KEGG ENZYME: 2.3.2.15

ENZYME: 2.3.2.15

Entry

EC 2.3.2.15                 Enzyme

Name

glutathione gamma-glutamylcysteinyltransferase;
phytochelatin synthase;
gamma-glutamylcysteine dipeptidyl transpeptidase

Class

Transferases;
Acyltransferases;
Aminoacyltransferases

Sysname

glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase

Reaction(IUBMB)

glutathione + [Glu(-Cys)]n-Gly = Gly + [Glu(-Cys)]n+1-Gly [RN:R03956]

Reaction(KEGG)

R03956

Substrate

glutathione [CPD:C00051];
[Glu(-Cys)]n-Gly [CPD:C02471]

Product

Gly [CPD:C00037];
[Glu(-Cys)]n+1-Gly [CPD:C02755]

History

EC 2.3.2.15 created 1992

Orthology

K05941

glutathione gamma-glutamylcysteinyltransferase

Genes

CIN:	100178336 100186228

SCLV:

120325959 120340772 120340773

CEL:	CELE_F54D5.1(pcs-1)

CBR:	CBG_02855(Cbr-pcs-1)

BMY:	BM_BM4359(Bma-pcs-1)

LOA:	LOAG_03454

NAI:	NECAME_01843

HRO:	HELRODRAFT_167837 HELRODRAFT_72755

LGI:	LOTGIDRAFT_126155 LOTGIDRAFT_137593 LOTGIDRAFT_146582

PCAN:

112567184

BGT:

106057552

GAE:	121384806 121384808

HRF:

124138280

HRJ:

124269210

CRG:

105340851

MYI:

110459071

PMAX:

117327503 117328362

OBI:

106869885

OSN:

115222911

LAK:	106151538 106162300

SMM:	Smp_072740

SHX:	MS3_00002296(PCS3)

OVI:	T265_13386

EGL:

EGR_05319

NVE:	5502512 5511053 5515808 5516558

EPA:	110234748 110234785 110245189

ATEN:

116296105 116300871 116305086

ADF:

107347323

AMIL:

114953249

PDAM:

113680149

SPIS:

111336955 111336957 111336959

DGT:	114520332 114520520

XEN:

124435507

HMG:

100213020

ATH:	AT1G03980(PCS2) AT5G44070(CAD1)

ALY:	9299691 9325551

CRB:

17874871

CSAT:

104725048 104738906 104754519 104760541 104771564 104778551

EUS:	EUTSA_v10003193mg EUTSA_v10003194mg EUTSA_v10007644mg

BRP:	103827929 103839206 103839325 103843677 103848856

BNA:	106365411 106381954 106387111 106403103 106406684 106410475 106410482 106411423 106416883 106417837 106417894

BOE:	106306174 106309808 106316809 106316852 106327302

RSZ:	108806450 108855485 108857205 108859194

THJ:	104801141 104815967

CPAP:

110807653 110807687

CIT:	102626992 102627849 102628145 102628437

CIC:	CICLE_v10019812mg CICLE_v10019857mg CICLE_v10020222mg CICLE_v10024202mg

PVY:	116123094 116123100 116143112

MINC:

123209706 123215385

TCC:	18613100 18613101

GRA:

105766126

GHI:	107922692 107922779 107937656 107955409

GAB:	108468678 108487459

DZI:	111305317 111305318

EGR:	104416196 104429807 104456285 104456288

GMX:	100778828 100782042 100808418 100813002 547627(PCS1)

GSJ:	114373175 114374931 114398368 114406940 114406941

PVU:	PHAVU_001G162600g PHAVU_001G1627001

VRA:	106757134 106757457

VAR:	108323244 108323248

VUN:	114163757 114163774

CCAJ:

109803358 109803463 109803580 109803796

APRC:

113863844 113863845

MTR:	25499283 25499284

CAM:	101494765 101495095

PSAT:

127126013 127126023

LJA:	Lj1g3v4515570.1(Lj1g3v4515570.1) Lj1g3v4515590.1(Lj1g3v4515590.1) Lj5g3v1117270.1(Lj5g3v1117270.1) Lj5g3v1117290.1(Lj5g3v1117290.1) Lj6g3v0927380.1(Lj6g3v0927380.1)

ADU:	107477440 107490548 107491737 107491738

AIP:	107634183 107642091 107646261 107646262

AHF:	112695181 112735758 112751025 112758743 112758744 112789329 112799809

LANG:

109333647 109334561 109334562

FVE:	101294901 101304357

RCN:	112172820 112174178

PPER:

18768401 18768506

PMUM:

103334440 103334442

PAVI:

110757423 110757529

PDUL:

117637360 117638181

MDM:	103435737 103435918 103445605

PXB:	103928761 103928762 103958854

ZJU:	107425745 107425778 107425788 107425809 107425810 107425813

MNT:	21389378 21389379

CSV:	101205022 101205258 101206852

CMO:	103497160 103497195 103498912 103498913 103499404

BHJ:	120067127 120068464

MCHA:

111024196

CMAX:

111488492 111488495

CMOS:

111456253 111456254

CPEP:

111807202 111807203

RCU:

8279693

JCU:

105644508

HBR:	110663356 110663371

MESC:

110630093

POP:	7455714 7464424

PEU:	105115283 105119463

PALZ:

118039661 118039662

JRE:	108996032 108996048

CILL:

122305365 122305366

QSU:	112031602 112031627 112031640

QLO:	115961054 115962285

TWL:	120007930 120011380

VVI:

100266944

VRI:

117918877

SLY:

101251125

SPEN:

107031688

SOT:	102580078 102589889(pcs1) 102600824(pcs6)

SSTN:

125870634

CANN:

107863883

NTA:	107820529(PCS1) 107826728

NSY:

104247600

NTO:

104090966

NAU:

109229239

INI:

109182785

ITR:

116026318

SIND:

105165666 105172177

OEU:	111369747 111403327 111407759 111407761

EGT:

105950186

SSPL:

121749053 121794403

APAN:

127244344 127260027

HAN:	110864979 110936785

ECAD:

122581761 122592595

LSV:	111891546 111893694

CCAV:

112506469 112513093

DCR:	108210641 108220616

CSIN:

114264971 114271994 114272163 114284746 114285270 114302608 114319460

BVG:	104899195 104899197 104899198

SOE:	110787047 110787089 110787091

CQI:	110689750 110689751 110689752 110727974 110727975 110727978

NNU:	104600915(PCS) 104602827 104604383 104610426

MING:

122090863

TSS:

122656950

PSOM:

113280455 113318209 113349886

OSA:	4338799 4339838

DOSA:

Os05t0415200-00(Os05g0415200) Os06t0102300-01(Os06g0102300)

OBR:	102706657 102717159

OGL:	127773120 127776707

BDI:

100826819

ATS:	109765261 109779397

TDC:	119304200 119329590 119337742

TAES:

123099057 123108424 123149751 123158478 542834

TUA:	125511537 125520077

LPER:

127317461

SBI:	8079537 8080495

ZMA:

100382428

SITA:

101759348 101760841

SVS:	117858241 117858242

PVIR:

120675585 120705637 120705638

PHAI:

112895072 112895169

PDA:	103706919 103721843 103723014

EGU:	105032919 105055703 105061348

MUS:	103970581 104000433

ZOF:	121971480 121976172 122021446 122052674

DCT:	110107635 110115128

PEQ:

110031890

AOF:

109827790

NCOL:

116252981 116253328

ATR:

18447187

SMO:	SELMODRAFT_105477 SELMODRAFT_98967

CRE:	CHLRE_07g319500v5

VCN:	VOLCADRAFT_33691 VOLCADRAFT_63429

MNG:

MNEG_2503

CSL:	COCSUDRAFT_19902

CVR:	CHLNCDRAFT_25686

APRO:

F751_5280

CME:	CYME_CMI111C

TML:	GSTUM_00001002001

SPO:	SPAC3H1.10

WSE:	WALSEDRAFT_7313

WIC:	J056_001618

PGR:	PGTG_03320 PGTG_03321

MLR:	MELLADRAFT_33495

DDI:	DDB_G0291187

DPP:	DICPUDRAFT_53337

DFA:	DFA_10091 DFA_10730

ACAN:

ACA1_073300 ACA1_255500

TET:	TTHERM_00088060

PTM:	GSPATT00014601001

SMIN:

v1.2.019049.t1(symbB.v1.2.019049.t1) v1.2.028032.t1(symbB.v1.2.028032.t1)

PTI:	PHATRDRAFT_9478

FCY:	FRACYDRAFT_208526(PCS_1)

TPS:	THAPSDRAFT_34418

AAF:	AURANDRAFT_3544 AURANDRAFT_53895(PCS1)

PIF:	PITG_05730 PITG_05733

PSOJ:

PHYSODRAFT_563256

EHX:	EMIHUDRAFT_221497 EMIHUDRAFT_43058 EMIHUDRAFT_76324

GTT:	GUITHDRAFT_144409

NGR:	NAEGRDRAFT_32272 NAEGRDRAFT_72098

GEI:	GEI7407_1721

ONI:	Osc7112_2808

CEP:	Cri9333_0746

» show all

Reference

1 [PMID:16594069]

Authors

Grill E, Loffler S, Winnacker EL, Zenk MH.

Title

Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase).

Journal

Proc Natl Acad Sci U S A 86:6838-6842 (1989)
DOI:10.1073/pnas.86.18.6838

Other DBs

ExplorEnz - The Enzyme Database:

2.3.2.15

IUBMB Enzyme Nomenclature:

2.3.2.15

ExPASy - ENZYME nomenclature database:

2.3.2.15

BRENDA, the Enzyme Database:

2.3.2.15

CAS:	125390-02-5

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