KEGG   ENZYME: 2.3.1.6Help
Entry
EC 2.3.1.6                  Enzyme                                 

Name
choline O-acetyltransferase;
choline acetylase;
choline acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:choline O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + choline = CoA + O-acetylcholine [RN:R01023]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
choline [CPD:C00114]
Product
CoA [CPD:C00010];
O-acetylcholine [CPD:C01996]
Comment
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.
History
EC 2.3.1.6 created 1961
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K00623  choline O-acetyltransferase
Genes
HSA: 1103(CHAT)
PTR: 450451(CHAT)
PPS: 100976056(CHAT)
GGO: 101129095(CHAT)
PON: 100444631(CHAT)
NLE: 100584675(CHAT)
MCC: 709977(CHAT)
MCF: 102146741(CHAT)
CSAB: 103215827(CHAT)
RRO: 104677712(CHAT)
RBB: 108537812(CHAT)
CJC: 100391258(CHAT)
SBQ: 101042797(CHAT)
MMU: 12647(Chat)
RNO: 290567(Chat)
CGE: 100756785(Chat)
NGI: 103735013(Chat)
HGL: 101711939(Chat)
CCAN: 109683982(Chat)
OCU: 100342226(CHAT)
TUP: 102490742(CHAT)
CFA: 486775(CHAT)
AML: 100475264(CHAT) 105240673
UMR: 103668061(CHAT)
ORO: 101377526(CHAT)
FCA: 751512(CHAT)
PTG: 102955228(CHAT)
AJU: 106989815(CHAT)
BTA: 524732(CHAT)
BOM: 102275818(CHAT)
BIU: 109553654(CHAT)
PHD: 102330683(CHAT)
CHX: 102182280(CHAT)
OAS: 101117817(CHAT)
SSC: 396896(CHAT)
CFR: 102512463(CHAT)
CDK: 105093435(CHAT)
BACU: 103017639(CHAT)
LVE: 103087947(CHAT)
OOR: 101288890(CHAT)
ECB: 100062632(CHAT)
EPZ: 103552164(CHAT)
EAI: 106824271(CHAT)
MYB: 102248169(CHAT) 102255670
MYD: 102773878(CHAT)
HAI: 109389479(CHAT)
RSS: 109446572(CHAT)
PALE: 102879671(CHAT)
LAV: 100662470(CHAT)
TMU: 101347293
MDO: 100019640(CHAT)
OAA: 100077991(CHAT)
GGA: 395314(CHAT)
MGP: 100543253(CHAT)
CJO: 107315570(CHAT)
APLA: 101793965(CHAT)
ACYG: 106032106(CHAT)
TGU: 100231848(CHAT)
GFR: 102039969(CHAT)
FAB: 101817021(CHAT)
PHI: 102110760(CHAT)
PMAJ: 107206533(CHAT)
CCAE: 111931590(CHAT)
CCW: 104690200(CHAT)
FPG: 101920651(CHAT)
FCH: 102047610(CHAT)
CLV: 102093477(CHAT)
EGZ: 104122701(CHAT)
AAM: 106499858(CHAT)
ASN: 102377196(CHAT)
AMJ: 102569949(CHAT)
PSS: 102449796(CHAT)
CMY: 102935845(CHAT)
CPIC: 101946401(CHAT)
ACS: 100558883(chat)
PVT: 110080700(CHAT)
GJA: 107124840(CHAT)
XLA: 108696296(chat.L) 108703349(chat.S)
XTR: 100485221(chat)
NPR: 108788608(CHAT)
DRE: 100170938(chata)
IPU: 108262900(chat) 108273528
AMEX: 103043285 103044316(chat)
XMA: 102218840 102227259(chat)
PRET: 103476855(chat) 103481435
NFU: 107375923(chat) 107387807
LCF: 108880384(chat) 108899013
SDU: 111219604 111235159(chat)
HCQ: 109509950 109523969(chat)
BPEC: 110159153(chat) 110166454
MALB: 109961990(chat) 109962946
OTW: 112239448
ELS: 105009941(chat)
SFM: 108939585(chat)
LCM: 102347699(CHAT)
CMK: 103181719(chat)
CIN: 445622(chat)
SPU: 574696(chat)
APLC: 110986841
SKO: 100369252
DME: Dmel_CG12345(ChAT)
DER: 6553866
DPE: 6588486
DSI: Dsimw501_GD19246(Dsim_GD19246)
DWI: 6650420
MDE: 101889931
AAG: 5573378
AME: 408934
BIM: 100746556
BTER: 100650308
AEC: 105143074
ACEP: 105623295
PBAR: 105427135
HST: 109504566
DQU: 106741916
CFO: 105252134
LHU: 105672719
PGC: 109853390
PCF: 106786480
NVI: 100121638
TCA: 664403
DPA: 109542904
BMOR: 101743075
PRAP: 111000844
HAW: 110378252
PXY: 105387875
API: 100159222
DNX: 107162847
CLEC: 106664013
FCD: 110862640
TUT: 107366463
CEL: CELE_cha-1(cha-1)
CBR: CBG08305(Cbr-cha-1)
BMY: Bm1_31295
CRG: 105343100
MYI: 110441481
OBI: 106867711
LAK: 106155833
SHX: MS3_08397
EGL: EGR_03641
 » show all
Taxonomy
Reference
1  [PMID:13115440]
  Authors
BERMAN R, WILSON IB, NACHMANSOHN D.
  Title
Choline acetylase specificity in relation to biological function.
  Journal
Biochim Biophys Acta 12:315-24 (1953)
DOI:10.1016/0006-3002(53)90150-4
Reference
2  [PMID:13799882]
  Authors
BERRY JF, WHITTAKER VP.
  Title
The acyl-group specificity of choline acetylase.
  Journal
Biochem J 73:447-58 (1959)
Reference
3  [PMID:14299645]
  Authors
FRITZ IB, SCHULTZ SK.
  Title
CARNITINE ACETYLTRANSFERASE. II. INHIBIITON BY CARNITINE ANALOGUES AND BY SULFHYDRYL REAGENTS.
  Journal
J Biol Chem 240:2188-92 (1965)
Reference
4
  Authors
Schuberth, J.
  Title
Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction.
  Journal
Biochim Biophys Acta 122:470-481 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.6
IUBMB Enzyme Nomenclature: 2.3.1.6
ExPASy - ENZYME nomenclature database: 2.3.1.6
BRENDA, the Enzyme Database: 2.3.1.6
CAS: 9012-78-6

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