KEGG ENZYME: 2.3.1.60

ENZYME: 2.3.1.60

Entry

EC 2.3.1.60                 Enzyme

Name

gentamicin 3-N-acetyltransferase;
gentamycin acetyltransferase I;
aminoglycoside acetyltransferase AAC(3)-1;
gentamycin 3-N-acetyltransferase;
acetyl-CoA:gentamycin-C N3-acetyltransferase;
acetyl-CoA:gentamicin-C N3'-acetyltransferase (incorrect);
gentamicin 3'-N-acetyltransferase (incorrect)

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:gentamicin-C N3-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + gentamicin C = CoA + N3-acetylgentamicin C [RN:R03767]

Reaction(KEGG)

R03767

Substrate

acetyl-CoA [CPD:C00024];
gentamicin C [CPD:C01918]

Product

CoA [CPD:C00010];
N3-acetylgentamicin C [CPD:C03297]

Comment

Also acetylates sisomicin.

History

EC 2.3.1.60 created 1976, modified 2015

Orthology

K03395

aminoglycoside 3-N-acetyltransferase I

Genes

ECLE:

ECNIH2_24920

KPZ:	KPNIH27_26715

CFD:	CFNIH1_26030

LEI:	C2U54_26560(aac(3)-I)

LEH:	C3F35_26175(aac(3)-I)

PANT:

PSNIH1_20595

PANP:

PSNIH2_21655

PSLP:

BHQ29_06840

PMY:

Pmen_3087

PTY:	JWV26_02365

PHF:	NLY38_07190

PCHE:

QYM18_23985

PAGR:

E2H98_08440(aac(3)-I)

HASM:

QAO71_07420

ABY:	ABAYE3573(aacC1)

ABN:	AB57_06370(aacC1)

ABX:

ABK1_1589

ABZ:	ABZJ_04725

ABR:	ABTJ_02576

ABD:	ABTW07_3898(aacC1)

CELL:

CBR65_15830

SDE:

Sde_1840

MKE:	OOT55_14350

MPIN:

LGT42_002625

THIM:

KFB96_17190

TGR:

Tgr7_1824

TKM:

TK90_1523

TTI:	THITH_16680

SHAI:

LMH63_09965

WEZ:	IC757_01785(aac(3)-I)

HCH:

HCH_06852

HAHH:

O5O45_07115

HALO:

BWR19_11225

HCAM:

I4484_09000

HAMC:

HNO52_05765

PAUR:

FGL86_11545(aac(3)-I)

ADI:

B5T_01209

AKA:	TKWG_00750

RHOA:

HZ993_23480(aac(3)-I)

VAP:	Vapar_6035

VPD:	VAPA_2c12490

VAE:	RZE79_31905

HYB:

Q5W_22495

HYN:	F9K07_00465(aac(3)-I)

HYY:	JNX00_00595

HYDR:

SOM08_00470

STHM:

IS481_17955(aac(3)-I)

PBH:	AAW51_5190

KIA:	G8A07_27110

PHT:	BLM14_01090

SMEG:

C770_GR4pA056

ABAW:

D5400_01570(aac(3)-I)

RBK:	E0H22_04355(aac(3)-I)

BOF:	FQV39_31035(aac(3)-I)

MEA:	Mex_1p4325

MDI:

METDI4935

MEX:

Mext_3943

MCH:

Mchl_4311

MZA:	B2G69_01610

METQ:

MSPGM_39380

METD:

C0214_21740(aac(3)-I)

METS:

DK389_24610(aac(3)-I)

METI:

DK427_18640(aac(3)-I)

MECL:

CLZ_19455(aac(3)-I)

MENI:

GU700_19460(aac(3)-I)

MOC:	BB934_22755

MTEZ:

HPT29_015965

HNI:	W911_17470

FIL:	BN1229_v1_2436

FIY:	BN1229_v1_3478

AUB:	LXB15_00630

TSV:	DSM104635_00059

PGA:	PGA1_c21930

PGL:	PGA2_c20850

PGD:

Gal_01206

PHP:	PhaeoP97_02161

PPIC:

PhaeoP14_02006

PHQ:	D1820_06420

MARU:

FIU81_12820

PDE:	Pden_3159 Pden_3355

PYE:	A6J80_10650(aac(3)-I)

PZH:	CX676_10170(aac(3)-I)

PMUT:

DPM13_08945(aac(3)-I)

PVER:

E3U25_11050(aac(3)-I)

LIT:	FPZ52_07035(aac(3)-I)

CACT:

HZ995_13520(aac(3)-I)

GABY:

AB6B38_07310

SAL:

Sala_0626

SPHP:

LH20_01610

SMAG:

AN936_15480

SPHQ:

BWQ93_19925

SPHX:

E5675_14415(aac(3)-I)

SPEG:

SPYCW_0711

SPFD:

SPYCA_2206

SPYF:

EAO27_12050(aac(3)-I)

SRHI:

H9L12_04890(aac(3)-I)

SSED:

H9L14_08585

SPAI:

FPZ24_04025(aac(3)-I)

SSAU:

H8M03_11195(aac(3)-I)

SSUA:

FPZ54_17545(aac(3)-I)

SGLC:

M1K48_13045

SRAD:

LLW23_07685

SBD:	ATN00_16835

SPHB:

EP837_02353

PARJ:

J4G78_16045

PHAO:

HF685_12040(aac(3)-I)

SMIC:

SmB9_13380

SFLV:

IC614_04005

SAND:

H3309_12420

ALH:	G6N82_10180

AMX:	AM2010_1970

PMAS:

NCF86_10875

ADO:	A6F68_02429

ERF:	FIU90_00630

ERYT:

KDC96_14665

PORC:

CBR61_00170

CAEN:

K5X80_15615

AFLV:

QQW98_08160

SHUM:

STHU_26160

ECOG:

FIV45_17670(aac(3)-I)

MYM:	A176_003294

AGE:	AA314_08409

MRM:	A7982_04191 A7982_08521

TIM:	GMBLW1_41980

HPRI:

P0082_11175

LBI:	LEPBI_I0207

LBF:

LBF_0202

LMIL:

AB3N58_00935

LIOW:

AB3N60_01005

LMGO:

AB3N62_01005

TPX:	Turpa_0921

GPH:	GEMMAAP_00630

CBAE:

COR50_00475

CHIT:

FW415_00155

CHOR:

MKQ68_12600

NIA:	A8C56_20380

PHE:

Phep_2612

SHG:	Sph21_2136

OLI:	FKG96_07610

CHU:

CHU_0641

SMON:

AWR27_00890

RHOZ:

GXP67_18375

ALS:	DJ013_05135

RUN:	DR864_26475 DR864_29240

ADD:	HUW48_20795

ASWU:

HUW51_18380

MTT:	Ftrac_3599

FBT:	D770_22710

FUA:	LVD17_19820

PRHO:

PZB74_13800

TPEL:

P0M28_04020

COC:

Coch_0210

CSTO:

CGC58_08185

MOD:	AS202_15290 AS202_15580 AS202_20065

FLG:	LV716_06705

SPON:

HME9304_01693

CTAK:

4412677_00734

FLU:	CHH17_15920

CRM:	K6119_05430

CPSS:

M5V91_05315

SFOR:

QNH23_11900 QNH23_11960

AHAL:

FTX54_002475

GMO:	NCTC11323_01623

PLW:	D5F53_14260

COH:	EAV92_07810

PRT:	AUC31_05320

PLX:	CW734_06150

ACAE:

HYG86_05020

SGZ:	C0216_25990

SUBT:

KPL76_14065

ARW:	MB46_05265

PSEY:

GU243_03385

PPC:	HMPREF9154_1783

NANO:

G5V58_09845

CAI:

Caci_6551

SYNE:

Syn6312_0967

CGC:	Cyagr_0740 Cyagr_2371

CMP:	Cha6605_1569 Cha6605_2143

LBO:	LBWT_36680

LEPI:

EDM05_016970

SFRI:

RBJ76_17830

HHG:	XM38_051250(aacC1)

PSER:

ABRG53_4276

GLP:	Glo7428_0873

LEP:	Lepto7376_3261

SYNN:

NIES970_07190

CSAU:

ACL6C3_14265

OAC:	Oscil6304_2225

NSH:

GXM_08809

NOST:

GJB62_32920

TTQ:	NIES37_69840

ALAX:

NIES50_67390

DFO:	Dform_01321(aac3-I)

DETH:

HX448_08075(aac(3)-I)

MEME:

HYG87_00730

MRID:

FGU46_10095

» show all

Reference

1 [PMID:6281224]

Authors

Angelatou F, Litsas SB, Kontomichalou P.

Title

Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa.

Journal

J Antibiot (Tokyo) 35:235-44 (1982)
DOI:10.7164/antibiotics.35.235

Reference

2 [PMID:820250]

Authors

Biddlecome S, Haas M, Davies J, Miller GH, Rane DF, Daniels PJ.

Title

Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.

Journal

Antimicrob Agents Chemother 9:951-5 (1976)
DOI:10.1128/aac.9.6.951

Reference

3 [PMID:764855]

Authors

Williams JW, Northrop DB.

Title

Purification and properties of gentamicin acetyltransferase I.

Journal

Biochemistry 15:125-31 (1976)
DOI:10.1021/bi00646a019

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.60

IUBMB Enzyme Nomenclature:

2.3.1.60

ExPASy - ENZYME nomenclature database:

2.3.1.60

BRENDA, the Enzyme Database:

2.3.1.60

CAS:	58500-58-6

All links

Gene (393)   
   MGENES (376)   
   RefGene (17)   
Protein sequence (52)   
   UniProt (51)   
   SWISS-PROT (1)   
DNA sequence (86)   
   GenBank (44)   
   EMBL (42)   
Protein domain (2)   
   InterPro (2)   
All databases (533)   

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