KEGG   ENZYME: 2.3.2.33
Entry
EC 2.3.2.33                 Enzyme                                 

Name
RCR-type E3 ubiquitin transferase;
MYCBP2;
PHR1
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
Sysname
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RCR-type)
Reaction(IUBMB)
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine (overall reaction);
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;
(1b) [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [RCR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
Substrate
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine;
[acceptor protein]-L-threonine;
[RCR-type E3 ubiquitin transferase]-L-cysteine;
[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Product
[E2 ubiquitin-conjugating enzyme]-L-cysteine;
[acceptor protein]-3-O-ubiquitinyl-L-threonine;
[RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine;
[RCR-type E3 ubiquitin transferase]-L-cysteine
Comment
RCR-type E3 ubiquitin transferases is a class of RING-type E3 ubiquitin transferase (see EC 2.3.2.27) that mediates ubiquitylation of acceptor proteins via an internal cysteine residue. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue on a mediator loop of the RCR-type ligase. The ubiquitin may be transferred to a second internal cysteine before the transfer of the ubiquitin from the RCR-type ligase to the substrate.
History
EC 2.3.2.33 created 2019
Orthology
K10693  RCR-type E3 ubiquitin transferase
Genes
HSA: 23077(MYCBP2)
PTR: 452608(MYCBP2)
PPS: 100984032(MYCBP2)
GGO: 101142597(MYCBP2)
PON: 100451266(MYCBP2)
NLE: 100581654(MYCBP2)
MCC: 696734(MYCBP2)
MCF: 101867408(MYCBP2)
CSAB: 103214597(MYCBP2)
CATY: 105597929(MYCBP2)
RRO: 104671175(MYCBP2)
RBB: 108516636(MYCBP2)
TFN: 117063665(MYCBP2)
CJC: 100413363(MYCBP2)
SBQ: 101053013(MYCBP2)
MMUR: 105855857(MYCBP2)
MMU: 105689(Mycbp2)
MCAL: 110309324(Mycbp2)
MPAH: 110325255(Mycbp2)
RNO: 290447(Mycbp2)
MCOC: 116085304(Mycbp2)
MUN: 110560794
CGE: 100763589(Mycbp2)
PLEU: 114690201(Mycbp2)
NGI: 103724869(Mycbp2)
HGL: 101712951(Mycbp2)
OCU: 100350249(MYCBP2)
TUP: 102472161(MYCBP2)
CFA: 476952(MYCBP2)
AML: 100469795(MYCBP2)
UMR: 103659207(MYCBP2)
UAH: 113251431(MYCBP2)
ORO: 101376178(MYCBP2)
ELK: 111146914
MPUF: 101692610(MYCBP2)
EJU: 114211543(MYCBP2)
FCA: 101089233(MYCBP2)
PTG: 102972230(MYCBP2)
PPAD: 109264206(MYCBP2)
AJU: 106965757(MYCBP2)
BTA: 534496(MYCBP2)
BOM: 102265576(MYCBP2)
BIU: 109566887(MYCBP2)
BBUB: 102416199(MYCBP2)
CHX: 102190428(MYCBP2)
OAS: 101102993(MYCBP2)
SSC: 100156216(MYCBP2)
CFR: 102510373(MYCBP2)
CDK: 105103149(MYCBP2)
BACU: 103016264(MYCBP2)
LVE: 103069781(MYCBP2)
OOR: 101289007(MYCBP2)
DLE: 111176477(MYCBP2)
PCAD: 102995571(MYCBP2)
ECB: 100053014(MYCBP2)
EPZ: 103556062
EAI: 106843084(MYCBP2)
MYB: 102253398(MYCBP2)
MYD: 102761670(MYCBP2)
MMYO: 118649623(MYCBP2)
MNA: 107539858(MYCBP2)
HAI: 109389062(MYCBP2)
DRO: 112312466(MYCBP2)
SHON: 118996124(MYCBP2)
AJM: 119047869(MYCBP2)
MMF: 118622279(MYCBP2)
PALE: 102879756(MYCBP2)
RAY: 107513073(MYCBP2)
MJV: 108404968(MYCBP2)
LAV: 100661251(MYCBP2)
TMU: 101355836
MDO: 100013024(MYCBP2)
SHR: 100931136(MYCBP2)
PCW: 110198796(MYCBP2)
OAA: 100081768(MYCBP2)
GGA: 418808(MYCBP2)
MGP: 100545152(MYCBP2)
CJO: 107308046(MYCBP2)
NMEL: 110408390(MYCBP2)
APLA: 101790448(MYCBP2)
ACYG: 106043922(MYCBP2)
TGU: 100224418(MYCBP2)
LSR: 110480244(MYCBP2)
SCAN: 103812272(MYCBP2)
GFR: 102032331(MYCBP2)
FAB: 101817180(MYCBP2)
PHI: 102102663(MYCBP2)
PMAJ: 107202200(MYCBP2)
CCAE: 111927766(MYCBP2)
CCW: 104695873(MYCBP2)
ETL: 114062623(MYCBP2)
FPG: 101918329(MYCBP2)
FCH: 102047786(MYCBP2)
CLV: 102096062(MYCBP2)
EGZ: 104127059(MYCBP2)
NNI: 104018833(MYCBP2)
ACUN: 113480407(MYCBP2)
PADL: 103923690(MYCBP2)
AAM: 106491626(MYCBP2)
ASN: 102370186(MYCBP2)
AMJ: 102567283(MYCBP2)
PSS: 102460319(MYCBP2)
CMY: 102943545(MYCBP2)
CPIC: 101938064(MYCBP2)
ACS: 100560904(mycbp2)
PVT: 110073859(MYCBP2)
PBI: 103060974(MYCBP2)
PMUR: 107303127(MYCBP2)
TSR: 106547866(MYCBP2)
PMUA: 114596589(MYCBP2)
GJA: 107108913(MYCBP2)
XLA: 108708496(mycbp2.L) 447587(mycbp2.S)
XTR: 100379925(mycbp2)
NPR: 108794355(MYCBP2)
DRE: 368439(mycbp2)
SRX: 107728238(mycbp2) 107749028
IPU: 108266340(mycbp2)
PHYP: 113524237(mycbp2)
AMEX: 103045757(mycbp2)
EEE: 113577106
TRU: 101073276(mycbp2)
LCO: 104921457(mycbp2)
NCC: 104958638(mycbp2)
MZE: 101484105(mycbp2)
ONL: 100697810(mycbp2)
OLA: 101162404(mycbp2)
XMA: 102221295(mycbp2)
XCO: 114148233(mycbp2)
PRET: 103480554(mycbp2)
CVG: 107104580(mycbp2)
NFU: 107389738(mycbp2)
KMR: 108232441(mycbp2)
ALIM: 106527137(mycbp2)
AOCE: 111568452(mycbp2)
CSEM: 103391933(mycbp2)
POV: 109637960(mycbp2)
LCF: 108901224(mycbp2)
SDU: 111218291(mycbp2)
SLAL: 111673036(mycbp2)
HCQ: 109531235(mycbp2)
BPEC: 110170545(mycbp2)
MALB: 109965418(mycbp2)
SASA: 100380858(mycb2) 106581613
OTW: 112225044(mycbp2) 112234653
SALP: 111959629(mycbp2) 111973092
ELS: 105029423(mycbp2)
SFM: 108920533(mycbp2) 108929997
PKI: 111836683(mycbp2)
LCM: 102364952(MYCBP2)
CMK: 103176899(mycbp2)
RTP: 109911799 109933918(mycbp2)
BFO: 118420307
CIN: 100183875
SPU: 584171
APLC: 110979774
SKO: 100368165(MYCBP2)
DME: Dmel_CG32592(hiw)
DER: 6550644
DSE: 6619582
DSI: Dsimw501_GD15825(Dsim_GD15825)
DAN: 6504741
DSR: 110181491
DPE: 6600054
DMN: 108154658
DWI: 6641243
DAZ: 108619000
DHE: 111591907
MDE: 101898302
LCQ: 111675316
AAG: 5564066
AME: 551203
BIM: 100743303
BTER: 100651327
OBB: 114880196
SOC: 105208061
MPHA: 105833137
PBAR: 105429007
VEM: 105569266
HST: 105186389
DQU: 106745457
CFO: 105248657
LHU: 105675379
PGC: 109864218
OBO: 105286692
PCF: 106786843
NVI: 100120311
MDL: 103573916
TCA: 660160(Hiw)
DPA: 109543312
ATD: 109601882
BMOR: 101743860
BMAN: 114252803
TNL: 113504190
DNX: 107162655
AGS: 114130748
RMD: 113552204
CLEC: 106673766
ZNE: 110827698
FCD: 110851038
PVM: 113828273
DPTE: 113790071
CSCU: 111637900
PTEP: 107440653
CEL: CELE_C01B7.6(rpm-1) CELE_F07B7.12(F07B7.12)
CBR: CBG00759(Cbr-rpm-1)
BMY: Bm1_29655
TSP: Tsp_05625
PCAN: 112560664
CRG: 105342162
MYI: 110442255
OBI: 106869699
LAK: 106166199
AQU: 100633012
 » show all
Reference
1  [PMID:29643511]
  Authors
Pao KC, Wood NT, Knebel A, Rafie K, Stanley M, Mabbitt PD, Sundaramoorthy R, Hofmann K, van Aalten DMF, Virdee S
  Title
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
  Journal
Nature 556:381-385 (2018)
DOI:10.1038/s41586-018-0026-1
  Sequence
[hsa:23077]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.33
IUBMB Enzyme Nomenclature: 2.3.2.33
ExPASy - ENZYME nomenclature database: 2.3.2.33
BRENDA, the Enzyme Database: 2.3.2.33

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