KEGG   ENZYME: 2.3.2.21
Entry
EC 2.3.2.21                 Enzyme                                 
Name
cyclo(L-tyrosyl-L-tyrosyl) synthase;
Rv2275 (gene name);
cYY synthase;
cyclodityrosine synthase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
Sysname
L-tyrosyl-tRNATyr:L-tyrosyl-tRNATyr tyrosyltransferase (cyclizing)
Reaction(IUBMB)
2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl) [RN:R10335]
Reaction(KEGG)
R10335
Substrate
L-tyrosyl-tRNA(Tyr) [CPD:C02839]
Product
tRNA(Tyr) [CPD:C00787];
cyclo(L-tyrosyl-L-tyrosyl) [CPD:C20516]
Comment
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1].
History
EC 2.3.2.21 created 2013
Orthology
K17484  cyclo(L-tyrosyl-L-tyrosyl) synthase
Genes
MTURv2275
MTVRVBD_2275
MTCMT2335
MRAMRA_2294
MTFTBFG_12300
MTBTBMG_01707
MTKTBSG_01717
MTZTBXG_001690
MTGMRGA327_14020
MTIMRGA423_14140
MTECCDC5079_2108
MTURCFBS_2408
MTLCCDC5180_2080
MTOMTCTRI2_2310
MTDUDA_2275
MTJJ112_12200
MTUCJ113_15835
MTUEJ114_12195
MTUTHKBT1_2399
MTUUHKBT2_2401
MTQHKBS1_2405
MBOBQ2027_MB2298
MBBBCG_2292
MBTJTY_2286
MBMBCGMEX_2280
MBKK60_023600
MBXBCGT_2099
MAFMAF_22850
MMICRN08_2522
MCEMCAN_22991
MCQBN44_50221
MCVBN43_31517
MCXBN42_40196
MLJMLAC_22960
MOTLTS72_08585
NOZDMB37_28470
NAHF5544_25080
NIEKV110_23810
NGPLTT66_12440
SCTSCAT_0901 SCAT_4268
SCYSCATT_02100 SCATT_09020 SCATT_42550
SVESVEN_1864
SALUDC74_296
SALLSAZ_01935
SVTSVTN_10705
SLDT261_0959 T261_7889
STRCAA958_00575
SCXAS200_15075
SRWTUE45_00818
SLEsle_63980(sle_63980)
SRNA4G23_04818
SGSAVL59_26770
SSIAA7J05_34625
SPUNBFF78_39735
SGVB1H19_02835 B1H19_37505
SLAUSLA_2552
SLXSLAV_12475
SGEDWG14_07853
SLKSLUN_02675
SDXC4B68_39405
SCYAEJ357_25515
SASTCD934_31310
SGZC0216_06100
SVNCP980_02825
SFICEIZ62_17690
SBYH7H31_00035 H7H31_08660 H7H31_19485
SSUBCP968_10475
SCHACP983_19785
SGXH4W23_11125
SSPBCP982_02350
SNFJYK04_05848 JYK04_07984
SBROGQF42_05400
SHUNDWB77_02434
SFEUIM697_43410
SFBCP974_25780
SHKJ2N69_29170
SGOBtest1122_04680
SLFJEQ17_48465
KITCFP65_5976 CFP65_6205
NALB005_4463(albC)
NOABKM31_22265
AMYCCU254_04905
AORISD37_03085
APRECNX65_23090
AMIAmir_4627
SESPBN6_23810
KPHYAOZ06_24710 AOZ06_47915
LEDBBK82_41775
ACTIUA75_17765
ACADUA74_17230
SACEGIY23_12525
MSAGGCM10017556_38040
AEYCDG81_12915
 » show all
Reference
1  [PMID:19430487]
  Authors
Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courcon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL
  Title
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
  Journal
Nat Chem Biol 5:414-20 (2009)
DOI:10.1038/nchembio.175
  Sequence
[mtu:Rv2275]
Reference
2  [PMID:20852636]
  Authors
Vetting MW, Hegde SS, Blanchard JS
  Title
The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.
  Journal
Nat Chem Biol 6:797-9 (2010)
DOI:10.1038/nchembio.440
  Sequence
[mtu:Rv2275]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.21
IUBMB Enzyme Nomenclature: 2.3.2.21
ExPASy - ENZYME nomenclature database: 2.3.2.21
BRENDA, the Enzyme Database: 2.3.2.21

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