KEGG   ENZYME: 2.3.1.81Help
Entry
EC 2.3.1.81                 Enzyme                                 

Name
aminoglycoside 3-N-acetyltransferase;
3-aminoglycoside acetyltransferase;
3-N-aminoglycoside acetyltransferase;
aminoglycoside N3-acetyltransferase;
acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase (incorrect);
aminoglycoside N3'-acetyltransferase (incorrect)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:2-deoxystreptamine-antibiotic N3-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic [RN:R04348]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
2-deoxystreptamine antibiotic [CPD:C03922]
Product
CoA [CPD:C00010];
N3-acetyl-2-deoxystreptamine antibiotic [CPD:C04504]
Comment
Different from EC 2.3.1.60 gentamicin 3-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin.
History
EC 2.3.1.81 created 1984, modified 2015
Orthology
K00662  aminoglycoside 3-N-acetyltransferase
K19275  aminoglycoside 3-N-acetyltransferase II
K19276  aminoglycoside 3-N-acetyltransferase IV
K19277  aminoglycoside 3-N-acetyltransferase VI
Genes
ECV: APECO1_O1R90(aac3-VI)
SEM: STMDT12_L00560
SENH: CFSAN002069_23190
SEEH: SEEH1578_00390
SEE: SNSL254_p_0145(aacC)
KPM: KPHS_p300760
KPH: KPNIH24_26565
KPNE: KU54_01075
KOE: A225_1935 A225_R1p0530
CFAR: CI104_26755
XNE: XNC1_3140
XNM: XNC2_3020
PRG: RB151_017470(yokD)
ABAU: IX87_12745
LLG: 44548918_00186(yokD)
AHA: AHA_4186
ASA: ASA_0140
ACAV: VI35_00690
CTI: RALTA_B1716(aacC2)
CGD: CR3_2924(aacC)
BGO: BM43_2030(yokD)
AXX: ERS451415_00991(yokD)
RTA: Rta_21470
CJE: Cj1298
CJU: C8J_1239
CJM: CJM1_1278
CJER: H730_07430
CJQ: UC78_1248
CJR: CJE1488
CFZ: CSG_16000
CCQ: N149_1258
CCY: YSS_07040
CCOF: VC76_06505
CIS: CINS_1264
CHYO: CHH_1505
CSPF: CSF_1289
CCUN: CCUN_0614
CCX: COCOR_05937(aacC)
SUR: STAUR_8370(aacC)
HOH: Hoch_4195
SME: SMc02813(aacC)
SMX: SM11_chr0969(aacC)
SMI: BN406_02113(aacC4) BN406_03656(aacC3)
SMEL: SM2011_c02813(aacC)
SMER: DU99_12805
SMD: Smed_2214
RET: RHE_CH01086(aacC1)
REC: RHECIAT_CH0001181(aacC)
REL: REMIM1_CH01107(aacC)
REP: IE4803_CH01119(aacC)
REI: IE4771_CH01171(aacC)
RLE: RL1183(aacC)
RHN: AMJ98_CH01107(aacC)
RPHA: AMC79_CH01119(aacC)
RHX: AMK02_CH01128(aacC)
RHK: Kim5_CH01236(aacC)
REZ: AMJ99_CH01186(aacC)
BRS: S23_22540
MNO: Mnod_5177
PHL: KKY_650
MCG: GL4_2196
KVL: KVU_0834(aacC)
SSAN: NX02_26590
SPHF: DM480_17860(aac(3))
BLAS: BSY18_1223
GOX: GOX0638
GOH: B932_0729
NCB: C0V82_09610(aac(3))
BSU: BSU21630(yokD)
BSH: BSU6051_21630(yokD)
BSUT: BSUB_02327(yokD)
BSUL: BSUA_02327(yokD)
BSQ: B657_21630(yokD)
BAN: BA_2930(aacC7)
BAR: GBAA_2930(aacC7)
BAT: BAS2722
BAH: BAMEG_1674(aacC7)
BAI: BAA_2984(aacC7)
BANT: A16_29560
BANR: A16R_30010
BANS: BAPAT_2809
BANV: DJ46_1695(yokD)
BCE: BC2919
BCA: BCE_2969(aacC7)
BCZ: BCE33L2651(yokD)
BCR: BCAH187_A2976(aacC7)
BCB: BCB4264_A2939(aacC7)
BCU: BCAH820_2929(aacC7)
BCG: BCG9842_B2306(aacC7)
BCQ: BCQ_2761(yokD)
BCX: BCA_3002(aacC7)
BAL: BACI_c28860(yokD)
BNC: BCN_2786
BCF: bcf_14295
BCER: BCK_20230
BTK: BT9727_2673(yokD)
BTL: BALH_2620
BTB: BMB171_C2626(aacC7)
BTT: HD73_3050
BTHI: BTK_15115
BTC: CT43_CH2918(aacC7)
BTM: MC28_2112
BTG: BTB_c30450(yokD)
BTI: BTG_04750
BTW: BF38_4087(yokD)
BWW: bwei_2105(yokD)
BMYO: BG05_3097(yokD)
BMYC: DJ92_14(yokD)
BPU: BPUM_0309
BPUM: BW16_01940
BPUS: UP12_01945
BMD: BMD_3116
BMH: BMWSH_2085(yokD)
BMEG: BG04_25(yokD)
BAG: Bcoa_0608
BCOA: BF29_3088(yokD)
BACW: QR42_01900
BACO: OXB_0813
BACL: BS34A_23850(yokD)
BBEV: BBEV_2934
BSE: Bsel_0397
LMO: lmo1708
LMOE: BN418_2042
LMOB: BN419_2047
LMOD: LMON_1775
LMOW: AX10_02755
LMOQ: LM6179_2466(yokD)
LMR: LMR479A_1812(yokD)
LMOM: IJ09_01315
LMOG: BN389_17360(yokD)
LMP: MUO_08785
LMOX: AX24_06245
LMQ: LMM7_1798
LMS: LMLG_1533
LMOK: CQ02_08875
LIN: lin1820
LWE: lwe1728
LSG: lse_1676
LIV: LIV_1684
ESI: Exig_1207
EAN: Eab7_1163
PPY: PPE_03865
PPM: PPSC2_20310(yokD)
PPO: PPM_4069(yokD)
PPOL: X809_36445
PPOY: RE92_16885
PSWU: SY83_12745
LLC: LACR_D33
SIE: SCIM_1412
SANG: SAIN_1591
SCG: SCI_0098
SCON: SCRE_0078
SCOS: SCR2_0078
LJO: LJ_1212
LJH: LJP_0949c
LAC: LBA0034
LAD: LA14_0033
LAF: SD55_0034
LBR: LVIS_0098
LGA: LGAS_1039
LHE: lhv_0617
LHD: HUO_09060
LAM: LA2_00180
CML: BN424_2485(yokD)
JDA: BW727_101692(yokD)
CAC: CA_C2197
CAE: SMB_G2230
CAY: CEA_G2211
CBE: Cbei_4839
CBZ: Cbs_4839
CBEI: LF65_05388
CBV: U729_1506(yokD)
HSC: HVS_04470
FPA: FPR_05070
BFI: CIY_27620
CPY: Cphy_3617
HSD: SD1D_1366
EUC: EC1_13460
ABRA: BN85310540
SCO: SCO1927(SCC22.09)
SALB: XNR_4876
SMA: SAVERM_5714(aac2)
SHY: SHJG_3375
SDV: BN159_6563(yokD)
SALS: SLNWT_2860
SFI: SFUL_837
STRM: M444_09040
SAMB: SAM23877_1998(yokD)
SRN: A4G23_05115(yokD)
STRD: NI25_29560
SLAU: SLA_0138
SALF: SMD44_02081(aacC)
SALJ: SMD11_0424(aacC)
SLX: SLAV_28755(yokD)
SFK: KY5_1848
KSK: KSE_44730
BCV: Bcav_0391
XCE: Xcel_0724
CFI: Celf_2310
MPH: MLP_08460
NDA: Ndas_3033
NAL: B005_5600(yokD)
NML: Namu_0547
SEN: SACE_3604(aacC1)
SAQ: Sare_2653
ASE: ACPL_1492(yokD) ACPL_3641(yokD)
CAI: Caci_0513
HHG: XM38_036710(yokD)
AMR: AM1_3129(aacC) AM1_A0084(aacC3) AM1_B0404(aacC3)
GVI: gll0484
ANA: alr1528
DFO: Dform_00555(aacC)
PBF: CFX0092_B0354(yokD)
DGE: Dgeo_1202
DGO: DGo_CA1037(aacC)
PUV: PUV_07730
ABAS: ACPOL_2011
ABAC: LuPra_05894(yokD)
GBA: J421_1089
PGI: PG_0113
IAL: IALB_1029
DTN: DTL3_1735
RCI: RCIX166(aacC)
HALH: HTSR_1673
HHSR: HSR6_1741
HMA: rrnAC1974(aacC)
HVO: HVO_1318(aacC)
HME: HFX_1385(yokD)
NMG: Nmag_3405(aacC)
NMR: Nmar_0144
LOKI: Lokiarch_04250(yokD_1) Lokiarch_53270(yokD_2)
 » show all
Taxonomy
Reference
1  [PMID:356726]
  Authors
Davies J, O'Connor S.
  Title
Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin.
  Journal
Antimicrob Agents Chemother 14:69-72 (1978)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.81
IUBMB Enzyme Nomenclature: 2.3.1.81
ExPASy - ENZYME nomenclature database: 2.3.1.81
BRENDA, the Enzyme Database: 2.3.1.81
CAS: 60120-42-5

DBGET integrated database retrieval system