KEGG ENZYME: 2.3.1.5

ENZYME: 2.3.1.5

Entry

EC 2.3.1.5                  Enzyme

Name

arylamine N-acetyltransferase;
arylamine acetylase;
beta-naphthylamine N-acetyltransferase;
4-aminobiphenyl N-acetyltransferase;
acetyl CoA-arylamine N-acetyltransferase;
2-naphthylamine N-acetyltransferase;
arylamine acetyltransferase;
indoleamine N-acetyltransferase;
N-acetyltransferase (ambiguous);
p-aminosalicylate N-acetyltransferase;
serotonin acetyltransferase;
serotonin N-acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:arylamine N-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + an arylamine = CoA + an N-acetylarylamine

Reaction(KEGG)

(other) R02387 R07940 R08036 R08248 R08250 R11902

Substrate

acetyl-CoA [CPD:C00024];
arylamine [CPD:C00292]

Product

CoA [CPD:C00010];
N-acetylarylamine [CPD:C07565]

Comment

Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.

History

EC 2.3.1.5 created 1961

Pathway

ec00232

Caffeine metabolism

ec00633

Nitrotoluene degradation

ec00983

Drug metabolism - other enzymes

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

ec01120

Microbial metabolism in diverse environments

Orthology

K00622

arylamine N-acetyltransferase

Genes

HSA:	10(NAT2) 9(NAT1)

PTR:	464023(NAT1) 464024(NAT2)

PPS:	100990661(NAT2) 100991667(NAT1)

GGO:	101150362(NAT1) 101152545(NAT2)

PON:	100435042(NAT1) 129060827(NAT2)

PPYG:

129043088(NAT1) 129043091(NAT2)

NLE:	100580331(NAT1) 100580987(NAT2)

HMH:	116472373(NAT2) 116473764(NAT1)

SSYN:

129486608(NAT1) 129491107(NAT2)

MCC:	704019(NAT1) 704357(NAT2)

MCF:	102119914(NAT1) 102121561

MTHB:

126961452 126961453

MNI:	105482132(NAT2) 105482138

CSAB:

103215401(NAT1) 103215403(NAT2)

CATY:

105601399(NAT1) 105601400(NAT2)

PANU:

101009542(NAT1) 101010131

TGE:	112630309(NAT2) 112630315(NAT1)

MLEU:

105539373(NAT1) 105539376(NAT2)

RRO:	104655225 104655226

RBB:	108526475 108526477

TFN:	117092730(NAT1) 117092749

PTEH:

111545658 111545783(NAT2)

CANG:

105506650(NAT1) 105506651(NAT2)

CJC:	100397995(NAT1)

SBQ:	101045716(NAT1) 101047286(NAT2)

CIMI:

108311997(NAT1) 108312024

ANAN:

105705356(NAT1)

CSYR:

103262334 103263194

MMUR:

105882540 105882541 105882543

LCAT:

123626451 123626489

PCOQ:

105825236 105825299

OGA:	100944436 100964262 100964577

MMU:	17960(Nat1) 17961(Nat2) 17962(Nat3)

MCAL:

110300118 110300659 110300688

MPAH:

110336889 110336987 110337099

RNO:	116631(Nat1) 116632(Nat2) 290681(Nat3)

MCOC:

116069400 116071440 116071442

ANU:	117721345 117721637 117721644 117721781 117722081

ASYL:

127668461 127668796 127668798

MUN:	110564517 110564518 110564521

CGE:	100689282(Nat2) 100755335

MAUA:

101840278(Nat1) 101840555(Nat2)

PROB:

127220208 127220209

PLEU:

114703125 114703126 114703138

MORG:

121462774 121463089 121463146

MFOT:

126513742 126513743 126513749

AAMP:

119812563 119813085 119813102

NGI:	103745801 103745803 103745813

CPOC:

100723784 100724067(Nat1) 100724343

CCAN:

109680577 109701090 109701091

DORD:

105991867 105992221 105992232

DSP:	122126233 122126857 122126940

PLOP:

125339574

NCAR:

124983865 124983866

MMMA:

107153956 107153957

ITI:	101967579 101967864

OCU:	100008974(NAT2) 100328959(NAT1)

OPI:	101523061 101527236

TUP:	102486411(NAT1) 102487228

GVR:

103581914

AML:

100480317

UMR:

103677031

UAH:

113245585

UAR:

123780321

ELK:

111156822

LLV:

125092831

MPUF:

101671731

MNP:

132006506

MLK:

131820345

NVS:

122889838

ORO:

101367643

EJU:

114224832

ZCA:	113924821 118356728

MLX:

118009895

NSU:

110573124

LWW:

102735960

FCA:

101095575

PYU:

121044338

PCOO:

112858633

PBG:

122472729

PVIV:

125163242

LRUF:

124520911

LGF:

123587970

AJU:

106976139

PTG:	102955781(NAT1)

PPAD:

109262233

PUC:

125923850

PLEZ:

122217552

HHV:

120233984

BTA:	512603(NAT1)

BOM:

102275700

BIU:

109553540

BBUB:

102403863

BBIS:

104993240

CHX:

102169935

OAS:	101120889(NAT1)

BTAX:

128068387

CSUM:

138078417

ODA:	120865875(NAT1)

CCAD:

122432509

MREE:

136176713

OVR:

110125822

MBEZ:

129549450

SSC:

100511905

CFR:

102510309

CBAI:

105071173

CDK:

105086440

VPC:	102525084 102532768

BACU:

102999256

BMUS:

118889524

LVE:

103082317

OOR:

101280132

LALB:

132512574

DLE:

111173572

PCAD:

102994472 112061838

PSIU:

116746861

NASI:

112408499

ECB:

100049837

EPZ:

103540532

EAI:

106833608

MYD:	102752765(NAT1) 102753338 102760162

MMYO:

118651804 118651805 118651806 118652085

MLF:	102423110 102423981 102426077 102432866 102433484 102433788

MDT:	132226430 132228582 132228583

MYUM:

139004911 139004912 139004913 139004914

PKL:	118729707 118730409 118730410

EFUS:

103288199 103288200

MNA:

107523940

DRO:	112308289 112321515 112321529

SHON:

118984275

AJM:	119046537 119047229 128626642

PDIC:

114508650 114508709

PHAS:

123807498 123807795

MMF:

118622555

PPAM:

129064672

RFQ:

117021026

PGIG:

120607072

PVP:	105310958 105311124 105311126 105311249 105311413

RAY:

107503880

MJV:	108388000 108401168

TOD:

119256975

LAV:	100677179 100677461 100677744

TMU:	101354440 101354690

ETF:

101645644

DNM:

101444633

MDO:

100027666

GAS:	123237038 123253986 123256592

SHR:

100919466

AFZ:

127548676

PCW:

110212707

TVP:

118841645

PBRV:

138149217

OAA:

100077007

TACU:

119934774

GGA:	396283(PNAT10) 396537(NAT) 415809(PNAT3)

PCOC:

116244056 116244057 116244058

MGP:	100548608 100548761 100549991

CJO:	107319387 107319388 107319389

TPAI:

128082059 128082061 128082062

LMUT:

125699048 125699049 125699050(NAT1)

NMEL:

110404203 110404204 110404205(NAT1)

APLA:

101791461 101791654 101791850

ACYG:

106044860 106044861 106044862

CATA:

118246522 118246524 126913100

AFUL:

116494024 116494025 116494216

TGU:	100218405 100222183 100225095 115490547(NAT1)

LSR:	110476354 110476355 110476356

SCAN:

103816733 103816734 103816736

PMOA:

120506955 120507956 120507957 120507958

OTC:	121334052 121334053 121334054

PRUF:

121348889 121348890 121348891

ATRC:

139596441 139596442 139596444

GFR:	102038858 102039206 102040232

FAB:	101810372(NAT1) 101810563 101810753

OMA:	130257723 130257724 130257725

PHI:	102102516 102102700 102102890

PMAJ:

107209900 107209901 107209902

CCAE:

111934448(NAT1) 111934450 111934451

CCW:	104691827 104691828 104691831(NAT1)

CBRC:

103620104(NAT1) 103620105 103620106

ACOE:

138117176 138117177 138117178

ETL:	114060984 114060995 114060998 114061034 114061043 114072393 114072394

ZAB:	102065473 102065658 102065843 102066138

ZLE:	135452954 135452955 135452956 135452957

ACHL:

103804389 103804390 103804391

SVG:	106852083 106852084 106852085(NAT1)

MMEA:

130577276 130577277 130577278

HRT:	120757677 120757679 120757680

SATI:

136366468 136366469 136366470

CCIC:

134048401 134048417 134048431

FPG:	101913996 101915036 101915205

FCH:	102049096 102049271 102058986

CCRI:

104154561 104155316 104157136

NNT:	104403771 104403772 104403773

SHAB:

115619602 115619603 115619604

ACUN:

113484381 113484382 113484384 113484499

TALA:

104357345 104357346 104357347

ACHC:

115345663 115345664 115345665

HALD:

104318014 104318015 104318016

HLE:	104839379 104839380 104839381

AGEN:

126041009 126041010 126041011

HHAR:

128145664 128145665 128145666(NAT1)

GCL:	127021161 127021236 127021288

CSTI:

104559015 104559016 104559018

LDI:	104339725 104340115 104340225 104340516

MNB:	103777207 103777208 103777210

DPUB:

104300826 104300827 104300853

PPUS:

135184344 135184345 135184346

AVIT:

104271546 104271553 104271560

BRHI:

104502124 104502125 104502126

EGZ:	104133744 104133745 104133747

NNI:	104014602 104014613 104014733

PCRI:

104035480 104035481 104035483

PCAO:

104039455 104045893 104045894

PADL:

103923868 103923870 103923871

AFOR:

103897303 103897304 103897305

FGA:	104069109 104070059 104072378

GSTE:

104254174 104254175 104254176

CBOY:

140656527 140656947 140656948

CLV:	102085619(NAT1) 102086109 106145649

MUI:	104533194 104533262 104534016

PGUU:

104457474 104457553 104458470

PLET:

104623649 104623650 104623651

EHS:	104513556 104513557 104513558

CMAC:

104479291 104479292 104479293

CUCA:

104059382 104059383 104059384

TEO:	104384680 104384691 104384698

BREG:

104639886 104639887 104639888

OHA:	104339200 104339201 104339202

ACAR:

104517457 104518346 104520000

CPEA:

104396361 104396362 104396363

CVF:	104291175 104291176 104291177

RTD:	128908553 128908554 128908555

CRID:

134515583 134515584 134515585

AAM:	106483271 106483273 106483274 106483355

AROW:

112962676 112962682 112962715

NPD:	112949882 112949883 112949884

TGT:	104567368 104567369 104567370

DNE:	112978850 112978870 112978871

SCAM:

104149333 104149334 104149335

ASN:	102378789 102379045 102379284

AMJ:	102574773 102575009 102575242

CPOO:

109310363 109310654 109310655

GGN:	109289318 109289459 109289460

PSS:	102453745 102457700

CMY:

102931077

CCAY:

125620893(NAT1)

DCC:

119841141

CPIC:

101940914 101950692 112059549

TST:	117886635 117886745

CABI:

116816708 116816709

MRV:	120384422 120384755

ACS:	100565208 100565405

ASAO:

132782918

PVT:

110090098

SUND:

121937445

PBI:

103059580

PMUR:

107287706

CTIG:

120312148

TSR:

106544720

PGUT:

117670905

APRI:

131184232

PTEX:

113445044

NSS:	113432006 113432190

VKO:	123022336 123022377

PMUA:

114602208 114602209

PRAF:

128419441 128419442

ZVI:	118086513 118086514

HCG:	128334422 128334521

GJA:	107109832 107109835(NAT1)

STOW:

125424946 125442403

EMC:	129344101 129344172 129344230

NPR:

108786559

RTEM:

120917951

PWL:	138267835 138267904 138268135

MUO:	115458623 115469905 115470904

GSH:	117359629(NAT1)

DRE:	445194(zgc:101040) 449801(zgc:103601) 794381(si:dkey-78a14.4) 795256(si:dkey-78a14.5)

SRX:	107715136 107722424 107738535

SANH:

107679010 107692750 107696680

SGH:	107551480 107588554

CCAR:

109093152 109098442 109110276 122137977

CAUA:

113061297 113078644 113095182 113106067 113106068 113118583

CGIB:

127934489 127949349 127962690 127962693 127977538

PTET:

122349706 122363038 122363039

LROH:

127167916 127180534(zgc:101040)

OMC:	131524455(zgc:101040) 131543707 131544392

PPRM:

120468823 120473881

RKG:	130069731 130077737(zgc:101040)

MAMB:

125254297(zgc:101040) 125265051(zgc:103601)

CIDE:

127499905(zgc:101040) 127515493

CERY:

137022595(zgc:101040) 137031334(zgc:103601)

MASI:

127417039(zgc:101040) 127446442 127453914

TROS:

130563177 130563245

TDW:	130435750 130435786

MANU:

129419780 129444933

PDAB:

135732888 135778885

IPU:	100528628(ary1) 108259233 108259370 108259371

IFU:	128602852 128602853 128602855

PHYP:

113540997 113540999

SMEO:

124379781 124379782 124379783 124379784 124380209

TFD:	113656370 113656372 113656374

TVC:	132838727 132838733 132838994

CGAR:

128519177 128519366 128519394 128519399 128519404 128519407

NGRA:

132874877 132874924

TRN:

134304214

AMEX:

103021503 103022041 103025468

CMAO:

118817416 118817417 118817670

EEE:	113576704 113576721 113576722

CHAR:

105901338 105907209

SPIL:

134069288 134069293 134069299

LCO:

104920774

NCC:

104955050

TBEN:

117496663 117496691 117496694 117496705

PGEO:

117441194

GACU:

117549051 117549058

EMAC:

134863556

ELY:	117251663 117252379

EFO:	125878937 125878942 125878950

PLEP:

121939460 121940038

SLUC:

116037558

ECRA:

117952649

ESP:

116688385

PFLV:

114558570

GAT:	120812918 120834089

PPUG:

119221143 119226185 119226194

AFB:

129104588

CLUM:

117728759

PSWI:

130192663

CANA:

137786917

CVE:	137887500 137887513 137887581 137887630

MSAM:

119889962 119890093

SCHU:

122864443

CUD:	121514049 121515489

SPUL:

138589585 138593019

LMIX:

132979992

ALAT:

119018174

MZE:	101481779 101482061

ONL:	100704032 100704303(nat1)

OAU:	116325620 116325644

OLA:	101157683 101165718

OML:	112160719 112160720

CSAI:

133421465 133463896

XMA:	102230777(nat1)

XCO:

114142912

XHE:	116718490 116718491

PRET:

103462640 103462641

PFOR:

103138061 103138062

PLAI:

106957721 106957722

PMEI:

106927342(nat1)

GAF:

122847283

PPRL:

129364259 129364260

CVG:

107088494

CTUL:

119781943(si:dkey-78a14.4)

GMU:	124867200 124867201 124867202

NFU:	107373583 107382082

KMR:

108243328

ALIM:

106536371

NWH:

119430146

AOCE:

111572268(si:dkey-78a14.4)

EJA:	138213255 138213425 138213430 138213431

BFRE:

138616153 138616225

MCEP:

125005824 125005825

CSEM:

103383261

SSEN:

122772820(si:dkey-78a14.4)

SSOE:

131460081

LCF:	108876876 108877018

SDU:	111217696(nat1)

SLAL:

111672246 111672358

XGL:

120794177

HCQ:

109514002

SBIA:

133498172 133498365

PEE:

133397884

PTAO:

133474151

BPEC:

110171948 110175435 110175484

ENY:	140380616 140380957 140380958

MALB:

109954313 109955857 109955859 109955860

BSPL:

114852283 114852644 121201626

SJO:	128356562 128357018

SSCO:

133981405 133981413

GMH:	115558426 115558950

SASA:

106562381(ARY1) 106587573(ARY1)

STRU:

115167037 115203284

OTW:	112249348 121842893

OMY:

110526592

OGO:

124033090

ONE:

115111137

OKI:

109881655

OKE:

118382098

OMM:

135550907

OCLA:

139412232

SALP:

111969532 111974736

SNH:

120056583

CCLU:

121534753 123487512

ELS:

105025705

OEP:

134027978

SFM:	108932932 108932960

PKI:

111832738

AANG:

118214903 118214904 118214905 118214923

AROT:

135241993 135242345 135242348 135242350

CCOG:

133111706 133111975 133112025 133112080 133112100

LOC:

102689755

PSPA:

121296609 121325857

ARUT:

117424387 117425908 117425909

PSEX:

120535561

CMK:

103172656

RTP:

109923912

CPLA:

122545466

HOC:

132826407

SCLV:

120325539 120326277 120348690

DSV:	119462240 119462542

CCAC:

CcaHIS019_0302480(CcaverHIS019_0302480)

BEQ:	BEWA_013780

SPPH:

KFK14_00460

PELG:

ACJ7K1_17650

MTU:	Rv3566c(nat)

MTV:	RVBD_3566c

MTC:	MT3671(nhoA)

MRA:	MRA_3605(nat)

MTF:	TBFG_13599

MTB:	TBMG_03605

MTK:	TBSG_03632

MTZ:	TBXG_003580

MTG:	MRGA327_22015

MTI:	MRGA423_22535

MTE:	CCDC5079_3307

MTUR:

CFBS_3782(nat)

MTL:	CCDC5180_3259

MTO:	MTCTRI2_3630(nat)

MTD:	UDA_3566c(nat)

MTN:	ERDMAN_3911(nat)

MTJ:	J112_19200

MTUB:

MT7199_3628

MTUC:

J113_24975

MTUE:

J114_19070

MTX:	M943_18330

MTUH:

I917_25040

MTUL:

TBHG_04161

MTUT:

HKBT1_3767(nat)

MTUU:

HKBT2_3776(nat)

MTQ:	HKBS1_3779(nat)

MBO:	BQ2027_MB3596C(nat)

MBB:	BCG_3630c(nat)

MBT:	JTY_3631(nat)

MBM:	BCGMEX_3628c(nat)

MBK:	K60_037040

MAF:	MAF_35780(nat)

MMIC:

RN08_3943

MCE:	MCAN_35771(nat)

MCQ:	BN44_110058(nat)

MCV:	BN43_90064(nat)

MCX:	BN42_90063(nat)

MCZ:	BN45_100065(nat)

MORY:

MO_003723(nat)

MPA:	MAP_0501(nhoA)

MAO:

MAP4_3366

MAVI:

RC58_16695

MAVU:

RE97_16730

MAV:

MAV_0595

MAVM:

MAA44156_00514(nat)

MIT:

OCO_05040

MIA:

OCU_05080

MID:

MIP_00946

MYO:

OEM_05100

MCHI:

AN480_02515

MIR:

OCQ_05190

MMAL:

CKJ54_02455

MMAN:

MMAN_47990(nat)

MSER:

MTY59_24340(nat)

MSA:	Mycsm_00165

MUL:	MUL_4131(nat)

MMI:	MMAR_5055(nat)

MMAE:

MMARE11_48700(nat)

MLI:	MULP_05313(nat)

MPSE:

MPSD_52550(nat)

MSHO:

MSHO_05370(nat)

MMC:

Mmcs_0211

MKM:

Mkms_0221

MJL:

Mjls_0201

MMM:

W7S_02460

MKN:	MKAN_12065

MYV:	G155_01320

MHAD:

B586_04480

MFJ:	MFLOJ_40720(nat)

MSTO:

MSTO_44690(nat)

MSIM:

MSIM_29140(nat)

MSAK:

MSAS_29110(nat)

MKU:	I2456_25660

MLW:	MJO58_25065

MNV:	MNVI_19580

MPAG:

C0J29_27735

MNM:	MNVM_16320

MGOR:

H0P51_25790

MCOO:

MCOO_27240(nat)

MBAI:

MB901379_04445(nat)

MSEO:

MSEO_34500(nat)

MGAU:

MGALJ_47190

MLJ:	MLAC_47380(nat)

MBRD:

MBRA_12980

MSHJ:

MSHI_38690(nat)

MMAM:

K3U93_22670

MSPG:

F6B93_20470

MOT:	LTS72_27935

MPAA:

MKK62_02425

MKY:	IWGMT90018_57440(nat)

MADI:

A7U43_01145

MWU:	PT015_15540

MYW:	BVC93_15365

MYJ:	BCA37_27420

MSM:	MSMEG_0306

MSG:	MSMEI_0299(nat)

MSB:	LJ00_01535

MSN:	LI99_01535

MSH:	LI98_01535

MVA:

Mvan_0235

MGI:

Mflv_0433

MSP:	Mspyr1_03210

MNE:	D174_02890

MYN:	MyAD_02825

MFT:	XA26_02810

MRH:	MycrhN_1510

MCHT:

MCHIJ_07140

MAUU:

NCTC10437_00240(nat)

MFX:	MFAL_05890

MALV:

MALV_32910

MTY:	MTOK_10520

MARZ:

MARA_36070

MGAD:

MGAD_45510

MMAT:

MMAGJ_18890

MBOK:

MBOE_15090

MFG:	K6L26_30050

MSEI:

MSEDJ_15380

MFLV:

NCTC10271_04893(nat)

MCEE:

MCEL_30040

MBRM:

L2Z93_002188

MMON:

EWR22_01155

MGO:	AFA91_08360

MHOL:

K3U96_25400

MSEN:

K3U95_01405

MRF:	MJO55_01130

MDF:	K0O62_01880

MAUS:

JN090_18770

MFRE:

EXE63_13665

MBUG:

MU0053_004353

MKR:	MKOR_28740

MPAK:

MIU77_17755

MJD:	JDM601_0190(nat)

MMIN:

MMIN_19310

MHIB:

MHIB_33190

MHER:

K3U94_01120

MVM:	MJO54_00975

MKK:	MU0083_000157

GOM:	D7316_01282(nat)

GAM:	GII34_13175

GPD:	GII33_12405

GMG:	NWF22_23505

TSD:	MTP03_45680

» show all

Reference

1 [PMID:12980945]

Authors

CHOU TC, LIPMANN F.

Title

Separation of acetyl transfer enzymes in pigeon liver extract.

Journal

J Biol Chem 196:89-103 (1952)

Reference

2 [PMID:4748369]

Authors

Paul RC, Ratledge C.

Title

Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes.

Journal

Biochim Biophys Acta 320:9-15 (1973)
DOI:10.1016/0304-4165(73)90160-8

Reference

3 [PMID:13084583]

Authors

TABOR H, MEHLER AH, STADTMAN ER.

Title

The enzymatic acetylation of amines.

Journal

J Biol Chem 204:127-38 (1953)

Reference

4 [PMID:14005907]

Authors

WEISSBACH H, REDFIELD BG, AXELROD J.

Title

The exzymic acetylation of serotonin and other naturally occurring amines.

Journal

Biochim Biophys Acta 54:190-2 (1961)
DOI:10.1016/0006-3002(61)90954-4

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.5

IUBMB Enzyme Nomenclature:

2.3.1.5

ExPASy - ENZYME nomenclature database:

2.3.1.5

UM-BBD (Biocatalysis/Biodegradation Database):

2.3.1.5

BRENDA, the Enzyme Database:

2.3.1.5

CAS:

9027-33-2

DBGET integrated database retrieval system