Entry
Name
tubulin N-terminal N-acetyltransferase NAT9;
NAT9 (gene name);
microtubule-associated N-acetyltransferase NAT9
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:N-terminal-Met-[tubulin] Met-Nalpha-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an N-terminal-L-methionyl-[tubulin] = an N-terminal-Nalpha-acetyl-L-methionyl-[tubulin] + CoA [RN:
R12978 ]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:
C00024 ];
N-terminal-L-methionyl-[tubulin] [CPD:
C22490 ]
Product
N-terminal-Nalpha-acetyl-L-methionyl-[tubulin] [CPD:
C22491 ];
CoA [CPD:
C00010 ]
Comment
The enzyme, characterized from the fruit fly (Drosophila melanogaster), acetylates the N-terminal of both alpha- and beta-tubulin. The enzyme acts cotranslationally, and can't act on a preformed tubulin alpha/beta heterodimer.
History
EC 2.3.1.308 created 2022
Orthology
K25762 tubulin N-terminal N-acetyltransferase
Genes
RAY : 107498097 107503800(NAT9)
XLA : 108701102(nat9.L) 108702799(nat9.S)
SANH : 107684049 107702469
CCAR : 109094701 109100003
CAUA : 113069511 113073772 113111606
CGIB : 127969465 128025388
MASI : 127423336 127426908
MALB : 109959351 109961957
LPIC : 129272385 129272386
DSI : Dsimw501_GD16381(Dsim_GD16381)
ASTE : 118510135 118516925
CPII : 120422650 120431519
LHU : 105674925(Mnat9) 136997995
CFEL : 113366350 113366351
CEL : CELE_Y67D2.5(Y67D2.5)
MAEA : 128218055 128244339
MCAZ : 138059393 138060335
CSAT : 104698690 104747157 104766520 104767889
AHF : 112709668 112751959 112776169
PCIN : 129295772 129315584 129315600
MSYL : 126597710 126634470
TAES : 123084964 123093144 123098417
PVIR : 120647003 120691916
SPO : 2540260(SPOM_SPBC577.03C)
CDEP : 91085379(L203_101165)
KMG : 30161413(I203_105788)
KNE : 92183695(IAR55_006437)
CCAC : CcaHIS019_0704240(CcaverHIS019_0704240)
ABP : AGABI1DRAFT47168(AGABI1DRAFT_47168)
ABV : AGABI2DRAFT123203(AGABI2DRAFT_123203)
SCM : SCHCO_014064(SCHCODRAFT_014064)
» show all
Taxonomy
Reference
Authors
Mok JW, Choi KW.
Title
Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.308