Entry
Name
[beta-tubulin]-L-lysine N-acetyltransferase;
San;
NatE;
NAA50 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:[beta-tubulin]-L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a [beta-tubulin]-L-lysine = CoA + a [beta-tubulin]-N6-acetyl-L-lysine
Substrate
acetyl-CoA [CPD:
C00024 ];
[beta-tubulin]-L-lysine
Product
CoA [CPD:
C00010 ];
[beta-tubulin]-N6-acetyl-L-lysine
Comment
The enzyme acetylates L-lysine at position 252 of beta-tubulin, which is located at the interface of alpha/beta-tubulin heterodimers and interacts with the phosphate group of the alpha-tubulin-bound GTP. The acetylation is thought to attenuate tubulin incorporation into microtubules. The enzyme catalysing this activity (NAA50) also catalyses the acetylation of certain N-terminal methionyl residues. That activity is classified as EC
2.3.1.258 , N-terminal methionine Nalpha-acetyltransferase NatE. cf. EC
2.3.1.108 , alpha-tubulin N-acetyltransferase.
History
EC 2.3.1.309 created 2022
Orthology
K20793 N-alpha-acetyltransferase 50
Genes
GGO : 101125174(NAA50) 101146213
PANU : 101006365(NAA50) 101009854
LCAT : 123630531(NAA50) 123635239
MFOT : 126505636 126513718
PLOP : 125343536 125350689 125351702(Naa50)
NCAR : 124987448 124993194
OPI : 101524694 101529751(NAA50)
MLK : 131807460 131825120(NAA50)
MLX : 118004533 118007095(NAA50)
NSU : 110577036 110582457(NAA50)
BOM : 102279372(NAA50) 138986228
OAS : 101115755(NAA50) 114111483
ODA : 120851758(NAA50) 120869153
CCAD : 122423613 122445556(NAA50)
MBEZ : 129556504(NAA50) 129561633
BACU : 103015576 103017541(NAA50)
BMUS : 118882364 118883055 118894825(NAA50) 118896482
OOR : 101271269(NAA50) 125961628
PCAD : 102980570 102997042(NAA50)
PSIU : 116753060(NAA50) 116754643
RFQ : 117032896 117034723(NAA50)
GAS : 123238913 123242383(NAA50)
XLA : 108707810(naa50.L) 444177(naa50.S)
SANH : 107654230 107701670
CCAR : 109049786 109050223 109058574
CAUA : 113041904 113066279
CGIB : 127946483 128013368
MAMB : 125258526(naa50) 125262137
MASI : 127431885 127434286
SLAL : 111652286 111662955(naa50)
SASA : 106579447(NAT13) 106590472(NAT13)
STRU : 115151423 115195477
OMY : 110489676 110535359(naa50)
OKE : 118361724(naa50) 118370077
SALP : 111972947 112070189
SNH : 120028013(naa50) 120050967
CCLU : 121549828 121569266
ARUT : 117406190 117972617
PMRN : 116948132 116955907
LRJ : 133342049 133358550(NAA50)
DSI : Dsimw501_GD15393(Dsim_GD15393)
RZE : 108363047 108363048 108363049 108376621
CLON : 129616330 129617562
AALB : 109399354 109433368
LSM : 121117263 121117264 121117680
PMEO : 129587110 129599879
CEL : CELE_F40F4.7(F40F4.7)
CRQ : GCK72_022941 GCK72_022995 GCK72_023004 GCK72_024058
MCAZ : 138028814 138030048
CSAT : 104705399 104735149 104769360
BNA : 106372415 106385048 106391318 106416179 125581399 125581403 125596310
MINC : 123194644 123200093
GHI : 107918018 107948626 107948627 107950706 107951977 121205113
GAB : 108463727 108481945 108483489
HSYR : 120116505 120124126 120130961 120148845 120177632 120202325 120212027 120216470
LANG : 109327518 109342176
PCIN : 129299812 129318857
QSA : O6P43_015655 O6P43_019410
MSYL : 126605770 126632077
CSAV : 115720888 115721250 115721311
CMAX : 111491844 111496342
CMOS : 111454591 111462371
CPEP : 111798081 111804972
HBR : 110637314 110653358 110654078
MESC : 110603829 110611804
PALZ : 118050325 118051186
CAVE : 132189117 132189118 132189119 132190076
SPEN : 107023839 107028434
SSTN : 125841739 125873101
SDUL : 129889369 129900788
CANN : 107839058 107872811
NTA : 107773898 107791703 107821620 107829079
NAU : 109227292 109232097 109240885
SSPL : 121742499 121745113
SMIL : 131024984 131024985
HAN : 110898507 110923776 110923796 110923805
CSIN : 114308342 114317834
AEW : 130756589 130756666 130766205 130788220
PSOM : 113278543 113355651
TAES : 123061450 123070096 123078542
MFLO : 136452377 136458485
PVIR : 120673038 120707373
PAUA : 133907047 133915620
ACAK : 137946153 137950093
SMO : SELMODRAFT_121528 SELMODRAFT_6402 SELMODRAFT_6403 SELMODRAFT_94349
OLU : OSTLU_17952 OSTLU_36663
CGR : 2890295(GVI51_K08877)
NCS : NCAS_0B01180(NCAS0B01180) NCAS_0C01230(NCAS0C01230)
NDI : NDAI_0E01060(NDAI0E01060) NDAI_0K01240(NDAI0K01240)
TPF : TPHA_0G01490(TPHA0G01490)
TBL : TBLA_0B03740(TBLA0B03740)
TDL : TDEL_0A06420(TDEL0A06420)
KAF : KAFR_0A03960(KAFR0A03960)
KNG : KNAG_0G02670(KNAG0G02670)
LBG : 92206755(LODBEIA_P15590)
CAL : CAALFM_CR04070WA(NAT5)
YLI : 2905923(YALI2_A00530g)
NTE : NEUTE1DRAFT92946(NEUTE1DRAFT_92946)
SMP : 10810066(SMAC4_01264)
TATV : 25783174(TrAtP1_012483)
TASP : 90967141(TrAFT101_010242)
MAW : 19249134(J3458_019821)
PLJ : 28882349(PLICBS_001614)
CDET : 87944312(CDEST_07809)
CPW : 9694760(D8B26_005649)
PTRR : 6343884(PtrM4_108250)
ADAC : 96089641(ACET3X_009319)
CDEP : 91090362(L203_106154)
KMG : 30167346(I203_103094)
KNE : 92181323(IAR55_004065)
CCAC : CcaHIS019_0408650(NAT5)
RSX : RhiXN_01541 RhiXN_06973 RhiXN_10565
ABP : AGABI1DRAFT112462(AGABI1DRAFT_112462)
ABV : AGABI2DRAFT192431(AGABI2DRAFT_192431)
SCM : SCHCO_01173242(SCHCODRAFT_01173242)
NCE : NCER_100923 NCER_101596
VNX : VNE69_04025 VNE69_05106
PTM : GSPATT00001433001 GSPATT00003266001 GSPATT00004941001
PIF : PITG_08302 PITG_12865 PITG_12868
PSOJ : PHYSODRAFT_489357 PHYSODRAFT_510427 PHYSODRAFT_513686
LMAT : 92517908(LSCM1_08053)
LOI : 92364014(LSCM4_08210)
LEIS : 94183403(GH5_08192)
LENR : 94175488(CUR178_08350)
LEIN : 94191773(JIQ42_08212)
PHET : 94293711(JKF63_07703)
NGR : NAEGRDRAFT_67730 NAEGRDRAFT_69954
TVA : TVAG_2v0222470 TVAG_2v0616650 TVAG_2v0770460 TVAG_2v0908490 TVAG_2v0948720
» show all
Taxonomy
Reference
Authors
Chu CW, Hou F, Zhang J, Phu L, Loktev AV, Kirkpatrick DS, Jackson PK, Zhao Y, Zou H.
Title
A novel acetylation of beta-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.309