT9)

TGT:	104569084(NAT9)

DNE:	112982535(NAT9)

SCAM:

104146709(NAT9)

ASN:	102372034(NAT9)

AMJ:	102562471(NAT9)

CPOO:

109315042(NAT9)

GGN:	109297778(NAT9)

PSS:	102457917(NAT9)

CMY:	102947725(NAT9)

CPIC:

101951433(NAT9)

TST:	117887350(NAT9)

CABI:

116827508(NAT9)

MRV:	120383215(NAT9)

ACS:	100566602(nat9)

PVT:	110085798(NAT9)

SUND:

121921634(NAT9)

PBI:	103064871(NAT9)

PMUR:

107290916(NAT9)

CTIG:

120307764(NAT9)

TSR:	106539709(NAT9)

PGUT:

117660543(NAT9)

VKO:	123035603(NAT9)

PMUA:

114590576(NAT9)

ZVI:	118079800(NAT9)

HCG:	128342912(NAT9)

GJA:	107110037(NAT9)

STOW:

125429250(NAT9)

XLA:	108701102(nat9.L) 108702799(nat9.S)

XTR:	100495076(nat9)

RTEM:

120919226(NAT9)

BBUF:

121003804(NAT9)

BGAR:

122942563(NAT9)

DRE:	326898(nat9)

SRX:	107722187 107755518

SANH:

107684049 107702469

SGH:	107566461 107581577

CCAR:

109094701 109100003

CAUA:

113069511 113073772 113111606

CGIB:

127969465 128025388

PPRM:

120474627(nat9)

MAMB:

125255484(nat9)

CIDE:

127523915

MASI:

127423336 127426908

IPU:	100526711(nat9)

PHYP:

113527131(nat9)

SMEO:

124388940(nat9)

TFD:	113651624(nat9)

AMEX:

103023977(nat9)

EEE:	113572831(nat9)

TRU:	101069711(nat9)

TNG:	GSTEN00012903G001

LCO:	104923423(nat9)

NCC:	104946509(nat9)

CGOB:

115025126(nat9)

ELY:	117247194(nat9)

EFO:	125880545(nat9)

PLEP:

121965205

SLUC:

116061160(nat9)

ECRA:

117936468(nat9)

ESP:	116671764(nat9)

PFLV:

114548213(nat9)

GAT:	120819731(nat9)

PPUG:

119212833(nat9)

MSAM:

119916178(nat9)

CUD:	121528341(nat9)

ALAT:

119010373(nat9)

MZE:	101486523(nat9)

ONL:	100690219(nat9)

OAU:	116326002(nat9)

OLA:	101164695(nat9)

OML:	112154651(nat9)

XMA:	102226290(nat9)

XCO:	114152321(nat9)

XHE:	116727546(nat9)

PRET:

103481619(nat9)

PFOR:

103151080(nat9)

PLAI:

106939019(nat9)

PMEI:

106928961(nat9)

GAF:	122822854(nat9)

CVG:	107090921(nat9)

CTUL:

119799085(nat9)

GMU:	124874947(nat9)

NFU:	107387716(nat9)

KMR:	108246405(nat9)

ALIM:

106516667(nat9)

NWH:	119423756(nat9)

AOCE:

111587460

MCEP:

125022938(nat9)

CSEM:

103381784(nat9)

POV:	109640956(nat9)

SSEN:

122758835(nat9)

HHIP:

117753090(nat9)

HSP:	118100784(nat9)

LCF:

108876329

SDU:	111219867(nat9)

SLAL:

111673538(nat9)

XGL:	120794333(nat9)

HCQ:	109516503(nat9)

SSCV:

125991232

BPEC:

110164395(nat9)

MALB:

109959351 109961957

BSPL:

114845822(nat9)

SASA:

100194599(nat9)

STRU:

115153484(nat9)

OTW:	112257506(nat9)

OMY:	110502755(nat9)

OGO:	124038449(nat9)

ONE:	115113002(nat9)

SALP:

111977886(nat9)

SNH:	120046681(nat9)

CCLU:

121575569(nat9)

ELS:	105007196(nat9)

SFM:	108940178(nat9)

PKI:	111848634(nat9)

AANG:

118221466(nat9)

LOC:	102688314(nat9)

PSPA:

121295843(nat9)

ARUT:

117422854(nat9)

PSEX:

120518193(nat9)

LCM:	102362144(NAT9)

CMK:	103175443(nat9)

RTP:	109917341(nat9)

CPLA:

122561973(nat9)

BFO:

118428898

BBEL:

109483311

CIN:

100177307

SCLV:

120342362

SPU:	115918668 586164

APLC:

110980907

AJC:

117116852

SKO:

102802618

DME:	Dmel_CG11539(Mnat9)

DER:

6554300

DSE:

6619506

DSI:	Dsimw501_GD16381(Dsim_GD16381)

DYA:	Dyak_GE23310

DAN:

6505901

DSR:

110186253

DPO:

4801114

DPE:

6588454

DMN:

108156484

DWI:

6647946

DMO:	Dmoj_GI24198

DAZ:

108610551

DNV:

108654277

DHE:

111594487

DVI:

6629745

CCAT:

101448723

BOD:

106617410

RZE:	108364285 108372879

MDE:

101893670

LCQ:

111682402

LSQ:

119604055

HIS:

119660148

AGA:	AgaP_AGAP007378

ACOZ:

120948142

AARA:

120894718

AMER:

121592715

ASTE:

118510135 118516925

AAG:

5569894

AALB:

109399231

CQU:	CpipJ_CPIJ019114

CPII:

120422650 120431519

BCOO:

119081123

AME:

551818

ACER:

107997645

BIM:

112211976

BBIF:

117208963

BVK:

117233754

BVAN:

117160609

BPYO:

122569031

CCAL:

108632381

OBB:

114882717

MGEN:

117222041

NMEA:

116430425

SOC:

105204815

MPHA:

105838136

AEC:

105152261

ACEP:

105620345

PBAR:

105422285

VEM:

105558664

HST:

105191135

CFO:

105256403

FEX:

115237840

LHU:

105674925

PGC:

109856772

OBO:

105275544

PCF:

106785058

PFUC:

122520001

VPS:

122631829

NVI:

100122277

CSOL:

105368510

TPRE:

106652313

MDL:

103579532

FAS:

105272315

DAM:

107036373

AGIF:

122849299

CINS:

118064024

CCIN:

107262896

TCA:

659678

DPA:

109544902

SOY:

115877929

ATD:	109594083 109606555

CSET:

123321003

AGB:

108916235

LDC:

111507784

NVL:

108570011

APLN:

108743371

PPYR:

116180400

OTU:

111417406

BMOR:

101740766

BMAN:

114250347

MSEX:

115446980

DPL:	KGM_208723

BANY:

112043135

NIQ:

126775701

PMAC:

106712380

PPOT:

106111195

PXU:

106117366

PRAP:

110997859

PBX:

123717665

PNAP:

125061700

ZCE:

119829977

CCRC:

123704842

HAW:	110383743 126055110

HZE:

124636359

TNL:

113492854

SLIU:

111354167

OFU:

114355722

CFEL:

113366350 113366351

BTAB:

109040758

DCI:

103520290

CLEC:

106672556

HHAL:

106684780

NLU:

111044642

PHU:	Phum_PHUM233560

FOC:

113207758

TPAL:

117644001

ZNE:

110834041

CSEC:

111869239

SGRE:

126356000

FCD:

110847193

DPX:	DAPPUDRAFT_306678

DMK:

116931727

DPZ:

124349981

PVM:

113807881

PJA:

122243168

PCHN:

125042747

HAME:

121875829

PCLA:

123767926

PTRU:

123510092

ESN:

126984396

HAZT:

108667477

EAF:

111702509

LSM:

121117316

PPOI:

119092281

DSV:

119453340

RSAN:

119399845

RMP:

119180023

VDE:

111247405

VJA:

111264340

DPTE:

113796016

DFR:

124491651

CSCU:

111632690

PTEP:

107456162

SDM:

118195410

CEL:	CELE_Y67D2.5(Y67D2.5)

CBR:

CBG_11716

BMY:	BM_BM7000(Bm7000)

LOA:	LOAG_08006

NAI:	NECAME_02500

HRO:	HELRODRAFT_157613

LGI:	LOTGIDRAFT_195719

PCAN:

112564492

BGT:

106079305

GAE:

121380147

HRF:

124110842

HRJ:

124291681

CRG:

105340332

MYI:

110467350

PMAX:

117336994

MCAF:

127709073

MMER:

123564595

DPOL:

127866556

OBI:

106882876

OSN:

115209791

LAK:

106156707

NVE:

5506891

EPA:

110238091

ATEN:

116291150

ADF:

107341579

AMIL:

114957649

PDAM:

113664274

SPIS:

111328312

HMG:

100205319

TAD:	TRIADDRAFT_20514

ATH:

AT2G04845

ALY:

9321841

CRB:

17891561

CSAT:

104698690 104747157 104766520 104767889

EUS:	EUTSA_v10002661mg

BRP:

103860317

BNA:	106439802 111204594

BOE:

106331981

RSZ:

108857640

THJ:

104826618

CPAP:

110824119

CIT:

102617341

CIC:	CICLE_v10016673mg

PVY:

116126385

MINC:

123222444

TCC:

18612421

GRA:

105799896

GHI:	107952802 107954665

GAB:

108468064

DZI:	111305565 111314526

EGR:

104424664

GMX:

100817900

GSJ:

114380809

PVU:	PHAVU_006G013300g

VRA:

106779961

VAR:

108319771

VUN:

114186811

CCAJ:

109817982

APRC:

113853803

MTR:

11436556

CAM:

101498957

PSAT:

127083256

LJA:	Lj0g3v0001809.1(Lj0g3v0001809.1) Lj0g3v0274749.1(Lj0g3v0274749.1)

ADU:

107463685

AIP:

107644966

AHF:	112709668 112751959 112776169

LANG:

109344404

FVE:

101314159

RCN:

112187035

PPER:

18784363

PMUM:

103329221

PAVI:

110770226

PDUL:

117622309

MDM:

103442969

PXB:

103955047

ZJU:

107416988

MNT:

21402948

CSV:

101211998

CMO:

103500531

BHJ:

120077832

MCHA:

111007921

CMAX:

111468317

CMOS:

111455101

CPEP:

111811812

RCU:

8275952

HBR:

110650408

MESC:

110628354

POP:

7455974

PEU:

105110228

PALZ:

118033253

JRE:

109012636

CILL:

122305457

QSU:	112018541 112040943

QLO:

115955599

TWL:

120000983

VVI:

100240921

VRI:

117927341

SLY:

101254389

SPEN:

107020740

SOT:

102589732

SSTN:

125869305

CANN:

107867768

NTA:

107796380

NSY:	104210517 104224824

NTO:

104105519

NAU:

109208939

INI:

109155596

ITR:

115995583

SIND:

105178767

OEU:	111370203 111382391

EGT:

105951890

SSPL:

121810896

APAN:

127265844

HAN:

110895245

ECAD:

122596056

LSV:

111918692

CCAV:

112517218

DCR:

108220054

CSIN:

114256406

BVG:

104902795

SOE:

110803826

CQI:	110691861 110701907

NNU:

104606573

MING:

122093582

TSS:

122639824

PSOM:

113336895

OSA:

4331926

DOSA:

Os03t0194400-01(Os03g0194400)

OBR:

102700315

OGL:

127768068

BDI:

100840353

ATS:

109764666

TDC:	119284807 119291392

TAES:

123084964 123093144 123098417

TUA:

125531131

LPER:

127297087

SBI:

8054260

ZMA:

100217178

SITA:

101767593

SVS:

117838576

PVIR:

120647003 120691916

PHAI:

112878094

PDA:	103713376 120111047

EGU:

105056197

MUS:

103973431

ZOF:	121975142 122033905

PEQ:

110024496

AOF:

109820047

NCOL:

116259733

ATR:

18446634

SMO:	SELMODRAFT_108827

VCN:	VOLCADRAFT_56363

MNG:

MNEG_9268

CVR:	CHLNCDRAFT_20902

OLU:	OSTLU_7831

OTA:	OT_ostta04g03750

MIS:	MICPUN_60338

MPP:	MICPUCDRAFT_7579

GSL:	Gasu_33900

CCP:	CHC_T00008016001

BBRX:

BRETT_001911

SPO:	SPBC577.03c

CNE:

CNH03620

CNB:

CNBI3150

CNG:	CNAG_05268

CGI:	CGB_I4110C

TMS:	TREMEDRAFT_18845

TASA:

A1Q1_01935

PPL:	POSPLDRAFT_88240

TVS:	TRAVEDRAFT_55891

DSQ:	DICSQDRAFT_113419

PCO:	PHACADRAFT_132799

SHS:	STEHIDRAFT_88429

HIR:	HETIRDRAFT_109040

PSQ:	PUNSTDRAFT_78124

FME:	FOMMEDRAFT_167742

GTR:	GLOTRDRAFT_69772

LBC:	LACBIDRAFT_300463

CCI:	CC1G_15149

ABP:	AGABI1DRAFT47168(AGABI1DRAFT_47168)

ABV:	AGABI2DRAFT123203(AGABI2DRAFT_123203)

PCUB:

JR316_0011364

MPR:	MPER_08010

MRR:	Moror_1808

E1B28_006063

SCM:	SCHCO_014064(SCHCODRAFT_014064)

CPUT:

CONPUDRAFT_151165

SLA:	SERLADRAFT_468094

WSE:	WALSEDRAFT_4358

WIC:	J056_003526

UMA:	UMAG_10032

PFP:	PFL1_00273

MGL:

MGL_1789

MRT:

MRET_2025

MSYM:

MSY001_0912

PGR:	PGTG_15959

MLR:	MELLADRAFT_101377

SRE:	PTSG_00086

DDI:	DDB_G0272710(nat9)

DPP:	DICPUDRAFT_26513

DFA:	DFA_05686(nat9)

PTI:	PHATRDRAFT_34301

FCY:	FRACYDRAFT_195167

TPS:	THAPSDRAFT_38370

AAF:	AURANDRAFT_15371

SPAR:

SPRG_10361

GTT:	GUITHDRAFT_164154

» show all

Reference

1 [PMID:33479178]

Authors

Mok JW, Choi KW.

Title

Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development.

Journal

Proc Natl Acad Sci U S A 118:e2010140118 (2021)
DOI:10.1073/pnas.2010140118

Sequence

[dme:Dmel_CG11539]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.308

IUBMB Enzyme Nomenclature:

2.3.1.308

ExPASy - ENZYME nomenclature database:

2.3.1.308

BRENDA, the Enzyme Database:

2.3.1.308

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (714)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (713)   
Protein sequence (28)   
   UniProt (3)   
   SWISS-PROT (3)   
   RefSeq(pep) (22)   
DNA sequence (22)   
   RefSeq(nuc) (22)   
Protein domain (3)   
   InterPro (3)   
All databases (772)   

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