Entry |
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Name |
fatty-acid synthase system;
FASN (gene name);
fatty-acid synthase
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Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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Sysname |
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
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Reaction(IUBMB) |
acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+ [RN: R05188]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase system.
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History |
EC 2.3.1.85 created 1984, modified 2019
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Pathway |
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Orthology |
K00665 | fatty acid synthase, animal type |
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Genes |
NLE: | 100596750 100597701(FASN) |
HMH: | 116483000(FASN) 116810414 |
RBB: | 108525064 108534089(FASN) |
MORG: | 121444071 121444583 |
SARA: | 101537514(FASN) 101539044 |
SRX: | 107722180 107755500(fasn) |
SANH: | 107684061(fasn) 107702482 |
SGH: | 107565779 107581585(fasn) |
CCAR: | 109053232 109084667 |
CAUA: | 113055967 113064170 113111640 |
CGIB: | 127968867 128025400 |
MASI: | 127423087 127426869 |
SASA: | 106589612 106610271 |
STRU: | 115152886 115201394(fasn) |
ONE: | 115113815 115144264(fasn) |
SALP: | 111978091 112080426 |
SNH: | 120029534(fasn) 120045991 |
CCLU: | 121547561(fasn) 121577692 |
PSPA: | 121295320 121296635 |
ARUT: | 117423032 117424309 |
RTP: | 109913760 109914699(fasn) |
SKO: | 100369299 100369443 100370573 100374692 100376755 102807132 |
DME: | Dmel_CG17374(FASN3) Dmel_CG3523(FASN1) Dmel_CG3524(FASN2) |
DER: | 6541559 6542433 6543504 |
DSE: | 116803584 6613200 6620584 |
DSI: | Dsimw501_GD17693(Dsim_GD17693) Dsimw501_GD23206(Dsim_GD23206) Dsimw501_GD23207(Dsim_GD23207) |
DYA: | Dyak_GE18209 Dyak_GE18210 Dyak_GE28239 |
DAN: | 26514500 6497225 6497226 |
DSR: | 110180482 110187237 110187238 |
DPO: | 4817018 4817023 6897794 |
DPE: | 6589179 6589180 6594365 |
DMN: | 108154969 108162261 108162262 |
DWI: | 6651198 6651818 6651866 |
DGR: | 6561996 6561997 6570749 6570831 6571452 6571616 |
DMO: | Dmoj_GI10509 Dmoj_GI10520 Dmoj_GI23207 |
DAZ: | 108610876 108610878 108621673 |
DNV: | 108649396 115562427 115563001 |
DHE: | 111598659 111603989 111604008 |
DVI: | 6628103 6628141 6630926 |
CCAT: | 101452110 101463409 |
RZE: | 108358418 108360622 108374844 |
SCAC: | 106087025 106090589 |
LCQ: | 111681404 111690930 111690931 |
LSQ: | 119604430 119604500 119606902 |
AGA: | AgaP_AGAP001899 AgaP_AGAP008468 AgaP_AGAP009176 |
ACOZ: | 120953445 120957046 120957047 120957376 |
AARA: | 120897655 120901692 120901693 120902683 |
AMER: | 121588791 121596133 121596134 121597373 |
ASTE: | 118506620 118512534 118514284 118514285 |
AAG: | 5568814 5570229 5573927 5573929 5573930 5573931 |
AALB: | 109407207 109419595 109421176 109421178 109421326 109421327 109426323 109427809 109427811 115265184 115265185 115265533 115265534 115265569 |
CQU: | CpipJ_CPIJ003494 CpipJ_CPIJ003495 CpipJ_CPIJ005595 CpipJ_CPIJ008367 |
CPII: | 120414303 120416311 120429905 120429917 |
CNS: | 116337764 116340889 116344296 116344424 116348279 116348400 116348460 116349479 116351032 116351271 116352489 |
BCOO: | 119066110 119067832 119071053 119077605 119077681 119078059 119078233 119078601 119082139 |
ACER: | 107993563 108000565 |
ALAB: | 122713456 122719538 |
BBIF: | 117207135 117216471 |
BVAN: | 117158763 117160845 |
BTER: | 100644763 100652317 |
BPYO: | 122570077 122571176 |
CCAL: | 108621920 108628229 108628230 108628231 108629850 |
MGEN: | 117224267 117224750 |
NMEA: | 116426715 116430914 |
CGIG: | 122396376 122397043 |
SOC: | 105196297 105197914 105198903 105199688 105200156 105202179 105202319 105202483 105202557 105202953 105202956 105203128 105205000 105205264 105208165 |
MPHA: | 105831114 105836966 105839757 105840656 |
AEC: | 105145358 105145528 105151862 105153178 105153179 105153181 |
ACEP: | 105617602 105621803 105621939 105621944 105626385 105626590 |
PBAR: | 105423444 105426819 105426871 105427550 105430349 105430537 |
VEM: | 105556117 105556674 105558192 105558962 105561532 105561632 105563525 105563598 105564674 105566143 105567646 105570994 |
HST: | 105180672 105182083 105182544 105185168 105185960 105186441 105186768 105187141 105187401 105188623 105191040 105191892 112588711 112589354 112590320 112590570 |
DQU: | 106742303 106742577 106745715 106748386 |
CFO: | 105247751 105247758 105248514 105249037 105249406 105250095 105250609 105251211 105254251 105254262 105256048 105256223 105256457 105256463 105256816 105257505 105258076 105259522 105259561 112637545 112637552 112637553 112637864 112638128 112638761 112639698 112639847 |
FEX: | 115233254 115233345 115233533 115234497 115235366 115238468 115238469 115241467 115241706 115241716 115242725 115245677 115246003 |
LHU: | 105667548 105667688 105667834 105668496 105668646 105668856 105669150 105670251 105670847 105672402 105673445 105673457 105674779 105675105 105676017 105676185 105676405 105676834 105678596 105679005 105679169 105679281 105679506 105679904 105680084 105680116 |
PGC: | 109853513 109854413 109856138 109856394 109858510 109859046 109859048 109859110 109860414 109860910 109861364 109861672 109862058 109862386 109862585 109862656 109862685 109864161 |
OBO: | 105276900 105277111 105278724 105278763 105279620 105285513 105286065 105287194 105287903 105288090 |
PCF: | 106785473 106793071 106793252 |
PFUC: | 122513549 122513550 122513696 122517792 122517837 122522081 122524428 122525851 |
VPS: | 122627509 122627510 122628351 122628583 122629032 122629201 122633870 122634824 |
NVI: | 100119597 100121447 100122083 100122099 100124027 100678737 103316303 |
CSOL: | 105361728 105363109 105366359 105366362 |
TPRE: | 106650713 106652998 106653506 106656993 106659131 106659766 |
MDL: | 103577141 103577902 103577904 |
CGLO: | 123261598 123261635 123261644 |
FAS: | 105267945 105271484 105272765 105272766 |
DAM: | 107038444 107038445 107038474 107038498 107038503 107047821 |
AGIF: | 122850599 122854259 122856284 122856308 122856310 122858803 122858805 122858806 |
CINS: | 118065921 118071190 |
CCIN: | 107264238 107266560 |
TCA: | 103314884 658024 658944 659179 660113 660178 662899 |
DPA: | 109541738 109542929 109542979 109544836 |
SOY: | 115874547 115876592 115876924 115876927 115876930 115876931 115883152 115886869 115887549 115887569 |
ATD: | 109594991 109596773 109597610 109597612 109597613 109606028 109608696 |
CSET: | 123308581 123309761 123318444 123320890 123320891 123321139 123322789 |
AGB: | 108904619 108907685 108907709 108909811 108910339 108911983 108913380 108914573 108915456 108915506 108915555 108915676 108917957 |
LDC: | 111502191 111502521 111503529 111508240 111508890 111517530 |
NVL: | 108557772 108557787 108558974 108560588 108565026 108567254 108568351 |
APLN: | 108738620 108738636 108744646 108744885 112903898 |
PPYR: | 116160978 116161073 116161396 116161505 116161688 116161905 116161906 116161916 116161945 116161975 116161982 116161983 116162162 116162361 116163445 116171981 116173285 116173286 116174065 116174198 116174377 116174560 116174561 116181966 116181967 116181975 116181979 |
OTU: | 111416369 111417792 111418554 111423847 111428957 111428975 111428976 111428987 |
BMOR: | 101740134 101742625 110385087 110385370 693037 693038 |
BMAN: | 114240500 114242082 114242083 114242139 114243311 114247718 114247719 114248778 114248779 114251936 114252855 |
MSEX: | 115441336 115444304 115444306 115450916 115450926 115450927 115451366 |
DPL: | KGM_206960A KGM_207082 KGM_212360 |
BANY: | 112043408 112046001 112047759 112048406 112048408 112048427 112055250 112055255 112055352 112055693 112055695 112055697 |
NIQ: | 126774097 126775405 126775406 126775407 126775408 126775409 126775410 126775411 126775685 126775686 126775687 126775689 |
PMAC: | 106713011 106716463 106718579 106718893 |
PPOT: | 106105818 106106067 |
PXU: | 106114262 106114263 106117824 106117869 106120940 |
PRAP: | 110997060 110997061 110999406 110999413 111001727 111002699 |
PBX: | 123709609 123712767 123712768 123712770 |
PNAP: | 125048659 125063044 125063045 |
ZCE: | 119828244 119834958 119835685 119835701 119835711 119835720 119835731 |
CCRC: | 123694608 123700596 |
HAW: | 110369798 110369799 110369828 110370851 110370854 110370856 110373731 110380738 |
HZE: | 124634824 124636558 124636625 124636626 124639396 124639663 124639722 |
TNL: | 113495949 113498344 113502875 113502960 113503009 |
SLIU: | 111356608 111356850 111359194 111359981 111360101 111360159 111360201 111360202 111360472 |
OFU: | 114351871 114351872 114352147 114352958 114354373 114361471 |
PXY: | 105386886 105386888 105386889 105386890 105386891 105393935 |
CFEL: | 113368221 113374636 113377117 |
API: | 100158855 100158857 100159146 100160920 100162692 100163154 100164777 100166426 100166618 100167255 100570193 103308252 115033631 |
DNX: | 107162347 107162355 107162370 107162813 107164658 107167281 107172899 107172901 |
AGS: | 114121653 114121660 114121661 114121664 114121759 114121761 114121762 114122899 114125345 114129891 |
RMD: | 113550201 113550202 113551735 113551933 113551934 113552284 113552745 113554502 113554570 113554723 113555001 113560874 113561322 |
BTAB: | 109030324 109030326 109030328 109030331 109030398 109030399 109030416 109030430 109030431 109030434 109033165 109034371 109034713 109035771 109037047 109040649 109043544 |
CLEC: | 106661142 106663460 106664590 106667274 106667275 |
HHAL: | 106683409 106687012 106687027 106689658 106690460 106690461 |
NLU: | 111045930 111046194 111052494 111062415 |
PHU: | Phum_PHUM080440 Phum_PHUM448390 Phum_PHUM565830 |
FOC: | 113202264 113202279 113207792 113208063 113210546 113210547 113210548 113210549 113210550 113213144 113213186 113214773 113217410 |
TPAL: | 117639322 117642648 117643551 117647203 117647484 117650852 117651001 |
ZNE: | 110830700 110834624 110834625 110836042 110837190 110841318 |
CSEC: | 111862485 111868235 111869163 111872264 111872433 111874236 111874303 |
DSV: | 119444321 119444325 119444367 119444470 119445413 119445414 119453329 119453373 119453374 119454055 119454056 119454112 119454113 119454267 119454364 |
RSAN: | 119390905 119391816 119391817 119391856 119391859 119391860 119398657 119398658 119398705 119398707 119398708 119398960 119398989 119398992 119399780 119400146 |
RMP: | 119179026 119179100 119179104 119179201 119179258 119179504 119179527 119185144 |
TUT: | 107359791 107360391 107361055 107361744 107361815 107366193 107368728 107369476 107370796 107371424 |
DPTE: | 113788529 113789596 113790804 113792212 113794834 |
DFR: | 124494631 124494962 124496635 124497991 124499044 |
PTEP: | 107439709 107441937 107447920 107451272 107454900 122272360 |
SDM: | 118187786 118187796 118199791 |
CEL: | CELE_F32H2.5(fasn-1) |
CBR: | CBG_12408(Cbr-fasn-1) |
CRG: | 105318687 105334039 105338805 |
MYI: | 110448576 110453408 110453914 |
PMAX: | 117332675 117336733 117338653 |
MMER: | 123528595 123530400 123554103 123564054 |
LAK: | 106159135 106163103 106172289 |
TAD: | TRIADDRAFT_31339 TRIADDRAFT_34034 TRIADDRAFT_34041 |
CSL: | COCSUDRAFT_42572 COCSUDRAFT_44339 COCSUDRAFT_47508 COCSUDRAFT_49000 COCSUDRAFT_58178 COCSUDRAFT_58179 COCSUDRAFT_58181 |
GTR: | GLOTRDRAFT_123623(pks6) |
MRR: | Moror_3083 Moror_3093 |
» show all
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Reference |
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Authors |
Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM. |
Title |
Physicochemical studies of the rat liver and adipose fatty acid synthetases. |
Journal |
J Biol Chem 254:7418-26 (1979) |
Reference |
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Authors |
Wakil SJ, Stoops JK, Joshi VC. |
Title |
Fatty acid synthesis and its regulation. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.3.1.85 |
ExPASy - ENZYME nomenclature database: | 2.3.1.85 |
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