KEGG   ENZYME: 2.3.1.320
Entry
EC 2.3.1.320                Enzyme                                 
Name
taxoid C-13 O-(3-amino-3-phenylpropanoyl)transferase;
BAPT;
baccatin III:3-amino-3-phenylpropanoyltransferase;
baccatin III-3-amino-13-phenylpropanoyltransferase;
3'-N-de-benzoyl-2'-deoxytaxol-N-benzoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
(3R)-3-amino-3-phenylpropanoyl-CoA:baccatin III C-13 O-((3R)-3-amino-3-phenylpropanoyl)transferase
Reaction(IUBMB)
baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = 3'-N-debenzoyl-2'-deoxytaxol + CoA [RN:R08172]
Reaction(KEGG)
R08172
Substrate
baccatin III [CPD:C11900];
(3R)-3-amino-3-phenylpropanoyl-CoA [CPD:C16833]
Product
3'-N-debenzoyl-2'-deoxytaxol [CPD:C16523];
CoA [CPD:C00010]
Comment
The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew).
History
EC 2.3.1.320 created 2024
Pathway
ec00904  Diterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K27849  taxoid C-13 O-(3-amino-3-phenylpropanoyl)transferase
Genes
CJF: 131056475
Reference
1  [PMID:12232048]
  Authors
Walker K, Fujisaki S, Long R, Croteau R.
  Title
Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis.
  Journal
Proc Natl Acad Sci U S A 99:12715-20 (2002)
DOI:10.1073/pnas.192463699
  Sequence
[ag:AAL92459]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.320
IUBMB Enzyme Nomenclature: 2.3.1.320
ExPASy - ENZYME nomenclature database: 2.3.1.320
BRENDA, the Enzyme Database: 2.3.1.320

  All links  
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (2)   

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