KEGG   ENZYME: 2.3.1.43Help
Entry
EC 2.3.1.43                 Enzyme                                 

Name
phosphatidylcholine---sterol O-acyltransferase;
lecithin---cholesterol acyltransferase;
phospholipid---cholesterol acyltransferase;
LCAT (lecithin-cholesterol acyltransferase);
lecithin:cholesterol acyltransferase;
lysolecithin acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
phosphatidylcholine:sterol O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester [RN:R02114]
Reaction(KEGG)
Substrate
phosphatidylcholine [CPD:C00157];
sterol [CPD:C00370]
Product
1-acylglycerophosphocholine [CPD:C04230];
sterol ester [CPD:C01958]
Comment
Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.
History
EC 2.3.1.43 created 1972, modified 1976
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K00650  lecithin-cholesterol acyltransferase
Genes
HSA: 3931(LCAT)
PTR: 743056(LCAT)
PPS: 100976085(LCAT)
GGO: 109023671(LCAT)
PON: 103892697(LCAT)
NLE: 100590850(LCAT)
MCC: 701872(LCAT)
MCF: 102126888(LCAT)
CSAB: 103233251(LCAT)
RRO: 104655608(LCAT)
RBB: 108515381(LCAT)
CJC: 108587667(LCAT)
SBQ: 101036892(LCAT)
MMU: 16816(Lcat)
MCAL: 110299959(Lcat)
MPAH: 110337669(Lcat)
RNO: 24530(Lcat)
MUN: 110545854(Lcat)
CGE: 100751451(Lcat)
NGI: 103738876(Lcat)
HGL: 101700977(Lcat)
CCAN: 109691255(Lcat)
OCU: 100008978(LCAT)
TUP: 102475836(LCAT)
CFA: 479680(LCAT)
VVP: 112929443(LCAT)
AML: 100469078(LCAT)
UMR: 103673641(LCAT)
UAH: 113252389(LCAT)
ORO: 101381788(LCAT)
ELK: 111153035
FCA: 101083225(LCAT)
PTG: 102970547(LCAT)
PPAD: 109270744(LCAT)
AJU: 106971916(LCAT)
BTA: 510960(LCAT)
BOM: 102264672(LCAT)
BIU: 109572303(LCAT)
BBUB: 102394576(LCAT)
CHX: 102189984(LCAT)
OAS: 100302343(LCAT)
SSC: 100303723(LCAT)
CFR: 102521480(LCAT)
CDK: 105088423(LCAT)
BACU: 103016695(LCAT)
LVE: 103082679(LCAT)
OOR: 101284170(LCAT)
DLE: 111179614(LCAT)
PCAD: 114483914(LCAT)
ECB: 100053753(LCAT)
EPZ: 103549703(LCAT)
EAI: 106822471(LCAT)
MYB: 102263247(LCAT)
MYD: 102767701(LCAT)
MNA: 107527882(LCAT)
HAI: 109389599(LCAT)
DRO: 112300810(LCAT)
PALE: 102882548(LCAT)
RAY: 107520404(LCAT)
MJV: 108386440(LCAT)
LAV: 100663727(LCAT)
TMU: 101354314
MDO: 100021772(LCAT)
SHR: 100916426(LCAT)
PCW: 110210384(LCAT)
OAA: 100073500(LCAT)
GGA: 396136(LCAT)
MGP: 100539055(LCAT)
CJO: 107319111(LCAT)
NMEL: 110404108(LCAT)
APLA: 101801832(LCAT)
ACYG: 106033314(LCAT)
TGU: 100226110(LCAT)
LSR: 110476261(LCAT)
SCAN: 103816691(LCAT)
GFR: 102045237(LCAT)
FAB: 101808995(LCAT)
PHI: 102109484(LCAT)
PMAJ: 107209690(LCAT)
CCAE: 111934506(LCAT)
CCW: 104691778(LCAT)
ETL: 114069561(LCAT)
FPG: 101919855(LCAT)
FCH: 102054279(LCAT)
CLV: 102095422(LCAT)
EGZ: 104130251(LCAT)
NNI: 104017431(LCAT)
ACUN: 113484238(LCAT)
PADL: 103913233(LCAT)
AAM: 106484516(LCAT)
ASN: 102378544(LCAT)
AMJ: 102562663(LCAT)
PSS: 102457801
CMY: 102935489
CPIC: 101933197(LCAT)
ACS: 100564490(lcat)
PVT: 110081332(LCAT)
PBI: 103048717(LCAT)
PMUR: 107284167(LCAT)
TSR: 106551707(LCAT)
PMUA: 114601886(LCAT)
GJA: 107108015(LCAT)
XLA: 447501(lcat.L)
XTR: 448241(lcat)
NPR: 108804121(LCAT)
DRE: 793137(lcat)
SANH: 107674949
SGH: 107572072(lcat)
CCAR: 109050579(lcat)
IPU: 100528492(lcat)
PHYP: 113546498(lcat)
AMEX: 103041308(lcat)
EEE: 113581779(lcat)
TRU: 101068878(lcat)
LCO: 104935935(lcat)
MZE: 101464448(lcat)
ONL: 100690438(lcat)
OLA: 101172491(lcat)
XMA: 102230865
XCO: 114133868
PRET: 103466226(lcat)
CVG: 107103417(lcat)
NFU: 107389202(lcat)
KMR: 108246908
ALIM: 106520220(lcat)
AOCE: 111571376 111580988(lcat)
CSEM: 103379476(lcat)
POV: 109640722(lcat)
LCF: 108902284(lcat)
SDU: 111222526
SLAL: 111658753
HCQ: 109530510(lcat)
BPEC: 110169665(lcat)
MALB: 109962590(lcat)
OTW: 112218440(lcat) 112239001
ELS: 105018521(lcat) 105030834
SFM: 108926635(lcat)
PKI: 111859180(lcat)
LCM: 102355092(LCAT)
CMK: 103187891(lcat)
RTP: 109923672
TUT: 107371496
EGL: EGR_09212
MNG: MNEG_2131
EHI: EHI_031360(63.t00024) EHI_136400(33.t00023)
PYO: PY17X_1129600(PY04170)
PCB: PCHAS_112760(PC000649.03.0)
HSC: HVS_05275
KAL: KALB_6769
 » show all
Taxonomy
Reference
1
  Authors
Bartlett, K., Keat, M.J. and Mercer, E.I.
  Title
Biosynthesis of sterol esters in Phycomyces blakesleeanus.
  Journal
Phytochemistry 13:1107-1113 (1974)
Reference
2  [PMID:7061477]
  Authors
Buckley JT, Halasa LN, MacIntyre S.
  Title
Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase.
  Journal
J Biol Chem 257:3320-5 (1982)
Reference
3  [PMID:4868699]
  Authors
Glomset JA.
  Title
The plasma lecithins:cholesterol acyltransferase reaction.
  Journal
J Lipid Res 9:155-67 (1968)
Reference
4  [PMID:4877146]
  Authors
Vahouny GV, Treadwell CR.
  Title
Enzymatic synthesis and hydrolysis of cholesterol esters.
  Journal
Methods Biochem Anal 16:219-72 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.43
IUBMB Enzyme Nomenclature: 2.3.1.43
ExPASy - ENZYME nomenclature database: 2.3.1.43
BRENDA, the Enzyme Database: 2.3.1.43
CAS: 9031-14-5

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