Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy

[lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine:NAD+ lipoyltranferase (NAD+-hydrolysing; 2''-O-lipoyl-ADP-D-ribose-forming)

[lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine + NAD+ + H2O = [lipoyl-carrier protein]-L-lysine + 2''-O-lipoyl-ADP-D-ribose + nicotinamide [RN:R13186]

R13186
Reaction

[lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine;
NAD+ [CPD:C00003];
H2O [CPD:C00001]

The enzyme, a member of the sirtuin family, removes the lipoyl group from the dihydrolipoamide acyltransferase (E2) component of 2-oxo acid dehydrogenase complexes such as EC 1.2.1.104, pyruvate dehydrogenase system. The enzyme often has additional activities and can remove other modifications of lysine residues such as acetyl and biotinyl groups. cf. EC 3.5.1.138, lipoamidase.

EC 2.3.1.313 created 2023