Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer

acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]

acetyl-CoA + H2O + oxaloacetate = citrate + CoA [RN:R00351]

R00351

acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
oxaloacetate [CPD:C00036]

The stereospecificity of this enzyme is opposite to that of EC 2.3.3.3, citrate (Re)-synthase, which is found in some anaerobes. Citrate synthase for which the stereospecificity with respect to C2 of oxaloacetate has not been established are included in EC 2.3.3.16, citrate synthase.

EC 2.3.3.1 created 1961 as EC 4.1.3.7, transferred 2002 to EC 2.3.3.1, modified 2014