KEGG   ENZYME: 2.3.1.325
Entry
EC 2.3.1.325                Enzyme                                 
Name
17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase;
Wieland-Gumlich aldehyde N-malonyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase
Reaction(IUBMB)
malonyl-CoA + 17,18-epoxy-17-hydroxycur-19-ene = CoA + prestrychnine [RN:R13334]
Reaction(KEGG)
R13334
Substrate
malonyl-CoA [CPD:C00083];
17,18-epoxy-17-hydroxycur-19-ene [CPD:C22925]
Product
CoA [CPD:C00010];
prestrychnine [CPD:C22927]
Comment
The enzyme, characterized from the tree Strychnos nux-vomica, catalyses the last step in the biosynthesis of strychnine. The product, prestrychnine, undergoes a slow spontaneous decarboxylation and cyclization, forming strychnine.
History
EC 2.3.1.325 created 2024
Pathway
ec00901  Indole alkaloid biosynthesis
Orthology
K27784  17,18-epoxy-17-hydroxycur-19-ene N-malonyltransferase
Reference
1  [PMID:35794473]
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
  Sequence
[ag:UQZ09626]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.325
IUBMB Enzyme Nomenclature: 2.3.1.325
ExPASy - ENZYME nomenclature database: 2.3.1.325
BRENDA, the Enzyme Database: 2.3.1.325

  All links  
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (11)   

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