KEGG   ENZYME: 2.3.1.80
Entry
EC 2.3.1.80                 Enzyme                                 
Name
cysteine-S-conjugate N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:S-substituted L-cysteine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an L-cysteine-S-conjugate = CoA + an N-acetyl-L-cysteine-S-conjugate [RN:R04950]
Reaction(KEGG)
R04950
Substrate
acetyl-CoA [CPD:C00024];
L-cysteine-S-conjugate [CPD:C02882]
Product
CoA [CPD:C00010];
N-acetyl-L-cysteine-S-conjugate
Comment
S-Benzyl-L-cysteine and, in decreasing order of activity, S-butyl-L-cysteine, S-propyl-L-cysteine, O-benzyl-L-serine and S-ethyl-L-cysteine, can act as acceptors.
History
EC 2.3.1.80 created 1984
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K20838  N-acetyltransferase 8
Genes
HSA9027(NAT8)
PTR470406(NAT8) 739241(NAT8B)
PPS100967484(NAT8) 100971190
GGO101133830 109025735(NAT8)
PON100173062(NAT8) 100435458 100436198
NLE100606331 100606676
HMH116484090(NAT8)
MCC706820(NAT8)
MCF102119614(NAT8)
MTHB126934068
MNI105465271(NAT8)
CSAB103220050
CATY105576587
PANU101009924(NAT8)
TGE112604608(NAT8)
MLEU105540169
RRO104661367(NAT8)
RBB108532437(NAT8)
TFN117062027(NAT8)
PTEH111550503(NAT8)
CANG105514053
CJC100394433 100407076
SBQ101032039(NAT8)
CIMI108299588 108299596
CSYR103270032(NAT8)
MMUR105866750 105884612
LCAT123637054(NAT8) 123637055
PCOQ105812074 105821475
OGA100948530 100949350 111721719
MMU100043497(Nat8f7) 100504710(Nat8f6) 66116(Nat8f1) 68396(Nat8) 69049(Nat8f5) 93673(Nat8f2) 93674(Nat8f3)
MCAL110296074 110296552 110296554 110296685 110296691
MPAH110316573 110316574(Nat8) 110317018 110317030 110317113 110317171
RNO102549803(Nat8f4) 113892(Nat8f3) 114020(Nat8f5) 500237(Nat8f2) 59300(Nat8f1) 64570(Nat8)
MCOC116098219(Nat8) 116098220 116098221 116099166 116099167 116099169 116099949
ANU117715170 117715418 117715419 117715420 117715455 117715464
MUN110547154 110547165 110547168 110547169 110547171 110547186
CGE100767690 100767982 100771416 100771708 113837001 113837005 113837015 113837953
MAUA101829072 101829335 101829882 101835612 101837324 121136634 121136636
PROB127235527(Nat8) 127235534 127235540 127235552 127235568
PLEU114685558 114685560 114688544 114688545 114688549 114688551
MORG121435510 121435534 121440077 121441282 121441537 121465738
MFOT126496580 126515321 126515323 126515325 126515328 126515331
AAMP119806382 119806383 119806384 119808025 119808026 119808027
NGI103749950(Nat8b)
HGL101720890
CPOC100714111 100714389 100714665 100714943 100715229
CCAN109679392 109679393 109692614 109699979 109702888 109702890 109702891
DORD106000492 106000493 106000497 106000498 106000499 106000512
DSP122125133 122125135 122125153 122125159
PLOP125355966 125356342 125356343 125356345
NCAR124962937 124962938 124962939 124962940 124963647
MMMA107134923 107134924 107135121 107136962 107137080 107137081 107137165 107137168
OCU100352648 100352904
OPI101516522(NAT8)
TUP102482811(NAT8)
GVR103589248
CFA100856478(NAT8)
CLUD112664220(NAT8)
VVP112916821(NAT8)
VLG121491024(NAT8)
NPO129501450(NAT8)
AML100481005(NAT8)
UMR103671389(NAT8)
UAH113243903(NAT8)
UAR123786058(NAT8)
ELK111148203
LLV125109058
MPUF101692477(NAT8B)
MNP132022508(NAT8)
MLK131808059(NAT8)
NVS122914989(NAT8)
ORO101363205(NAT8B)
EJU114218970(NAT8)
ZCA113937264(NAT8)
MLX118007970(NAT8)
NSU110588834(NAT8)
LWW102725855(NAT8)
FCA101098621(NAT8)
PYU121019250(NAT8)
PCOO112869680(NAT8)
PBG122497015(NAT8)
LRUF124503932
PTG102957307(NAT8B)
PPAD109262891(NAT8)
PUC125936331
AJU106967787
HHV120237022(NAT8)
BTA101902604(NAT8)
BOM102278525(NAT8)
BIU109565932(NAT8)
BBUB102392037(NAT8)
BBIS104980907
CHX102181787(NAT8)
OAS101104899(NAT8)
BTAX128056835(NAT8)
ODA120851256(NAT8)
CCAD122441406(NAT8)
MBEZ129540078(NAT8)
SSC100516363(NAT8)
CFR102507921(NAT8) 116669040
CBAI105078088 105082464
CDK105085749 116157529
VPC102532352(NAT8)
BACU103001786(NAT8) 103011589(NAT8B)
OOR101283003
DLE111167883(NAT8)
PCAD112067510(NAT8)
PSIU116764085(NAT8)
NASI112412336(NAT8)
ECB100058571 100058847
EPZ103542782
EAI106828286 106828287(NAT8)
MYB102238886(NAT8B) 102258540 102264232(NAT8)
MYD102759258 102760011 102772700
MMYO118668852(TPRKB) 118668853 118674545
MLF102421789 102426829
PKL118717542 118717543
EFUS103284800 129147002 129147003
MNA107529202 107529203 107537368
DRO112303117(NAT8)
SHON118988517(NAT8)
AJM119038406(NAT8)
PDIC114500389(NAT8) 114500391
PHAS123811987(NAT8)
MMF118630912(NAT8)
PPAM129086796(NAT8)
HAI109371189 109371193
RFQ117032749(NAT8)
PALE102895046 102895288 102896662
PGIG120594618(NAT8) 120611045
PVP105290779(NAT8) 105311326
RAY107502947
MJV108389752(NAT8)
TOD119238577 119259071 119259860
SARA101550682 101550950
LAV100669016 100669295 100669579
TMU101353867
ETF101654648(NAT8)
MDO100021822 100022265 100022287 100022311 100022341 100022462 100027946 103094600
GAS123233125 123234509 123234510 123234514 123234515 123242189 123251307
SHR100927631 100933401 100935099 105749210(NAT8)
AFZ127539996 127547363 127547368 127547369 127553357
PCW110218372 110218391 110218393(NAT8) 110218423 110221068 110223576
OAA100076893(NAT8) 100083900 100086348 100091934 114805410
GGA107056278 429762(NAT8) 776932(NAT8B)
PCOC116225638 116225639 116241588
MGP104916712
CJO107306852 107306853 107306860
TPAI128072965 128072966
LMUT125691849 125691850
NMEL110390949 110390950 110390953
ACYG125180668 125180669
CATA118260592 118260593
TGU115494848(NAT8)
LSR110469863(NAT8)
PMOA120509254(NAT8)
OTC121335083(NAT8)
PRUF121356940(NAT8)
OMA130252111(NAT8)
PHI102103115
PMAJ107199384(NAT8)
ETL114070483
SVG106853121
MMEA130586300(NAT8)
HRT120748361(NAT8)
FPG101923652 101923830
FCH102052756 102052929
CLV110365702
NNI104011623 104011626
AFOR103905799(NAT8)
ACHC115338093 115338094
HLE104832357 104832358
AGEN126051712 126051723
SHAB115610597 115610598
DPUB104308800
RTD128910087(NAT8)
TEO104382294
AAM106485319
ASN102374866 102375188
AMJ102570938 102572312
PSS102454462 102460069
CMY102930433 102947988(NAT8)
CCAY125635184
DCC119854481 119855204 119855702
CPIC101931009 101931016 101932235 101935729 101935906 101940281 101941653 101944101 101946392 101946587 101953511 101953710
TST117870377 117870378
CABI116829277(NAT8) 116829278
MRV120406350 120406354 120406356 120406357
ACS100565860 100566062 103281262
ASAO132777116 132777117 132777118
PVT110086606 110086612 110086613
SUND121931876(NAT8) 121931877
PBI103050100 103053349
PMUR107287842 107287863
CTIG120319721 120319726
TSR106545778 106555384
APRI131203028(NAT8)
PTEX113452539 113452862 113453793 113453794
NSS113427796 113427798 113432297 113432306
VKO123022809 123023014 123023015
PMUA114604315 114604606(NAT8)
PRAF128420536(NAT8) 128420537
ZVI118077537 118077548
HCG128326397 128328322 128328458
GJA107115846 107125475
STOW125440179 125440180 125440181
EMC129336464 129336803
XLA108696285(nat8.1.L) 108696290(nat8.2.L) 108697419(nat8.5.L) 108705738(nat8.7.S) 108719400(nat8.3.L) 108719408(nat8.6.L) 373623(nat8.6.S) 414583(nat8.1.S)
XTR100124951(nat8.1) 100145252(nat8.7) 100489204(nat8.2) 100489358(nat8.3) 100489520(nat8.5) 100489681 100489847(nat8.9) 101731538(nat8.6) 493291(nat8.4)
NPR108796050 108796051 108796057 108796941 108796942 108796943 108796955 108796956 108798959 108798962 108798963
RTEM120917942 120924304 120924316 120924336 120924478 120924504 120924516 120924523 120924575 120924588 120924605 120924614 120924770 120924771 120924772 120924774 120924775 120924776
BBUF120982821 120982822 120990545 120990548 120990549 120990551 120991106 120991107 120991854 120991855 120991858 120991859 120991860
BGAR122924386 122933993 122934015 122934025 122934036 122934054 122934069 122934080 122934093 122934128
MUO115461243 115461244
GSH117364626 117364633 117364641
DRE100002956(si:ch211-195e19.1) 100004652(nat8l2)
SRX107733671 107733716 107744405 107747598 107758781
SANH107664162 107666411 107666562 107667058 107696411
SGH107560502 107562255 107580815 107585290 107587650 107587914
CCAR109048520 109057670 109069999 109070000 109084742 109086990 109087021
CAUA113051076 113051077 113057103 113065360 113076083 113078344 113078346 113112814
CGIB127969742 128016029 128016031 128026325
PTET122346403(nat8l2) 122357046(nat8)
LROH127166426 127166427 127174762(nat8)
OMC131542460(nat8l2) 131552183(nat8)
PPRM120479462(nat8) 120493384(nat8l2)
RKG130102893(nat8) 130104156(nat8l2)
MAMB125273353(nat8l2) 125276750 125276751(nat8)
CIDE127514897 127525391
MASI127412326 127413960 127446027
TROS130557061(nat8l2) 130558944(nat8)
TDW130424850(nat8l2) 130424911 130431797(nat8)
MANU129415900(nat8) 129449884 129450637 129450638 129450639 129450878
IPU100528621(cmlo) 108271756(nat8l2)
IFU128605446 128614909(nat8l2)
PHYP113537203 113543984
SMEO124377245(nat8) 124393567(nat8l2) 124401823
TFD113642683(nat8l2) 113644995(nat8)
TVC132843975(nat8l2) 132847157(nat8)
AMEX103027576 103035650 103037014 103037654 103041541 111193667 111193668
CMAO118807572 118807639 118808507 118810247 118810251
EEE113571638 113585848 113585855
CHAR105899616(nat8) 105906356 105907821(nat8l2)
TRU101061992 101068639 101071337(nat8) 101077733 105418616
TFS130513325(nat8) 130524397 130524398 130524400 130524401 130524402 130530099
TNGGSTEN00038389G001
LCO104923878 104932474(nat8) 104935383
NCC104950447 104952185 104952196 104962577
TBEN117483385 117489794(nat8l2) 117493881 117493886
CGOB115007748 115011241 115027023(nat8)
PGEO117446249 117449210 117467512 117468201
GACU117537344 117539573(nat8l2) 117550054 117558812 117558814
EMAC134870815 134881574 134881575 134882414(nat8l2)
ELY117256715 117257323 117257433 117258832 117266763
EFO125880609 125891875 125900880
PLEP121946499 121950294 121955196 121955213 121963702(nat8)
SLUC116043752 116051432 116057583(nat8) 118492926
ECRA117935776(nat8) 117943980 117943982 117948297
ESP116686114(nat8) 116688076 116688079 116693066
PFLV114546333(nat8) 114554526 114554838
GAT120828685 120833091(nat8) 120835658(nat8l2)
PPUG119194184(nat8l2) 119222708 119227272
AFB129100419 129103849 129106273(nat8l2)
CLUM117725244(nat8) 117731303(nat8l2) 117733147
PSWI130200075 130201828(nat8) 130208941(nat8l2)
MSAM119886117(nat8l2) 119905082 119910379
SCHU122861852(nat8) 122883485 122884840(nat8l2)
CUD121517538 121525780 121525781 121528410(nat8l2)
ALAT119005023(nat8) 119020938 119020941 119020942 119022272
MZE101465996(nat8) 101475129 101486240 106676491 112429980 112429981 112434796 112434827 112434830
ONL100691576 100693555 100694594(nat8) 100703402 109202228 109202229
OAU116315189(nat8) 116319325 116319467 116319474 116321972
OLA101159785 101160033 101160718 101173140 101173383 101173914
OML112145217 112145245 112145690(nat8l2) 112159627
CSAI133449288(nat8l2) 133456241 133462069 133462399
XMA102216856 102222280 102225553 102228442
XCO114133745 114134804 114134960 114140321
XHE116708613 116708614 116719670
PRET103458191 103458195 103464674 103467845
PFOR103134572 103150063 103150064 103150962
PLAI106952056 106952057 106960248 106962796
PMEI106912905 106919286 106919301 106932893
GAF122833041 122834765(nat8l2) 122846155 122846157
PPRL129372782(nat8l2) 129377192 129377367 129377445
CVG107083706 107096798 107096799 107097103
CTUL119777220 119779708 119779709 119788653(nat8l2)
GMU124855153(nat8) 124855633 124875078
NFU107385408 107390441 107391881 107391882
KMR108229320(nat8) 108237615
ALIM106527420 106536673 106536674 106536675
NWH119416705 119427278(nat8)
AOCE111566213 111578760 111578761 111579626 111579628
MCEP124998381 125007415(nat8l2) 125023178(nat8)
CSEM103381413 103381421 103385248 103386735
POV109635574 109636400 109640482
SSEN122767715(nat8l2) 122777586 122783219(nat8)
HHIP117756335(nat8) 117761448(nat8l2) 117764580
HSP118105071(nat8l2) 118111282 118116809
SMAU118285828 118316822
LCF108873565(nat8l2) 108876605 108892940
SDU111225478 111233597 111234875
SLAL111644242 111660675 111672808(nat8)
XGL120783050(nat8l2) 120795010 120804435
HCQ109513340 109528151
SSCV125981287 125989035
SBIA133495288 133513128
PEE133412346 133413418
PTAO133474620 133487378
BPEC110154604 110157443 110171160 110171190
MALB109962441(nat8) 109970779 109971435
BSPL114848064(nat8) 114856116(nat8l2) 114859234
SJO128354909(nat8l2) 128357229 128375256
SASA106567325 106572644 106583684 106591868 106607815
STRU115150085 115161846(nat8) 115168810 115173041
OTW112221405 112226697(nat8) 112255536(nat8l2) 112256967 121846867
OMY110492903 110498316(nat8) 110505940 110528564(nat8l2)
OGO124001187 124018552(nat8l2) 124045143 124046829(nat8)
ONE115101688 115120942
OKI109869680 109885472 109885473(nat8) 109890304
OKE118359487 118373225(nat8l2) 118376168 118402427
SALP111970525 111977091 112074940
SNH120023112 120060110 120061125 120064658(nat8l2)
CCLU121544218 121545290 121546734 121577965(nat8l2)
ELS105013642 105015843(nat8) 105016676
SFM108930887 108935794 108936586
PKI111835899 111845766 111845802 111845803 111853952
AANG118210912 118227525 118231241
LOC102685310
PSPA121294220 121302749
ARUT117408398 117420953 117421097
PSEX120527924(nat8) 120528651
LCM102349209 102349485 102349767 102351352 102360089
RTP109916921 109919252
CPLA122546044 122546618(nat8)
HOC132813312 132813314 132820068(nat8) 132824846
LERI129694188 129715937 129716276
LRJ133348929
BFO118417186 118419854 118427483
BBEL109464417 109471269 109473416 109473417
SCLV120339126
SKO102801948 102804750 102807544
LDC111513548
PJA122251805 122261856
HAME121865169
HAZT108672794
EAF111714301
LSM121119190
TCF131892700
BGT106072930
HRF124136965
OBI106868182
LAK106159074 106159075 106159098 106174736 112042394
NVE5507724 5507725
EPA110234338
ATEN116293235 116307908 116307913
ADF107355193
AMIL114947431 114968931
PDAM113664653 113673068 113673069 113673081 113673086 113673088 113677701 113677707
SPIS111333733 111333875 111333876 111333883 111333889 111333899 111337850 111346407
LBCLACBIDRAFT_293252 LACBIDRAFT_315392
CCICC1G_12505
MRRMoror_15052
MOREE1B28_005684 E1B28_005685 E1B28_005701 E1B28_006773 E1B28_009367
ACANACA1_044750
TETTTHERM_00304180
PSOJPHYSODRAFT_375526
 » show all
Reference
1  [PMID:6892478]
  Authors
Duffel MW, Jakoby WB.
  Title
Cysteine S-conjugate N-acetyltransferase from rat kidney microsomes.
  Journal
Mol Pharmacol 21:444-8 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.80
IUBMB Enzyme Nomenclature: 2.3.1.80
ExPASy - ENZYME nomenclature database: 2.3.1.80
BRENDA, the Enzyme Database: 2.3.1.80
CAS: 81725-80-6

DBGET integrated database retrieval system