KEGG   ENZYME: 2.3.2.33
Entry
EC 2.3.2.33                 Enzyme                                 
Name
RCR-type E3 ubiquitin transferase;
MYCBP2;
PHR1
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
Sysname
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RCR-type)
Reaction(IUBMB)
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine (overall reaction);
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;
(1b) [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [RCR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
Substrate
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine;
[acceptor protein]-L-threonine;
[RCR-type E3 ubiquitin transferase]-L-cysteine;
[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Product
[E2 ubiquitin-conjugating enzyme]-L-cysteine;
[acceptor protein]-3-O-ubiquitinyl-L-threonine;
[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;
[RCR-type E3 ubiquitin transferase]-L-cysteine
Comment
RCR-type E3 ubiquitin transferases is a class of RING-type E3 ubiquitin transferase (see EC 2.3.2.27) that mediates ubiquitylation of acceptor proteins via an internal cysteine residue. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue on a mediator loop of the RCR-type ligase. The ubiquitin may be transferred to a second internal cysteine before the transfer of the ubiquitin from the RCR-type ligase to the substrate.
History
EC 2.3.2.33 created 2019
Orthology
K10693  RCR-type E3 ubiquitin transferase
Genes
HSA23077(MYCBP2)
PTR452608(MYCBP2)
PPS100984032(MYCBP2)
GGO101142597(MYCBP2)
PON100451266(MYCBP2)
PPYG129011747(MYCBP2)
NLE100581654(MYCBP2)
HMH116467497(MYCBP2)
SSYN129463536(MYCBP2)
MCC696734(MYCBP2)
MCF101867408(MYCBP2)
MTHB126940497
MNI105481778(MYCBP2)
CSAB103214597(MYCBP2)
CATY105597929(MYCBP2)
PANU101009741(MYCBP2)
TGE112610727(MYCBP2)
MLEU105554273(MYCBP2)
RRO104671175(MYCBP2)
RBB108516636(MYCBP2)
TFN117063665(MYCBP2)
PTEH111522156(MYCBP2)
CANG105520253(MYCBP2)
CJC100413363(MYCBP2)
SBQ101053013(MYCBP2)
CIMI108282823(MYCBP2)
ANAN105730664(MYCBP2)
CSYR103254969(MYCBP2)
MMUR105855857(MYCBP2)
LCAT123649302(MYCBP2)
PCOQ105804984(MYCBP2)
OGA100965082(MYCBP2)
MMU105689(Mycbp2)
MCAL110309324(Mycbp2)
MPAH110325255(Mycbp2)
RNO290447(Mycbp2)
MCOC116085304(Mycbp2)
ANU117705748(Mycbp2)
ASYL127691191(Mycbp2)
MUN110560794(Mycbp2)
CGE100763589(Mycbp2)
MAUA101827749(Mycbp2)
PROB127230123(Mycbp2)
PLEU114690201(Mycbp2)
MORG121462632(Mycbp2)
MFOT126503151
AAMP119800431(Mycbp2)
NGI103724869(Mycbp2)
HGL101712951(Mycbp2)
CPOC100726232(Mycbp2)
CCAN109687459 109687461
DORD105980304(Mycbp2)
DSP122112742(Mycbp2)
DMER138811651 138814037(Mycbp2)
PLOP125348188(Mycbp2)
NCAR124984839
MMMA107153259(Mycbp2)
ITI101963233(Mycbp2)
OCU100350249
OPI101522353(MYCBP2)
TUP102472161(MYCBP2)
GVR103588560(MYCBP2)
CFA476952(MYCBP2)
CLUD112655748(MYCBP2)
VVP112907184 112934310
VLG121476887(MYCBP2)
NPO129516386(MYCBP2)
AML100469795(MYCBP2)
UMR103659207(MYCBP2)
UAH113251431(MYCBP2)
UAR123801013(MYCBP2)
ELK111146914
LLV125094715
MPUF101692610(MYCBP2)
MNP132002776(MYCBP2)
MLK131814063(MYCBP2)
NVS122907162(MYCBP2)
ORO101376178(MYCBP2)
EJU114211543(MYCBP2)
ZCA113921027(MYCBP2)
MLX118009319(MYCBP2)
NSU110587605(MYCBP2)
LWW102750624(MYCBP2)
FCA101089233(MYCBP2)
PYU121037827(MYCBP2)
PCOO112860301(MYCBP2)
PBG122483640(MYCBP2)
PVIV125162475(MYCBP2)
LRUF124513066
LGF123598804(MYCBP2)
AJU106965757
PTG102972230(MYCBP2)
PPAD109264206(MYCBP2)
PUC125933879
PLEZ122213902(MYCBP2)
HHV120245403(MYCBP2)
BTA534496(MYCBP2)
BOM102265576(MYCBP2)
BIU109566887(MYCBP2)
BBUB102416199(MYCBP2)
BBIS104999578(MYCBP2)
CHX102190428(MYCBP2)
OAS101102993(MYCBP2)
BTAX128057836(MYCBP2)
CSUM138089168(MYCBP2)
ODA120883026(MYCBP2)
CCAD122447358(MYCBP2)
MREE136144437(MYCBP2)
OVR110152935(MYCBP2)
MBEZ129556432(MYCBP2)
SSC100156216(MYCBP2)
CFR102510373(MYCBP2)
CBAI105083657(MYCBP2)
CDK105103149(MYCBP2)
VPC102527240(MYCBP2)
BACU103016264(MYCBP2)
BMUS118884105(MYCBP2)
LVE103069781(MYCBP2)
OOR101289007(MYCBP2)
LALB132508951(MYCBP2)
GMF115843038(MYCBP2)
DDP132413581(MYCBP2)
DLE111176477(MYCBP2)
PCAD102995571(MYCBP2)
PSIU116743054(MYCBP2)
PPHC136137681(MYCBP2)
NASI112405500(MYCBP2)
ECB100053014(MYCBP2)
EPZ103556062(MYCBP2)
EAI106843084(MYCBP2)
MYB102253398(MYCBP2)
MYD102761670(MYCBP2)
MMYO118649623(MYCBP2)
MLF102421448(MYCBP2)
MDT132228456(MYCBP2)
MYUM139006566(MYCBP2)
PKL118728828(MYCBP2)
EFUS103288387(MYCBP2)
MNA107539858(MYCBP2)
DRO112312466(MYCBP2)
SHON118996124(MYCBP2)
AJM119047869(MYCBP2)
PDIC114508478(MYCBP2)
PHAS123818846(MYCBP2)
MMF118622279(MYCBP2)
PPAM129080923(MYCBP2)
HAI109389062(MYCBP2)
RFQ117021816(MYCBP2)
PALE102879756(MYCBP2)
PGIG120621519(MYCBP2)
PVP105304179(MYCBP2)
RAY107513073(MYCBP2)
MJV108404968(MYCBP2)
TOD119259908(MYCBP2)
SARA101546532(MYCBP2)
SFUM130019254(MYCBP2)
SETR126016351(MYCBP2)
LAV100661251(MYCBP2)
TMU101355836
ETF101654526(MYCBP2)
DNM101434779(MYCBP2)
MDO100013024(MYCBP2)
GAS123242659(MYCBP2)
SHR100931136(MYCBP2)
AFZ127553327
PCW110198796(MYCBP2)
TVP118846042(MYCBP2)
PBRV138145176(MYCBP2)
MLAO141492217(MYCBP2)
OAA100081768(MYCBP2)
TACU119942314(MYCBP2)
GGA418808(MYCBP2)
PCOC116239268(MYCBP2)
MGP100545152(MYCBP2)
CJO107308046(MYCBP2)
TPAI128092196(MYCBP2)
LMUT125703269(MYCBP2)
NMEL110408390(MYCBP2)
APLA101790448(MYCBP2)
ACYG106043922(MYCBP2)
CATA118255219(MYCBP2)
AFUL116487061(MYCBP2)
TGU100224418(MYCBP2)
LSR110480244(MYCBP2)
SCAN103812272(MYCBP2)
PMOA120504803(MYCBP2)
OTC121344202(MYCBP2)
PRUF121355637(MYCBP2)
ATRC139591859(MYCBP2)
GFR102032331(MYCBP2)
FAB101817180(MYCBP2)
OMA130253038(MYCBP2)
PHI102102663(MYCBP2)
PMAJ107202200(MYCBP2)
CCAE111927766(MYCBP2)
CCW104695873(MYCBP2)
CBRC103624432(MYCBP2)
ACOE138107374(MYCBP2)
ETL114062623(MYCBP2)
ZAB102068990(MYCBP2)
ZLE135447887(MYCBP2)
ACHL103803051(MYCBP2)
SVG106849995(MYCBP2)
MMEA130573787(MYCBP2)
HRT120748754(MYCBP2)
SATI136357817(MYCBP2)
CCIC134041276(MYCBP2)
FPG101918329(MYCBP2)
FCH102047786(MYCBP2)
SHAB115603828(MYCBP2)
ACUN113480407(MYCBP2)
TALA104356944(MYCBP2)
ACHC115350547(MYCBP2)
HLE104838346(MYCBP2)
AGEN126045180
HHAR128141322(MYCBP2)
GCL127023281
CSTI104550189(MYCBP2)
LDI104350390
MNB103776402(MYCBP2)
DPUB104310323(MYCBP2)
PPUS135191462(MYCBP2)
BRHI104498957(MYCBP2)
EGZ104127059(MYCBP2)
NNI104018833(MYCBP2)
PADL103923690(MYCBP2)
AFOR103900939(MYCBP2)
FGA104072385
CBOY140646315(MYCBP2)
CLV102096062(MYCBP2)
CNIC135999954(MYCBP2)
MUI104548329(MYCBP2)
PLET104622936
CUCA104064920(MYCBP2)
BREG104636606(MYCBP2)
OHA104336658(MYCBP2)
CPEA104393986(MYCBP2)
CVF104294427(MYCBP2)
RTD128912547(MYCBP2)
CRID134516055(MYCBP2)
AAM106491626(MYCBP2)
AROW112971751(MYCBP2)
NPD112951751(MYCBP2)
TGT104570872(MYCBP2)
DNE112995711(MYCBP2)
SCAM104147473(MYCBP2)
ASN102370186(MYCBP2)
AMJ102567283(MYCBP2)
CPOO109305504(MYCBP2)
GGN109302262(MYCBP2)
PSS102460319(MYCBP2)
CMY102943545(MYCBP2)
CCAY125637725(MYCBP2)
DCC119841927(MYCBP2)
CPIC101938064(MYCBP2)
TST117870877(MYCBP2)
CABI116828231(MYCBP2)
MRV120389425(MYCBP2)
ACS100560904(mycbp2)
ASAO132771438(MYCBP2)
PVT110073859(MYCBP2)
SUND121927234(MYCBP2)
PBI103060974(MYCBP2)
PMUR107303127(MYCBP2)
CTIG120318201(MYCBP2)
TSR106547866(MYCBP2)
PGUT117665293(MYCBP2)
PCAE139317206(MYCBP2)
APRI131200083(MYCBP2)
PTEX113439429(MYCBP2)
NSS113415878(MYCBP2)
VKO123027233(MYCBP2)
PMUA114596589(MYCBP2)
PRAF128411960(MYCBP2)
ZVI118085426(MYCBP2)
HCG128349363(MYCBP2)
GJA107108913(MYCBP2)
STOW125431096(MYCBP2)
EMC129326703(MYCBP2)
XLA108708496(mycbp2.L) 447587(mycbp2.S)
XTR100379925(mycbp2)
NPR108794355(MYCBP2)
ACAT141127640(MYCBP2)
BGAR122930948(MYCBP2)
DTC141094538(MYCBP2)
PWL138250400(MYCBP2)
MUO115468682(MYCBP2)
GSH117362656(MYCBP2)
DRE368439(mycbp2)
SRX107728238(mycbp2) 107749028
SANH107664005 107670894
SGH107549765 107549904
CCAR109079135(mycbp2) 109095687
CAUA113053452 113109035(mycbp2)
CGIB127965571 128019527
PTET122351391(mycbp2)
LROH127171304(mycbp2)
GRF141301158 141340845(mycbp2)
OMC131547410(mycbp2)
PPRM120487163(mycbp2)
RKG130086075(mycbp2)
MAMB125269903(mycbp2)
CIDE127518813
CERY137035504(mycbp2)
MASI127446741 127447813
TROS130556189(mycbp2)
TDW130427320(mycbp2)
MANU129451899(mycbp2)
PDAB135782639(mycbp2)
IPU108266340
IFU128608803(mycbp2)
PHYP113524237(mycbp2)
SMEO124383197(mycbp2)
TFD113654589(mycbp2)
TVC132850174(mycbp2)
CGAR128524548(mycbp2)
NGRA132891841(mycbp2)
TRN134324277(mycbp2)
AMEX103045757(mycbp2)
CMAO118803685(mycbp2)
EEE113577106
CHAR105893397(mycbp2)
SPIL134078062(mycbp2)
TRU101073276(mycbp2)
TFS130536858(mycbp2)
TNGGSTEN00001239G001 GSTEN00027943G001
LCO104921457(mycbp2)
NCC104958638(mycbp2)
TBEN117481080(mycbp2)
CGOB115026614(mycbp2)
PGEO117466450(mycbp2)
GACU117544521(mycbp2)
EMAC134867035(mycbp2)
ELY117251270(mycbp2)
EFO125900161(mycbp2)
PLEP121948718(mycbp2)
SLUC116043573(mycbp2)
ECRA117953404(mycbp2)
ESP116698463(mycbp2)
PFLV114564481(mycbp2)
GAT120833792(mycbp2)
PPUG119228511(mycbp2)
AFB129104589(mycbp2)
CLUM117750210(mycbp2)
PSWI130203569(mycbp2)
CANA137782756(mycbp2)
CVE137866311(mycbp2)
MSAM119904339(mycbp2)
SCHU122885868(mycbp2)
CUD121522435(mycbp2)
SPUL138592326(mycbp2)
LMIX132986681(mycbp2)
ALAT119026456(mycbp2)
ASTR137605523(mycbp2)
MZE101484105(mycbp2)
ONL100697810(mycbp2)
OAU116316041(mycbp2)
OLA101162404(mycbp2)
OML112155131(mycbp2)
CSAI133446223(mycbp2)
XMA102221295(mycbp2)
XCO114148233(mycbp2)
XHE116723172(mycbp2)
PRET103480554(mycbp2)
PFOR103134730(mycbp2)
PLAI106962344(mycbp2)
PMEI106927724(mycbp2)
GAF122840370(mycbp2)
PPRL129361105(mycbp2)
CVG107104580(mycbp2)
CTUL119794710(mycbp2)
GMU124870900(mycbp2)
NFU107389738(mycbp2)
KMR108232441(mycbp2)
ALIM106527137(mycbp2)
NWH119419371(mycbp2)
AOCE111568452(mycbp2)
EJA138201086(mycbp2)
BFRE138625822(mycbp2)
MCEP125017437(mycbp2)
CSEM103391933(mycbp2)
POV109637960(mycbp2)
SSEN122763265(mycbp2)
SSOE131450774(mycbp2)
HHIP117754800(mycbp2)
HSP118120431(mycbp2)
PPLT128455606(mycbp2)
SMAU118320546(mycbp2)
LCF108901224
SDU111218291(mycbp2)
SLAL111673036(mycbp2)
XGL120801543(mycbp2)
HCQ109531235(mycbp2)
SSCV125974064(mycbp2)
SBIA133512756(mycbp2)
PEE133410976(mycbp2)
PTAO133486395(mycbp2)
BPEC110170545(mycbp2)
ENY140359717(mycbp2)
MALB109965418(mycbp2)
BSPL114847386(mycbp2)
SJO128367943(mycbp2)
SSCO133993409(mycbp2)
GMH115532818(mycbp2)
SASA100380858(mycb2) 106581613
STRU115156251(mycbp2) 115160590
OTW112225044(mycbp2) 112234653
OMY110501235(mycbp2) 110519948
OGO124041573 124043719
ONE115107163 115133812
OKI109870670(mycbp2) 109904047
OKE118367218 118385901(mycbp2)
OMM135519932 135547044(mycbp2)
OCLA139380072 139395705
SALP111959629(mycbp2) 111973092
SNH120058172 120064471
CCLU121536600(mycbp2) 121554853
ELS105029423(mycbp2)
OEP134017650(mycbp2)
SFM108920533(mycbp2) 108929997
PKI111836683(mycbp2)
AANG118213737(mycbp2)
AROT135241408(mycbp2)
CCOG133116615(mycbp2)
LOC102688269(mycbp2)
PSPA121320927(mycbp2) 121327729
ARUT117405836 117407076(mycbp2)
PSEX120523768(mycbp2)
LCM102364952(MYCBP2)
CMK103176899(mycbp2)
RTP109933918(mycbp2)
CPLA122550534(mycbp2)
HOC132816397(mycbp2)
LERI129697970(mycbp2)
HAKA140715463(mycbp2)
PMRN116943639(MYCBP2)
LRJ133349976(MYCBP2)
BFO118420307
BBEL109487224
CIN100183875
SPU584171
LPIC129260933
AJJ139980240
APLC110979774
ARUN117293291
AAMU139935669
AFIL140159991
SKO100368165(MYCBP2)
PFLL139130331
DMEDmel_CG32592(hiw)
DER6550644
DSE6619582
DSIDsimw501_GD15825(Dsim_GD15825)
DYADyak_GE16076
DAN6504741
DSR110181491
DPO4816080
DPE6600054
DMN108154658
DWI6641243
DGR6565248
DMODmoj_GI15368
DAZ108619000
DNV108656489 115565145
DHE111591907
DVI6633673(hiw)
CCAT101450568
BOD106622527
BDR105225017
AOQ129238267 129239679
ALUD128858449 128858453
TDA119671985
MDE101898302
SCAC106082007
LCQ111675316
LSQ119602240
CVJ135956855(hiw)
GFS119637478
ECOE129947427
HIS119658384
ACOZ120955749
AARA120900964
AMER121599147
ASTE118506212
AFUN125769531
AAG5564066
AALB109427738 109431372
ASUA134205483
CQUCpipJ_CPIJ003142 CpipJ_CPIJ003145
CPII120418076 120419869
CNS116344161
BCOO119069621
LLL129790814
PPAP129807775
AME551203
ACER107992715
ALAB122716509
ADR102673032
AFLR100865814
BIM100743303
BBIF117204381
BVK117233223
BVAN117153411
BHUN126863494
BTER100651327
BAFF126921060
BPYO122569292
BPAS132916557
FVI122535297
CCAL108625172 108625982
OBB114880196
OLG117608635
MGEN117219034
NMEA116430480
CGIG122395262
SOC105208061
MPHA105833137
AEC105149206 105149212
ACEP105626860 105626861
CCOA108783114
PBAR105429007
VEM105569266
COBS139109985(Hiw)
TLN139813339(Hiw)
HST105186389
DQU106745457
CFO105248657
FEX115240302
PMEC138934915(Hiw)
LHU105675379(hiw)
PGC109864218
OBO105286692
PCF106786843
PFUC122518817
VPS122637981
VCRB124426647
VVE124947222
NVI100120311
CSOL105360333 105360334
TPRE106652084
LHT122497957
LBD127288535
MDL103573916
CGLO123266981
CTYP141528941(Hiw)
FAS105274087
DAM107045271
CINS118066596
VCAN122417356
CCIN107274254
DSM124404320
NPT124213143(hiw)
NFB124174877
NLO107222725
NVG124297258
AROA105688075
TCA660160(Hiw)
TMOL138134692(hiw)
DPA109543312
ESIM136411366(hiw)
EFOR136339456(hiw)
SOY115880273
AGRG126739392
ATD109601882
CSET123319905
HAXR123673488
LDC111505595
DVV126889923
NVL108569690 108569691
APLN108741475
PPYR116174287
OTU111421061
BMOR101743860
BMAN114252803
DPLKGM_203404 KGM_203405
MJU123880463
PMAC106715875 106715876
PXU106113726
BPHI137919628(hiw)
ZCE119835531
AAGE121739399
HAW110381715
TNL113504190
SLIU111360638
ONU135087030
ATRA106133742
GMW113518531
PGW126380209
LGLY125240457
CSTB134754459
CFUM141433257(hiw)
CCRN123294595
API100161379 115033055
DNX107162655
AGS114130748
RMD113552204
ACOO126834901
DVT126905604
BTAB109030725 109034485
DCI103512713
CLEC106673766
HHAL106688077(hiw)
NLU111048490
HVI124369695
MQU128993926
PHUPhum_PHUM483630 Phum_PHUM483780
FOC113212940
TPAL117640307
ZNE110827698
CSEC111868086
PAME138703007(hiw)
SGRE126267346
BROR134538847
HAMR139692077(hiw)
FCD110851038
DPXDAPPUDRAFT_324455
DMK116924887
DPZ124330474
AFRA136040940
PVM113800512(hiw)
PJA122264032
PCHN125044663
PMOO119582672
HAME121859514
PCLA123745661(hiw)
CQD128697542(hiw)
PTRU123514289
ESN127007549
MNZ135224515
MRJ136843670(hiw)
PORN139755541(hiw)
HAZT108676629
EAF111697381
LSM121123134(hiw)
TCF131877328
PPOI119092560
DSV119449561
RSAN119382556
RMP119163190
VDE111246318
VJA111262692
GOE100901248
DPTE113790071
DFR124499080
CSCU111637900
CVS136986983
PTEP107440653
ABRU129966743
UDV129232959
SDM118203453
CELCELE_C01B7.6(rpm-1) CELE_F07B7.12(rpms-1)
CBRCBG_00759(Cbr-rpm-1)
CRQGCK72_018930
BMYBM_BM1864(Bm1864)
LOALOAG_17782
TSPTsp_05625
HROHELRODRAFT_188971
LGILOTGIDRAFT_153260 LOTGIDRAFT_205644
PCAN112560664
BGT106053387
GAE121373896
HRF124139629
HRJ124283800
HASI137274241
HCRA139449803
CRG105342162
CANU128191831
CVN111125018
OED125678670
MYI110442255
PMAX117329498
AIRR138327888
MMER123556504
RPHI132728510
DPOL127880259
MAEA128226745 128227140
OBI106869699
OSN115218378
LJP135473059
LAK106166199
LLON135493778
AQU100633012
MBRMONBRDRAFT_33522
SREPTSG_02092 PTSG_11546
 » show all
Reference
1  [PMID:29643511]
  Authors
Pao KC, Wood NT, Knebel A, Rafie K, Stanley M, Mabbitt PD, Sundaramoorthy R, Hofmann K, van Aalten DMF, Virdee S
  Title
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
  Journal
Nature 556:381-385 (2018)
DOI:10.1038/s41586-018-0026-1
  Sequence
[hsa:23077]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.33
IUBMB Enzyme Nomenclature: 2.3.2.33
ExPASy - ENZYME nomenclature database: 2.3.2.33
BRENDA, the Enzyme Database: 2.3.2.33

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