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Entry
EC 2.3.2.31                 Enzyme                                 

Name
RBR-type E3 ubiquitin transferase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RBR-type)
Reaction(IUBMB)
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine (overall reaction);
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;
(1b) [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [RBR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
Substrate
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine;
[acceptor protein]-L-lysine;
[RBR-type E3 ubiquitin transferase]-L-cysteine;
[RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Product
[E2 ubiquitin-conjugating enzyme]-L-cysteine;
[acceptor protein]-N6-ubiquitinyl-L-lysine;
[RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;
[RBR-type E3 ubiquitin transferase]-L-cysteine
Comment
RBR-type E3 ubiquitin transferases have two RING fingers separated by an internal motif (IBR, for In Between RING). The enzyme interacts with the CRL (Cullin-RING ubiquitin Ligase) complexes formed by certain RING-type E3 ubiquitin transferase (see EC 2.3.2.27), which include a neddylated cullin scaffold protein and a substrate recognition module. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue in the RING2 domain, followed by the transfer of the ubiquitin from RING2 to the substrate [4]. Once the substrate has been ubiquitylated by the RBR-type ligase, it can be ubiqutylated further using ubiquitin carried directly on E2 enzymes, in a reaction catalysed by EC 2.3.2.27. Activity of the RBR-type enzyme is dependent on neddylation of the cullin protein in the CRL complex [2,4]. cf. EC 2.3.2.26, HECT-type E3 ubiquitin transferase, EC 2.3.2.27, RING-type E3 ubiquitin transferase, and EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase.
History
EC 2.3.2.31 created 2017
Orthology
K04556  parkin
K10630  RanBP-type and C3HC4-type zinc finger-containing protein 1
K11967  ankyrin repeat and IBR domain-containing protein 1
K11968  ariadne-1
K11969  ariadne-2
K11971  E3 ubiquitin-protein ligase RNF14
K11972  E3 ubiquitin-protein ligase RNF19A
K11973  E3 ubiquitin-protein ligase RNF19B
K11974  E3 ubiquitin-protein ligase RNF31
K11975  E3 ubiquitin-protein ligase RNF144
K11976  E3 ubiquitin-protein ligase RNF216
K11977  E3 ubiquitin-protein ligase RNF217
K20779  E3 ubiquitin-protein ligase RNF168
K20804  E3 ubiquitin-protein ligase RNF34
K20805  E3 ubiquitin-protein ligase RNF169
K22157  E3 ubiquitin-protein ligase RNF183
Genes
HSA: 10425(ARIH2) 10616(RBCK1) 117584(RFFL) 127544(RNF19B) 138065(RNF183) 154214(RNF217) 165918(RNF168) 254225(RNF169) 255488(RNF144B) 25820(ARIH1) 25897(RNF19A) 5071(PRKN) 54467(ANKIB1) 54476(RNF216) 55072(RNF31) 80196(RNF34) 9604(RNF14) 9781(RNF144A)
PTR: 452810(RNF31) 453561(ARIH1) 454582(RFFL) 458025(RBCK1) 459008(RNF144A) 460355(ARIH2) 462463(RNF144B) 462979(RNF217) 463248(RNF216) 463530(ANKIB1) 464315(RNF19A) 464672(RNF183) 466707(RNF169) 467145(RNF34) 469169(RNF19B) 471678(RNF14) 741350(PRKN) 743342(RNF168)
PPS: 100967348(RNF19A) 100967594(RNF144B) 100971470(ARIH2) 100971526(RNF31) 100976201(RNF14) 100976794(RFFL) 100978701(PARK2) 100981890(RBCK1) 100983261(RNF217) 100983613(RNF19B) 100984163(ANKIB1) 100984639(RNF144A) 100987350(ARIH1) 100988460(RNF34) 100989258(RNF216) 100991152(RNF169) 100991662(RNF168) 100995289(RNF183)
GGO: 101128710(RNF144B) 101129059(RNF217) 101129265(RNF168) 101129382(ARIH2) 101129442(ANKIB1) 101131929(RFFL) 101132680(RNF216) 101136416(RNF19B) 101138314(ARIH1) 101139553(RNF14) 101141080(RNF144A) 101142171(RNF183) 101146596(RNF31) 101146894(RNF19A) 101147960(RBCK1) 101148003(RNF169) 101149349(RNF34) 101154322(PRKN)
PON: 100172179(RNF216) 100172433(PRKN) 100172822(RNF14) 100173871(RNF34) 100431820(RNF19B) 100433825(RNF31) 100437369(RNF168) 100438712(RBCK1) 100440879(ARIH1) 100441581(RNF183) 100443815(RNF144A) 100445309(RNF144B) 100445834(RNF217) 100448516(ARIH2) 100456262(ANKIB1) 100456389(RNF19A) 100457169(RFFL) 100462391(RNF169)
NLE: 100585186(RNF217) 100588492(RNF183) 100589757(PRKN) 100590842(RNF34) 100591331(ANKIB1) 100592018(RNF169) 100592722 100593086(RNF144B) 100593260(RNF19A) 100596919(ARIH2) 100599217(RNF168) 100599583(RNF14) 100599764(RNF144A) 100600435(RNF19B) 100602744(ARIH1) 100603577(RBCK1) 100604408(RFFL) 100606080(RNF31)
MCC: 106993960(RFFL) 694119(RNF169) 700062(RNF34) 701819 702912(ARIH1) 703273(ANKIB1) 705099(RNF144B) 705118(RNF19A) 705363(RNF14) 705679(RNF183) 708356(ARIH2) 709903(RNF168) 710523(RNF19B) 710899(PRKN) 714692(RBCK1) 715239(RNF31) 716637 716647(RNF217) 722223(RNF144A)
MCF: 101865319(RNF19A) 101866888(RFFL) 101867163(ARIH2) 101925453(RNF31) 101926204(RNF19B) 101926421(RNF14) 101926742(RNF34) 102118565(ANKIB1) 102118830(RNF217) 102119270(ARIH1) 102126740(RBCK1) 102128579 102133846(RNF183) 102133957(RNF144A) 102134446(PARK2) 102139086(RNF216) 102141486 102142858(RNF144B) 102143070(RNF168) 102147180(RNF169)
CSAB: 103218219 103218993(RNF183) 103220882(RNF144A) 103222100(RNF144B) 103225948(RNF19B) 103226565(ANKIB1) 103227609(ARIH2) 103228711(RNF31) 103237214(RNF19A) 103239281(RNF34) 103240428(RNF217) 103240862(PARK2) 103241996(RNF168) 103242724(RFFL) 103244709(RNF14) 103245372(ARIH1) 103246827(RNF216) 103247827(RBCK1) 103248045(RNF169)
RRO: 104653657(RNF144B) 104654934(RNF19B) 104658891(RNF217) 104659048(RNF144A) 104660808(RBCK1) 104662695(RNF31) 104665203(RNF169) 104665232(RNF216) 104666276(RNF34) 104667652(ARIH2) 104667869(RNF183) 104669996(PRKN) 104670822(RNF19A) 104673094 104675102(RFFL) 104676379(RNF168) 104679649(ARIH1) 104681830(RNF14) 104682687(ANKIB1)
RBB: 108520179(RNF19A) 108522661(RNF217) 108524746 108527012(ARIH2) 108527984(PARK2) 108528496(ANKIB1) 108529635(RNF34) 108530214(RNF14) 108531017(RNF144B) 108532160(RNF183) 108537303(RNF19B) 108537629(RNF169) 108538321 108540921(RNF31) 108541382(RFFL) 108542275(RNF168) 108544535(RBCK1) 108544583(ARIH1) 108545151(RNF144A)
CJC: 100385886(ARIH2) 100387184(RNF168) 100387994(ANKIB1) 100388155(RNF14) 100388243(RNF169) 100390242(PARK2) 100392127(RNF183) 100394354(RNF217) 100394986(RNF34) 100395354(ARIH1) 100400367(RNF144B) 100405928(RNF216) 100407708(RNF31) 100409790(RNF144A) 100411512(RBCK1) 100413811(RNF19B) 100414714(RNF19A) 100895959(RFFL)
SBQ: 101028360(RNF183) 101029163(RFFL) 101029277(PARK2) 101033751(RNF169) 101037001(RNF19B) 101037472(RNF168) 101038162(ANKIB1) 101038299(RBCK1) 101038579(RNF14) 101041413(RNF19A) 101041725(RNF144B) 101044956(RNF34) 101044978(ARIH2) 101047703(RNF217) 101048716(RNF31) 101050576(RNF216) 101051504(ARIH1) 101053520(RNF144A)
MMU: 108086(Rnf216) 108089(Rnf144a) 108937(Rnf169) 218215(Rnf144b) 23806(Arih1) 23807(Arih2) 24105(Rbck1) 268291(Rnf217) 268749(Rnf31) 30945(Rnf19a) 50873(Prkn) 56736(Rnf14) 67338(Rffl) 70238(Rnf168) 70797(Ankib1) 75234(Rnf19b) 76072(Rnf183) 80751(Rnf34)
MCAL: 110284393(Rbck1) 110285151(Rnf14) 110286429 110292074(Rnf183) 110292218(Rnf19b) 110294045(Ankib1) 110294350(Rnf216) 110294498(Rnf34) 110297579(Rnf169) 110301117(Arih2) 110301233(Arih1) 110303269(Rnf217) 110304691(Rffl) 110306826(Rnf144a) 110307992(Rnf144b) 110309048(Rnf31) 110310383(Rnf19a) 110311537(Rnf168) 110312630(Prkn)
MPAH: 110312784(Rnf34) 110316161(Ankib1) 110317671(Rbck1) 110323204(Rnf19b) 110323953(Rnf183) 110324406(Rnf144a) 110325297(Rnf31) 110327200(Arih2) 110327218(Arih1) 110329797(Rnf168) 110330638(Rnf169) 110332505(Rffl) 110332892(Rnf14) 110334009(Rnf144b) 110334868(Rnf19a) 110338070(Rnf217) 110338080(Prkn) 110339176(Rnf216)
RNO: 102557137(RGD1560267) 282844(Rffl) 282845(Rnf34) 292188(Rnf217) 300756(Arih1) 304294(Rnf216) 313806(Rnf19b) 316005(Arih2) 362900(Rnf19a) 364386(Rnf31) 364681(Rnf144b) 368062(Ankib1) 500474(Rnf183) 500636(Rnf144a) 56816(Park2) 60383(Rbck1) 619577(Rnf14) 685009(Rnf169) 690043(Rnf168)
MUN: 110540467 110540858 110543641 110545110(Rnf19a) 110545329(Rnf34) 110547635 110547637 110548680(Rnf19b) 110549563(Arih1) 110549709(Rnf144b) 110551833(Rffl) 110555557(Rnf183) 110555817(Rbck1) 110556518(Rnf31) 110557118(Rnf144a) 110558181(Rnf216) 110562270(Rnf169) 110564878 110564880 110565417(Arih2) 110566588(Rnf14)
CGE: 100751183(Rnf14) 100753166(Rnf168) 100753211(Rnf183) 100753623(Rnf144a) 100755555(Arih1) 100756962(Rnf19a) 100756964(Rnf169) 100757011(Rnf19b) 100758416(Rnf216) 100759287(Ankib1) 100760689(Rnf31) 100761016(Rbck1) 100762229(Rnf217) 100762975(Rnf144b) 100764359(Prkn) 100764705(Arih2) 100765673(Rffl) 100766863(Rnf34) 103159657
NGI: 103725204(Ankib1) 103725393 103729225 103730899(Rnf19b) 103732831(Rnf19a) 103734526(Rnf183) 103735130(Rnf217) 103736079(Rnf14) 103736849(Arih1) 103737054(Park2) 103738509(Rnf168) 103739070(Rnf34) 103739429(Rnf31) 103743068(Rnf169) 103745170(Rnf144b) 103746064(Rffl) 103747637(Rnf144a) 103748657(Rnf216) 103749130 103750209(Arih2) 103751631(Rbck1)
HGL: 101696643(Arih2) 101697249(Rnf19b) 101699936(Rffl) 101700770(Park2) 101701481(Rnf144b) 101702384(Rnf31) 101703970(Rnf183) 101708108(Rnf168) 101710073(Rnf144a) 101710516(Rnf217) 101714536(Rnf14) 101715043(Rnf216) 101718033(Arih1) 101718909(Rnf19a) 101719812(Rnf169) 101721667(Rbck1) 101722631(Ankib1) 101725498(Rnf34)
CCAN: 109681342(Rnf14) 109684108(Rnf183) 109684682(Ankib1) 109684710 109685866(Rnf31) 109686394(Rnf34) 109687017(Rbck1) 109687613(Rnf216) 109688031 109688416(Arih1) 109688417 109691985(Arih2) 109692978(Rnf19b) 109694505(Rnf168) 109695524 109696863(Rnf144b) 109697136(Rnf19a) 109698277(Rnf217) 109699542(Rnf169) 109700409(Rnf144a)
OCU: 100339939(RNF19B) 100340283(RNF144B) 100341415(RNF19A) 100341909(RNF216) 100343614(RNF144A) 100345531(RFFL) 100346464(RNF217) 100347560(RBCK1) 100348420(RNF31) 100348840(RNF168) 100350039(RNF34) 100351028(ARIH1) 100352371(RNF183) 100353098(ARIH2) 100355128(ANKIB1) 100355608(RNF14) 100356853(RNF169) 100358886(PARK2)
TUP: 102469732(PARK2) 102473005(RFFL) 102473168(RBCK1) 102473630(RNF217) 102475563(RNF168) 102475862(RNF14) 102480775(RNF216) 102481336(WDR31) 102487735(RNF169) 102491570(RNF34) 102492224(RNF19A) 102492317(ANKIB1) 102496618(RNF19B) 102496915(RNF31) 102497561(RNF144A) 102498381(ARIH2) 102498489(ARIH1) 102499590(RNF144B)
CFA: 100684892(RNF183) 475049(RNF19A) 475226(ANKIB1) 476633(ARIH2) 477470(RNF34) 478042(RNF14) 478146(RNF19B) 478359(ARIH1) 479760(RNF216) 480259(RNF31) 484112(RNF217) 485818(RBCK1) 488029(RNF168) 488237(RNF144B) 491144(RFFL) 609037(RNF144A) 609300(RNF169) 612316(PRKN)
VVP: 112909903(RBCK1) 112911866(ARIH2) 112913532(RNF168) 112916962(RNF19A) 112917996(RFFL) 112920513(RNF144B) 112923075(RNF183) 112923878(ANKIB1) 112926536(RNF31) 112927741(RNF144A) 112928737(RNF169) 112929328(RNF216) 112930930(RNF217) 112931739(RNF19B) 112932949(PRKN) 112934694(RNF14) 112935011(ARIH1) 112935206(RNF34)
AML: 100464169(RNF144A) 100464626(RNF14) 100464760(RFFL) 100465415(PARK2) 100466635(RNF34) 100470833(RNF217) 100471387(RBCK1) 100471858(ARIH1) 100475726(RNF31) 100476120(RNF183) 100476839(ANKIB1) 100478141(RNF168) 100479311(RNF169) 100480091(ARIH2) 100480727(RNF19A) 100480757(RNF19B) 100481429(RNF144B) 100482162(RNF216)
UMR: 103657797(RNF144A) 103658712(ANKIB1) 103660821(PARK2) 103661165(RNF34) 103661640(RNF19A) 103663522(RNF217) 103663716(RNF14) 103664876(RNF144B) 103666733(RNF19B) 103667433(RFFL) 103670088(RNF216) 103674489(RBCK1) 103674840(ARIH2) 103678119(RNF169) 103678596(RNF183) 103678933(RNF168) 103679136(ARIH1) 103679278(RNF31)
UAH: 113240941(ARIH1) 113245982(RNF31) 113252875(RNF19A) 113252962(RNF168) 113255364(RNF14) 113256850(ARIH2) 113258444(RBCK1) 113259330(PRKN) 113259409(RNF217) 113259879(ANKIB1) 113264509(RNF144B) 113266312(RNF183) 113266947(RNF34) 113267960(RNF216) 113268206(RNF19B) 113268972(RFFL) 113269319(RNF169) 113269418(RNF144A)
ORO: 101363543(RNF19B) 101364866(RNF183) 101365486(RNF14) 101368016(RNF34) 101368179(RNF168) 101374350(RBCK1) 101375895(RNF216) 101376796(ARIH2) 101378248(RFFL) 101378850(RNF217) 101378944(RNF144B) 101379401(ARIH1) 101380103(RNF31) 101380537(RNF169) 101381128(ANKIB1) 101382230(RNF144A) 101385500(PARK2) 101386590(RNF19A)
FCA: 101080912(RNF169) 101081275(RNF14) 101081895(RNF217) 101083280(RNF19B) 101083505(RBCK1) 101084015(ANKIB1) 101086920(RNF168) 101090511(RNF144A) 101091116(ARIH1) 101094706(RNF34) 101096179(RNF183) 101097376(RNF19A) 101098228(PRKN) 101098501(RFFL) 101099009(RNF216) 101099205(RNF144B) 101100727(RNF31) 101101117(ARIH2)
PTG: 102948700(RNF34) 102951154(RNF183) 102952602(ANKIB1) 102953085(RNF217) 102953687(RNF216) 102954168(RNF169) 102956362(RNF31) 102957419(RNF144B) 102960168(ARIH1) 102964504(RNF14) 102964689(PARK2) 102965051(RNF19A) 102965998(RNF168) 102968688(ARIH2) 102968752(RNF144A) 102970756(RBCK1) 102971663(RFFL) 102972604(RNF19B)
PPAD: 109245483(PARK2) 109247783(ARIH2) 109248499(RNF217) 109249578(RNF144B) 109251171(RNF216) 109251936(RFFL) 109252220(RNF14) 109254989(RNF31) 109255291(RNF19B) 109262729(ARIH1) 109263680(ANKIB1) 109266547(RNF168) 109267195(RNF169) 109269022(RNF144A) 109269953(RNF183) 109272618(RBCK1) 109277680(RNF34) 109278011(RNF19A)
AJU: 106967201(RNF14) 106967546(RNF34) 106969981(ANKIB1) 106972382(RFFL) 106973217(RNF19B) 106974214(ARIH1) 106978000(RNF169) 106978351(RNF183) 106979225(ARIH2) 106980048(RNF19A) 106982954(RNF144A) 106984515(RNF216) 106985022(PRKN) 106985976(RBCK1) 106987469(RNF168) 106987844(RNF31) 106988504(RNF217) 106989604(RNF144B)
BTA: 504400(RBCK1) 505204(ANKIB1) 505320(ARIH2) 506764(RNF34) 508410(ARIH1) 509774(RNF19B) 509856(RNF31) 524166(RNF144B) 525756(RNF169) 530263(RFFL) 530858(PARK2) 534455(RNF216) 539200(RNF183) 540195(RNF19A) 540274(RNF14) 541287(RNF217) 613812(RNF168) 618176(RNF144A)
BOM: 102268433(RNF144B) 102268917(RNF31) 102270304 102271295(RNF19B) 102274796(RNF34) 102275101(ARIH2) 102275629(RFFL) 102279757(RNF183) 102280624(RBCK1) 102280689(RNF168) 102282296(RNF144A) 102282958(RNF19A) 102283079(RNF217) 102283921(ANKIB1) 102284805 102284919(ARIH1) 102286329(RNF216) 102287070(RNF169) 102287602(RNF14)
BIU: 109558196(ANKIB1) 109562149(RNF14) 109562650(RNF168) 109563366(RNF183) 109563485(RNF217) 109564101(PARK2) 109564747(ARIH1) 109564780(RNF31) 109566415(RNF144A) 109567335(RBCK1) 109568479(RNF19A) 109569759(RNF169) 109571126(RNF34) 109573806(RFFL) 109575997(RNF19B) 109576133(ARIH2) 109577036(RNF144B) 109578434(RNF216)
BBUB: 102391521(ARIH2) 102394663(RNF31) 102395541(RNF183) 102397902(RNF34) 102402252(RNF19B) 102403200(RNF217) 102404601(RNF168) 102404742(RNF19A) 102405828(RNF144A) 102406619(PRKN) 102406740(RFFL) 102406758(RBCK1) 102407565(RNF14) 102409356(RNF144B) 102411934(ARIH1) 102412470(ANKIB1) 102413972(RNF169) 102415593(RNF216)
CHX: 102169814(RNF19B) 102169816(RNF144B) 102169890(RNF169) 102172288(RNF34) 102172812(PARK2) 102174697(RNF168) 102174939(ARIH1) 102176326(RNF183) 102176805(RNF19A) 102178594(ANKIB1) 102179061(RNF216) 102181220(RBCK1) 102182790(RNF217) 102185615(ARIH2) 102186047(RFFL) 102186586(RNF14) 102190329(RNF144A) 102191244(RNF31)
OAS: 101102266(RNF34) 101103734(RNF19A) 101104466(RNF19B) 101105600(RNF169) 101107329(RNF183) 101108651(RNF14) 101109306(ARIH2) 101111273(ANKIB1) 101113503(PRKN) 101115266(RNF144A) 101116578(ARIH1) 101116911(RNF31) 101117640(RNF216) 101118456(RFFL) 101119141(RNF217) 101121991(RNF168) 101122207(RBCK1) 101122473(RNF144B) 114116429
SSC: 100155665(RNF144B) 100511268(ARIH1) 100512591(RNF14) 100514456(RNF144A) 100517844(ANKIB1) 100519985(RBCK1) 100524765(ARIH2) 100621544(RNF19B) 100622036(RNF183) 100625422(RNF216) 100627054(RFFL) 100738102(RNF217) 100739168(RNF169) 102167889 110256771(RNF34) 654326(RNF19A) 733673(PRKN)
CFR: 102503965(RNF34) 102505122(RNF168) 102507388(RNF144A) 102508809(PRKN) 102510476(RNF217) 102511188(RNF19B) 102511989(RNF216) 102512423(RNF144B) 102512644(ARIH2) 102512925(RNF14) 102513471(RBCK1) 102514122(ANKIB1) 102514539(RNF183) 102515421(RNF169) 102515825(RNF19A) 102519793(RFFL) 102519901(RNF31) 102523661(ARIH1)
CDK: 105085823(RNF19B) 105086287(PRKN) 105087289(ARIH1) 105087382(ANKIB1) 105087863(ARIH2) 105089115(RNF144B) 105090539(RNF19A) 105090807(RNF14) 105096314(RNF217) 105098180(RNF169) 105099392(RNF216) 105100807(RBCK1) 105101287(RNF168) 105102415(RNF31) 105102509(RNF34) 105103763(RNF183) 105104267(RNF144A) 105106564(RFFL)
BACU: 102998158(RNF31) 102998407(RNF169) 103000245(RBCK1) 103001826(RNF183) 103003438(RNF34) 103003963(RNF19B) 103006032(PARK2) 103006444(RNF217) 103007013(ARIH2) 103008522(RNF144A) 103008813(RNF19A) 103008983(RNF168) 103010281(RNF144B) 103013154(ARIH1) 103013845(RNF216) 103013890(ANKIB1) 103016957(RNF14) 103017693(RFFL)
LVE: 103068380(ARIH2) 103069602(RNF31) 103072488(PARK2) 103075518(RNF19B) 103075876(RNF169) 103076492(RNF216) 103081365(RNF217) 103081521(ARIH1) 103082694(ANKIB1) 103083828 103084080(RNF168) 103084197(RNF183) 103084814(RBCK1) 103087409(RNF19A) 103088057(RFFL) 103088302(RNF144B) 103088525(RNF144A) 103089409(RNF34) 103090128(RNF14)
OOR: 101270388(RNF144B) 101270873(RFFL) 101273068(RNF31) 101273752(ANKIB1) 101273890(RNF168) 101274389(RNF217) 101274605(RNF144A) 101276605(RNF19A) 101276835(RNF216) 101277934(ARIH1) 101279170(RNF14) 101279418(RNF169) 101280764(RNF34) 101285270(RBCK1) 101286051(PARK2) 101287965(RNF19B) 101288709(ARIH2) 101290291(RNF183)
DLE: 111164115(RNF31) 111164442(RNF144A) 111165313(RNF217) 111168498(AGPAT4) 111170361(RNF216) 111170822(RFFL) 111172210(RNF168) 111174418(ARIH2) 111175534(RNF19B) 111177307(RNF183) 111177795(ARIH1) 111180382(RNF19A) 111180857(ANKIB1) 111181397(RNF144B) 111183030(RNF14) 111184340(RBCK1) 111184861(RNF169) 111186957(RNF34)
PCAD: 102973447(RNF19B) 102974197(RNF144A) 102975508(RNF168) 102975839(RNF34) 102977045(RBCK1) 102977296(RNF14) 102978216(RNF217) 102978948(RNF183) 102980221(RNF169) 102982022(PRKN) 102982398(RNF19A) 102982577(RFFL) 102982811(RNF144B) 102988166(RNF216) 102990231(ANKIB1) 102990544 102993320(RNF31) 102996504(ARIH1) 112062936
ECB: 100050237(RNF183) 100052124(RNF144B) 100053691(ARIH2) 100055939(RNF19A) 100057284(RNF144A) 100057832(PRKN) 100058179(RFFL) 100059097(RNF216) 100059653(RNF34) 100061269(ANKIB1) 100061332(RNF14) 100063423(ARIH1) 100064984(RNF169) 100067987(RBCK1) 100069836(RNF168) 100070073(RNF19B) 100073006(RNF217)
EPZ: 103541377(RNF34) 103547894(RNF216) 103549162(RNF144B) 103549186(ANKIB1) 103549688(RNF144A) 103553387(ARIH2) 103554862(RNF169) 103555475(ARIH1) 103556916(RBCK1) 103557788(RNF19B) 103558678(RNF19A) 103559496(RFFL) 103559948(RNF168) 103564024(RNF31) 103564294(RNF14) 103565651(RNF183) 103566388(RNF217)
EAI: 106822723(RNF183) 106827319(RNF216) 106829014(RNF19B) 106830671(ARIH2) 106832252(ANKIB1) 106833755(RBCK1) 106836970(RNF14) 106838724(RNF217) 106838811(RNF169) 106841592(RNF144B) 106842050(PARK2) 106842293(RNF34) 106844638(RFFL) 106847493(RNF144A) 106847840(RNF19A) 106848320(RNF168) 106848580(RNF31)
MYB: 102240312(ARIH2) 102240497(RNF144B) 102241135(RNF169) 102241901(RFFL) 102243635(RNF183) 102247091(RNF168) 102247888(RNF217) 102248937(RNF144A) 102249571(RNF19B) 102251738(RNF34) 102252422(RBCK1) 102253242(RNF31) 102254245(RNF14) 102255484(PARK2) 102256846(RNF216) 102259444(RNF19A) 102260139(ANKIB1) 102260588(ARIH1)
MYD: 102752193(RNF34) 102753253(RNF168) 102754132(RNF19B) 102755013(RNF183) 102757960(PARK2) 102759068(RBCK1) 102763075(RNF14) 102765589(ANKIB1) 102766259(RNF144A) 102766970(RFFL) 102767669(RNF31) 102768134(RNF19A) 102769957(RNF144B) 102770547(RNF169) 102771441(RNF216) 102771991(RNF217) 102772238(ARIH1) 102773561(ARIH2)
MNA: 107524481(RNF169) 107526136(RNF19A) 107526650(RNF144A) 107527269(RNF168) 107527772(RBCK1) 107528367(ARIH1) 107529436(ARIH2) 107529589(RNF34) 107531155(RNF144B) 107531503(RNF14) 107531721(RNF31) 107532592(RFFL) 107535544(RNF183) 107535732(PARK2) 107536880(RNF217) 107537590(RNF216) 107541019(RNF19B) 107541692(ANKIB1)
HAI: 109373173(RFFL) 109375166(RNF144B) 109376241(ARIH2) 109377263(ANKIB1) 109379298(RNF183) 109380203(RNF216) 109382805(RNF19A) 109384455(RBCK1) 109384718(RNF144A) 109386070(RNF34) 109386309(RNF169) 109387714(RNF168) 109390741(RNF19B) 109391762(ARIH1) 109393167(RNF217) 109393686(RNF31) 109393907(RNF14) 109394305
DRO: 112297240(RNF217) 112297296 112297700(RNF144A) 112298626(RFFL) 112299330(RNF19B) 112301153(RNF31) 112301827(ARIH1) 112304086(RBCK1) 112306257(RNF183) 112309251(RNF144B) 112309551(ARIH2) 112310618(RNF34) 112315430(RNF19A) 112315967(RNF169) 112318110(RNF14) 112319671(RNF216) 112319872(ANKIB1) 112320624(RNF168)
PALE: 102879300(RNF19B) 102882232(RNF183) 102882290(RNF169) 102883637(RNF34) 102883796(RNF216) 102884021(RBCK1) 102885224(RNF168) 102885572(ARIH2) 102885646(RNF217) 102888644(RNF144B) 102888747(PRKN) 102893150(RNF144A) 102894410(RNF19A) 102894740(ANKIB1) 102895242(RNF31) 102895793(RNF14) 102896071(RFFL) 102898538(ARIH1)
RAY: 107498005(RNF31) 107498224(RNF144A) 107499690(RNF14) 107500746(RNF183) 107501086(ARIH1) 107501685(PARK2) 107502498(RNF19A) 107505268(RNF168) 107512902(RBCK1) 107513337(ARIH2) 107513612(RNF19B) 107515243(RNF34) 107515933(RNF216) 107516280(RNF144B) 107519056(ANKIB1) 107519081(RNF217) 107519152(RNF169) 107519950(RFFL)
MJV: 108384038 108384947(RNF168) 108386842(ANKIB1) 108387306(RNF183) 108387452 108389619 108390402(RNF34) 108391108(RNF31) 108391803 108396551(RNF19A) 108399417(RNF216) 108400431(RBCK1) 108401570 108401807(RNF19B) 108403589(RFFL) 108403981 108404255(RNF169) 108408602(RNF144A) 108409262(ARIH2) 108409315(RNF144B)
LAV: 100653883(RNF31) 100654220(RBCK1) 100655187(RNF216) 100656284(ANKIB1) 100657240(ARIH2) 100657272(RNF144B) 100660302(RNF19B) 100661869(RNF217) 100661925(ARIH1) 100662389(RNF144A) 100663025(RNF183) 100663195(RNF14) 100665442(PRKN) 100667158(RNF169) 100668014 100669869(RFFL) 100669893(RNF34) 100672051(RNF168) 100674144(RNF19A)
MDO: 100010996(RNF183) 100011102(RBCK1) 100012888(RNF169) 100015550(RNF216) 100016251(ARIH1) 100018074(RFFL) 100020639(ARIH2) 100021251(RNF34) 100022084(RNF168) 100023095(RNF14) 100025103(RNF144B) 100028173(ANKIB1) 100028271(RNF144A) 100030572(RNF19A) 100030618(RNF217) 100030741(RNF31) 100032415(RNF19B) 100032502(PARK2)
SHR: 100914651(RFFL) 100915026(RNF31) 100915640(RNF14) 100916613(RNF19A) 100916771(RNF183) 100916835(ANKIB1) 100918829(ARIH1) 100919033(RBCK1) 100920623(ARIH2) 100920720(RNF169) 100920905(RNF217) 100923232(RNF216) 100924196(RNF34) 100928463(PRKN) 100929569(RNF19B) 100931005(RNF144A) 100935193(RNF144B) 105750883(RNF168)
PCW: 110193700(RNF183) 110195063(RNF31) 110196194(RNF19A) 110196815(RNF34) 110206240(RNF19B) 110208171(RNF168) 110208624(PRKN) 110208710(RNF144B) 110208835(RNF217) 110209158(ANKIB1) 110210578(RNF169) 110211403(RBCK1) 110212617(RNF144A) 110213686 110213911(ARIH1) 110216942(ARIH2) 110220850(RNF14) 110221478(RFFL) 110223170(RNF216)
OAA: 100073394(ARIH2) 100077207(ARIH1) 100077320(RNF144B) 100077454(RNF19B) 100078857(RNF14) 100079228(RNF34) 100079895(RNF144A) 100081654(RNF216) 100081764(RNF169) 100089256(ANKIB1) 100089846(RNF168) 100092043(RNF19A) 107546885(RNF183) 114806007(RBCK1) 114808913 114809076(RNF217) 114809162(PRKN) 114817690(RFFL)
GGA: 107051192 415319(ARIH1) 416061(ARIH2) 416340(RNF14) 416486(RNF216) 416843(RNF34) 417529(RFFL) 419055(RNF169) 419669(RNF19B) 420251(RNF19A) 420550(ANKIB1) 420827(RNF144B) 421577(PARK2) 421922(RNF144A) 426209(RNF217) 770166(RNF168)
MGP: 100540292(ARIH2) 100540607(RNF216) 100541719(ARIH1) 100542178(RNF168) 100542550(RNF34) 100545288(RFFL) 100546851 100547468(RNF144B) 100548535(RNF217) 100549562(RNF144A) 100549852(RNF19B) 100549874(RNF19A) 100550612(RNF14) 100551415(ANKIB1) 100551448(RNF169) 104915434(RBCK1)
CJO: 107307646 107308618(RNF169) 107309003(ANKIB1) 107309717(RNF144B) 107310408(RNF19A) 107311526(PRKN) 107311850(RNF217) 107312184(RNF144A) 107312278 107317909(RNF168) 107318498(ARIH1) 107319913(ARIH2) 107320041(RNF14) 107320603(RNF216) 107321120(RNF34) 107322523(RFFL) 107323959(RNF19B)
NMEL: 110387260(RNF19B) 110391473 110392146(RNF169) 110393594(ANKIB1) 110393855(RNF19A) 110394725(RNF144B) 110395328(TPD52L1) 110395838(RNF144A) 110395954(PRKN) 110396274 110399115(RNF168) 110403598(ARIH1) 110404836(ARIH2) 110405218(RNF14) 110406152(RNF216) 110406586(RNF34) 110407599(RFFL)
APLA: 101790320(RFFL) 101790415(ARIH1) 101790666(RNF144A) 101791675(RNF19A) 101791826(ANKIB1) 101792682(RNF217) 101793521(RNF144B) 101793852(RNF168) 101796091(PRKN) 101798950(RNF169) 101800882(RNF216) 101801802(RNF34) 101804156(RNF14) 101804187(RNF19B) 101804527(ARIH2)
ACYG: 106030699(RNF144A) 106031150(RNF34) 106032078(RNF216) 106032409(RNF217) 106032741(RNF14) 106035285(RNF19A) 106035470(ARIH2) 106037883(RNF19B) 106039251(RNF168) 106039539(PARK2) 106039677(ANKIB1) 106041447(RFFL) 106041702(RNF144B) 106042404(RNF169) 106044226(ARIH1) 106049319
TGU: 100220050(ANKIB1) 100220883(RNF34) 100221229(PRKN) 100222286 100224511(ARIH1) 100225291(RNF14) 100227841(RNF144A) 100229686(RNF19A) 100229928(RNF169) 100230372(ARIH2) 100231804(RNF144B) 100232075(RNF217) 100232444(RNF19B) 100232818(RNF216) 101233851(RFFL) 115492363 115493026 115493035(RNF31) 115496451(RNF168)
LSR: 110467968(RNF144A) 110470072(RNF19A) 110470946(ARIH2) 110471757(RNF34) 110475342(RNF19B) 110476392(RNF14) 110477868(RNF169) 110477920(PRKN) 110478510 110478644(RNF168) 110479468 110479698(RNF217) 110481021(RNF31) 110481102(RNF216) 110482098(RFFL) 110482437(ANKIB1) 110483465(RNF144B) 110483965(ARIH1)
SCAN: 103812814(ANKIB1) 103813857(RNF19A) 103815514(RNF168) 103815945(ARIH1) 103817060(ARIH2) 103817394(RNF14) 103817619(RNF216) 103818166(RNF34) 103818217(RNF217) 103818385(RNF169) 103819405(RNF144B) 103820084(RFFL) 103820360(RNF144A) 103821619(PRKN) 103823490(RNF19B) 103824584
GFR: 102031490(RNF14) 102033204(RNF144B) 102034665(ANKIB1) 102035053(RNF144A) 102035129(RNF19A) 102035350(ARIH1) 102035695(RNF168) 102037016(RNF169) 102037061(RFFL) 102039266(RNF19B) 102039746(RNF217) 102041098(RNF216) 102043879(PARK2) 102044729(ARIH2) 102044909(RNF34)
FAB: 101805970(RNF144B) 101808815(RFFL) 101810988(PARK2) 101811392(RNF168) 101811904(RNF144A) 101812977(RNF216) 101813565(ARIH1) 101813644(RNF34) 101816503(RNF19A) 101816688(ANKIB1) 101817033(RNF14) 101818723(ARIH2) 101819716(RNF169) 101819774(RNF19B) 101821219(RNF31) 101821573 101822113(RNF217)
PHI: 102099437(RNF217) 102099953(RNF144B) 102102627(RNF14) 102103366(ARIH2) 102105199(PARK2) 102106515(RNF168) 102106565(RFFL) 102106906(SHARPIN) 102107209(RNF19A) 102107232(RNF216) 102107949(RNF144A) 102108806(ARIH1) 102109060(RNF169) 102113207(RNF19B) 102113498(RNF34) 102113728(ANKIB1) 106628698 106628974(RNF31)
PMAJ: 107198715 107199894(RNF19A) 107199920(ANKIB1) 107200788(RNF144B) 107201771(RNF217) 107201839(RNF144A) 107202287(PARK2) 107208870(RNF168) 107209447(ARIH1) 107210292(ARIH2) 107210833(RNF14) 107211288(RNF216) 107211565(RNF34) 107212889(RFFL) 107214042(RNF19B) 107214317(RNF169)
CCAE: 111923747(RNF144B) 111924214(ANKIB1) 111924500(RNF19A) 111925930(RNF144A) 111926948(PRKN) 111927215(RNF217) 111927455 111933726(RNF168) 111934294(ARIH1) 111935021(ARIH2) 111935796(RNF14) 111936116(RNF216) 111936392(RNF34) 111937716(RFFL) 111938968(RNF19B) 111942510(RNF169)
CCW: 104683330(ARIH2) 104684351(PRKN) 104684498 104684797(RNF216) 104685457(RNF144A) 104688701(RNF34) 104689179(ANKIB1) 104689480(RNF14) 104690914(RNF217) 104691094(RFFL) 104691432(RNF144B) 104692717(RNF19A) 104694672(RNF19B) 104696718(RNF168) 104697510(ARIH1) 104698113(RNF169)
ETL: 114054957(RNF34) 114055652(PRKN) 114056788(ARIH2) 114059465 114059949(ARIH1) 114060183(RNF216) 114060754(RNF144A) 114062132(ANKIB1) 114064240(RNF217) 114065022(RFFL) 114066952(RNF14) 114067558(RNF19A) 114068681 114069003(RNF19B) 114069385(RNF168) 114069803(RNF169)
FPG: 101911083(RNF19A) 101911249(ARIH2) 101912567(RNF34) 101912893(RNF216) 101913654 101914357(RNF168) 101914399(RNF144A) 101915291(RNF14) 101917453(SHARPIN) 101917576(RNF144B) 101918371(PARK2) 101918736(RNF217) 101920797(ANKIB1) 101920802(RNF169) 101921271(ARIH1) 101921349(RFFL) 101923190(RNF19B)
FCH: 102047647 102047834(ARIH2) 102047886(ANKIB1) 102048210(PRKN) 102049057(RNF168) 102049766(RNF14) 102050607(RNF34) 102050954(RNF216) 102051230(RNF144A) 102051575(RNF144B) 102053611 102054937(RNF169) 102055582(RNF19B) 102056273(RFFL) 102056850(RNF217) 102057801(ARIH1) 102059373(RNF19A)
CLV: 102084040(PRKN) 102085427(RNF34) 102086720(RNF216) 102087134(RNF19B) 102087570(RNF168) 102089683(RNF144B) 102089788 102090426(RNF14) 102090610 102091001(RNF19A) 102092300(ARIH2) 102092355(ANKIB1) 102092848(RNF217) 102093412(ARIH1) 102095486(RNF169) 102096621(RNF144A) 102098586(RFFL) 106146052
EGZ: 104125481(RNF144B) 104125877(RNF19A) 104127154(RNF144A) 104128909(ANKIB1) 104130105(RNF34) 104130703(ARIH1) 104131284(RNF168) 104131677 104131910(RFFL) 104131973(RNF217) 104132542 104132629(RNF216) 104133059(RNF169) 104133436(RNF14) 104134794(ARIH2) 104134983(RNF19B)
NNI: 104008913(RNF217) 104009154(RNF144A) 104010641(RNF168) 104011065 104012021(RNF14) 104014024(ANKIB1) 104015102(RNF216) 104016091(RFFL) 104016439(RNF19A) 104016705(ARIH1) 104016902(ARIH2) 104017870(RNF19B) 104018239 104018425(PARK2) 104019504(RNF34) 104021800(RNF144B) 104022759(RNF169)
ACUN: 113476686(RNF144B) 113476865(RNF19A) 113477432(ANKIB1) 113477882(PRKN) 113478290(RNF144A) 113478612(RNF217) 113481328(RNF169) 113483675(RNF168) 113483928(ARIH1) 113484672(ARIH2) 113485297(RNF14) 113485676(RNF216) 113486073(RNF34) 113487246(RFFL) 113488234(RNF19B) 113490525
PADL: 103913427(ARIH1) 103914142(RNF216) 103914151(PARK2) 103914527(RNF34) 103915932(RNF168) 103916125(RNF19A) 103918338(RNF217) 103918680(RFFL) 103918904(ARIH2) 103919054(RNF144B) 103921115(RNF169) 103922386(ANKIB1) 103923134(RNF14) 103923781(RNF19B) 103924046(RNF144A)
AAM: 106482447(RNF144B) 106483621(ANKIB1) 106483893(RNF19A) 106484162 106486123(ARIH1) 106486766(PARK2) 106487276(RNF14) 106489593(ARIH2) 106490216 106492629(RNF168) 106493282(RNF19B) 106494721 106494723 106495638 106495698(RNF34) 106496900(RNF216) 106497336(RFFL) 106497879(RNF217)
ASN: 102368583(ARIH1) 102369612 102369989(RNF14) 102372451(RNF144A) 102372467(RNF216) 102374341(SHARPIN) 102376207(RFFL) 102376359 102379782(RNF19A) 102379979(RNF34) 102381622(ARIH2) 102381829(RBCK1) 102381887(PRKN) 102383271 102385842(RNF144B) 102385975(RNF31) 102386874(ANKIB1) 102386883(RNF168) 102387332(RNF19B) 102387360(RNF169) 102388339
AMJ: 102558249(RNF14) 102558277 102559458(ARIH2) 102560035(RNF144B) 102561171 102561195(RNF144A) 102561551(RNF183) 102561826(RNF31) 102564389 102565152(RNF34) 102565394(RBCK1) 102566505(RNF169) 102567663(ANKIB1) 102569330(RNF19B) 102571866(RNF216) 102572254(RNF168) 102573688(PARK2) 102576415(ARIH1) 106736996(RFFL) 106737011(RNF19A) 106737227(RNF217) 106739496
PSS: 102443400(ARIH1) 102445893(RNF144B) 102446554(RNF34) 102447566 102449037(RNF19B) 102450880(RNF168) 102451074(ANKIB1) 102451201(RNF14) 102451562(PRKN) 102451652(RFFL) 102451860 102455299(RNF217) 102455311(ARIH2) 102456959(RNF144A) 102458213(RNF169) 102461157(RNF19A)
CMY: 102929571(RNF19B) 102931334(RNF168) 102931587(RNF144A) 102932567(RNF144B) 102933052(RNF14) 102933319(RNF34) 102933957(RBCK1) 102934874(RNF169) 102935998(PARK2) 102937584(RNF216) 102940430(RNF217) 102941216(ARIH2) 102942146(ARIH1) 102943805(RNF183) 102944326(RNF19A) 102944891(ANKIB1) 102947109(RFFL)
CPIC: 101931900(ARIH1) 101932362(RNF14) 101936162(RNF19A) 101937235(ANKIB1) 101938614(RFFL) 101939751(RNF144B) 101940616(RNF216) 101941171(PARK2) 101941212(RNF34) 101943590(RNF168) 101943634(RNF144A) 101951677(RNF31) 101952193(RNF169) 101952313(SHARPIN) 101952611(RNF217) 101953432(RNF183) 101953541(RNF19B) 101953806(ARIH2) 101954121(RBCK1)
ACS: 100556556(rnf31) 100558007(arih2) 100558586 100558904(rnf216) 100558966(rnf169) 100559435(park2) 100559961(rnf183) 100560085(rnf19a) 100560956(rnf144a) 100560998(rnf19b) 100561030(rnf168) 100562548(rnf144b) 100562899(rbck1) 100564158(sharpin) 100565098(rnf14) 100565294 100566686(ankib1) 100567694(rnf217) 100568014(arih1) 103280929(rnf34)
PVT: 110069788(RNF144A) 110074745(ANKIB1) 110074798(RNF19A) 110075280(RNF168) 110078115(RNF169) 110079213(RNF217) 110079932(ARIH2) 110081678(RNF144B) 110082755(RNF19B) 110082971(RNF183) 110083722(RNF216) 110083886(RNF34) 110084390 110084511(RFFL) 110084806 110085759(RNF14) 110087285(PRKN) 110087544 110090830(RBCK1)
PBI: 103048775(RNF216) 103049727(RNF14) 103050073(RNF168) 103050408(RFFL) 103051756(RNF19B) 103051791 103053864(RNF31) 103054488(RNF144B) 103054619 103055331(RNF169) 103056080(RNF34) 103058189(RNF217) 103059672(ARIH1) 103059936(RNF19A) 103062180(RNF183) 103063372(ARIH2) 103063472 103064049(ANKIB1) 103064329 103067153(RNF144A)
PMUR: 107282806(ANKIB1) 107283716(RNF19B) 107285147(RNF19A) 107286346(RNF144B) 107286440 107286831(RNF14) 107287008(RNF34) 107287024(RNF169) 107288939(RFFL) 107292531(RNF217) 107292777(ARIH2) 107293085(RNF31) 107294697 107294965(RNF168) 107295102(PRKN) 107297692(ARIH1) 107298093(RNF144A) 107299778 107299797 107302818(RNF183) 107302933(RNF216)
TSR: 106538372(ANKIB1) 106538534 106539634(RNF169) 106544138(RFFL) 106544355(RNF144B) 106544550(RNF19A) 106545890 106548036(RNF217) 106549808 106550246 106550720(PARK2) 106552809(ARIH1) 106554652(RNF168) 106554902(ARIH2) 106555857(RNF14) 106555932(RNF34) 106556075(RNF183) 106556840(RNF19B)
PMUA: 114581718(RNF31) 114584612(ARIH1) 114584999(RNF216) 114585060(RFFL) 114586202(RNF34) 114589489(RNF183) 114591230(RNF14) 114591901(ARIH2) 114593769(RNF144A) 114594110(RNF217) 114594313(PRKN) 114595042 114595527(RNF169) 114597730(RNF168) 114599814(RBCK1) 114600121(SHARPIN) 114600370(RNF19A) 114600857(RNF144B) 114601699(RNF19B) 114607497(ANKIB1)
GJA: 107105834(RNF19A) 107107699(RFFL) 107108232(ANKIB1) 107109899(RNF144B) 107113335(PARK2) 107113795 107114559(RNF168) 107115105(RNF31) 107115885(RNF34) 107115952(RNF19B) 107116389(RNF169) 107117859(SHARPIN) 107118842 107119331(RBCK1) 107119618(ARIH2) 107120152(RNF216) 107120430(RNF183) 107121011(RNF217) 107124053(ARIH1) 107125609(RNF144A) 107125765(RNF14)
XLA: 100037145 100137689(rnf216.L) 108695391(rnf19a.S) 108695474 108698126(rnf183.L) 108707161(rnf34.S) 108707636(rnf169.L) 108709599(rnf19b.S) 108710062(rnf169.S) 108710923 108710924 108710926 108712991(arih1.S) 108713273 108717170(rnf144a.L) 108718197(rnf168.S) 108718231(rnf144a.S) 108718834(ankib1.L) 108719149(rnf144b.L) 108719312 108719342(rnf19a.L) 108719472 108719895(ankib1.S) 108720117(rnf144b.S) 399027(arih2.S) 432198(rnf168.L) 443657(rnf34.L) 446677(rffl.S) 447349(rffl.L) 495084 733410(rnf19b.L) 734643(rnf217.L) 734686(rnf14.L) 734889(arih1.L) 779150(arih2.L) 779341(rnf31.S)
XTR: 100036616(rnf31) 100124307(rnf144a) 100124330(rnf144b) 100144656(rnf19a) 100144731(arih1) 100144920(rnf168) 100145487(ankib1) 100379757(rnf217) 100485068(rnf14.4) 100485226(rnf14.5) 100485699(rnf19b) 100491300(rbck1) 100493580(rnf169) 105946807(rnf14.3) 108645237 116408217(rnf183) 448178(arih2) 493480(rnf14.2) 549588(rnf216) 550050(rffl) 779671(rnf34)
NPR: 108784057(ARIH1) 108785391 108785395 108787877(RNF34) 108787912(ANKIB1) 108788007(RNF144A) 108789330(RNF19A) 108789373(RNF183) 108789575(RNF144B) 108790143(RNF168) 108792922(RNF217) 108793545(RNF19B) 108794557(RNF14) 108795117(RFFL) 108797950(RNF31) 108802101(RBCK1) 108804180(RNF169) 108804413(ARIH2)
DRE: 100334178 327005(arih1) 334081(rnf168) 334203(rnf34a) 394112(rnf144b) 405832(rffl) 405859(arih1l) 406417(arih2) 415177(rnf14) 431715(rbck1) 437000(rnf144ab) 550328(prkn) 557995(rnf19a) 558876 559441(rnf216) 561277(ankib1b) 562396(rnf19b) 566524(ankib1a) 567287(rnf217) 567642(si:dkey-181m9.8) 568165(si:ch211-278j3.3) 568879(rnf34b) 569903(shrprbck1r) 570968(rnf144aa) 795694(zgc:171740) 795748(rnf169)
IPU: 108255080(rbck1) 108255597 108256380 108257134(rnf19b) 108257217(rnf216) 108257280(rnf19a) 108257871 108257890(rnf217) 108263700(park2) 108264557(arih1) 108264913 108265741(arih2) 108267140(ankib1) 108268220 108270364(rnf144a) 108270676(arih1) 108277312 108277805(rffl) 108278176(rnf168) 108278214(rnf169) 108278995(rnf14) 108279333 108280439(rnf31) 108280771
LCO: 104917783(rnf14) 104918350(arih2) 104918640 104922143(rnf144a) 104922306(rbck1) 104922367 104922451 104924332(arih1) 104924529(ankib1) 104925642(rnf217) 104926264(rnf144b) 104930820(rnf19b) 104931171 104932077(rnf216) 104932664 104932698(rnf168) 104933276 104934697(prkn) 104936291(rnf34) 104936359(rnf19a) 104937172 104938047(rnf169) 104938278(rffl) 104939164(rnf31) 104939449
PRET: 103456714(rnf31) 103457620 103457730(rnf217) 103458795(rnf144a) 103460775 103466556(arih1) 103467128(arih2) 103468542(rnf216) 103470611 103472378 103472441 103472982(rnf19b) 103473722 103475244(rnf168) 103475279(rnf169) 103475291(rffl) 103475361(rnf14) 103478204 103478353(ankib1) 103478832(rnf19a) 103482437 108166280(rbck1)
AOCE: 111562492 111563777 111564497(rnf19b) 111565940(rnf144a) 111566759 111566840(rnf217) 111568847(rnf168) 111568988 111569392(rnf19a) 111569406(rnf144b) 111570370 111574119 111575563(rffl) 111575701(arih1) 111576256(rbck1) 111579557(rnf14) 111581157(arih2) 111581381(rnf34) 111581841 111585317(rnf216) 111586586(rnf169) 111587713 111588467 111589035(ankib1)
SDU: 111216316(rnf217) 111216534 111216836(rnf169) 111216839(rnf168) 111216938(rffl) 111220853(rnf19b) 111223034 111223178 111223871(prkn) 111225624(rnf144a) 111226495(rnf34) 111227635(rnf19a) 111227658(ankib1) 111227726(rnf144b) 111228727(arih1) 111230331(rnf216) 111230739(arih2) 111233929 111234146 111234631(rnf14) 111237288 111237348 111238327(rnf31) 111239703(rbck1) 111240385
SLAL: 111644770(rnf144a) 111644945(rnf34) 111645581(rnf19b) 111646364(rnf216) 111646701(rnf168) 111647268 111648339 111653477 111655167 111655929(ankib1) 111656069(prkn) 111657059 111658140(rnf144b) 111659303 111659337 111662905 111663343(rffl) 111663393(rnf169) 111664110(rnf19a) 111666384(arih2) 111666902(arih1) 111669673(rbck1) 111672100(rnf14) 111672695(rnf217)
LCM: 102345183(RNF34) 102345215(RNF19A) 102349730(SHARPIN) 102349954(RBCK1) 102350660(RNF169) 102350995 102351542(RFFL) 102351857(RNF144A) 102352879(ARIH1) 102352961(RNF14) 102354152(RNF19B) 102354811(RNF144B) 102356416(ANKIB1) 102357849(RNF217) 102358723(RNF31) 102359755(ARIH2) 102361948(RNF216) 102364509(RNF168) 102364711(RNF183) 102366187
CMK: 103173333(rnf168) 103176050(park2) 103176649(arih2) 103178315 103179690(sharpin) 103180748 103181232(ankib1) 103182338(rnf217) 103182983(rnf183) 103183640(rnf19a) 103184307(rnf34) 103184902(rnf144b) 103185658(rnf19b) 103186868(rnf216) 103186898(rffl) 103187112(rnf144a) 103188626(rbck1) 103188676(arih1) 103189392(rnf14)
RTP: 109911746(rnf168) 109911829(arih1) 109913951(rnf34) 109914116 109914832(rnf216) 109915406(rnf169) 109915425 109915520(rnf14) 109915760(ankib1) 109920465 109922619(rffl) 109924100(rnf217) 109925227(rnf183) 109927415(arih2) 109928919(rnf19a) 109929810(rnf19b) 109930665(rnf144a) 109930721(rnf144b) 109930842 109935122 109938984(rbck1)
CIN: 100169995(zf(ring/rbz)-1) 100169999(zf(ring/c6hc)-7) 100170050(zf(ring/c6hc)-6) 100170051(zf(ring/c6hc)-1) 100176524 100178192 100179266 100185600 778886(zf(ring)-23)
DME: Dmel_CG10523(park) Dmel_CG11321(LUBEL) Dmel_CG12362(CG12362) Dmel_CG17019(CG17019) Dmel_CG33144(CG33144) Dmel_CG5659(ari-1) Dmel_CG5709(ari-2)
DSI: Dsimw501_GD11654(Dsim_GD11654) Dsimw501_GD12138(Dsim_GD12138) Dsimw501_GD14237(Dsim_GD14237) Dsimw501_GD22542(Dsim_GD22542) Dsimw501_GD25803(Dsim_GD25803) Dsimw501_GD25960(Dsim_GD25960) Dsimw501_GD27673(Dsim_GD27673)
CEL: CELE_C17H11.6(C17H11.6) CELE_C27A12.6(ari-1.3) CELE_C27A12.7(ari-1.2) CELE_C27A12.8(ari-1.1) CELE_F56D2.2(F56D2.2) CELE_F56D2.5(F56D2.5) CELE_K08E3.7(pdr-1) CELE_T12E12.1(ari-2) CELE_Y49F6B.9(Y49F6B.9) CELE_Y73F8A.34(ari-1.4)
ATH: AT1G05880(ARI12) AT1G05890(ARI5) AT1G32340(NHL8) AT1G65430(ARI8) AT2G16090(ARI2) AT2G25360 AT2G31510(ARI7) AT2G31760(ARI10) AT2G31770(ARI9) AT2G31780(ARI11) AT3G14250 AT3G27710(ARI3) AT3G27720(ARI4) AT3G53690 AT4G34370(ARI1) AT5G08730(ARI16) AT5G63730(ARI14) AT5G63750(ARI13) AT5G63760(ARI15)
LJA: Lj0g3v0107819.1(Lj0g3v0107819.1) Lj0g3v0107819.2(Lj0g3v0107819.2) Lj0g3v0288699.1(Lj0g3v0288699.1) Lj0g3v0288719.1(Lj0g3v0288719.1) Lj0g3v0308069.1(Lj0g3v0308069.1) Lj0g3v0308069.2(Lj0g3v0308069.2) Lj0g3v0321849.1(Lj0g3v0321849.1) Lj2g3v1496120.1(Lj2g3v1496120.1) Lj2g3v1496130.1(Lj2g3v1496130.1) Lj3g3v2575830.1(Lj3g3v2575830.1) Lj3g3v3302740.1(Lj3g3v3302740.1) Lj3g3v3338240.1(Lj3g3v3338240.1) Lj3g3v3338240.2(Lj3g3v3338240.2) Lj3g3v3338240.3(Lj3g3v3338240.3) Lj3g3v3386780.1(Lj3g3v3386780.1) Lj3g3v3386830.1(Lj3g3v3386830.1) Lj3g3v3386830.2(Lj3g3v3386830.2) Lj3g3v3386830.3(Lj3g3v3386830.3) Lj4g3v0343360.1(Lj4g3v0343360.1) Lj5g3v2060620.1(Lj5g3v2060620.1) Lj5g3v2267350.1(Lj5g3v2267350.1) Lj6g3v1149690.1(Lj6g3v1149690.1) Lj6g3v1150710.1(Lj6g3v1150710.1) Lj6g3v1150730.1(Lj6g3v1150730.1)
DOSA: Os02t0694700-01(Os02g0694700) Os03t0233500-01(Os03g0233500) Os03t0625800-01(Os03g0625800) Os03t0625933-00(Os03g0625933) Os03t0626100-01(Os03g0626100) Os04t0492100-01(Os04g0492100) Os04t0593700-01(Os04g0593700) Os08t0451800-01(Os08g0451800) Os08t0540300-01(Os08g0540300) Os09t0419500-01(Os09g0419500) Os09t0419600-01(Os09g0419600) Os09t0420000-00(Os09g0420000) Os09t0420100-01(Os09g0420100) Os09t0513800-01(Os09g0513800) Os09t0559000-00(Os09g0559000)
ATS: 109733273(LOC109733273) 109742557(LOC109742557) 109742763(LOC109742763) 109744328(LOC109744328) 109744332(LOC109744332) 109748750(LOC109748750) 109753488(LOC109753488) 109755399(LOC109755399) 109759405(LOC109759405) 109764055(LOC109764055) 109765091(LOC109765091) 109767319(LOC109767319) 109768816(LOC109768816) 109770709(LOC109770709) 109770711(LOC109770711) 109770714(LOC109770714) 109770719 109771999(LOC109771999) 109774001(LOC109774001) 109774007(LOC109774007) 109774008(LOC109774008) 109774011(LOC109774011) 109774360(LOC109774360) 109778610(LOC109778610) 109780439(LOC109780439) 109780760(LOC109780760) 109782364(LOC109782364) 109782763(LOC109782763) 109784445(LOC109784445) 109785646(LOC109785646) 109787274(LOC109787274)
SCE: YKR017C(HEL1) YML068W(ITT1)
ERC: Ecym_6331
NCS: NCAS_0A06110(NCAS0A06110) NCAS_0B07650(NCAS0B07650)
NDI: NDAI_0B05000(NDAI0B05000) NDAI_0D03090(NDAI0D03090)
TPF: TPHA_0B01690(TPHA0B01690) TPHA_0I01020(TPHA0I01020)
TBL: TBLA_0B06360(TBLA0B06360) TBLA_0C02810(TBLA0C02810)
TDL: TDEL_0D00860(TDEL0D00860) TDEL_0D01540(TDEL0D01540)
KAF: KAFR_0A03540(KAFR0A03540) KAFR_0I00350(KAFR0I00350)
CAL: CAALFM_C114170WA(CaO19.7224) CAALFM_C304790WA(CaO19.5942)
SLB: AWJ20_3047(HEL1) AWJ20_5218(ITT1)
NTE: NEUTE1DRAFT36619(NEUTE1DRAFT_36619) NEUTE1DRAFT85203(NEUTE1DRAFT_85203) NEUTE1DRAFT99120(NEUTE1DRAFT_99120)
ANG: ANI_1_1666134(An15g06200) ANI_1_212054(An06g01720) ANI_1_246134(An15g01450)
PBL: PAAG_03936 PAAG_04600 PAAG_11981(PAAG_05055)
ABP: AGABI1DRAFT116918(AGABI1DRAFT_116918) AGABI1DRAFT132652(AGABI1DRAFT_132652) AGABI1DRAFT35947(AGABI1DRAFT_35947) AGABI1DRAFT79739(AGABI1DRAFT_79739)
ABV: AGABI2DRAFT120411(AGABI2DRAFT_120411) AGABI2DRAFT190043(AGABI2DRAFT_190043) AGABI2DRAFT195409(AGABI2DRAFT_195409) AGABI2DRAFT212592(AGABI2DRAFT_212592) AGABI2DRAFT71267(AGABI2DRAFT_71267)
MGL: MGL_2946
MRT: MRET_3547
EHI: EHI_096780(24.t00013) EHI_165120(127.t00014)
PYO: PY17X_0404600(PY00504)
PCB: PCHAS_040330(PC000325.04.0)
SMIN: v1.2.001610.t1(symbB.v1.2.001610.t1) v1.2.004103.t1(symbB.v1.2.004103.t1) v1.2.010992.t1(symbB.v1.2.010992.t1) v1.2.011698.t1(symbB.v1.2.011698.t1) v1.2.020353.t1(symbB.v1.2.020353.t1) v1.2.023489.t1(symbB.v1.2.023489.t1) v1.2.037294.t1(symbB.v1.2.037294.t1)
 » show all
Taxonomy
Reference
1  [PMID:21532592]
  Authors
Wenzel DM, Lissounov A, Brzovic PS, Klevit RE
  Title
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
  Journal
Nature 474:105-8 (2011)
DOI:10.1038/nature09966
Reference
2  [PMID:24076655]
  Authors
Kelsall IR, Duda DM, Olszewski JL, Hofmann K, Knebel A, Langevin F, Wood N, Wightman M, Schulman BA, Alpi AF
  Title
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
  Journal
EMBO J 32:2848-60 (2013)
DOI:10.1038/emboj.2013.209
Reference
3  [PMID:23707686]
  Authors
Duda DM, Olszewski JL, Schuermann JP, Kurinov I, Miller DJ, Nourse A, Alpi AF, Schulman BA
  Title
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.
  Journal
Structure 21:1030-41 (2013)
DOI:10.1016/j.str.2013.04.019
Reference
4  [PMID:27565346]
  Authors
Scott DC, Rhee DY, Duda DM, Kelsall IR, Olszewski JL, Paulo JA, de Jong A, Ovaa H, Alpi AF, Harper JW, Schulman BA
  Title
Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.
  Journal
Cell 166:1198-1214.e24 (2016)
DOI:10.1016/j.cell.2016.07.027
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.31
IUBMB Enzyme Nomenclature: 2.3.2.31
ExPASy - ENZYME nomenclature database: 2.3.2.31
BRENDA, the Enzyme Database: 2.3.2.31

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