Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy

acetyl-CoA:acetyl-CoA C-acetyltransferase

2 acetyl-CoA = CoA + acetoacetyl-CoA (overall reaction) [RN:R00238];
(1a) acetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine = [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + CoA;
(1b) [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + acetyl-CoA = acetoacetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine

R00238;
(other) R00927 R01177
Reaction

acetyl-CoA [CPD:C00024];
[acetyl-CoA C-acetyltransferase]-L-cysteine;
[acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine

The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.

EC 2.3.1.9 created 1961, modified 2019