KEGG   ENZYME: 2.3.2.29
Entry
EC 2.3.2.29                 Enzyme                                 

Name
aspartate/glutamate leucyltransferase;
leucylD,E-transferase;
bpt (gene name)
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
Sysname
L-leucyl-tRNALeu:[protein] N-terminal L-glutamate/L-aspartate leucyltransferase
Reaction(IUBMB)
(1) L-leucyl-tRNALeu + N-terminal L-glutamyl-[protein] = tRNALeu + N-terminal L-leucyl-L-glutamyl-[protein] [RN:R11547];
(2) L-leucyl-tRNALeu + N-terminal L-aspartyl-[protein] = tRNALeu + N-terminal L-leucyl-L-aspartyl-[protein] [RN:R11548]
Reaction(KEGG)
R11547 R11548
Substrate
L-leucyl-tRNA(Leu) [CPD:C02047];
N-terminal L-glutamyl-[protein] [CPD:C21456];
N-terminal L-aspartyl-[protein] [CPD:C21458]
Product
tRNA(Leu) [CPD:C01645];
N-terminal L-leucyl-L-glutamyl-[protein] [CPD:C21455];
N-terminal L-leucyl-L-aspartyl-[protein] [CPD:C21457]
Comment
The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-aspartate or L-glutamate residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. cf. EC 2.3.2.6, lysine/arginine leucyltransferase, and EC 2.3.2.8, arginyltransferase.
History
EC 2.3.2.29 created 2016
Orthology
K21420  leucyl-tRNA---protein transferase
Genes
NVE: 116606148
PSHI: SAMEA2665130_1283
XFA: XF_1018
XFT: PD_0309(ate1)
XFM: Xfasm12_0334
XFN: XfasM23_0304
XFF: XFLM_06930
XFL: P303_00995
XFS: D934_02615
XFH: XFHB_10365
XCC: XCC1141(ate1)
XCB: XC_3101
XCP: XCR_1366
XCV: XCV1273(ate)
XAX: XACM_1214
XAC: XAC1239(ate1)
XCI: XCAW_03114(ate1)
XOM: XOO1494(XOO1494)
XOO: XOO1611(ate1)
XOP: PXO_04859
XOR: XOC_3478
XAL: XALC_0908(ate)
XPH: XppCFBP6546_05290(XppCFBP6546P_05290)
SML: Smlt1266
SMT: Smal_1109
SMZ: SMD_1181(ate1)
PSUW: WQ53_02675
PSD: DSC_06155
LEZ: GLE_1597
LEM: LEN_3363
DKO: I596_1420
RBD: ALSL_0939
VCH: VC1736
VCS: MS6_1513
VCI: O3Y_08425
VVU: VV1_2124
VVY: VV2320
VPA: VP1017
VPB: VPBB_0968
VAG: N646_0081
VSP: VS_1076
VAN: VAA_02184
VSC: VSVS12_02199(ate1)
VTA: A1651(ate)
VFI: VF_1763
PPR: PBPRA1154
PAE: PA2618
PAEV: N297_2698
PAEI: N296_2698
PAU: PA14_30260(ate1)
PNC: NCGM2_3634(ate1)
PAEB: NCGM1900_3895(ate1)
PAEP: PA1S_12515
PAEM: U769_12080
PAEL: T223_12665
PAEG: AI22_21395
PAEC: M802_2695
PAEO: M801_2564
PMY: Pmen_2391
PMK: MDS_2379
PRE: PCA10_25160(ate)
PPSE: BN5_1869(ate)
PPU: PP_4006(ate)
PPF: Pput_1827
PPT: PPS_3416
PPI: YSA_08761
PPX: T1E_0532
PPUH: B479_16995
PPUT: L483_22440
PPUN: PP4_17470(ate)
PPUD: DW66_3863
PMON: X969_16275
PMOT: X970_15920
PSB: Psyr_3181
PSYR: N018_15990
PVD: CFBP1590__3276(ate)
PFL: PFL_3883
PPRC: PFLCHA0_c39410(ate)
PPRO: PPC_3980
PFS: PFLU_3803
PFB: VO64_0893
PMAN: OU5_1171(ate)
PEN: PSEEN2209
PSA: PST_2296
PSTT: CH92_09210
PKC: PKB_3377(ate)
PSES: PSCI_5408
PSEM: TO66_20130
PSEC: CCOS191_3312(ate)
PSOS: POS17_4003
PANR: A7J50_3438
PSET: THL1_2479
PSIL: PMA3_19575
PALL: UYA_11415
ACB: A1S_0873
ABM: ABSDF2563
ABY: ABAYE2942
ABN: AB57_0920
ABX: ABK1_0860
ABH: M3Q_1068
ABAD: ABD1_08190
ABAZ: P795_13405
ABAU: IX87_01790
ABAA: IX88_06340
ACC: BDGL_000136(ate)
ACI: ACIAD0888
ASJ: AsACE_CH00674(ate)
AGU: AS4_35180(ate)
AUG: URS_1720
SON: SO_2624(bpt)
SDN: Sden_1836
SFR: Sfri_2252
SAZ: Sama_2054
SBL: Sbal_2470
SLO: Shew_1568
SSE: Ssed_1888
SPL: Spea_2530
SHL: Shal_1723
SWD: Swoo_2697
SWP: swp_1873
SVO: SVI_1829(ate)
SPSW: Sps_00568
SBK: SHEWBE_2377(bpt)
ILO: IL0672
CPS: CPS_2764
PHA: PSHAa1722
PTN: PTRA_a2131(ate1)
PAT: Patl_2372
PSM: PSM_A1317
PSEO: OM33_10385
PEA: PESP_a2148(ate1)
PSPO: PSPO_a1549(ate1)
PART: PARC_a1772(ate1)
PTU: PTUN_a1946(ate1)
PNG: PNIG_a2247(ate1)
PTD: PTET_a1513(ate1)
PAGA: PAGA_a1757(ate1)
MAQ: Maqu_1755
MHC: MARHY1553(ate)
MAD: HP15_2078(ate)
MBS: MRBBS_2365(ate)
MARJ: MARI_14440(bpt)
AMAL: I607_08545
AMAE: I876_08845
AMAO: I634_08925
AMAD: I636_09355
AMAI: I635_09655
AMAG: I533_08925
AMAC: MASE_08525
AAUS: EP12_09245
GNI: GNIT_2122
GPS: C427_2016
SALH: HMF8227_01612(ate1)
FBL: Fbal_1985
MVS: MVIS_3376
MYA: MORIYA_4108(bpt)
CJA: CJA_2566
SDE: Sde_1690
SAGA: M5M_03115
MCA: MCA1791
METL: U737_20100
MMAI: sS8_5339
MEJ: Q7A_1249
MEC: Q7C_628
CYQ: Q91_1161
TIG: THII_0419
NOC: Noc_2597
NHL: Nhal_3736
NWA: Nwat_0521
TEE: Tel_10095
AEH: Mlg_1714
HHA: Hhal_1398
TGR: Tgr7_0648
TKM: TK90_0181
TNI: TVNIR_0237(ate_[H])
TVR: TVD_00885
GAI: IMCC3135_24875(ate)
HCH: HCH_02342
CSA: Csal_2438
HEL: HELO_3059(ate)
HAM: HALO3341
HBE: BEI_2449
ABO: ABO_1287
ADI: B5T_01986
APAC: S7S_08955
AXE: P40_09450
KKO: Kkor_1462
KGE: TQ33_0988
TOL: TOL_1793
OAI: OLEAN_C18680(ate)
AHA: AHA_1859
ASA: ASA_2444(ate)
AVR: B565_2284
AMED: B224_2671
ASR: WL1483_1703(ate)
TAU: Tola_2318
OCE: GU3_07070
SLIM: SCL_1965
SVA: SVA_2250
TBN: TBH_C1704
GPB: HDN1F_15720(ate)
ENM: EBS_1552(ateI)
CVI: CV_1799(ate1)
CHAE: CH06BL_31270(ate)
LHK: LHK_01433(ate)
PSE: NH8B_2924
AMAH: DLM_0723
RSO: RSc1616(ate)
RSN: RSPO_c01693(ate)
RSE: F504_1723
RPI: Rpic_1931
REH: H16_A1402(ate)
CNC: CNE_1c14300(ate)
RME: Rmet_1214(ate)
CGD: CR3_1593(ate1)
BMA: BMA1252
BMAL: DM55_2905
BMAE: DM78_1347
BMAQ: DM76_2889
BMAI: DM57_3152
BMAF: DM51_972
BMAZ: BM44_2295
BMAB: BM45_1860
BPS: BPSL1865
BPSE: BDL_396
BPSM: BBQ_1732
BPSU: BBN_1858
BPSD: BBX_2335
BPK: BBK_3360
BPSH: DR55_2970
BPSA: BBU_568
BPSO: X996_2587
BUT: X994_1040
BTE: BTH_I2510
BTQ: BTQ_1511
BTJ: BTJ_944
BTZ: BTL_2185
BTD: BTI_2145
BTV: BTHA_2385
BTHE: BTN_2582
BTHM: BTRA_2466
BTHA: DR62_2729
BTHL: BG87_2406
BOK: DM82_1082
BOC: BG90_3522
BVE: AK36_2328
BCN: Bcen_1075
BCJ: BCAL1612
BCEN: DM39_1458
BCEW: DM40_2184
BCEO: I35_1460
BAM: Bamb_1456
BMJ: BMULJ_01566(ate1)
BMU: Bmul_1677
BMK: DM80_77
BMUL: NP80_1657
BCT: GEM_1875
BCED: DM42_138
BDL: AK34_1612
BCON: NL30_15445
BUB: BW23_173
BLAT: WK25_07695
BTEI: WS51_18050
BSEM: WJ12_07695
BPSL: WS57_26290
BMEC: WJ16_07540
BSTG: WT74_08055
BGU: KS03_2806
BGO: BM43_3145
BUK: MYA_1395
BUE: BRPE67_ACDS16330(ate)
BUL: BW21_2215
BGP: BGL_1c16600(ate)
BXE: Bxe_A2506
BXB: DR64_200
BPH: Bphy_1663
BFN: OI25_3803
PNU: Pnuc_0742
PNE: Pnec_1079
PPNO: DA70_06210
PPNM: LV28_24490
PPUL: RO07_18830
PSPU: NA29_18395
PAPI: SG18_17530
HYF: DTO96_101925(ate)
CABA: SBC2_21310(bpt)
BPE: BP3443
BPC: BPTD_3395
BPER: BN118_3701
BPET: B1917_3222
BPEU: Q425_6600
BPAR: BN117_1126
BPA: BPP3539
BBR: BB3974
BPT: Bpet0932(ate)
BAV: BAV2752(ate)
BHO: D560_0274
BHM: D558_0269
BTRM: SAMEA390648700337(ate)
AXY: AXYL_01023(ate)
PUT: PT7_1980
AMIM: MIM_c10380(ate)
AFQ: AFA_14350
ODI: ODI_R1089
RFR: Rfer_2348
POL: Bpro_2325
PNA: Pnap_1724
AAV: Aave_3105
AJS: Ajs_1987
AAA: Acav_2178
ACRA: BSY15_2990
VEI: Veis_3623
DAC: Daci_4859
CTES: O987_10465
RTA: Rta_22880
LIM: L103DPR2_01569(ate)
LIH: L63ED372_01998(ate)
HYB: Q5W_12825
HPSE: HPF_14115
CBAA: SRAA_0531(ate1)
CBAB: SMCB_0404(ate1)
MPT: Mpe_A1468
HAR: HEAR2443
MMS: mma_2512(ate1)
JAG: GJA_1165
CFU: CFU_3007
CARE: LT85_1560
LCH: Lcho_1979
TIN: Tint_2289
THI: THI_2662
RGE: RGE_21450(ate)
BBAG: E1O_16090
NEU: NE2220
NET: Neut_0647
METR: BSY238_209
DOE: DENOEST_1664(bpt)
TBD: Tbd_2042
MMB: Mmol_1511
MEH: M301_1607
MEP: MPQ_1165
MBAC: BN1209_0594(ate)
MBAT: BN1208_0661(ate)
SLT: Slit_2385
GCA: Galf_2360
NIM: W01_16130(ate)
SDR: SCD_n01860(ate)
SPLB: SFPGR_24270(ate)
SNIV: SFSGTM_10630(ate)
EBA: ebA4890(ate)
DSU: Dsui_2973
OTR: OTERR_19390(ate)
DAR: Daro_1195
AZO: azo2209(ate)
AOA: dqs_2342
AZA: AZKH_1805(ate)
TCL: Tchl_2615
BPRC: D521_1028
HHE: HH_1829
HMS: HMU12250(ate)
HCP: HCN_0931
WSU: WS1276
SUA: Saut_0324
SULC: CVO_07940
SULR: B649_10665
CJE: Cj1035c
CJU: C8J_0972
CJI: CJSA_0978
CJM: CJM1_1010(ate)
CJS: CJS3_1084
CJEJ: N564_01002
CJEU: N565_01048
CJEN: N755_01041
CJEI: N135_01071
CJER: H730_06145
CJV: MTVDSCj20_1037(ate)
CJY: QZ67_01108(ate)
CJQ: UC78_0992(ate)
CJR: CJE1179
CFT: CFF04554_0687(ate)
CFV: CFVI03293_0646(ate)
CFX: CFV97608_0697(ate)
CFZ: CSG_6780
CAMP: CFT03427_0669(ate)
CLA: CLA_0589(ate)
CLR: UPTC16701_0589(ate)
CLM: UPTC16712_0595(ate)
CLQ: UPTC4110_0598(ate)
CLN: UPTC3659_0625(ate)
CLL: CONCH_0596(ate)
CCQ: N149_0970
CCF: YSQ_03845
CCY: YSS_05600
CCOI: YSU_03875
CCOF: VC76_05035
CAJ: CIG1485E_0961(ate)
CIS: CINS_0510(ate)
CVO: CVOL_0526(ate)
CPEL: CPEL_0543(ate)
CAMR: CAQ16704_0623(ate)
CSM: CSUB8521_0626(ate)
CSF: CSUB8523_0614(ate)
CGRA: CGRAC_1245(ate)
CURE: CUREO_0758(ate)
CHYO: CHH_0853(ate)
CHV: CHELV3228_1434(ate)
CSPF: CSF_1245(ate)
CCUN: CCUN_1250(ate)
CLX: CLAN_1034(ate)
CAVI: CAV_1012(ate)
CAMZ: CVIC12175_0986(ate)
CAMY: CSUIS_1112(ate)
COJ: CORN_0611(ate)
CUX: CUP3940_0492(ate)
CRX: CRECT_1426(ate)
ABU: Abu_1772(ate)
ABT: ABED_1609
ABL: A7H1H_1709(ate)
AHS: AHALO_2101(ate)
AMYT: AMYT_2180(ate)
AMAR: AMRN_2219(ate)
ATP: ATR_0844(ate)
ACAA: ACAN_2218(ate)
AELL: AELL_2168(ate)
AAQI: AAQM_1940(ate)
AMOL: AMOL_2142(ate)
APAI: APAC_2010(ate)
ACIB: ACBT_0783(ate)
APOC: APORC_1385(ate)
AFC: AFAEC_0534(ate)
HBV: ABIV_0500(ate)
HEBR: AEBR_2405(ate)
PACO: AACT_2320(ate)
ARC: ABLL_2270
SDL: Sdel_1020
SMUL: SMUL_1508(ate)
SHAL: SHALO_1478
SULJ: SJPD1_1485
HYO: NNO_2000
SUN: SUN_1699
NIS: NIS_0160
DBA: Dbac_0535
DPS: DP2839
DSF: UWK_02178
MXA: MXAN_2360
CCX: COCOR_05705(ate)
SCL: sce3919(ate1)
MLO: mll8364
MHUA: MCHK_1684
MES: Meso_1127
PLA: Plav_2883
SME: SMc01764
SMX: SM11_chr2462(ate)
SMEL: SM2011_c01764(ate)
SMER: DU99_06225
SMD: Smed_0810
SFD: USDA257_c09230(ate)
SAME: SAMCFNEI73_Ch1271(ate)
EAD: OV14_2234
ATU: Atu1159
ARA: Arad_1744(ate)
AVI: Avi_1601
RET: RHE_CH01502(ate)
REL: REMIM1_CH01517(ate)
REP: IE4803_CH01506(ate)
REI: IE4771_CH01557(ate)
RLE: RL1614
RLG: Rleg_1260
RHL: LPU83_1458(ate)
RGA: RGR602_CH01390(ate)
RHN: AMJ98_CH01544(ate)
RPHA: AMC79_CH01526(ate)
RHT: NT26_1186
RHX: AMK02_CH01551(ate)
RHK: Kim5_CH01631(ate)
REZ: AMJ99_CH01623(ate)
NEN: NCHU2750_10840(ate1)
SHZ: shn_06580
BME: BMEI1199
BMEL: DK63_211
BMEE: DK62_650
BMF: BAB1_0778
BABO: DK55_775
BABR: DO74_1114
BABT: DK49_533
BABB: DK48_1343
BABU: DK53_759
BABS: DK51_698
BABC: DO78_680
BMS: BR0755
BSUI: BSSP1_I0950(ate)
BSUP: BSPT1_I0963(ate)
BSUV: BSPT2_I0950(ate)
BSUC: BSSP2_I0764(ate)
BMT: BSUIS_A0790(ate)
BSZ: DK67_1666
BOV: BOV_0750
BCS: BCAN_A0770(ate)
BCAR: DK60_822
BCAS: DA85_03595
BMR: BMI_I753
BPP: BPI_I792
BPV: DK65_608
OAN: Oant_2538
OAH: DR92_1993
BJA: blr5039
BRA: BRADO4438
BBT: BBta_4657
BRS: S23_31690
AOL: S58_33080
BRAD: BF49_6535
RPA: RPA2710
RPB: RPB_2621
RPC: RPC_2649
RPD: RPD_2658
RPE: RPE_3011
RPT: Rpal_2986
NWI: Nwi_1911
NHA: Nham_2242
OCA: OCAR_5853
OCG: OCA5_c21650(ate)
OCO: OCA4_c21640(ate)
XAU: Xaut_4292
AZC: AZC_1540
SNO: Snov_1642
MEA: Mex_1p4636(ate)
MDI: METDI5245(ate)
MEX: Mext_4241
MCH: Mchl_4611
MPO: Mpop_4761
MET: M446_6838
MNO: Mnod_7576
MOR: MOC_6218
META: Y590_21190
BID: Bind_1204
MSL: Msil_2121
MTUN: MTUNDRAET4_2038(bpt)
BBAR: RHAL1_01374(bpt)
HDN: Hden_1516
HMC: HYPMC_2507(ate)
RVA: Rvan_1361
PHL: KKY_1110
FIL: BN1229_v1_3080(ate)
FIY: BN1229_v1_2838(ate)
BVR: BVIR_2194
BLAG: BLTE_11560(ate)
MSC: BN69_0756(ate)
MMED: Mame_03614
MCG: GL4_1958
THD: BHV28_09440(ate)
HDI: HDIA_1362
RBM: TEF_13770
CCR: CC_1572
CAK: Caul_3062
CSE: Cseg_2631
PZU: PHZ_c1688
SIL: SPO2569(ate)
RSP: RSP_2639
RCP: RCAP_rcc02416(ate)
JAN: Jann_1903
RDE: RD1_2805(ate)
PDE: Pden_2168
DSH: Dshi_1082(ate)
KVL: KVU_0682
KVU: EIO_1184
KRO: BVG79_00951(ate)
PSF: PSE_3601(ate)
PGD: Gal_01385
OTM: OSB_19050
LAQU: R2C4_06925
CID: P73_2945
MALG: MALG_02033
RSU: NHU_02452
RHC: RGUI_3856
MALU: KU6B_26460(ate)
HNE: HNE_0893(ate)
HBA: Hbal_1353
GAK: X907_1682
NAR: Saro_1101
SAL: Sala_0342
SPHK: SKP52_04390(ate)
SPHP: LH20_03275
SMAZ: LH19_17425
SGI: SGRAN_1237(ate)
SPHU: SPPYR_2709(ate)
SWI: Swit_2393
SPHD: HY78_13550
SPHM: G432_16045
STAX: MC45_11380
SPHI: TS85_15570
SSAN: NX02_20575
SPKC: KC8_00295
SECH: B18_25530
SSY: SLG_32510(ate)
SPMI: K663_06545
SPHB: EP837_00453(ate1)
SPHR: BSY17_2784
SINB: SIDU_07000
SPHT: K426_08530
BLAS: BSY18_1867
SMIC: SmB9_22470(ate)
ELI: ELI_01635
AAY: WYH_01378
ALB: AEB_P3280
GOX: GOX0072
GOH: B932_2452
GOY: GLS_c00750(ate)
ACR: Acry_0237
AMV: ACMV_02630(ate)
GDI: GDI3015(ate)
GDJ: Gdia_3351
GXY: GLX_06100
GXL: H845_1724
KEU: S101446_00994(ate1)
APK: APA386B_849(ate)
ASZ: ASN_663(ate)
SHUM: STHU_32030(ate)
SVC: STVA_19490(ate)
RRU: Rru_A1845
RRF: F11_09485
RCE: RC1_1364
RPM: RSPPHO_00857(ate)
MAG: amb2581
MGRY: MSR1_11680
MAGX: XM1_3391(ate)
MAGN: WV31_06355
AZL: AZL_012820(ate1)
TMO: TMO_1611
TXI: TH3_10155
MAGQ: MGMAQ_1961
HTQ: FRZ44_30180(ate)
HADH: FRZ61_17330(ate)
MGM: Mmc1_0019
BBA: Bd0115
BBAC: EP01_12590
AFR: AFE_0249(ate)
ACU: Atc_2622
ATX: GCD22_00337(bpt)
HTL: HPTL_1634
MRB: Mrub_1912
RBA: RB10567(ate1)
PSL: Psta_2665
RUL: UC8_36710
IPA: Isop_3091
LIL: LA_1974
LIE: LIF_A1594
LIC: LIC_11930
LIS: LIL_12051
LBJ: LBJ_1540
LBL: LBL_1764
LST: LSS_12297
CHU: CHU_2143(ate)
SLI: Slin_2595
FAE: FAES_4984(ate)
HSW: Hsw_4227
CACI: CLOAM0212
 » show all
Reference
1  [PMID:16492767]
  Authors
Graciet E, Hu RG, Piatkov K, Rhee JH, Schwarz EM, Varshavsky A
  Title
Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen.
  Journal
Proc Natl Acad Sci U S A 103:3078-83 (2006)
DOI:10.1073/pnas.0511224103
  Sequence
[vvu:VV1_2124]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.29
IUBMB Enzyme Nomenclature: 2.3.2.29
ExPASy - ENZYME nomenclature database: 2.3.2.29
BRENDA, the Enzyme Database: 2.3.2.29

DBGET integrated database retrieval system