Entry
Name
aralkylamine N-acetyltransferase;
serotonin acetyltransferase;
serotonin acetylase;
arylalkylamine N-acetyltransferase;
serotonin N-acetyltransferase;
AANAT;
melatonin rhythm enzyme
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:2-arylethylamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine [RN:
R03760 ]
Reaction(KEGG)
Substrate
Product
Comment
Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC
2.1.1.4 , acetylserotonin O-methyltransferase). Differs from EC
2.3.1.5 arylamine N-acetyltransferase.
History
EC 2.3.1.87 created 1986, modified 2005
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K00669 arylalkylamine N-acetyltransferase
K22450 aralkylamine N-acetyltransferase
Genes
BTA : 112442710 281583(AANAT)
BBUB : 102401346 102412521(AANAT)
CHX : 100860947(AANAT) 102190991(AANAT)
OAS : 105601853 443531(AANAT)
BTAX : 128065506 128065508
ODA : 120859233 120859234 120866544(AANAT)
CCAD : 122424699 122442155
MBEZ : 129544688 129544691
CFR : 102522698 116669211 116669239
XLA : 100335045(aanat.S) 100335046(aanat.L)
DRE : 30685(aanat2) 393677(aanat1)
SRX : 107711187 107715487(aanat) 107742556 107754039
SANH : 107670449 107672440 107702983(aanat)
SGH : 107561337(aanat) 107588006 107596820
CCAR : 109056260 109056933 109059207
CAUA : 113042439 113050725(aanat) 113082008 113095415
CGIB : 127952843 127953320 128016227
PTET : 122339818(aanat2) 122347060(aanat1)
LROH : 127162811(aanat2) 127167246(aanat1)
OMC : 131537300(aanat2) 131542210(aanat1)
PPRM : 120466727(aanat1) 120489294(aanat2)
RKG : 130081164(aanat1) 130086874(aanat2)
MAMB : 125268979(aanat2) 125273287(aanat1)
CIDE : 127509052 127513808
CERY : 137010876(aanat1) 137017848(aanat2)
MASI : 127449031 127449977 127452121
TROS : 130556448(aanat1) 130561671(aanat2)
TDW : 130424783(aanat1) 130425558(aanat2)
IPU : 108257103(aanat2) 108273103(aanat1)
IFU : 128600255(aanat2) 128616144(aanat1)
PHYP : 113536007 113538260(aanat)
SMEO : 124376137(aanat2) 124383978(aanat1)
TFD : 113634427(aanat1) 113640464(aanat2)
TVC : 132844830(aanat1) 132864220(aanat2)
TRN : 134301211(aanat2) 134316555(aanat1)
AMEX : 103029239(aanat2) 103031094(aanat1)
CMAO : 118805779(aanat2) 118807506(aanat1)
CHAR : 105898567 105900207(aanat1) 105907855(aanat2) 116222096
TRU : 101065059 101069944(aanat) 101071652
TFS : 130515251(aanat2) 130515355 130527336(aanat1)
TNG : GSTEN00007250G001 GSTEN00010408G001 GSTEN00032513G001
LCO : 104918698 104932979(aanat) 104938975
TBEN : 117480002 117482324(aanat1) 117493183(aanat2)
CGOB : 115009663(aanat) 115011759 115012355
PGEO : 117447000(aanat1) 117451480(aanat2)
GACU : 117537866(aanat1) 117548728(aanat2)
EMAC : 134864399(aanat1) 134878286(aanat2) 134878314
ELY : 117254966(aanat1) 117268622(aanat2) 117268670
EFO : 125879145 125879210(aanat2) 125884970(aanat1)
PLEP : 121939806 121941854(aanat1) 121956108(aanat2)
SLUC : 116042642(aanat1) 116059525(aanat2) 116065468
ECRA : 117957840 117958329(aanat2) 117960910(aanat1)
ESP : 116700109(aanat) 116703094 116703551
PFLV : 114569609 114569801 114569809
GAT : 120825377(aanat1) 120827539 120827719(aanat2)
PPUG : 119218418(aanat1) 119220452 119220746(aanat2)
AFB : 129095288(aanat1) 129098669 129098679(aanat2)
CLUM : 117734499(aanat2) 117735083 117738296(aanat1)
PSWI : 130188900 130189293(aanat2) 130189953(aanat1)
MSAM : 119883952 119891562(aanat2) 119899313(aanat1)
SCHU : 122868535(aanat2) 122869406 122873583(aanat1)
CUD : 121503573 121503576(aanat2) 121508637(aanat1)
ALAT : 119014348(aanat2) 119014811 119026957(aanat1)
MZE : 101470946 101472579(aanat) 101479147
ONL : 100689833 100690180 100706826(aanat)
OAU : 116310830(aanat1) 116318401(aanat2) 116327149
OLA : 100049467(aanat) 100049488(aanat2) 100049507(aanat1b)
OML : 112146110 112146445(aanat2) 112157294(aanat1)
CSAI : 133421525 133422430(aanat2) 133449813 133450473
XMA : 102226079 102233098 102235970(aanat)
XCO : 114145405 114159590 114160189
XHE : 116720846 116735180 116735883
PRET : 103468403 103468705 103469693
PFOR : 103143668 103143768 103143770 103153197
PLAI : 106937025 106942159 106950860 106964066
PMEI : 106911672 106918968 106934031 106934060
GAF : 122821519(aanat2) 122822124 122830249(aanat1)
PPRL : 129352508(aanat2) 129363416(aanat1)
CVG : 107083117 107100582(aanat) 107104616
CTUL : 119771323(aanat1) 119785324(aanat2) 119797287
GMU : 124862532 124863331 124864628 124865019 124868481(aanat1)
NFU : 107376253 107378383 107382246
KMR : 108236158 108243703(aanat2) 108248779(aanat1)
ALIM : 106518761 106523853 106528835
NWH : 119421791(aanat2) 119422146 119423194(aanat1)
AOCE : 111564217(aanat) 111567914 111574835
MCEP : 124997602(aanat2) 124997799 125003790(aanat1)
CSEM : 103383775 103392596 103393389
POV : 109627400 109634267 109644751
SSEN : 122763909(aanat2) 122770985(aanat1)
HHIP : 117763112(aanat1) 117766279 117766473(aanat2)
HSP : 118119218(aanat1) 118123053(aanat2) 118123157
PPLT : 128437020(aanat1) 128458762 128458796(aanat2)
SMAU : 118289025 118289414(aanat2) 118312186(aanat1)
LCF : 108875852(aanat1) 108879348 108898703 108902966
SDU : 111217515 111236294(aanat) 111238089
SLAL : 111659761 111660619 111673755
XGL : 120787793(aanat2) 120787961(aanat1)
HCQ : 109513811 109516440 109519790(aanat)
SSCV : 125969559 125983907 125984168
SBIA : 133505704(aanat1) 133514514 133514806(aanat2)
PEE : 133403527(aanat1) 133414872(aanat2) 133414889
PTAO : 133466295 133466440(aanat2) 133477514(aanat1)
BPEC : 110166218(aanat) 110170029 110172214
MALB : 109966005 109966258(aanat) 109974664
BSPL : 114855511(aanat1) 114860298 114860556(aanat2)
SJO : 128371938(aanat1) 128378755(aanat2) 128378769
SASA : 106588571(aanat) 106601142 106601410 106607000 106607367
STRU : 115170616 115170622 115178176 115201927 115203761
OTW : 112230148(aanat1) 112234611 112246025 112258719 112259441
OMY : 100135782 100135881(aanat-2) 110487522(aanat1) 110538456 110538513
OGO : 123999575 124000370 124015435 124016078(aanat1) 124016278
ONE : 115103555 115103628 115103642 115109882 115110646
OKI : 109865984 109892009 109892256 109897608 109897627
OKE : 118364760 118364952 118365364 118375063(aanat2) 118384683
SALP : 111955129 111980399 111981627
SNH : 120032934 120034461 120034465 120044556 120044615
CCLU : 121550932 121551145 121570396 121570428
ELS : 105013156 105013380 105021627(aanat)
SFM : 108935849 108939955(aanat)
PKI : 111843224 111848397(aanat)
AANG : 118219646(aanat1) 118221224(aanat2)
LOC : 102683533(aanat) 102686229
PSPA : 121295719 121296561(aanat1) 121330940(aanat2)
ARUT : 117418367 117423197(aanat1) 117424323 117431354
PSEX : 120517232(aanat1) 120542384(aanat2)
DSI : Dsimw501_GD15464(Dsim_Dat)
CLON : 129608762 129612152 129612400 129612611 129612809
AALB : 109404734 109414420
LDC : 111505099 111505728 111509399
PPYR : 116169540 116169784 116169786
OTU : 111427395 111427414 111427421
PRAP : 110992527 111002558
LSIN : 126974142 126974155
ACOO : 126841165 126841166 126841167
TPAL : 117643620 117644122 117654200
ATH : AT1G26220 AT1G32070(NSI)
CSAT : 104741233 104741234 104741802 104756917 104757576 104776667 104777238
EUS : EUTSA_v10008400mg EUTSA_v10008844mg
BNA : 106361844 106361908(BNACNNG04490D) 106365605 106451742 125594303 125603617
RSZ : 108819205 108862864 130503606
CPAP : 110812909 110814677
CIC : CICLE_v10012371mg CICLE_v10032841mg
PVY : 116105203 116119522 116136492
MINC : 123212972 123214469
GHI : 107888830 107895041 107918288 107951054
HSYR : 120118224 120134644 120138701 120145006 120152744 120211330
DZI : 111288139 111307603 111318209
GMX : 100778613 100799333(TAP1)
GSJ : 114388175 114396786 114425700
PVU : PHAVU_006G034800g PHAVU_006G035000g PHAVU_008G079900g
VUM : 124833506 124849128 124849129
CCAJ : 109788951 109789881
APRC : 113861492 113869644
TPRA : 123892756 123892842 123911603
PSAT : 127119068 127127271
ADU : 107470795 107479042 107485362
AHF : 112716098 112736334 112743881 112790407 112797253
LANG : 109352699 109355807
PCIN : 129287640 129322998
QSA : O6P43_016445 O6P43_032841
PMUM : 103341987 103342676
PAVI : 110757692 110771956
PDUL : 117613562 117616364 117631846
MSYL : 126594347 126594923
CSAV : 115716162 115725561
MCHA : 111017595 111025811
CMAX : 111478297 111484466
CMOS : 111432339 111452951 111458741
CPEP : 111781059 111803110 111807119
MEAN : 126665908 126674001
HBR : 110639106 110642611 110667725
MESC : 110621806 110630270
PALZ : 118039988 118047196
CILL : 122275624 122310679
CAVE : 132177625 132191859
QLO : 115951903 115954184 115957693
SPEN : 107002224 107020508
SSTN : 125866395 125869265
SDUL : 129874474 129877788
CANN : 107845856 107852754
NTA : 107779554 107789648 107817186 107819409
SIND : 105161683 105174689
SSPL : 121767538 121795666 121799307
SMIL : 130986285 131019820
SHIS : 125192541 125215736
APAN : 127251634 127261644
ECAD : 122582973 122587407
CCAV : 112513390 112515951
CSIN : 114268185 114297586
AEW : 130765043 130768593 130795532
SOE : 110804144 110804344 130459110
CQI : 110686034 110690742 110721014 110731833
ATRI : 130808628 130826892
MING : 122057651 122062521 122091214
PSOM : 113273943 113277521 113283619 113357903
OSA : 4339123(SNAT1) 4344423(OsJ_25726)
TDC : 119284027 119331884 119340732 119348706
TAES : 123060198 123137124 123147684 123162459 123169053 123182379
LPER : 127313597 127318898
LRD : 124681607 124683424 124707688
MFLO : 136476560 136501071 136513438 136516766
SITA : 101767823 101777356
PVIR : 120665135 120678457 120698338 120711072
PHAI : 112887367 112896668
ZOF : 121973620 121977966 122009012 122014621
MSIN : 131253666 131258005
NCOL : 116254480 116263430
SMO : SELMODRAFT_126619 SELMODRAFT_271611 SELMODRAFT_432148 SELMODRAFT_449074
PPP : 112275116 112285609 112288166
VCN : VOLCADRAFT_107031 VOLCADRAFT_64094
CSL : COCSUDRAFT_20526 COCSUDRAFT_8782
CVR : CHLNCDRAFT_143824 CHLNCDRAFT_57286
APRO : F751_1318 F751_1688
OLU : OSTLU_43627 OSTLU_7981
OTA : OT_ostta09g02380 OT_ostta14g00170
BPG : Bathy07g04480 Bathy10g02160
MIS : MICPUN_58705 MICPUN_72029
MPP : MICPUCDRAFT_33987 MICPUCDRAFT_6518
» show all
Taxonomy
Reference
Authors
Voisin P, Namboodiri MA, Klein DC.
Title
Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.
Journal
J Biol Chem 259:10913-8 (1984)
Reference
Authors
Ferry G, Loynel A, Kucharczyk N, Bertin S, Rodriguez M, Delagrange P, Galizzi JP, Jacoby E, Volland JP, Lesieur D, Renard P, Canet E, Fauchere JL, Boutin JA.
Title
Substrate specificity and inhibition studies of human serotonin N-acetyltransferase.
Journal
Reference
3
Authors
Khalil EM, Cole PA.
Title
A potent inhibitor of the melatonin rhythm enzyme.
Journal
J Am Chem Soc 120:6195-6196 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.87
ExPASy - ENZYME nomenclature database: 2.3.1.87