KEGG   ENZYME: 2.3.1.59
Entry
EC 2.3.1.59                 Enzyme                                 
Name
gentamicin 2'-N-acetyltransferase;
gentamycin acetyltransferase II;
gentamycin 2'-N-acetyltransferase;
acetyl-CoA:gentamycin-C1a N2'-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:gentamicin-C1a N2'-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + gentamicin C1a = CoA + N2'-acetylgentamicin C1a [RN:R03056]
Reaction(KEGG)
R03056
Substrate
acetyl-CoA [CPD:C00024];
gentamicin C1a [CPD:C00908]
Product
CoA [CPD:C00010];
N2'-acetylgentamicin C1a [CPD:C03524]
Comment
The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.
History
EC 2.3.1.59 created 1976
Orthology
K17840  aminoglycoside 2'-N-acetyltransferase I
Genes
PCIBF9282_06485
PSIS70_17610
PSXDR96_2475
PSTABGK56_19845
PRGRB151_031910(aac)
PRQCYG50_22025
PVCG3341_13465(aac(2')-Ia)
PAEUBN889_06966(aac)
CHROCXB49_21390
CHRIDK842_07705
CHRBDK843_13255
DUGHH213_17300
BBTBBta_1334 BBta_2407
BRSS23_63390
AOLS58_64430
BRKCWS35_11955
BOTCIT37_16855
BGQX265_32670
BSYMCIT39_01515
BARHWN72_43660
RPERPE_3842
VCPH9L18_07100
VHYG7082_13800
MTURv0262c(aac)
MTVRVBD_0262c
MTCMT0275(aac)
MRAMRA_0270(aac)
MTFTBFG_10266
MTBTBMG_00264
MTKTBSG_00268
MTZTBXG_000265
MTGMRGA327_01675
MTECCDC5079_0244
MTURCFBS_0279(aac)
MTLCCDC5180_0243
MTOMTCTRI2_0267(aac)
MTDUDA_0262c(aac)
MTNERDMAN_0290(aac)
MTJJ112_01410
MTUBMT7199_0267
MTUEJ114_01420
MTXM943_01385
MTUHI917_01870
MTULTBHG_00262
MTUTHKBT1_0279(aac)
MTUUHKBT2_0279(aac)
MTQHKBS1_0279(aac)
MBOBQ2027_MB0268C(aac)
MBBBCG_0300c(aac)
MBTJTY_0269(aac)
MBMBCGMEX_0269c(aac)
MBKK60_002830
MBXBCGT_0027
MAFMAF_02630(aac)
MMICRN08_0294
MCEMCAN_02691(aac)
MCQBN44_10301(aac)
MCVBN43_10296(aac)
MCXBN42_10308(aac)
MCZBN45_10288(aac)
MLEML2551(aac)
MLBMLBr02551(aac)
MSAMycsm_00227
MULMUL_1185(aac)
MMCMmcs_0265
MKMMkms_0275
MJLMjls_0255
MMIMMAR_0522(aac)
MMAEMMARE11_04790(aac)
MLIMULP_00526(aac)
MKNMKAN_16860
MYVG155_01705
MYEAB431_02080
MGOAFA91_09090
MHADB586_00975
MDXBTO20_34295
MSHGMSG_00462(aac)
MFJMFLOJ_30410(aac)
MSTOMSTO_34300(aac)
MSIMMSIM_20050(aac)
MSAKMSAS_38490(aac)
MGROFZ046_08145
MXEMYXE_46010(aac)
MNVMNVI_20170(aac)
MPAGC0J29_02945
MGORH0P51_02955
MCOOMCOO_36180(aac)
MBAIMB901379_00432(aac)
MPSEMPSD_06390(aac)
MSHOMSHO_19270(aac)
MHEKJMUB5695_04447(aac)
MGAUMGALJ_47570(aac)
MLJMLAC_39280(aac)
MBRDMBRA_12110(aac)
MSHJMSHI_32180(aac)
MKRMKOR_28230(aac)
MDFK0O62_02125
MMAMK3U93_02310
MHOLK3U96_25045
MHERK3U94_01390
MSENK3U95_01765(aac(2')-Ib)
MPAEK0O64_01720
MSPGF6B93_02005
MOTLTS72_23315
MLMMLPF_2801(aac)
MSMMSMEG_0434
MSGMSMEI_0423
MSBLJ00_02155
MSNLI99_02155
MSHLI98_02155
MVAMvan_0302
MGIMflv_0379
MSPMspyr1_03760
MCBMycch_0260
MNED174_03155
MYNMyAD_03080
MFTXA26_03650
MPHLMPHLCCUG_04827(aac)
MVQMYVA_0296
MLLB1R94_00295 B1R94_01695
MRHMycrhN_1459
MTHN4412656_00273(aac)
MHASMHAS_04592(aac)
MDUMDUV_40340(aac)
MCHTMCHIJ_06670(aac)
MDRMDOR_01050(aac)
MAUUNCTC10437_00295(aac)
MMAGMMAD_05630(aac)
MMORMMOR_01610(aac)
MAICMAIC_52800(aac)
MALVMALV_32270(aac)
MTYMTOK_10120(aac)
MPSCMPSYJ_06060(aac)
MARZMARA_35100(aac)
MGADMGAD_45920(aac)
MHEVMHEL_18440(aac_1) MHEL_23040(aac_2)
MSARMSAR_19180(aac) MSAR_20920
MANYMANY_44170(aac)
MAUBMAUB_37170(aac)
MPOFMPOR_08330(aac)
MPHUMPHO_33280(aac)
MMUCC1S78_001445
MMATMMAGJ_17760(aac)
MBOKMBOE_15910(aac) MBOE_22630
MFGK6L26_29690(aac(2')-Ib)
MSEIMSEDJ_16550(aac)
MFLVNCTC10271_04847(aac)
MABMAB_4395
MABBMASS_4433
MIZBAB75_24985
MSTEMSTE_04563
MSALDSM43276_04253(aac_2)
MTER4434518_00231(aac)
MMINMMIN_19790(aac)
MHIBMHIB_32720(aac)
MPAKMIU77_17555
CFNCFAL_07935
RHUA3Q40_02318(aac)
GOQACH46_12705
GOCCXX93_10645
GOILK459_19215
SMASAVERM_2721(aac1)
SGRSGR_1985
SGBWQO_25540
SHYSHJG_6618
SHOSHJGH_6378
SBHSBI_09091
SVESVEN_5199
SFISFUL_5379
SALUDC74_5946
SALLSAZ_12180
SGUSGLAU_23715
SVTSVTN_26725
STREGZL_02854
SCWTU94_23310
SLDT261_2154
SLCSL103_26740
SXISXIM_14240 SXIM_23280
STRMM444_24330
SAMBSAM23877_5271(aac)
SCZABE83_09775
SRWTUE45_06019(aac_2)
SLEsle_21330(sle_21330)
SRNA4G23_04081(aac_2)
STRTA8713_22410
SCLFBB341_06610
SGSAVL59_08650
STSIA4E84_28255
SALWCP975_25375
SCADDN051_12675
SNRSNOUR_12305
SNWBBN63_09105
SSIAA7J05_11225
SVUB1H20_26100
SPUNBFF78_13485
SGVB1H19_30025
SALFSMD44_06140(aac)
SALJSMD11_1742(aac)
SLXSLAV_12125(aac)
STROSTRMOE7_28605
SFKKY5_5685
SNZDC008_24765
SLKSLUN_27960
SQZFQU76_24645
STIRDDW44_21825
SKACP970_12650
SGZC0216_06380
SVNCP980_09865
SHAWCEB94_28875
SRKFGW37_24710
SFICEIZ62_08895
SSPODDQ41_20565
SFYGFH48_13355
SCAVCVT27_24930
SBYH7H31_06960
SRIMCP984_09780
SSUBCP968_10135
SCINCP977_24415 CP977_30300
STSUB7R87_24665
SCHACP983_13055
SGXH4W23_28230
SCOECP976_30475
SSPBCP982_29475
SNFJYK04_05918(aac_2)
SPLACP981_28995
STUIGCM10017668_50250(aac)
SATAC5746_29345
SCHFIPT68_26185
SHARHUT13_07825 HUT13_12290
SCYGS1361_27380(aac2)
SFEUIM697_35645
SDWK7C20_27730
SCALI6J39_25795
SAUHSU9_026395
SFBCP974_22055
SANUK7396_09150
KSKKSE_68370
KABB7C62_26815
MICRBMW26_08420
MFOLDXT68_08230
KFVAS188_13555
KIIKocCE7_08400
DNIHX89_14335
BCAUI6G59_10495
NCANoca_3357
NDKI601_2761
NOOFE634_15020
NMESH9L09_04580
NAQUENKNEFLB_01313(aac)
NGVCDO52_22840
MMARMODMU_5198
SACGFDZ84_01115
AOIAORI_7879
AJAAJAP_41090
AMQAMETH_1520
AMYBBKN51_32705
AABA4R43_05940
AORISD37_01225
AACDLWP59_15630
PSEAWY02_28020
PSEEFRP1_14705
PSEHXF36_14960
PSEQAD006_22370
PECQAD017_01955
PHHAFB00_22920
PAUTPdca_41060(aac)
SESPBN6_71470
SSYIEKG83_40005
KPHYAOZ06_09845
SACEGIY23_03690
ASEACPL_6034(aac)
ACTSACWT_5902
AIHAiant_17820(aac)
CATICS0771_50830(aac)
DVCDvina_34805
IAMHC251_16025
ERZER308_09125
DWUDVJ83_16985
HQIH9L05_21605
 » show all
Reference
1  [PMID:4209515]
  Authors
Benveniste R, Davies J.
  Title
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.
  Journal
Proc Natl Acad Sci U S A 70:2276-80 (1973)
DOI:10.1073/pnas.70.8.2276
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.59
IUBMB Enzyme Nomenclature: 2.3.1.59
ExPASy - ENZYME nomenclature database: 2.3.1.59
BRENDA, the Enzyme Database: 2.3.1.59
CAS: 50864-40-9

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