KEGG ENZYME: 2.3.2.32

ENZYME: 2.3.2.32

Entry

EC 2.3.2.32                 Enzyme

Name

cullin-RING-type E3 NEDD8 transferase;
RBX1 (gene name)

Class

Transferases;
Acyltransferases;
Aminoacyltransferases

Sysname

[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type)

Reaction(IUBMB)

[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-N6-[NEDD8-protein]-yl-L-lysine

Substrate

[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine;
[cullin]-L-lysine

Product

[E2 NEDD8-conjugating enzyme]-L-cysteine;
[cullin]-N6-[NEDD8-protein]-yl-L-lysine

Comment

Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form a complex with a cullin scaffold protein and a substrate recognition module, which is named CRL for Cullin-RING-Ligase. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. The transfer of NEDD8 from a NEDD8-specific E2 enzyme onto the cullin protein is a secondary function of the RING-type E3 ubiquitin transferase in the CRL complex. The process requires auxiliary factors that belong to the DCN1 (defective in cullin neddylation 1) family.

History

EC 2.3.2.32 created 2017

Orthology

K03868

E3 ubiquitin-protein ligase RBX1

Genes

HSA:	9978(RBX1)

PTR:	458860(RBX1)

PPS:	100970959 100981636(RBX1)

GGO:	101151577(RBX1)

PON:	100441665(RBX1)

PPYG:

129023107(RBX1)

NLE:	100596079(RBX1)

HMH:	116458544(RBX1)

SSYN:

129467895(RBX1)

MCC:	710252(RBX1)

MCF:	102132483(RBX1)

MNI:	105464390(RBX1)

CSAB:

103223367(RBX1)

CATY:

105572541(RBX1)

PANU:

101025661(RBX1)

TGE:	112633503(RBX1)

MLEU:

105538834(RBX1)

RRO:	104673455(RBX1)

RBB:	108528465(RBX1)

TFN:	117096433(RBX1)

PTEH:

111532697 111548968(RBX1)

CANG:

105527741(RBX1)

CJC:	100391523(RBX1) 103796394

SBQ:	101031903(RBX1)

CIMI:

108290508(RBX1)

ANAN:

105716995 105721831(RBX1)

CSYR:

103260489(RBX1)

MMUR:

105858549(RBX1)

LCAT:

123640318(RBX1)

PCOQ:

105805282(RBX1)

OGA:	100963359(RBX1)

MMU:	56438(Rbx1)

MCAL:

110310464(Rbx1)

MPAH:

110334961(Rbx1)

RNO:	300084(Rbx1)

MCOC:

116076358(Rbx1)

ANU:	117719097(Rbx1)

ASYL:

127664965 127667888(Rbx1)

MUN:	110550435(Rbx1)

CGE:	100762556(Rbx1)

MAUA:

101838028(Rbx1)

PROB:

127225828(Rbx1)

PLEU:

114694298(Rbx1) 114707186

MORG:

121444018 121461000(Rbx1)

MFOT:

126492120 126501446

AAMP:

119823435(Rbx1)

NGI:	103743488(Rbx1)

HGL:	101712475(Rbx1)

CPOC:

100714763(Rbx1)

CCAN:

109686914(Rbx1)

DORD:

105992090(Rbx1)

DSP:	122123619(Rbx1)

DMER:

138811784(Rbx1) 138825683 138833739

PLOP:

125350718 125358037(Rbx1)

NCAR:

124983356

MMMA:

107155854(Rbx1)

ITI:	101957126(Rbx1) 101970285

OCU:

103352470

OPI:	101519048(RBX1)

TUP:	102468598(RBX1)

GVR:	103585666(RBX1)

CFA:	474494(RBX1)

CLUD:

112667276(RBX1)

VVP:	112934005(RBX1)

VLG:	121491679(RBX1)

NPO:	129511746(RBX1)

UMR:	103674160(RBX1)

UAH:	113241739(RBX1)

UAR:	123780699(RBX1)

ELK:

111157501

LLV:

125106731

MPUF:

101687674(RBX1)

MNP:	132019190(RBX1)

MLK:	131839520(RBX1)

NVS:	122892604(RBX1) 122902420

ORO:	101363104(RBX1)

EJU:	114218392(RBX1)

ZCA:	113911560 113921968(RBX1)

MLX:	117998640(RBX1)

NSU:	110577946(RBX1)

LWW:	102748318(RBX1)

FCA:	101087758(RBX1)

PYU:	121040293(RBX1)

PCOO:

112863270(RBX1)

PBG:	122472803(RBX1)

PVIV:

125170397(RBX1)

LRUF:

124501699

LGF:	123591525(RBX1)

AJU:

113602716

PTG:	102955881(RBX1)

PPAD:

109265611(RBX1)

PUC:

125920366

PLEZ:

122225167(RBX1)

HHV:	120234320(RBX1) 120234672 120236827

BTA:	518880(RBX1) 780968

BOM:	102272719(RBX1)

BIU:	109559850(RBX1)

BBUB:

102414522(RBX1)

BBIS:

104981171(RBX1)

CHX:	102187112(RBX1) 102188771

OAS:	101109871(RBX1)

BTAX:

128047495(RBX1) 128067535

CSUM:

138077954(RBX1)

ODA:	120857602(RBX1)

CCAD:

122423474(RBX1) 122426581 122445122

MREE:

136174393(RBX1)

OVR:	110126940(RBX1)

MBEZ:

129536465(RBX1)

SSC:	110260638(RBX1)

CFR:	102515877(RBX1)

CBAI:

105073197(RBX1)

CDK:	105091911(RBX1)

VPC:	102535913(RBX1)

BACU:

102998295(RBX1)

BMUS:

118888805 118902305(RBX1)

LVE:	103090829(RBX1)

OOR:	101287254(RBX1) 101289349

LALB:

132528701(RBX1) 132529924

GMF:	115852756(RBX1)

DDP:	132434105(RBX1)

DLE:	111186303(RBX1)

PCAD:

102989901 112064697 129391324(RBX1)

PSIU:

116749210 116760644(RBX1)

PPHC:

136130874(RBX1)

NASI:

112394651(RBX1)

ECB:	100055581(RBX1)

EAI:	106842455(RBX1)

MYB:	102243164 102243482 102254932 102260998(RBX1)

MYD:	102760790(RBX1)

MMYO:

118650853(RBX1) 118659026 118663966 118663967

MLF:	102431403(RBX1)

MDT:	132216300 132217262 132226912(RBX1) 132234256 132240300

MYUM:

139007594(RBX1) 139022428

PKL:	118730800(RBX1)

EFUS:

103288833(RBX1)

MNA:	107531277(RBX1)

DRO:	112321770(RBX1)

SHON:

119002280(RBX1)

AJM:	119060371(RBX1)

PDIC:

114513192(RBX1)

PHAS:

123816194(RBX1)

MMF:	118618357 118624414(RBX1)

PPAM:

129077850(RBX1)

HAI:	109392275(RBX1)

RFQ:	117029081(RBX1)

PALE:

102893437(RBX1)

PGIG:

120602973(RBX1)

PVP:	105298053(RBX1)

RAY:	107519712(RBX1)

MJV:	108394317(RBX1)

TOD:	119247226(RBX1)

SARA:

101542238(RBX1) 101554111

SFUM:

130044857(RBX1)

SETR:

126006345(RBX1) 126032651

LAV:	100657479(RBX1)

TMU:

101349359

ETF:	101646762(RBX1) 101662489

DNM:	101444027(RBX1)

MDO:	100013521(RBX1)

GAS:	123250747(RBX1)

SHR:	100918404(RBX1)

AFZ:

127538369

PCW:	110205825(RBX1)

TVP:	118852353(RBX1)

PBRV:

138173025(RBX1)

MLAO:

141515442(RBX1)

OAA:	100076928(RBX1)

TACU:

119937248(RBX1)

GGA:	418001(RBX1)

PCOC:

116233383(RBX1)

MGP:	100543550(RBX1)

CJO:	107312930(RBX1)

TPAI:

128073610(RBX1)

LMUT:

125686379(RBX1)

NMEL:

110392307(RBX1)

APLA:

101796040(RBX1)

ACYG:

106035919(RBX1)

CATA:

118250500(RBX1)

AFUL:

116501779(RBX1)

TGU:	100190092(RBX1)

LSR:	110483089(RBX1)

SCAN:

103813288(RBX1)

PMOA:

120510088(RBX1)

OTC:	121342452(RBX1)

PRUF:

121361199(RBX1)

ATRC:

139588058(RBX1)

GFR:	102037823(RBX1)

FAB:	101806409(RBX1)

OMA:	130248223(RBX1)

PHI:	102102832(RBX1)

PMAJ:

107204430(RBX1)

CCAE:

111934630(RBX1)

CCW:	104696532(RBX1)

CBRC:

103618243(RBX1)

ACOE:

138104016(RBX1)

ETL:	114058064(RBX1)

ZAB:	102069638(RBX1)

ZLE:	135442487(RBX1)

ACHL:

103803839

SVG:	106856936(RBX1)

MMEA:

130587945(RBX1)

HRT:	120752174(RBX1)

SATI:

136361865(RBX1)

CCIC:

134043630(RBX1)

FPG:	101916874(RBX1)

FCH:	102049129(RBX1)

NNT:	104399424(RBX1)

SHAB:

115605825(RBX1)

ACUN:

113488055(RBX1)

TALA:

104364386(RBX1)

ACHC:

115352685(RBX1)

HALD:

104318900(RBX1)

HLE:	104829039(RBX1)

AGEN:

126047828

HHAR:

128143232(RBX1)

GCL:

127022521

CSTI:

104549877(RBX1)

PPUS:

135181797(RBX1)

PADL:

103915729(RBX1)

AFOR:

103907880(RBX1)

FGA:	104079903(RBX1)

CBOY:

140654741(RBX1)

CLV:	102095842(RBX1)

CNIC:

136000471(RBX1)

CUCA:

104055502(RBX1)

OHA:	104329873(RBX1)

ACAR:

104519277(RBX1)

CPEA:

104387596(RBX1)

RTD:	128901312(RBX1)

CRID:

134509872(RBX1)

AAM:	106488968(RBX1)

AROW:

112965730(RBX1)

NPD:	112946469(RBX1)

TGT:	104574103(RBX1)

DNE:	112984067(RBX1)

SCAM:

104137962(RBX1)

ASN:	102372162(RBX1)

AMJ:	102571619(RBX1)

CPOO:

109316717(RBX1)

GGN:	109295958(RBX1)

PSS:	102451113(RBX1)

CMY:	102943754(RBX1)

CCAY:

125629578(RBX1)

DCC:	119847713(RBX1)

CPIC:

101936281(RBX1)

TST:	117880076(RBX1)

CABI:

116829058(RBX1)

MRV:	120381008 120384740

ACS:	100566553(rbx1)

ASAO:

132775977(RBX1)

PVT:	110076073(RBX1)

SUND:

121932202(RBX1)

PBI:	103065423(RBX1)

PMUR:

107285413(RBX1)

CTIG:

120304681(RBX1)

TSR:	106537822(RBX1) 106553210

PGUT:

117655425(RBX1)

PCAE:

139319223(RBX1)

APRI:

131202643(RBX1)

PTEX:

113433975(RBX1)

NSS:	113432693(RBX1)

VKO:	123036074(RBX1)

PMUA:

114605459(RBX1)

PRAF:

128420865 128422195(RBX1)

ZVI:	118091458(RBX1)

HCG:	128327088(RBX1)

GJA:	107117140(RBX1)

STOW:

125435698(RBX1)

EMC:	129335725(RBX1)

XLA:	108714482(rbx1.L) 108715730(rbx1.S)

XTR:	100379935(rbx1)

NPR:	108788200(RBX1)

RTEM:

120945492(RBX1)

ACAT:

141103312(RBX1)

BBUF:

120979112(RBX1)

BGAR:

122943674(RBX1)

DTC:	141087459(RBX1)

PWL:	138292504(RBX1)

MUO:	115460141(RBX1)

GSH:	117355933(RBX1)

DRE:	449846(rbx1)

SRX:	107723609 107748812

SANH:

107672143(rbx1) 107695112

SGH:	107580054 107602336(rbx1)

CCAR:

109076699(rbx1) 122138158

CAUA:

113046818 113047604

CGIB:

127945830 127953577

PTET:

122332598(rbx1)

LROH:

127163576(rbx1)

GRF:	141324333(rbx1)

OMC:	131537527(rbx1)

PPRM:

120462132(rbx1)

RKG:	130075990(rbx1)

MAMB:

125273687(rbx1)

CIDE:

127509265

CERY:

137010318(rbx1)

MASI:

127450052 127452336

TROS:

130561726(rbx1)

TDW:	130426882(rbx1)

MANU:

129436478(rbx1)

PDAB:

135733791(rbx1)

IPU:	100528272(rbx1) 108279000 108279790

IFU:	128615623(rbx1) 128622163

PHYP:

113524074(rbx1)

SMEO:

124381909(rbx1)

TFD:	113640136(rbx1)

TVC:	132842552(rbx1)

CGAR:

128516011(rbx1)

NGRA:

132870575(rbx1)

TRN:	134334626(rbx1)

AMEX:

107197156 125799446

CMAO:

118805387(rbx1)

EEE:	113583718(rbx1)

CHAR:

105897984(rbx1)

SPIL:

134076652(rbx1)

TRU:	101079814 115248454 115249889 115249890

TFS:	130514717 130514727

TNG:	GSTEN00008999G001

LCO:	104932083(rbx1)

NCC:	104945083(rbx1)

TBEN:

117492884(rbx1)

CGOB:

115012294(rbx1)

PGEO:

117451336(rbx1)

GACU:

117534788(rbx1)

EMAC:

134878110(rbx1)

ELY:	117268068(rbx1)

EFO:	125879233(rbx1)

PLEP:

121956973(rbx1) 121966503

SLUC:

116065292(rbx1)

ECRA:

117958649(rbx1)

ESP:	116702801(rbx1)

PFLV:

114569772(rbx1)

GAT:	120827413(rbx1)

PPUG:

119220154(rbx1)

AFB:	129098657(rbx1)

CLUM:

117735638(rbx1)

PSWI:

130189005(rbx1)

CANA:

137786626(rbx1)

CVE:	137878316(rbx1)

MSAM:

119884920(rbx1)

SCHU:

122868958(rbx1)

CUD:	121529177(rbx1)

SPUL:

138604257(rbx1)

LMIX:

132995671(rbx1)

ALAT:

119013730(rbx1)

ASTR:

137594248 137608702 137609908

MZE:	101480103(rbx1)

ONL:	100696705(rbx1)

OAU:	116327876(rbx1)

OLA:	101170590(rbx1)

OML:	112146889(rbx1)

CSAI:

133421806(rbx1)

XMA:	102233269(rbx1)

XCO:	114160562(rbx1)

XHE:	116736204(rbx1)

PRET:

103468459(rbx1)

PFOR:

103153424(rbx1)

PLAI:

106961597(rbx1)

PMEI:

106930562(rbx1)

GAF:	122822198(rbx1)

PPRL:

129363787(rbx1)

CVG:	107093096(rbx1)

CTUL:

119799435(rbx1)

GMU:	124863171 124864508

NFU:	107376330(rbx1)

KMR:	108236172(rbx1)

ALIM:

106520678(rbx1)

NWH:	119422119(rbx1)

AOCE:

111570331(rbx1)

EJA:	138198259(rbx1)

BFRE:

138622481(rbx1)

MCEP:

124998308(rbx1)

CSEM:

103393328(rbx1)

POV:	109643626(rbx1)

SSEN:

122785647(rbx1)

SSOE:

131475391(rbx1)

HHIP:

117766292(rbx1)

HSP:	118122773(rbx1)

PPLT:

128458775(rbx1)

SMAU:

118289065(rbx1)

LCF:

108877581

SDU:	111230345(rbx1)

SLAL:

111647571(rbx1)

XGL:	120783375(rbx1)

HCQ:	109514860(rbx1)

SSCV:

125984196(rbx1)

SBIA:

133514858(rbx1)

PEE:	133414852(rbx1)

PTAO:

133465743(rbx1)

BPEC:

110162377(rbx1)

ENY:	140357743(rbx1) 140367229

MALB:

109952664(rbx1)

BSPL:

114860326(rbx1)

SJO:	128378727(rbx1)

SSCO:

133999119(rbx1)

GMH:	115531294(rbx1)

SASA:

100136424(rbx1) 106601243(rbx1)

STRU:

115171287 115199956

OTW:	112226161 112247600 112258810

OMY:	100301858(rbx1) 110486413

OGO:	124000287 124015661

ONE:	115104268 115109887

OKI:	109864917 109898526 109898577

OKE:	118365448 118384582

OMM:	135527084 135554200 135555565

OCLA:

139364790 139422236

SALP:

111965561 111981970 112072990

SNH:	120034372 120037660

CCLU:

121550972 121569034

ELS:	105025789(rbx1)

OEP:	134035250(rbx1)

SFM:	108926071(rbx1) 108939936 108939944

PKI:	111845210(rbx1) 111853244

AANG:

118216689(rbx1) 118218515

AROT:

135243800(rbx1) 135248837

CCOG:

133114742(rbx1) 133121511

PSPA:

121306188(rbx1)

PSEX:

120536924(rbx1)

LCM:	102352187(RBX1)

CMK:	103189242(rbx1)

RTP:	109921792(rbx1)

CPLA:

122542300(rbx1)

HOC:	132820883 132831298(rbx1)

LERI:

129713871(rbx1)

HAKA:

140719295(rbx1)

PMRN:

116951478(RBX1)

LRJ:	133340675(RBX1) 133360292 133360954

BFO:

118419573

BBEL:

109487751

CIN:

100182516

SCLV:

120342351

SPU:	115918507 591601

LPIC:

129261989

AJJ:

139979345

APLC:

110984414

ARUN:

117293427

AAMU:

139936103

AFIL:

140160928

AJC:

117111407

PFLL:

139131616

DME:	Dmel_CG16982(Roc1a) Dmel_CG16988(Roc1b)

DER:	6545155 6555510

DSE:	6610179 6615886

DSI:	Dsimw501_GD11014(Dsim_GD11014) Dsimw501_GD16520(Dsim_GD16520)

DYA:	Dyak_GE16630 Dyak_GE17622 Dyak_GE21084

DAN:	6496786 6500186 6504852

DSR:	110178156 110181408 110181527 110181780

DPO:	4814059 6898356 6901854 6902120

DPE:	6590337 6597670 6599516 6600097

DMN:	108151726 108157979 108158743 108164784

DWI:	124461521 124461729 124461882 124461913 6638168 6642959 6644881 6645940 6652807 6653602

DGR:	6558239 6559441 6562654 6569282

DMO:	Dmoj_GI14277 Dmoj_GI16422 Dmoj_GI16738 Dmoj_GI20142 Dmoj_GI25778

DAZ:	108609727 108613301 108618888 108620113

DNV:	108651181 108655043 108656193 115562720

DHE:	111601088 111603518 111604779 111605125

DVI:	6622041(Roc1b) 6626811 6634529(Roc1a) 6635721

CCAT:

101452937 101454374

BOD:	106621760 106627011 118679759 118681423

BDR:	105225495 105233202

RZE:	108368697 108368698 108377436 108382225

AOQ:	129239202 129239593

ALUD:

128856272 128856899

TDA:	119661908 119669149 119671315 119671343 119671347 119672072 119677018 119679884 119680239 119685952 119685953 119687493 119688891 119689574 119689652

MDE:	101897666 101900642 131800338

SCAC:

106096045

LCQ:	111684342 111688763

LSQ:	119604129 119604908

CVJ:	135953100 135956783(Roc1a)

GFS:	119631557 119637363

ECOE:

129945673

CLON:

129605516 129617551

HIS:

119656903

AGA:

1274908

ACOZ:

120947991

AARA:

120898375

AMER:

121594544 121601593

ASTE:

118509359

AMAP:

126563362

AFUN:

125771914

AMOU:

128304561

AMRS:

128711158

AALI:

118463432

ACOS:

131266045

AAG:

5565270

AALB:

109423057 109432379 115260693

ASUA:

134209161 134209169

CQU:	CpipJ_CPIJ012886

CPII:

120417029

CBRI:

134834062

CNS:

116347560

BCOO:

119080998

LLL:

129791202

PPAP:

129806647

AME:

408691

ACER:

107996873

ALAB:

122718323

ADR:

102681185

AFLR:

100864775

BIM:

100750218

BBIF:

117206781

BVK:

117236796

BVAN:

117155771

BHUN:

126868869

BTER:

100643234

BAFF:

126919016

BPYO:

122575860

BPAS:

132907852

FVI:

122537109

CCAL:

108631453

OBB:

114871947

OLG:

117600018

MGEN:

117217818

NMEA:

116430110

CGIG:

122398060

SOC:

105195164

MPHA:

105839647

AEC:

105148347

ACEP:

105626311

ACOC:

108686312

MZT:	108724961(Roc1a)

CCOA:

108782662

PBAR:

105432274

VEM:

105568857

COBS:

139105293(Roc1a)

TLN:	139817199(Roc1a)

HST:

105188519

DQU:

106740675

CFO:

105252239

FEX:

115233657

PMEC:

138942637(Roc1a)

LHU:	105674184(Roc1a)

PGC:

109852514

OBO:

105284276

PCF:

106787165

PFUC:

122515250

VPS:

122636059

VCRB:

124431779

VVE:

124955442

NVI:

100115578

CSOL:

105361251

TPRE:

106652040

LHT:

122505034

LBD:

127278836

MDL:

103578781

CGLO:

123261074

CTYP:

141526110(Roc1a)

FAS:

105267552

DAM:

107041044

AGIF:

122852012

CINS:

118068144

VCAN:

122414880

CCIN:

107266769

DSM:

124412593

NPT:	124220941 124221539

NFB:	124184195 124184196

NLO:	107219752 107219759

NVG:	124306744 124307051

AROA:

105690838

TCA:

655935

TMOL:

138133669(Roc1a)

DPA:

109536288

ESIM:

136408371(Roc1a)

EFOR:

136343080(Roc1a)

SOY:

115874647

AGRG:

126738105

ATD:

109606400

CSET:

123309188

HAXR:

123685006

AGB:

108917391

LDC:

111512846

DVV:

114329733

NVL:

108557707

DCOR:

135792359(Roc1a)

APLN:

108733335

PPYR:

116168719

OTU:

111417661

BMOR:

692971

BMAN:

114248509

MSEX:

115445862

DPL:	KGM_211860

BANY:

112053517

MJU:

123866146

NIQ:

126781640

VCD:

124543996

MCIX:

123670207

PMAC:

106708735

PPOT:

106100422

PXU:

106123473

BPHI:

137928787(Roc1a)

PRAP:

110992851

PBX:

123714871

PNAP:

125061084

ZCE:

119833226

CCRC:

123692168

LSIN:

126973728

AAGE:

121728616

HAW:

110372277

HZE:

124632258

TNL:

113508302

SLIU:

111358319

OFU:

114365077

ONU:	135073305 135073638

ATRA:

106131246

GMW:

113523580

PXY:

105397966

PGW:

126366142

LGLY:

125229067

CSTB:

134741555

CFUM:

141442676(Roc1a)

CFEL:

113372136 113373331

CCRN:

123293855

API:	100162035 100162097

DNX:

107162314

AGS:	114120761 126552116 126552761

RMD:	113552893 113556289

ACOO:

126836636 126840653

DVT:

126903840

BTAB:

109044484

DCI:	103511407 103524839 103524844

CLEC:

106666282

HHAL:

106682125(Roc1a)

NLU:

111058671

HVI:

124362577

MQU:

128989782

PHU:	Phum_PHUM087130

FOC:

113211873

TPAL:

117639298

ZNE:

110832453

CSEC:

111870542

PAME:

138714866(Roc1a)

SGRE:

126315376 126354682

BROR:

134531883

IEL:

124161943

HAMR:

139698174(Roc1a)

FCD:

110848901

DPX:	DAPPUDRAFT_40730 DAPPUDRAFT_60651 DAPPUDRAFT_65504 DAPPUDRAFT_65506 DAPPUDRAFT_65509

DMK:

116925355

DPZ:	124349781 124349791

AFRA:

136038535 136038991 136038992 136038993

PVM:	113818542(Roc1a)

PJA:

122244209

PCHN:

125046917

PMOO:

119591342

HAME:

121862336

PCLA:

123756750(Roc1a)

CQD:	128691684(Roc1a)

PTRU:

123509381

ESN:

127007764

MNZ:

135202188

MRJ:	136851259(Roc1a)

PORN:

139746061(Roc1a)

HAZT:

108678153

EAF:

111714026

TCF:

131889053

PPOI:

119099374 119099407 119105838 119105852

ISC:

8053429

DSV:

119449384

RSAN:

119382413

RMP:

119178187

VDE:

111249014

VJA:

111266216

GOE:

100907740

TUT:

107362230

DPTE:

113789362

DFR:

124497975

CSCU:

111619728 111633535 111638739 111640208

CVS:	136982268(Roc1a) 136982293

PTEP:

107454093

ABRU:

129968423

UDV:

129221561

SDM:

118193171

LPOL:

106472023

PMEO:

129583735

CEL:	CELE_ZK287.5(rbx-1)

CBR:	CBG_19342(Cbr-rbx-1)

CRQ:	GCK72_016980

NAI:	NECAME_02269

BMY:	BM_BM14000(Bma-rbx-1)

LOA:	LOAG_03239

HRO:	HELRODRAFT_86393

LGI:	LOTGIDRAFT_206883

PCAN:

112559116

LSAX:

138968695

GAE:

121375242

HRF:

124143675

HRJ:

124284529

HASI:

137274398

HCRA:

139449694

CRG:

105317988

CANU:

128191902

CVN:	111125628 111125715

OED:

125680396

MYI:

110455961

PMAX:

117328726

AIRR:

138327994

MCAF:

127714159

MMER:

123557832

RPHI:

132717376

DPOL:

127842647

MAEA:

128226536

OBI:

106882699

OSN:

115218629

LJP:

135472992

LAK:

106150763

OVI:	T265_11722

EGL:	EGR_00753 EGR_04378

LLON:

135493363

NVE:

5509443

EPA:

110249442

ATEN:

116291507

ADF:

107349974

AMIL:

114969829

MCAZ:

138016610

MFOO:

137998916

PDAM:

113677930

SPIS:

111341613

DGT:

114530307

XEN:

124445670

HMG:

100204043

HSY:

130655383

RES:

135686424

TAD:	TRIADDRAFT_50330

AQU:

100636037

ATH:	AT3G42830 AT5G20570(RBX1)

ALY:

9308017

CRB:	17881315 17886885

CSAT:

104706402 104710838 104736126 104770432 104780213 104790623

EUS:	EUTSA_v10015047mg

BRP:	103845664 103851357 103856451

BNA:	106371726 106385158 106408993 106425686 111213972

BOE:	106316076 106325067 106332287

RSZ:	108817515 108827876 108846167 130509350

THJ:	104808880 104811002 104815338 104826593

CPAP:

110817690

CIT:	102613162 102622192

CIC:	CICLE_v10009952mg CICLE_v10026815mg

PVY:	116120238 116126404

MINC:

123193858 123200043

TCC:

18588272

GRA:	105767665 105792942 105795701

GHI:	107903283 107929974 107932188 107932799 107960807 121204775

GAB:	108468083 108469121 108488019

HSYR:

120114829 120149883 120156633 120167838 120179762 120193390 120211863 120218694

DZI:	111274703 111286458 111299190 111303054

EGR:	104436408 104437993 104439002

RARG:

115740956 115746767

GMX:	100500045 100526919 100789570 100798515

GSJ:	114374500 114378027 114378451 114397039 114417297

PVU:	137832686 137835542

VRA:	106754365 106761091 106761707

VAR:	108333295 108338955

VUN:	114168583 114183876

VUM:	124820988 124829759 124829763

CCAJ:

109790424 109806089

APRC:

113855424 113858391

MTR:	11413962 25492127

TPRA:

123899636 123899965 123920291

CAM:	101496300 101503002

PSAT:

127086751 127105727

VVO:	131601747 131626399 131629058

LJA:	130747013 130749032 130749219

ADU:	107462077 107477744 127744049

AIP:	107613945 107624456 107629957

AHF:	112707013 112737543 112771395 112784986 112789617

LANG:

109325667 109352320 109353407

PCIN:

129309176 129320352

QSA:	O6P43_002658 O6P43_018413 O6P43_022498 O6P43_027535

FVE:	101301042 101302106 101307444

AANS:

126795624 126801715 126802014

RCN:	112174210 112179375 112196401 112199925

PPER:

18785603 18786902

PMUM:

103331948 103331952

PAVI:

110746319 110748081 110769275

PDUL:

117617435 117619981

MDM:	103405253 103439121 103450248

MSYL:

126613785 126613786 126628536

PXB:	103942118 103964642

PCOX:

137734081 137746753

ZJU:

107423885

MNT:

21410023

CSAV:

115707585

CSV:	101209538 101209687

CMO:	103492371 103498857

BHJ:	120071482 120079716

MCHA:

111016444 111021926

CMAX:

111465785 111467761 111485682

CMOS:

111440096 111444049 111461500

CPEP:

111779645 111793107 111798730

RCU:	8259356 8281168

MEAN:

126667731 126667732 126683098

JCU:	105631381 105637971

HBR:	110634308 110639647 110664598

MESC:

110612954 110626830

POP:	18094715 18100330 7471662

PEU:	105133432 105133967

PALZ:

118034841 118037983 118048083

PNZ:	133672759 133688128 133700613

JRE:	108981134 109009026

CILL:

122304274 122307828

CAVE:

132166206 132166306

AGLU:

133857147 133857303

QSU:	111993014 112001674

QLO:	115969583 115988613

TWL:	119982225 119992954 120005634

VVI:	100246271 100259489

VRI:	117921577 117925760

SLY:	101249890 101259644

SPEN:

107005489 107021447

SOT:	102583049 102595356 107059797

SSTN:

125857671 125862246 125872505

SDUL:

129871323 129899417

CANN:

107840900 107861671 107876064

LBB:	132633526 132636921 132645335

NTA:	107759896 107776199 107780326 107784644 107824015 107829306

NSY:	104214032 104219570 104236463

NTO:	104092250 104104527 104120680

NAU:	109217886 109221000 109225596 109239640

INI:	109147674 109158438 109186622

ITR:	115999746 116012189 116019189

SIND:

105161929 105173683

OEU:	111379972 111384856 111411455

EGT:	105968134 105970859

SSPL:

121746682 121750403 121783554 121786269 121793382 121801447

SMIL:

130987662 131021449 131021462

SHIS:

125186881 125192207 125209534

APAN:

127239533 127264161

HPUM:

140887545 140887985

PHUA:

140962257 140971466

PEBU:

140818406 140825833

HAN:	110880261 110893699 110897767 110916508

ECAD:

122588767 122588803 122607398

LSV:	111882147 111892622 111902717

CCAV:

112509462 112511044 112516390

DCR:	108193846 108211059 108219676 108224330

CSIN:

114302496 114302498

RVL:	131311724 131320017 131325324

AEW:	130756745 130761930 130782600 130784420 130796308

DLT:	127795893 127806936

BVG:	104883468 104899743

SOE:	110798000 110804025

CQI:	110682960 110684393 110688077 110733846

ATRI:

130813766 130815046 130827373

SLAF:

141592507 141597139 141605788

MOF:	131157457 131165092

NNU:

104600540

MING:

122076653 122083431

TSS:	122640521 122641411 122648264 122653778 122658402 122663617 122667975

PSOM:

113293923 113326900 113327705 113339765

OSA:	4326152 4330476

DOSA:

Os01g0106800 Os02g0708300

OBR:	102707436 102714616

OGL:	127762121 127775911

BDI:	100826136 100841533

ATS:	109737146 109777151

TDC:	119266566 119274241 119317601 119323775

TAES:

123068146 123128144 123137940 123145238 123172046 123172497

TUA:	125514298 125542236

LPER:

127306479 127341399

LRD:	124661924 124666909 124688142

SBI:	8073850 8079092

ZMA:	100192928 103634739 103649912

MFLO:

136451801 136457938 136464298

SITA:

101761659 101778950

SVS:	117835140 117856011

PVIR:

120649760 120656974 120676393 120706260

PHAI:

112879972 112893014

PAUA:

133895162 133908422 133919641 133921413

TANG:

140765692 140768233 140779625

PDA:	103701991 103711519 120113304

EGU:	105056281 105058733

MUS:	103977230 103981809 135614588 135625120

ZOF:	121967126 121981914 121985754 122010237 122017693 122052315

DCT:	110096489 110100420

PEQ:

110019661

AOF:	109828983 109844953

MSIN:

131227046 131251730

ACAK:

137956440 137959059

NCOL:

116259708 116262899

ATR:	105421056 18439492

CJF:

131061515

SMO:	SELMODRAFT_269625 SELMODRAFT_269937

PPP:	112284365 112288983 112295784

CRE:	CHLRE_12g543450v5

VCN:	VOLCADRAFT_75918

MNG:

MNEG_4176

CSL:	COCSUDRAFT_21809

APRO:

F751_6626

OLU:	OSTLU_119493(rbx1)

OTA:	OT_ostta02g00480

BPG:	Bathy07g04140

MIS:	MICPUN_113936(RBX1)

MPP:	MICPUCDRAFT_25062

CME:	CYME_CMQ353C

GSL:	Gasu_48170

CCP:	CHC_T00009192001

SCE:	YOL133W(HRT1)

SEUB:

DI49_2274

SPAO:

SPAR_O00240

AGO:	AGOS_ADL181W

ERC:

Ecym_2029

KLA:	KLLA0_E07151g

KMX:	KLMA_70161(HRT1)

LTH:	KLTH0F19228g

VPO:	Kpol_1014p16

ZRO:	ZYRO0C03058g

CGR:	9487983(RBX1)

NCS:	NCAS_0C04480(NCAS0C04480)

NDI:	NDAI_0G03860(NDAI0G03860)

TPF:	TPHA_0P01470(TPHA0P01470)

TBL:	TBLA_0B08710(TBLA0B08710)

TGB:	HG536_0E02510

TDL:	TDEL_0A00470(TDEL0A00470)

KAF:	KAFR_0C01780(KAFR0C01780)

KNG:	KNAG_0A01280(KNAG0A01280)

ZMK:	HG535_0F01980

SLUD:

SCDLUD_005007

DHA:	DEHA2F17666g

PIC:	PICST_37145(HRT1)

SPAA:

SPAPADRAFT_61897

LEL:	PVL30_002035(HRT1)

CAL:	CAALFM_C302450WA(HRT1)

CTP:	CTRG_02424

COT:	CORT_0B04130

CDU:	CD36_82410

CTEN:

18245613(HRT1)

CLU:	CLUG_04212

CLUS:

A9F13_04g03124

CAUR:

CJI96_0004926

ASAU:

88173715(PUMCH_002651)

PPA:	PAS_chr4_0436

PKZ:	C5L36_0C07065

BNN:	FOA43_001196

BBRX:

BRETT_002341

OPA:	HPODL_05342

YLI:	2906622(YALI2_C00737g)

NTE:	NEUTE1DRAFT116888(NEUTE1DRAFT_116888)

SMP:	10803180(SMAC4_07095)

PAN:	PODANSg5275

PBEL:

QC761_708750(HRT1)

PPSD:

QC762_708750(HRT1)

PPSP:

QC763_708750(HRT1)

PPSA:

QC764_708750(HRT1)

MTM:	MYCTH_2304045

CTHR:

CTHT_0023610

RTHE:

98121840(VTJ83DRAFT_1077)

MGR:

MGG_08844

PPEI:

PpBr36_00516

PGRI:

PgNI_04562

TMN:	UCRPA7_1639

SSCK:

SPSK_02774

FGR:	FGSG_02497

FPU:	FPSE_08616

FPOA:

FPOAC1_002619(RBX1)

FVN:	FVRRES_02914

FVR:	FVEG_09167

FOX:	FOXG_10518

NHE:	NECHADRAFT_42915

FFC:	NCS54_00847500

FKR:	NCS57_00890400

FMU:	J7337_005231(RBX1)

TRE:	TRIREDRAFT_121950

TRR:	M419DRAFT_104643

TATV:

25780966(TrAtP1_009786)

TASP:

36618731(ROC1A)

MAW:	19246207(HRT1)

MAJ:

MAA_00593

MBRN:

90967816(rbx1)

PCHM:

VFPPC_14152

CMT:

CCM_05836

AMUS:

LMH87_008205

PLJ:	90642691(PLICBS_002297)

PTKZ:

JDV02_002716(HRT1)

VAL:	VDBG_08639

VDA:	VDAG_06301

CFJ:	CFIO01_11879

CLUP:

CLUP02_03553

CHIG:

CH63R_02620

CDET:

87937362(CDEST_00859)

SAPO:

SAPIO_CDS3010

ELA:	UCREL1_3121

PFY:	PFICI_12609

SSL:	SS1G_00027

BFU:	BCIN_03g07500(Bchrt1)

MBE:

MBM_08230

PSCO:

LY89DRAFT_688943

GLZ:	GLAREA_01075

ANI:	ANIA_08844

AFM:	AFUA_5G05790

ACT:	ACLA_009060

NFI:	NFIA_037330

AOR:	AO090009000684

ANG:	An17g02100

AFV:	AFLA_010686

ALUC:

AKAW2_70780S(RBX1)

ACHE:

ACHE_11205A(RBX1)

APUU:

APUU_70423A(RBX1)

PCS:	N7525_008545

PDP:	PDIP_22460

POU:	POX_e06318

TMF:	EYB26_004703

TRG:	TRUGW13939_07977

CIM:	CIMG_06244

CPW:	9695080(RBX1_1)

URE:	UREG_04145

ABE:

ARB_07022

TVE:

TRV_07648

PBL:	PAAG_07371

PBN:	PADG_05868

AJE:	HCAG_03036

BGH:	BDBG_08548

PNO:	SNOG_09105

PTE:

PTT_16968

PTRR:

6339032(PtrM4_013440)

BZE:	COCCADRAFT_95811

BSC:	COCSADRAFT_82242

BOR:	COCMIDRAFT_103083

AALT:

CC77DRAFT_1049904

ADAC:

96088745(ACET3X_008423)

ARAB:

EKO05_0003090

ZTR:	MYCGRDRAFT_46230

PFJ:	MYCFIDRAFT_88404

FFU:	CLAFUR5_07092

CBET:

CB0940_09347

BCOM:

BAUCODRAFT_106019

NPA:	UCRNP2_3000

TML:	GSTUM_00002417001

SPO:	2541897(rbx1)

SOM:	SOMG_01994(rbx1)

CNE:

CNB03140

CNB:

CNBB2560

CNG:	CNAG_03823

CGI:	CGB_A3220W

CDEU:

CNBG_1541

CDEC:

89988848(IAS62_002074)

CTEG:

91988229(I308_101371)

CBAS:

91981410(I312_101362)

CDEP:

91086181(L203_101969)

KMG:	30164900(I203_108193)

KNE:	92177641(IAR55_000381)

KDJ:	28967417(I303_103702)

KBI:	30212791(I302_105105)

KPIN:

30169966(I206_103399)

KSH:	87956235(IL334_004104)

KER:	91107071(V865_008270)

TMS:	TREMEDRAFT_30658

CCAC:

CcaHIS019_0203440(HRT1)

TVS:	TRAVEDRAFT_31548

DSQ:	DICSQDRAFT_136248

PCO:	PHACADRAFT_253837

SHS:	STEHIDRAFT_96405

HIR:	HETIRDRAFT_441743

PSQ:	PUNSTDRAFT_80891

ADL:	AURDEDRAFT_83065

FME:	FOMMEDRAFT_126450

GTR:	GLOTRDRAFT_101369

RSX:	RhiXN_10954

LBC:	LACBIDRAFT_317013

CCI:	CC1G_08674

ABP:	AGABI1DRAFT130185(AGABI1DRAFT_130185)

ABV:	AGABI2DRAFT139777(AGABI2DRAFT_139777)

PCUB:

JR316_0006035 JR316_0013262

MRR:	Moror_7592

E1B28_013366(RBX1)

SCM:	SCHCO_02628431(SCHCODRAFT_02628431)

CPUT:

CONPUDRAFT_106740

SLA:	SERLADRAFT_385744

WSE:	WALSEDRAFT_27573

WIC:	J056_004250

UMA:	UMAG_10917

PFP:	PFL1_04680

SGRA:

EX895_002756

MGL:

MGL_0788

MRT:

MRET_0028

PGR:	PGTG_10430 PGTG_18192

PTRC:

PtA15_6A509 PtA15_8A735

PSTR:

Pst134EA_002618

MLR:	MELLADRAFT_106109

ECU:	ECU01_1095

EIN:	Eint_011010

EHE:	EHEL_010980

ERO:	EROM_010900

NCE:	NCER_101168

VNX:	VNE69_02195

RIE:	OCT59_020748

MBR:	MONBRDRAFT_18418

SRE:	PTSG_04800

DDI:	DDB_G0287629(rbx1)

DPP:	DICPUDRAFT_88388

EHI:	EHI_151630(2.t00108)

EDI:	EDI_254030

EIV:	EIN_381390 EIN_381400

ACAN:

ACA1_368020

PFA:	PF3D7_0319100

PFD:	PFDG_02979

PFH:	PFHG_00876

PREI:

PRSY57_0318400

PGAB:

PGSY75_0319100

PLAG:

39740038(PADL01_0318000)

PYO:	PY17X_0809400

PCB:	PCHAS_0806500

PBE:	PBANKA_0806200

PVV:	PVVCY_1000790

PKN:	PKNH_0822400

PVX:	PVX_095280

PCY:	PCYB_083070

PMAL:

PMUG01_08037000(RBX1)

PBRS:

92370500(MKS88_002412)

PREL:

PRELSG_0819000(RBX1)

PCOT:

PCOAH_00021320

TAN:

TA10565

TPV:

TP04_0669

TOT:	TOT_040000249

BBO:	BBOV_III007590

BMIC:

BmR1_04g06125

BBIG:

BBBOND_0306580

CPV:

cgd8_930

CHO:	Chro.80112

TGO:	TGME49_213690

BBES:

BESB_066840

TET:	TTHERM_00313710

PTM:	GSPATT00005494001 GSPATT00011131001 GSPATT00021114001 GSPATT00023020001 GSPATT00024170001 GSPATT00030724001

PTI:	PHATRDRAFT_39090(Rbx1)

FCY:	FRACYDRAFT_206499

TPS:	THAPSDRAFT_40817

NGD:	NGA_0441600(RBX1)

AAF:	AURANDRAFT_22764 AURANDRAFT_8889

PIF:	PITG_01524

PSOJ:

PHYSODRAFT_285454

BLAC:

94347193(CCR75_003427)

SPAR:

SPRG_11654

TBR:	Tb10.70.6035

TBG:	TbgDal_V5200 TbgDal_X2190 TbgDal_X9640

TCR:	503965.20 506495.9

LMA:	LMJF_21_0023 LMJF_24_1610

LIF:	LINJ_21_0040 LINJ_24_1680

LDO:	LDBPK_210040 LDBPK_241680

LMI:	LMXM_21_0023 LMXM_24_1610

LMAT:

92514592(LSCM1_04578) 92515105(LSCM1_05120)

LBZ:	LBRM_21_0040 LBRM_24_1670

LPAN:

LPMP_210030 LPMP_241580

LOI:	92361329(LSCM4_05455) 92361576(LSCM4_05710)

LEIS:

94180333(GH5_04921) 94181034(GH5_05677)

LENR:

94172219(CUR178_05014) 94173322(CUR178_06138)

LEIN:

94188486(JIQ42_04837) 94188846(JIQ42_05208)

PHET:

94291023(JKF63_04976) 94291677(JKF63_05643)

NGR:	NAEGRDRAFT_5552

TVA:	4744197(TVAGG3_0582920) 4757372(TVAGG3_1003330) 4757382(TVAGG3_1003460)

EHX:	EMIHUDRAFT_358602 EMIHUDRAFT_49116 EMIHUDRAFT_50030

GTT:	GUITHDRAFT_86348

» show all

Reference

1 [PMID:18826954]

Authors

Kim AY, Bommelje CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B

Title

SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.

Journal

J Biol Chem 283:33211-20 (2008)
DOI:10.1074/jbc.M804440200

Reference

2 [PMID:18206966]

Authors

Kurz T, Chou YC, Willems AR, Meyer-Schaller N, Hecht ML, Tyers M, Peter M, Sicheri F

Title

Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation.

Journal

Mol Cell 29:23-35 (2008)
DOI:10.1016/j.molcel.2007.12.012

Reference

3 [PMID:20832729]

Authors

Scott DC, Monda JK, Grace CR, Duda DM, Kriwacki RW, Kurz T, Schulman BA

Title

A dual E3 mechanism for Rub1 ligation to Cdc53.

Journal

Mol Cell 39:784-96 (2010)
DOI:10.1016/j.molcel.2010.08.030

Reference

4 [PMID:24949976]

Authors

Scott DC, Sviderskiy VO, Monda JK, Lydeard JR, Cho SE, Harper JW, Schulman BA

Title

Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.

Journal

Cell 157:1671-84 (2014)
DOI:10.1016/j.cell.2014.04.037

Reference

5 [PMID:23201271]

Authors

Monda JK, Scott DC, Miller DJ, Lydeard J, King D, Harper JW, Bennett EJ, Schulman BA

Title

Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.

Journal

Structure 21:42-53 (2013)
DOI:10.1016/j.str.2012.10.013

Other DBs

ExplorEnz - The Enzyme Database:

2.3.2.32

IUBMB Enzyme Nomenclature:

2.3.2.32

ExPASy - ENZYME nomenclature database:

2.3.2.32

BRENDA, the Enzyme Database:

2.3.2.32

All links

Gene (8271)   
   MGENES (93)   
   RefGene (8178)   
Protein sequence (1968)   
   UniProt (1930)   
   SWISS-PROT (5)   
   RefSeq(pep) (33)   
DNA sequence (84)   
   RefSeq(nuc) (53)   
   GenBank (17)   
   EMBL (14)   
Protein domain (4)   
   InterPro (4)   
All databases (10327)   

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