KEGG   ENZYME: 2.3.1.6
Entry
EC 2.3.1.6                  Enzyme                                 
Name
choline O-acetyltransferase;
choline acetylase;
choline acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:choline O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + choline = CoA + O-acetylcholine [RN:R01023]
Reaction(KEGG)
R01023
Substrate
acetyl-CoA [CPD:C00024];
choline [CPD:C00114]
Product
CoA [CPD:C00010];
O-acetylcholine [CPD:C01996]
Comment
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.
History
EC 2.3.1.6 created 1961
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K00623  choline O-acetyltransferase
Genes
HSA1103(CHAT)
PTR450451(CHAT)
PPS100976056(CHAT)
GGO101129095(CHAT)
PON100444631(CHAT)
NLE100584675(CHAT)
MCC709977(CHAT)
MCF102146741(CHAT)
MTHB126963211
CSAB103215827(CHAT)
CATY105591468(CHAT)
PANU101013111(CHAT)
TGE112631519(CHAT)
RRO104677712(CHAT)
RBB108537812(CHAT)
TFN117082451(CHAT)
PTEH111554547(CHAT)
CJC100391258(CHAT)
SBQ101042797(CHAT)
CSYR103257512(CHAT)
MMUR105860108(CHAT)
LCAT123649791(CHAT)
OGA100945012(CHAT)
MMU12647(Chat)
MCAL110309681(Chat)
MPAH110325356(Chat)
RNO290567(Chat)
MCOC116084493(Chat)
MUN110561617(Chat)
CGE100756785(Chat)
MAUA101829899(Chat)
PLEU114699355(Chat)
MORG121455245(Chat)
MFOT126500589
AAMP119827085(Chat)
NGI103735013(Chat)
HGL101711939(Chat)
CPOC100718930(Chat)
CCAN109683982(Chat)
DORD106001017(Chat)
DSP122122332(Chat)
NCAR124985917
OCU100342226
OPI101517234(CHAT)
TUP102490742(CHAT)
GVR103588316(CHAT)
CFA486775(CHAT)
CLUD112671986(CHAT)
VVP112921044(CHAT)
VLG121485195(CHAT)
AML105240673(CHAT)
UMR103668061(CHAT)
UAH113243089(CHAT)
UAR123800334(CHAT)
ELK111145252
LLV125085282
MPUF101678414(CHAT)
ORO101377526(CHAT)
EJU114205453(CHAT)
ZCA113918493(CHAT)
MLX118020652(CHAT)
NSU110589356(CHAT)
LWW102743973(CHAT)
FCA751512(CHAT)
PYU121036935(CHAT)
PBG122492973(CHAT)
LRUF124506677
PTG102955228(CHAT)
PPAD109264566(CHAT)
AJU106989815(CHAT)
HHV120232817(CHAT)
BTA524732(CHAT)
BOM102275818(CHAT)
BIU109553654(CHAT)
BBUB102401542(CHAT)
BBIS104999014(CHAT)
CHX102182280(CHAT)
OAS101117817(CHAT)
ODA120865504(CHAT)
CCAD122446180(CHAT)
SSC396896(CHAT)
CFR102512463(CHAT)
CBAI105075619(CHAT)
CDK105093435(CHAT)
VPC102526500(CHAT)
BACU103017639(CHAT)
LVE103087947(CHAT)
OOR101288890(CHAT)
DLE111169892(CHAT)
PCAD102973373(CHAT)
PSIU116741646(CHAT)
ECB100062632(CHAT)
EPZ103552164(CHAT)
EAI106824271(CHAT)
MYB102248169(CHAT) 102255670
MYD102773878(CHAT)
MMYO118679371(CHAT)
MLF102422909(CHAT)
MNA107527946(CHAT)
PKL118732120(CHAT)
HAI109389479(CHAT)
DRO112305557(CHAT)
SHON118994131(CHAT)
AJM119047680(CHAT)
PDIC114497439(CHAT)
PHAS123821002(CHAT)
MMF118632117(CHAT)
RFQ117035757(CHAT)
PALE102879671(CHAT)
PGIG120609738(CHAT)
PVP105288947(CHAT)
RAY107508908(CHAT)
MJV108390141(CHAT)
TOD119233714(CHAT)
SARA101549017(CHAT)
LAV100662470(CHAT)
TMU101347293
ETF101659176(CHAT)
DNM101432614(CHAT)
MDO100019640(CHAT)
GAS123236373(CHAT)
SHR116421926(CHAT)
PCW110215361(CHAT)
OAA100077991(CHAT)
GGA395314(CHAT)
PCOC116234793(CHAT)
MGP100543253(CHAT)
CJO107315570(CHAT)
NMEL110400574(CHAT)
APLA101793965(CHAT)
ACYG106032106(CHAT)
AFUL116491475(CHAT)
TGU100231848(CHAT)
LSR110473541(CHAT)
SCAN103814032(CHAT)
PMOA120507266(CHAT)
OTC121336139(CHAT)
PRUF121357563(CHAT)
GFR102039969(CHAT)
FAB101817021(CHAT)
PHI102110760(CHAT)
PMAJ107206533(CHAT)
CCAE111931590(CHAT)
CCW104690200(CHAT)
CBRC103623672(CHAT)
ETL114063577(CHAT)
ZAB102071390(CHAT)
ACHL103799667(CHAT)
FPG101920651(CHAT)
FCH102047610(CHAT)
CLV102093477(CHAT)
EGZ104122701(CHAT)
NNI104013529(CHAT)
PLET104613624(CHAT)
PCAO104046858(CHAT)
ACUN113481929(CHAT)
TALA104355590(CHAT)
PADL103925840(CHAT)
AFOR103901934(CHAT)
ACHC115348381(CHAT)
HALD104316829(CHAT)
HLE104831939(CHAT)
AGEN126042523
GCL127017983
CCRI104157567(CHAT)
CSTI104555700(CHAT)
EHS104512445(CHAT)
CMAC104480497(CHAT)
MUI104546528(CHAT)
FGA104069763(CHAT)
GSTE104250949(CHAT)
LDI104340305(CHAT)
MNB103779892(CHAT)
OHA104338470(CHAT)
NNT104399001(CHAT)
DPUB104301344(CHAT)
PGUU104462706(CHAT)
ACAR104529733(CHAT)
CPEA104391794(CHAT)
AVIT104274923(CHAT)
CVF104293536(CHAT)
CUCA104065088(CHAT)
TEO104370525(CHAT)
BRHI104497819(CHAT)
AAM106499858(CHAT)
AROW112968080(CHAT)
NPD112950528(CHAT)
TGT104566969(CHAT)
DNE112993305(CHAT)
SCAM104151035(CHAT)
ASN102377196(CHAT)
AMJ102569949(CHAT)
CPOO109324367(CHAT)
GGN109287315(CHAT)
PSS102449796(CHAT)
CMY102935845(CHAT)
CPIC101946401(CHAT)
TST117880976(CHAT)
CABI116839114(CHAT)
MRV120369091(CHAT)
ACS100558883(chat)
PVT110080700(CHAT)
SUND121924819(CHAT)
PBI103061793 103065039
PMUR107293833(CHAT)
CTIG120307983(CHAT)
TSR106557099(CHAT)
PGUT117675770(CHAT)
VKO123018257(CHAT)
PMUA114596702(CHAT)
ZVI118096392(CHAT)
GJA107124840(CHAT)
STOW125438075(CHAT)
XLA108696296(chat.L) 108703349(chat.S)
XTR100485221(chat)
NPR108788608(CHAT)
RTEM120909089(CHAT)
BBUF121005635(CHAT)
BGAR122942079(CHAT)
DRE100170938(chata)
SRX107707518 107716339 107746756 107756945
SANH107673961 107674393 107683741 107684585
SGH107569502 107585314 107588646
CCAR109064142 109073168 109073723 109086229 109094778 109108215
CAUA113056521 113096127 113112394
PPRM120479301(chata) 120487114
MAMB125255784 125276994(chata)
IPU108262900(chata) 108273528
PHYP113527245 113544018(chat)
SMEO124388469 124394734(chata)
TFD113639946(chata) 113652229
AMEX103043285 103044316(chat)
EEE113581952(chat) 113588411
TRU101061555 101076861
TNGGSTEN00016461G001 GSTEN00035908G001
LCO104930374(chat) 109136882
NCC104942458 104960833(chat) 104962666
CGOB115020276 115024188
ELY117246700 117248790(chata)
EFO125881098 125903176(chata)
PLEP121954585(chata) 121959181
SLUC116054475(chata) 116061426
ECRA117936737 117960760(chata)
ESP116670761 116705238
PFLV114548684 114572552(chat)
GAT120819616 120820971(chata)
PPUG119213280 119214551(chata)
MSAM119916239 119916892(chata)
CUD121511366(chata) 121528919
ALAT119009317 119034043(chata)
MZE101468574 101474042
ONL100690211 100700808
OAU116316601(chata) 116327444
OLA101156191 101173179
OML112154589 112162239(chata)
XMA102218840 102227259(chat)
XCO114137419(chat) 114152345
XHE116713855(chat) 116727462
PRET103476855(chat) 103481435
PFOR103142275 103147747(chat)
PLAI106954049 106959776(chat)
PMEI106904705(chat) 106931138
GAF122823272 122843031(chata)
CVG107089365 107089989
CTUL119774973 119788592(chata)
GMU124858764(chata) 124875759
NFU107375923(chat) 107387807
KMR108245700(chata) 108246008
ALIM106515353 106516582
NWH119419445(chata) 119423717
AOCE111564396 111582227
MCEP125018898(chata) 125022842
CSEM103381961 103387214
POV109626669 109630809(chat)
SSEN122759702 122781895(chata)
HHIP117752876 117775367(chata)
HSP118100677 118119151(chata)
LCF108880384(chata) 108899013
SDU111219604 111235159(chat)
SLAL111654634(chat) 111660222
XGL120794584 120796682(chata)
HCQ109509950 109523969(chat)
BPEC110159153(chat) 110166454
MALB109961990(chat) 109962946
BSPL114842057(chata) 114845889
SASA106589926 106609157
STRU115153558 115201731
OTW112239448 112258237 121840769
OMY110499558 110502837
OGO124037291 124039388
ONE115112945 115123577
SALP111978578(chat)
SNH120029340 120045988
CCLU121547759 121576447
ELS105009941(chat)
SFM108939585
PKI111859565(chat)
AANG118217564 118219722
LOC102697876(chat)
PSPA121322124 121326107
ARUT117416158 117418604
PSEX120519060(chata)
LCM102347699(CHAT)
CMK103181719(chata)
RTP109926257(chat)
BFO118412577 118424121 118427325
BBEL109478329
CIN445622(chat)
SCLV120344451
SPU574696
APLC110986841
AJC117109905
SKO100369252
DMEDmel_CG12345(ChAT)
DER6553866
DSE6613725
DSIDsimw501_GD19246(Dsim_GD19246)
DYADyak_GE25557
DAN6499911
DSR110186314
DPO4801339
DPE6588486
DMN108153961
DWI6650420
DGR6567386
DMODmoj_GI10809
DAZ108621686
DNV108659621
DHE111602640
DVI6634979
CCAT101451626
BOD106623800
RZE108364020
MDE101889931
SCAC106091888
LCQ111681257
LSQ119602903
HIS119658483
AGAAgaP_AGAP002370
ACOZ120947360
AARA120896360
ASTE118502852
AAG5573378
CQUCpipJ_CPIJ001609
CPII120422544
CNS116338183
BCOO119068511
AME408934
ACER107993140
BIM100746556
BBIF117215585
BVK117242175
BVAN117159906
BTER100650308
BPYO122571475
OBB114879061
MGEN117229688
NMEA116434666
CGIG122402217
AEC105143074
ACEP105623295
PBAR105427135
VEM105569893
HST109504566
DQU106741916
CFO105252134
LHU105672719
PGC109853390
OBO105279745
PCF106786480
PFUC122513656
VPS122635523
NVI100121638
CSOL105368480
CGLO123264461
FAS105266500
DAM107045444
AGIF122859102
CINS118065572
CCIN107264510
TCA664403
DPA109542904
SOY115891136
ATD109593867
CSET123318199
AGB108903777
LDC111510047
APLN108737878 112904479
PPYR116166618
OTU111413325
MSEX115442233 119190107
DPLKGM_210548
BANY112050460
NIQ126772986
PMAC106709632 106709640
PXU106116978
ZCE119837575
CCRC123695169
HZE124634718
TNL113493189
SLIU111356288
PXY105387875
CFEL113377696
API100159222
DNX107162847
RMD113550929
BTAB109040044
DCI103516828
CLEC106664013
HHAL106679902
NLU111047838 120355827
PHUPhum_PHUM569800
FOC113210661
TPAL117643867
FCD110862640
DPXDAPPUDRAFT_45346
DMK116932575 123476919
PVM113820314
PJA122254991
PCHN125036397
HAME121855707
PCLA123759656
PTRU123510419
HAZT108681745
EAF111700202
LSM121126814
PPOI119104615
ISCIscW_ISCW022171
DSV119436395
RMP119162362
VDE111245845
VJA111267853
TUT107366463
DPTE113797206
DFR124496979
CSCU111617375 111620797 111622737 111623493 111623495 111623912 111624353 111624972 111624987 111625007 111625354 111625365 111625375 111625394 111637170 111641253
PTEP107445027
SDM118183671
CELCELE_CHA-1(cha-1)
CBRCBG_08305(Cbr-cha-1)
BMYBM_BM7387(Bma-cha-1)
LOALOAG_12141
HROHELRODRAFT_84274
LGILOTGIDRAFT_107011
PCAN112572327
BGT106060968
GAE121379781
HRF124113721
HRJ124277725
CRG105343100
MYI110441481
PMAX117328266
MMER123564475
OBI106867711
LAK106155833
SMMSmp_146910
SHXMS3_00003817
OVIT265_06479
EGLEGR_03641
NVE5497657
EPA110245622
ATEN116293491 116300862
ACANACA1_069830
 » show all
Reference
1  [PMID:13115440]
  Authors
BERMAN R, WILSON IB, NACHMANSOHN D.
  Title
Choline acetylase specificity in relation to biological function.
  Journal
Biochim Biophys Acta 12:315-24 (1953)
DOI:10.1016/0006-3002(53)90150-4
Reference
2  [PMID:13799882]
  Authors
BERRY JF, WHITTAKER VP.
  Title
The acyl-group specificity of choline acetylase.
  Journal
Biochem J 73:447-58 (1959)
DOI:10.1042/bj0730447
Reference
3  [PMID:14299645]
  Authors
FRITZ IB, SCHULTZ SK.
  Title
CARNITINE ACETYLTRANSFERASE. II. INHIBIITON BY CARNITINE ANALOGUES AND BY SULFHYDRYL REAGENTS.
  Journal
J Biol Chem 240:2188-92 (1965)
Reference
4
  Authors
Schuberth, J.
  Title
Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction.
  Journal
Biochim Biophys Acta 122:470-481 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.6
IUBMB Enzyme Nomenclature: 2.3.1.6
ExPASy - ENZYME nomenclature database: 2.3.1.6
BRENDA, the Enzyme Database: 2.3.1.6
CAS: 9012-78-6

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