Entry
Name
aminoglycoside 6'-N-acetyltransferase;
aminoglycoside N6'-acetyltransferase;
aminoglycoside-6'-acetyltransferase;
aminoglycoside-6-N-acetyltransferase;
kanamycin acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:kanamycin-B N6'-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + kanamycin-B = CoA + N6'-acetylkanamycin-B [RN:
R01889 ]
Reaction(KEGG)
Substrate
Product
Comment
The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2 and sisomicin are substrates. The antibiotic tobramycin, but not paromomycin, can also act as acceptor. The 6-amino group of the purpurosamine ring is acetylated.
History
EC 2.3.1.82 created 1976 as EC 2.3.1.55, transferred 1999 to EC 2.3.1.82, modified 1999, modified 2015
Orthology
K00663 aminoglycoside 6'-N-acetyltransferase
K18815 aminoglycoside 6'-N-acetyltransferase I
K18816 aminoglycoside 6'-N-acetyltransferase I
K19278 aminoglycoside 6'-N-acetyltransferase Ib
K19301 aminoglycoside 6'-N-acetyltransferase II
K19883 bifunctional aminoglycoside 6'-N-acetyltransferase / aminoglycoside 2''-phosphotransferase
Genes
ECOS : EC958_A0125(aac(6')-Ib-cr)
SALZ : EOS98_11285(aac(6'))
EAX : AAHF05_23720(aac(6')-IIc)
KPH : KPNIH24_26780 KPNIH24_27070
KPY : KPNIH31_06350 KPNIH31_25940 KPNIH31_26530
KPG : KPNIH32_24370 KPNIH32_27925 KPNIH32_29460
KPA : KPNJ1_05670 KPNJ1_05818
KPX : PMK1_ndm00058(aacA4)
KPB : FH42_25800 FH42_26835
KPNE : KU54_00850 KU54_01300
KPNU : LI86_27905 LI86_28350
KOC : AB185_02710 AB185_03250
CFAR : CI104_19120(aacA4) CI104_25585(aacA4) CI104_26865(aacA4)
KAS : KATP_49760(aac(6)-IIc)
METY : MRY16398_p20050(aacA4'-3)
PVJ : LMA04_22005 LMA04_22210(aac(6')-IIc)
YMO : HRD69_15950(aac(6'))
SURI : J0X03_02775(aac(6'))
SNEM : NLX84_21845(aac(6'))
SNEV : OI978_09525(aac(6')) OI978_28375
SSAR : SSARUM_004168(aac(6'))
SERB : QEP77_00920(aac(6'))
PAY : PAU_02905(aac(6')-Ic)
PRQ : CYG50_00325 CYG50_00720(aac(6')-Ib) CYG50_12870
PVC : G3341_06790 G3341_20155
SPAQ : STNY_R32040(aac(6')-Iak)
PMEX : H4W19_04350 H4W19_09080
LAQ : GLA29479_741(aac(6')-Iy)
PNC : NCGM2_1758(aac(6')-Iae)
PAEB : NCGM1900_1411(aac(6')1b) NCGM1900_3684(aac(6')1b) NCGM1900_3707(aacA7)
PTRL : OU419_14235 OU419_22280
PBAU : OS670_08345 OS670_12140 OS670_20930 OS670_21295(aac(6')-Ib)
ADV : DJ533_01155(aac(6')-Ib)
ADS : FPL17_00505(aac(6')-I)
AGYL : FPL18_11915(aac(6')-I)
APRL : PY247_00340(aac(6')-I) PY247_21705
ACOI : NQU59_08250(aac(6')-I)
AVIV : LF296_13855(aac(6')-I)
ASUE : F2A31_10710(aac(6')-I)
MORA : NGM44_03975(aph(2'')-If)
LCJ : NCTC11976_01989(aacA-aphD)
LWA : SAMEA4504053_2788(aacA-aphD_1) SAMEA4504053_3020(aacA-aphD_2)
LADL : NCTC12735_00473(aacA-aphD)
ASIM : FE240_15555(aac(6')-Ib) FE240_15570
TCAR : U0034_09700(aac(6'))
NARM : N7E01_05270 N7E01_05340(aac(6')-Ib)
CKE : B5M06_08300 B5M06_08310
CRJ : QMY55_04450 QMY55_12280(aac(6')-Ib)
DLS : P4826_12370 P4826_18145
MELA : C6568_16830 C6568_16835
SME : SM_b21552(aacC4) SMc02576
SMK : Sinme_3388 Sinme_4720 Sinme_5240
SMQ : SinmeB_3163 SinmeB_3679 SinmeB_4155
SMX : SM11_chr3522 SM11_pD0608(aacC4) SM11_pD1097
SMEL : SM2011_b21552(aacC4) SM2011_c02576
SMER : DU99_00280 DU99_30665
RHI : NGR_b04750 NGR_c13960 NGR_c34060
SFH : SFHH103_00187 SFHH103_03555
SFD : USDA257_c26360 USDA257_c59200
SINO : SS05631_b63430 SS05631_c38280
ENU : PYH37_000068 PYH37_002246
EGI : PZN02_001192 PZN02_002817 PZN02_003000
STEG : QA637_09165 QA637_16990
EAH : FA04_12360 FA04_18015
ECAA : J3R84_12525 J3R84_17980
ENP : JVX98_22240 JVX98_27505
RGA : RGR602_CH00049 RGR602_CH01778 RGR602_PC02196
RSUL : N2599_18290 N2599_25775
RCT : PYR68_02265 PYR68_19925
RHIZ : QMO80_002864 QMO80_003705
PSXF : LDL70_06230(aac(6')-Ian)
MLD : U0023_15010(aac(6'))
LAP : ACP90_14530 ACP90_26215
BND : KWG56_14210 KWG56_14215
AEX : Astex_0762 Astex_0763
ASTD : ATDW_05630 ATDW_05640
ASTM : MMA231_00699(aacA4)
SSTL : ABFK29_00065(aac(6'))
PSAP : JHX88_14695 JHX88_18760
PALS : PAF20_10650 PAF20_16120
NRE : BES08_06150 BES08_20160
NOV : TQ38_018155 TQ38_024630 TQ38_028355
ABS : AZOBR_p1140049(aacA)
LUO : HHL09_08525 HHL09_23360
GAW : V144x_49040(aacA4_1)
CCOS : Pan44_34030(aacA4_2)
GMS : SOIL9_06060 SOIL9_70580
TPK : JO40_05655 JO40_09360
GMT : V3331_10885(aac(6'))
MOD : AS202_15285 AS202_15575
BHK : B4U37_10760 B4U37_14675
BCOH : BC6307_03040 BC6307_07870
TAP : GZ22_02545 GZ22_03325
VIR : X953_03730 X953_06465
VHL : BME96_02970 BME96_05675
FPN : ABE65_009855 ABE65_012120
BLEN : NCTC4824_03016(aacA-aphD)
ROSS : V2W31_07005 V2W31_17380
AND : GRQ40_08565 GRQ40_08800
SUW : SATW20_20700(aacA-aphD)
MLEN : H3V22_01730 H3V22_14150(aph(2'')-Ia)
MCL : MCCL_1032 MCCL_plsB0041
GYM : GYMC10_0163 GYMC10_0929
PAEH : H70357_14515 H70357_15735
PIH : UB51_11300 UB51_13395
PDH : B9T62_36550 B9T62_36750
PLW : D5F53_14745 D5F53_24930
PLUT : EI981_14610 EI981_17295
PGLU : A3958_10280 A3958_23160
SSIL : SOLI23_07690 SOLI23_07695
PMAT : BBI11_08930 BBI11_12495
PDEC : H1Q58_08050 H1Q58_11785
SSK : SSUD12_0549 SSUD12_1441
SMB : smi_1111 smi_1704(aacA-aphD)
SPAB : KQ224_01955 KQ224_03370 KQ224_09825
SLIN : SM123_06490(aac(6'))
EFAU : EFAU085_02347(aac(6')-Ii)
EAV : EH197_00430(aph(2'')-Ia)
ELAC : I4Q40_10800(aac(6'))
EMS : P3T75_11340(aac(6'))
VLU : M2919_02100(aph(2'')-Ia)
CDJ : BFC22_01165 BFC22_10685
CCB : Clocel_0153 Clocel_0716
CLT : CM240_2218 CM240_2905
CLD : CLSPO_c21500 CLSPO_c30030
CTAE : BGI42_04565 BGI42_14830
CARG : RSJ17_04855 RSJ17_09895 RSJ17_10455
RUK : A4V00_08375 A4V00_08715
CEW : EKH84_01430 EKH84_15910
PBQ : C3V37_03620 C3V37_07285
TUR : AT726_07160 AT726_09005
ERM : EYR00_02335 EYR00_03350
SCI : B446_02220 B446_33075
SKY : D0C37_10035(aac(6'))
SKA : CP970_06620(aac(6'))
SNK : CP967_02430(aac(6'))
SBY : H7H31_17560(aac(6'))
SGX : H4W23_02915 H4W23_38895
SPLA : CP981_12765(aac(6'))
SHUN : DWB77_00521(aacA4_1) DWB77_07243(aacA4_2)
SANU : K7396_24545(aac(6'))
SVIO : HWN34_08985(aac(6'))
SXT : KPP03845_100205(aacA4)
SLON : LGI35_43480 LGI35_44015(aac(6'))
STUD : STRTU_004853(aac(6'))
SYUN : MOV08_42845(aac(6'))
SHAU : K9S39_29810(aac(6'))
STRZ : OYE22_17285(aac(6'))
SRPA : HEP86_13855(aac(6'))
AGRA : AGRA3207_001808 AGRA3207_007619(aac(6'))
AMM : AMES_1894 AMES_5170 AMES_5323(rimI)
AMZ : B737_1895 B737_5170 B737_5323(rimI)
APRT : MUY14_11390 MUY14_26930
AMOG : QRX60_01135 QRX60_40395
ANW : QP939_01270 QP939_37660
PPEL : H6H00_23540 H6H00_30460
ACTU : Actkin_01885(aacA4)
CATI : CS0771_24570 CS0771_41890
BALA : DSM104299_02829(aacA4)
CMP : Cha6605_1560 Cha6605_2405 Cha6605_6175
CEP : Cri9333_0319 Cri9333_3222
KOV : K9N68_13285 K9N68_15820
CYC : PCC7424_2479 PCC7424_3976
NFL : COO91_03066 COO91_05696
NED : HUN01_22415 HUN01_32630
SCYS : NIES4073_27100 NIES4073_45420
BSEN : DP114_00295 DP114_22395
BOX : DP113_00295 DP113_22310
» show all
Taxonomy
Reference
Authors
Le Goffic F, Martel A.
Title
[Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase]
Journal
Reference
Authors
Benveniste R, Davies J.
Title
Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.
Journal
Reference
Authors
Dowding JE.
Title
Mechanisms of gentamicin resistance in Staphylococcus aureus.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.82
ExPASy - ENZYME nomenclature database: 2.3.1.82