KEGG   ENZYME: 2.3.1.326
Entry
EC 2.3.1.326                Enzyme                                 
Name
(19E)-17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase;
Wieland-Gumlich aldehyde N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:(19E)-17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + (19E)-17,18-epoxy-17-hydroxycur-19-ene = CoA + diaboline [RN:R13335]
Reaction(KEGG)
R13335
Substrate
acetyl-CoA [CPD:C00024];
(19E)-17,18-epoxy-17-hydroxycur-19-ene [CPD:C22925]
Product
CoA [CPD:C00010];
diaboline [CPD:C22926]
Comment
The enzyme has been characterized from a nonstrychnine-producing Strychnos sp. (Strychnos potatorum).
History
EC 2.3.1.326 created 2024
Pathway
ec00901  Indole alkaloid biosynthesis
Orthology
K27785  (19E)-17,18-epoxy-17-hydroxycur-19-ene N-acetyltransferase
Reference
1
  Authors
Singh H, Kapoor VK, Phillipson JD, Bisset NG.
  Title
Diaboline from Strychnos potatorum.
  Journal
Phytochemistry 14:587-588 (1975)
Reference
2  [PMID:35794473]
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
  Sequence
[ag:UQZ09635]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.326
IUBMB Enzyme Nomenclature: 2.3.1.326
ExPASy - ENZYME nomenclature database: 2.3.1.326
BRENDA, the Enzyme Database: 2.3.1.326

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (10)   

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