KEGG   ENZYME: 2.3.3.14
Entry
EC 2.3.3.14                 Enzyme                                 
Name
homocitrate synthase;
2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating);
acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase;
homocitrate synthetase;
HCS
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
Sysname
acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Reaction(IUBMB)
acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA [RN:R00271]
Reaction(KEGG)
R00271
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
2-oxoglutarate [CPD:C00026]
Product
(2R)-2-hydroxybutane-1,2,4-tricarboxylate;
CoA [CPD:C00010]
Comment
Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36, homoaconitate hydratase. The enzyme also acts with oxaloacetate as substrate, but more slowly [2,3].
History
EC 2.3.3.14 created 1972 as EC 4.1.3.21, transferred 2002 to EC 2.3.3.14
Pathway
ec00300  Lysine biosynthesis
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K01655  homocitrate synthase
K02594  homocitrate synthase NifV
K10977  methanogen homocitrate synthase
Genes
QSU112011564 112029854
SCEYDL131W(LYS21) YDL182W(LYS20)
SEUBDI49_0897
SPAOSPAR_D00610 SPAR_D01060
AGOAGOS_ADR107W
ERCEcym_8045
KLAKLLA0_E23695g KLLA0_F05489g
KMXKLMA_10771(LYS21) KLMA_60493(LYS21)
LTHKLTH0E12848g KLTH0H02486g
VPOKpol_2000p11
ZROZYRO0A13222g ZYRO0C09416g
CGRCAGL0J06402g CAGL0J09240g
NCSNCAS_0A13800(NCAS0A13800) NCAS_0E03640(NCAS0E03640)
NDINDAI_0A02240(NDAI0A02240) NDAI_0A02990(NDAI0A02990)
TPFTPHA_0P00840(TPHA0P00840)
TBLTBLA_0A05940(TBLA0A05940)
TDLTDEL_0B02910(TDEL0B02910) TDEL_0H01490(TDEL0H01490)
TGBHG536_0C05440 HG536_0H02920
KAFKAFR_0B01160(KAFR0B01160)
KNGKNAG_0B02880(KNAG0B02880) KNAG_0C04080(KNAG0C04080)
ZMKHG535_0A05750 HG535_0G01540
PPAPAS_chr1-1_0313 PAS_chr1-4_0421
DHADEHA2D13222g DEHA2F08514g
PICPICST_28701(LYS21) PICST_89386(LYS22)
PGUPGUG_01126 PGUG_01480
SPAASPAPADRAFT_136285(LYS22) SPAPADRAFT_58182
LELLELG_01048 LELG_01805
CALCAALFM_C104730CA(LYS21) CAALFM_C204460WA(LYS22)
CTPCTRG_01594 CTRG_04686
COTCORT_0A12020 CORT_0B06650
CDUCD36_04470 CD36_19070
CTENCANTEDRAFT_113002 CANTEDRAFT_115851
YLIYALI0F31075g
CLUCLUG_01219 CLUG_05100
CLUSA9F13_03g01375 A9F13_06g00154
CAURCJI97_000022 CJI97_003796
SLBAWJ20_418(LYS21)
PKZC5L36_0C01170 C5L36_0D05690
BNNFOA43_003157(LYS21)
BBRXBRETT_000905(LYS21_1) BRETT_003395(LYS21_2)
OPAHPODL_02806 HPODL_04767
SLUDSCDLUD_000290 SCDLUD_002024
NCRNCU05526(lys-5)
NTENEUTE1DRAFT68872(NEUTE1DRAFT_68872)
SMPSMAC_00737
PANPODANSg2772
TTTTHITE_2110530
MTMMYCTH_2307131
CTHRCTHT_0044760
MGRMGG_01092
PPEIPpBr36_08045
TMNUCRPA7_2646
SSCKSPSK_02501
FGRFGSG_03993 FGSG_11054
FPUFPSE_02427 FPSE_05284
FVRFVEG_00366 FVEG_08487 FVEG_11679
FOXFOXG_01149 FOXG_01159
NHENECHADRAFT_104905 NECHADRAFT_90471
TRETRIREDRAFT_123471
TRRM419DRAFT_111054
MAWMAC_04163 MAC_04755
MAJMAA_04642 MAA_08803
CMTCCM_06007
PLJVFPFJ_03902
VALVDBG_04044 VDBG_07402
VDAVDAG_01275 VDAG_06110
CFJCFIO01_11607
CHIGCH63R_05833
SAPOSAPIO_CDS8181
ELAUCREL1_11150
PFYPFICI_06350 PFICI_09647
SSLSS1G_14306
BFUBCIN_14g05400
MBEMBM_09052
PSCOLY89DRAFT_684190
GLZGLAREA_07760
ANIAN1990.2
AFMAFUA_4G10460
ACTACLA_049660
NFINFIA_105610
AORAO090003001165 AO090124000027
ANGANI_1_1952184(An04g06210)
AFVAFLA_000502 AFLA_009184
ALUCAKAW2_51586A(LYS1_2)
ACHEACHE_10778S(LYS1_1)
APUUAPUU_21064S(LYS1_1)
PCSPc22g13190(lys1)
PDPPDIP_24800
TMFPMAA_040420
TRGTRUGW13939_02747
CIMCIMG_09081
CPWCPC735_015150
UREUREG_05150
PBLPAAG_07089
PBNPADG_01615
ABEARB_01923
TVETRV_02108
AJEHCAG_06098
BGHBDBG_02311
PNOSNOG_08956
PTEPTT_15621
BZECOCCADRAFT_101614
BSCCOCSADRAFT_32571
BORCOCMIDRAFT_95545
AALTCC77DRAFT_1052185
ZTRMYCGRDRAFT_110230
PFJMYCFIDRAFT_86887
FFUCLAFUR5_12241
BCOMBAUCODRAFT_39689
NPAUCRNP2_8181
TMLGSTUM_00009173001
SPOSPBC1105.02c(lys4)
CNECND01200
CNBCNBD5100
CNGCNAG_00992
CGICGB_D3430W
TMSTREMEDRAFT_44559
TASAA1Q1_00939
PPLPOSPLDRAFT_89192
TVSTRAVEDRAFT_110523
DSQDICSQDRAFT_45747
PCOPHACADRAFT_159123
SHSSTEHIDRAFT_90937
HIRHETIRDRAFT_316739
ADLAURDEDRAFT_112769
FMEFOMMEDRAFT_76994
GTRGLOTRDRAFT_112070
LBCLACBIDRAFT_291144
CCICC1G_06438
ABPAGABI1DRAFT114278(AGABI1DRAFT_114278)
ABVAGABI2DRAFT191298(AGABI2DRAFT_191298)
PCUBJR316_0006175
MRRMoror_4622
MOREE1B28_011484(LYS4_1)
SCMSCHCO_02503178(SCHCODRAFT_02503178)
CPUTCONPUDRAFT_80635
SLASERLADRAFT_468311
WSEWALSEDRAFT_42693
WICJ056_002016
UMAUMAG_04115
PFPPFL1_06052
MGLMGL_3987
MRTMRET_4216
MSYMMSY001_2206
PGRPGTG_01903
MLRMELLADRAFT_50387
MBRMONBRDRAFT_34312
SREPTSG_03420
NGRNAEGRDRAFT_34642
ENRH650_03260
ENFAKI40_3036
KPVKPNIH29_17575
KVAKvar_1593
KPEKPK_1704(nifV)
KPKA593_02165
KVDKR75_26170
KVQSP68_06315
KOXKOX_24970
KOEA225_3846
KOYJ415_12630
KOMHR38_23055
KOKKONIH1_19295
KOCAB185_16985
KQUAVR78_21560
KQVB8P98_09530(nifV)
KLLBJF97_19205
KGRJJJ10_09475(nifV)
RONTE10_14840
RTGNCTC13098_03592(leuA_5)
REEelectrica_03306(leuA_2)
KSAC813_03870
KORAWR26_13330(nifV)
KRDA3780_10680(nifV)
KPSEIP581_10875(nifV)
METYMRY16398_27800
KINAB182_11850
PDZHHA33_15750(nifV)
EBCC2U52_22685(nifV)
SERASer39006_005380(nifV)
SERQCWC46_05375(nifV)
RACEJHW33_22800(nifV)
RAQRahaq2_5100
RAAQ7S_25861
ECAECA2944(nifV)
PATREV46_14530
PATOGZ59_29480(nifV)
PPOABJK05_08570
DDDDda3937_02173(nifV)
DSOA4U42_06295
CEDLH89_15245
DFNCVE23_19690(nifV)
DDQDDI_3740
DDADd703_0505
BGJAWC36_07340 AWC36_21445
BRBEH207_08550(nifV)
BNGEH206_10210(nifV)
BIZHC231_11325(nifV)
SLIGGTU79_13535(nifV)
PAMPANA_3289(leuA2)
PLFPANA5342_0779
PAQPAGR_g0792
PAOPat9b_4710
XBVXBW1_2048(leuA)
VNAPN96_19245
VEJVEJY3_18751
VASGT360_06370(nifV)
VZIG5S32_17245(nifV)
PSAPST_1352(nifV)
PSRPSTAA_1384(nifV)
AVNAvin_01640(nifV)
AVLAvCA_01640(nifV)
AVDAvCA6_01640(nifV)
ACXAchr_1500(nifV)
SDKKHX94_12855(nifV)
SYKKDN34_14205(nifV)
SAVIJYB87_02715(nifV)
AGZM0C34_08825(nifV)
TTUTERTU_1590(nifV)
MCAMCA0254(nifV)
METUGNH96_04000(nifV)
MMTMetme_3108
MDNJT25_013605
MDHAYM39_04515
MKOMKLM6_0904
METLU737_20460(nifV)
MPADKEF85_01905(nifV)
MELLIVG45_07500(nifV)
MBUREQU24_17350(nifV)
MPSYCEK71_18900(nifV)
MMAIsS8_5511
MMOBF6R98_03690(nifV)
MOZMoryE10_26780
MESLKKZ03_16595(nifV)
TIGTHII_3088
BLEPAL038_12335(nifV)
THISHZT40_02960(nifV)
TUNJ9260_09745(nifV)
TLOJ9253_07215(nifV)
TSBHMY34_13210(nifV)
ALVAlvin_1499
ATEPAtep_22370
TVIThivi_4287
TMBThimo_3234
MPURMARPU_02910
TSYTHSYN_10705
TTPE6P07_09595(nifV)
THIPN838_15805(nifV)
CJAPGWK36_11715(nifV)
THIMKFB96_21875(nifV)
TBOGLT988_18055(nifV)
HHAHhal_0279
HHKHH1059_12130
HHCM911_10550
EBSECTOBSL9_3086
HAZA9404_01550
HAMHALO1620
NIKF5I99_00395(nifV)
GSNYC6258_02011
TAUTola_2344
GBIPG2T_00440
ACIIC4901_14850(nifV)
ATYA9R16_013735(nifV)
SEDSAAY24_16725
CDIZCEDIAZO_02286(frbC)
VFFVITFI_CDS1636
AQLBXU06_12020
CTIpRALTA_0383(nifV)
BOKDM82_5473
BOCBG90_5135
BUUWS70_24305
BVIBcep1808_5987
BVEAK36_5464(nifV)
BSTGWT74_17305
BUGBC1001_PA6327(nifV1) BC1001_PA6490(nifV2)
BUKMYA_5482
BXEBxe_B1438
BXBDR64_6744(nifV)
BPHBphy_7741
BGEBC1002_6915
BPXBUPH_08515(nifV)
PSPWBJG93_028040(nifV) BJG93_16455(nifV) BJG93_16555(nifV) BJG93_32345(nifV)
PARBCJU94_33135(nifV)
PDIOPDMSB3_1662.1(nifV)
RACRA876_02570
PNAPnap_2310
HTNKI616_07790(nifV)
RGERGE_43100(nifV)
RBNRBXJA2T_04428
IDCLRM40_03230(nifV)
HSEHsero_2835(nifV)
HSZACP92_14195
HRBHrubri_2359(nifV)
LCHLcho_1366
BBAGE1O_13410
METRBSY238_1244(nifV)
SLTSlit_0807
FAMOYT1_ch1085
FKUFGKAn22_10410
SEMEMIZ01_0760
SULFCAP31_00225
SNIVSFSGTM_04470
SLACSKTS_08810
DSUDsui_0578
ARESIWH25_06420(nifV)
AIQAzoinq_05900(nifV)
NIVJY500_11765(nifV)
RBHB4966_06565
DARDaro_1398
DEYHYN24_06635(nifV)
DDENKI615_08440(nifV)
QAUKI612_04755(nifV)
FLEKI610_08670(nifV)
AZOazo0551(nifV)
AOAdqs_0561
AZAAZKH_0773
AZIAzCIB_0674
ACOMCEW83_19555(nifV)
AZDCDA09_08305(nifV)
AZRCJ010_03625(nifV)
AZQG3580_19130(nifV)
ZPAC3497_06150(nifV)
FMYHO273_13100(nifV)
APPCAP2UW1_4375
WSUWS1396(NIFV1)
SULGFJR48_03500(nifV)
SBALHUE88_05810(nifV)
SMASHUE87_07715(nifV)
SKUSulku_1509
SULRB649_06590
SBASulba_0991
SMULSMUL_1208(nifV)
SHALSHALO_1193
SULSSdiek1_1277
SULJSJPD1_1226
SULTFA592_12340(nifV)
ANTArnit_0082
AELLAELL_0053(nifV)
ASUIASUIS_0055(nifV)
AVPAVENP_0069(nifV)
ADZADFLV_0079(nifV)
ARCABLL_0069
PACOAACT_0059(nifV)
AMOLAMOL_2269(nifV)
HEBRAEBR_0107(nifV)
AANAAANAER_0113(nifV)
GSUGSU0937(nifV)
GSKKN400_0924(nifV)
GMEGmet_0692(nifV)
GPIGPICK_12140(aksA)
GBZJZM60_09095(nifV)
GEMGM21_2146
GEBGM18_1861
GEFFO488_16855(nifV)
GURGura_3368
GEOGeob_2573(nifV)
GLOGlov_0424
GBMGbem_2073(nifV)
GBNGEOBRER4_11490(nifV)
GERKP004_09360(nifV)
GSUBKP001_05825(nifV)
GNTKP003_08765(nifV)
GPLM1B72_11410(nifV)
PCAPcar_2110(nifV)
PACEA6070_04770(aksA)
PEFA7E78_00905
PPDPpro_3466
DESDSOUD_2514(nifV)
DEUDBW_0078
DVEDESUT3_35970(nifV)
DEPAOP6_2655(nifV)
DVUDVUA0016
DVLDvul_3089
DVMDvMF_2612
DVGDeval_3110
DFLDFE_1493
DSADesal_0448
DAFDesaf_0764
DASDaes_1020
DPIBN4_20067
DEJAWY79_07525
PPRFDPRO_3401
PSELGM415_09385
DDNDND132_1299
PSEFPSDVSF_12630
DBADbac_0833
DSFUWK_00329
DAKDaAHT2_2478
DALDalk_1511
DATHRM2_09760(nifV1)
DWDDSCW_30840(nifV)
DALKDSCA_50000(nifV)
DLIdnl_58130
DEKDSLASN_16140(nifV)
ADEAdeh_1436
ACPA2cp1_2511
AFWAnae109_2393
ANKAnaeK_2424
MCIMesci_5834
MOPMesop_6408
MAMMesau_05881
MAMOA6B35_32285
SAMESAMCFNEI73_pB0094(nifV)
BRABRADO5390(nifV)
BBTBBta_5875(nifV)
BRSS23_45990
AOLS58_23130
BRCBCCGELA001_31050
BICLMTR13_26450
BROBRAD285_1843(nifV)
BRQCIT40_01070(nifV)
BARHWN72_08700(nifV)
BVZBRAD3257_7801(nifV)
BELBE61_80510(nifV)
RPARPA4607(nifV)
RPBRPB_0982
RPCRPC_4450
RPDRPD_1086
RPERPE_4520
RPTRpal_5088
RPXRpdx1_4785
XAUXaut_0150
XDIEZH22_03890(nifV)
AZCAZC_3389
METM446_3580
BIDBind_0485
MSLMsil_3619
MTUNMTUNDRAET4_2336(nifV)
MLGCWB41_08170(nifV)
HMCHYPMC_3635(nifV)
RVARvan_1127
BVRBVIR_2279
BLAGBLTE_12000
MSCBN69_2668(nifV)
MBRYB1812_07905
MROSEHO51_16910(nifV)
MHEYH2LOC_019835(nifV)
MPARF7D14_08630(nifV) F7D14_19185(nifV)
MTWCQW49_08665(nifV)
PLEOOHA_1_01553(leuA_2)
HDIHDIA_0314(nifV)
MEYTM49_15540
YANAYJ57_00265
SAGUCDO87_16420(nifV)
RSPRSP_0529(nifV)
RSHRsph17029_2181
RSQRsph17025_1258
RSKRSKD131_1864
CAZTLV780_05935(nifV)
RCPRCAP_rcc03269(nifV)
RBLB6K69_06205
RSUNHU_01423
RHMB5V46_06570
RHCRGUI_2008
DAAAKL17_1562
ZMOZMO1835
ZMNZa10_1400
ZMMZmob_1319
ZMBZZ6_1307
ZMIZCP4_1343
ZMCA265_01343
ZMRA254_01342
ZMPZymop_1299
NDRHT578_08530(nifV)
SPHITS85_14275
GDIGDI0449(nifV)
GDJGdia_1557
RAPRHOA_0946(nifV)
AZLAZL_006540(leuA)
ALIAZOLI_0543(nifV)
ABSAZOBR_70111(nifV)
ABQABAZ39_10085
ABFAMK58_04575
ATIAL072_01085
AHUA6A40_02225
AZTTSH58p_07725(nifV)
AZMDM194_01955(nifV)
AZZDEW08_14855(nifV)
AOZHUE56_20495(nifV)
NAOY958_05410(nifV)
SKTIGS68_09325(nifV)
SMUCJL100_017910(nifV)
SROEJL101_016750(nifV)
RRURru_A2269
RRFF11_11670
RCERC1_3693(nifV)
RPMRSPPHO_01122
MAGamb1562
MGYMGMSRv2__0313(nifV)
MGRYMSR1_18880(leuA_3)
MAGXXM1_3948(nifV)
MAGNWV31_08715
TMOTMO_c0649
DEXHWD60_15190(nifV)
DVNHQ394_18590(nifV)
MGMMmc1_1190
AFRAFE_1506(nifV)
AFELferr_1224
AFIAcife_1634
AFJAFERRID_23260
AFPK1Y48_11625(nifV)
BRYM0696_19635
PARHI5S86_23695
PPOYRE92_06730
PTAHPL003_13115
PSABPSAB_18730
PDUPDUR_11815 PDUR_11820 PDUR_11870 PDUR_21125
PBDPBOR_29310
PGMPGRAT_26390
PODPODO_25015
PAENP40081_30915
PAEQR50912_27665
PSTEPSTEL_11485 PSTEL_20960
PAEAR70723_26505
PAEER70331_25210
PAEHH70357_28480
PRIPRIO_5532(nifV1)
PSONJI735_02625
PPEOABE82_05165
PDHB9T62_25600
PKBB4V02_20020
PSOPKP014_14795 KP014_14800 KP014_25280
PTRIKDC22_27035
PTJJRJ22_23555
KYRCVV65_08095
CACCA_C0260(nifV) CA_C0261(nifV)
CAESMB_G0265 SMB_G0266(nifV)
CAYCEA_G0266 CEA_G0267(nifV)
CBKCLL_A0128(nifV)
CBTCLH_0112(nifV)
CBECbei_0069 Cbei_2011 Cbei_2012
CBZCbs_0069(aksA) Cbs_2011 Cbs_2012
CBEILF65_00073(aksA) LF65_02180 LF65_02181
CKLCKL_1757(nifV1) CKL_1758(nifV2)
CKRCKR_1630 CKR_1631
CLJCLJU_c04970(nivfV) CLJU_c04980(nifV)
CCBClocel_2470 Clocel_2828 Clocel_2829
CLBClo1100_2596 Clo1100_2597
CSRCspa_c00800(leuA1) Cspa_c30980 Cspa_c30990
CPASClopa_3456 Clopa_3457
CPATCLPA_c14420(nifVo) CLPA_c14430(nifVa)
CPAECPAST_c14420(nifVo) CPAST_c14430(nifVa)
CSBCLSA_c00870(leuA2)
CAHCAETHG_2574 CAETHG_2575
CLTCM240_3129(nifV-ALPHA) CM240_3130
CBVU729_1236(nifV)
CACECACET_c05330(leuA1)
CBUTATN24_01900(aksA) ATN24_18615 ATN24_18620
CTYKCTK_C30180(nifV1) CTK_C30190(nifV2)
CEUA7L45_06285
CTAEBGI42_00525(nifV)
CFMBJL90_08385
CIABEN51_00490
CSEPCP523_08375(nifV)
CDYF3K33_00395(nifV) F3K33_10025 F3K33_10030
CGASJ1C67_05445(nifV)
CLOSDMR38_02135 DMR38_02140
CMAHC1I91_22445(nifV)
CRWCROST_005400 CROST_005410(frbC)
CFBCLFE_043140(frbC) CLFE_043150
CAUNCLAUR_024660(frbC) CLAUR_024670
CNNCNEO_0115 CNEO_1051
CGELpsyc5s11_00880 psyc5s11_35420(nifV)
AMTAmet_1321 Amet_3515
GFEGferi_18755
CCLClocl_1269 Clocl_1270
CCECcel_1624
RHEREHE19_001280 EHE19_001285
CTHDCDO33_05185
EHAEthha_1558 Ethha_1559 Ethha_2319 Ethha_2320
CFEMHCR03_07075 HCR03_07080
CLEClole_0460 Clole_0461
CEWEKH84_05550 EKH84_05555
ANRAna3638_13875 Ana3638_13880
ACELacsn021_23530(nifV_1) acsn021_23540(nifV_2)
ACHTbsdcttw_06510 bsdcttw_06520(nifV)
CDFCD630_08320(aksA)
PDCCDIF630_00951
CDCCD196_0781
CDLCDR20291_0762
PDFCD630DERM_08320(aksA)
ROCHF520_05795(nifV)
PHXKGNDJEFE_02031(leuA_1)
TEMJW646_18060(nifV)
TGCL0P85_09935(nifV)
IBRNQ514_07780(nifV)
SWOSwol_0375
SLPSlip_0508
SALQSYNTR_0238
DSYDSY3883 DSY4262
DHDDhaf_1059 Dhaf_1522
DDHDesde_1422
DDLDesdi_1263
DMTDESME_04715(aksA)
SGYSgly_0729
DORDesor_3919 Desor_5017
DAIDesaci_1215 Desaci_4028
DMIDesmer_3032 Desmer_4010
DEDDHBDCA_p1403
DECDCF50_p1415
DRSDEHRE_10895(aksA)
DCADesca_1143 Desca_1729
PTHPTH_2520(LeuA)
DRMDred_2339
DRUDesru_1307 Desru_3444
DFGB0537_12135
DAEDtox_0785 Dtox_1022
DKUDesku_1675 Desku_3339
DAUDaud_0409 Daud_1035
TFRBR63_02025 BR63_02030 BR63_18265(nifV)
FWADCMF_00390
AACXDEACI_3021 DEACI_3067
TJRTherJR_0701 TherJR_0874
DGIDesgi_2429 Desgi_2455
HMOHM1_0858(nifV) HM1_2993
HCVFTV88_1447 FTV88_2463
AWOAwo_c07850(nifV1) Awo_c07860(nifV2)
AWICHL1_002971 CHL1_002972
CBARPATL70BA_2426(nifV)
VPYHZI73_16015(aksA)
CTHMCFE_2283 CFE_2579
TTETTE0472(LeuA2)
TEXTeth514_0415
THXThet_0461
TPDTeth39_1820
TITThit_0443
TMTTmath_0527
TBOThebr_1867
TWIThewi_0531
TKITKV_c04530(leuA2)
CHYCHY_1104(nifV)
MTAMoth_1938
MTHOMOTHE_c19770(leuA2)
MTHZMOTHA_c20560(leuA2)
ADGAdeg_1099
TPZTph_c08720(nifV) Tph_c09000(leuA1)
TTMTthe_2229
TTOThethe_02308
TXYThexy_1926
TSHTsac_0029
TNRThena_0289 Thena_0491
TACITDSAC_0283 TDSAC_0468
MASMahau_0318
TEPTepRe1_0154
TAETepiRe1_0166(leuA)
HORHore_08050
HALSD7D81_06125(nifV)
IFNGM661_03605(nifV)
PUFUFO1_0042 UFO1_0043 UFO1_3851 UFO1_3852
PFTJBW_01018 JBW_01019 JBW_04455 JBW_04456
MANAMAMMFC1_00442(leuA_1) MAMMFC1_00443(leuA_2) MAMMFC1_02645(leuA_6) MAMMFC1_02721(leuA_7) MAMMFC1_02722(leuA_8)
STEDSPTER_11640(leuA_1) SPTER_11650(leuA_2) SPTER_42560(leuA_3) SPTER_42570(leuA_4)
SGRSGR_3476
SFISFUL_3348
SCZABE83_19120
SCXAS200_21995
SRWTUE45_06894(leuA_4)
SGSAVL59_12485
SLAUSLA_3047
STIRDDW44_16575
SNKCP967_01820 CP967_15215
SSPODDQ41_08085
SCAVCVT27_15430
SCYGS1361_31440(leuA4)
SGJIAG43_00710
STRYEQG64_16275
SDDD9753_06820
KABB7C62_16015
FRAFrancci3_4489
FREFranean1_4071
FALFRAAL6814(nifV)
FSYFsymDg_2806
KALKALB_5540
CYACYA_1820(nifV)
CYBCYB_0424(nifV)
LETO77CONTIG1_04713(leuA_4)
LBOLBWT_23140
LSCKIK02_24560(nifV)
LSKJ5X98_14365(nifV)
PSEUPse7367_2223
PSERABRG53_d046(nifV)
THEUHPC62_11700(nifV)
HAOPCC7418_1777
ENNFRE64_02085(nifV)
CYUUCYN_06080
CYTcce_0549(nifV)
CWACwatDRAFT_3845
CYPPCC8801_1776
CYHCyan8802_1804
CYCPCC7424_0947 PCC7424_2127
CYJCyan7822_1791 Cyan7822_3668
CYNCyan7425_2367
PPSUNO713_02601(nifV1)
MICMic7113_1300
MPROBJP34_16110
PHORJWS08_14995(nifV)
PYHNEA10_16890(nifV)
ANAalr1407(nifV1) alr2968(nifV2)
NPUNpun_F0430
NOSNos7107_0175 Nos7107_3310
NOPNos7524_2286 Nos7524_5258
NONNOS3756_17300(aksA_1) NOS3756_18600(aksA_2)
NFLCOO91_05479 COO91_05563
NOECLI64_00215(nifV) CLI64_05360(nifV)
NSHGXM_00779
NEDHUN01_22765(nifV) HUN01_23180(lysS)
AVAAva_0938 Ava_3956 Ava_4041
NAZAazo_1372
ANBANA_C10898(nifV)
ACYAnacy_0218
AWAAA650_19225(aksA)
ANNEH233_02680(nifV) EH233_03410(nifV) EH233_18315(nifV)
CSGCylst_5393
RSINB6N60_04441
CALOCal7507_0055 Cal7507_3999
CALTCal6303_1160
CALHIJ00_25035(aksA)
CALNNIES2098_35600 NIES2098_42590
RIVRiv7116_6370
FISFIS3754_34880
NSPBMF81_03733(nifV)
NSPHBDGGKGIB_00194(leuA_1) BDGGKGIB_00937(leuA_2)
DOUBMF77_04749(leuA_3)
DFSHGD76_20270(nifV)
CCURIAR63_11665
AFLOHEQ12_09385(nifV)
TOQHCG51_06030(nifV)
NCNBZZ01_06000 BZZ01_19685 BZZ01_20300
CTHEChro_4594
PLPPle7327_3518
CEOETSB_1480(aksA)
CERRGRSB_1535(aksA)
CAUCaur_0328
CHLChy400_0353
CAGCagg_3603
HAUHaur_3301
LEKhrd7_27850
CAPCLDAP_04770
KBSEPA93_38780
THUGKNN16_06535(lysS)
TTRTter_2761
PMETG4Y79_18420(lysS)
DRADR_1238
DGEDgeo_1257
DDRDeide_13980
DMRDeima_1358
DGODGo_CA1416
DPDDeipe_2766
DSWQR90_11530
DCHSY84_02355
DABAUC44_09460
DPUSU48_09295
DEZDKM44_08475(lysS)
DWUDVJ83_05005(lysS)
DFCDFI_09345
DEINDAAJ005_07905(lysS)
DGADEGR_18060
DPHEHF33_05040(lysS)
TRATrad_1388
TTHTT_C1550
TTJTTHA1914(TTHA1914)
TTSThthe16_1914
TTLTtJL18_1996
TSCTSC_c01850(lysS1)
THCTCCBUS3UF1_21080
TOSTheos_1940
TAQTO73_0091
TBCA0O31_00877
TANTKNN15_05095(lysS)
MRBMrub_2729
MREK649_08890
MSVMesil_0445
MTAIMtai_v1c23280
OPROcepr_1779
MHDMarky_0673
OBTOPIT5_01810 OPIT5_29700
CAACaka_2831
RUFIK0V07_13835
MINMinf_1877(leuA)
MKCkam1_429
MEAPMTHMO_1013(nifV)
VBSEGM51_10175
SSMSpirs_3010
STASTHERM_c03410
SPEREW093_07685
OCKEXM22_15160
SCORJ3U87_19125(lysS)
IPOIlyop_1399
APSCFPG_473
PPNPalpr_1434
DRCG0Q07_05260
MCOSGM418_15715
ASXCDL62_03355
MBASALGA_0874
CGLENCTC11432_00583(leuA_1)
CTECT1528(nifV)
CPCCpar_1614
CLZBIU88_03135
CCHCag_1229
CPHCpha266_1918
CPBCphamn1_1747
CLIClim_0690
PVICvib_1341
PLTPlut_1526
PPHPpha_1919
PAAPaes_1624
PROCPtc2401_01787(leuA_4)
PRSB9H02_03590
PROSCHL67_07880
CTSCtha_1654
HTHHTH_1130
HTEHydth_1122
TALThal_0418
TTATheth_0203
PMOPmob_1703
DTNDTL3_1459(leuA2)
DINSelin_2077
DAPDacet_1054
GTLEP073_06030(nifV)
CNICalni_0672
DTHDICTH_1519(nifV)
DTUDtur_1629
LFCLFE_2422
LFPY981_08930(aksA)
TIDThein_1048
TAVG4V39_02725
TMAIFVE67_04275
MJAMJ_0503
MFEMefer_0710
MVUMetvu_1576
MFSMFS40622_1791
MIFMetin_1354
MJHJH146_1425
MESGMLAUSG7_0108(aksA)
MESAMLASG1_1291(aksA)
MIGMetig_0696
MMPMMP0153(aksA)
MMQMmarC5_1522
MMXMmarC6_0797
MMZMmarC7_1153
MMDGYY_00785(aksA)
MMAKMMKA1_01580(cimA)
MMAOMMOS7_01840(cimA)
MMADMMJJ_09310(leuA_1)
MAEMaeo_0994
MVNMevan_1158
MVOMvol_1568
MOKMetok_0640
METFCFE53_04770(aksA)
MTHMTH_1630
MMGMTBMA_c02150(leuA2)
MWOMWSIV6_0176(aksA)
MTEEMTTB_13800(aksA)
METCMTCT_1489
METEtca_01580(leuA_3)
METZMETMT2_1469
METKFVF72_03475
MTHMFZP57_00770
METJFZP68_05780
MSTMsp_1099(leuA2)
METBAW729_10320(aksA)
MRUmru_0385(aksA)
MSIMsm_0722
MEBAbm4_0181(aksA)
MMILsm9_2160(aksA)
MEYETL18_01070(aksA)
MOLYLM1_0056
MAROMarbSA_09070(aksA_1) MarbSA_13810(aksA_2)
METVK4897_04155
MELMetbo_2071
MEWMSWAN_0569
METHMBMB1_0290(aksA)
MFCBRM9_1985(aksA)
MFIDSM1535_0177(aksA)
MCUBMCBB_0566(aksA)
MSUBBK009_11615(aksA)
METNBK008_07190(aksA)
METTCIT01_06835(aksA)
METOCIT02_05435(aksA)
MEMEHYG87_07555
MFVMfer_0964
MKAMK1209(leuA)
MBAMbar_A2192 Mbar_A2268 Mbar_A2269
MBYMSBRM_1356 MSBRM_1357 MSBRM_2239
MBWMSBRW_2477 MSBRW_2478 MSBRW_2549
MBARMSBR2_0170 MSBR2_1052 MSBR2_1053
MBAKMSBR3_1047
MACMA_1225(nifV) MA_1226(nifV) MA_3342(leuA)
MMAMM_2785
MMAZMmTuc01_2834
MMJMSMAS_1942
MMACMSMAC_1183
MVCMSVAZ_2030
MEKMSKOL_2008 MSKOL_2218 MSKOL_2219
MLSMSLAZ_1553
METMMSMTP_1363
MEFMSWH1_1527
MEQMSWHS_1780
MSJMSSAC_2553
MSZMSSIH_2157 MSSIH_2896 MSSIH_2897
MSWMSSIT_2270 MSSIT_2940 MSSIT_2941
MTHRMSTHT_0432
MTHEMSTHC_0289
MHORMSHOH_1618
MFZAOB57_000055(aksA)
MBUMbur_0854(cimA)
MMETMCMEM_0986
MELOJ7W08_02750(aksA)
MMHMmah_1162
MHAZBHR79_07725(aksA)
MEVMetev_0432
MZHMzhil_1141
MPYMpsy_2899
MZIHWN40_08205(aksA)
MHZMetho_0886
MTPMthe_1533
MCJMCON_2596(leuA)
MHIMhar_1932
MHUMhun_1801
MRTJKHC33_05405
MLAMlab_0232
MEMMemar_0633
MBGBN140_1718(aksA)
MEMAMMAB1_2210(aksA)
MCHKMchiMG62_07630(aksA)
MPIMpet_2488
MENDL6E24_09230
MBNMboo_0598
MFOMetfor_2593
MPLMpal_2142
MPDMCP_1960(aksA)
MEZMtc_1560(aksA)
RCIRCIX2647(leuA-4)
TARTALC_00557
MAXMMALV_05060
MEARMpt1_c02550(cimA)
MEUZKRP56_01640 KRP56_02715(nifV)
 » show all
Reference
1  [PMID:5836514]
  Authors
Strassman M, Ceci LN.
  Title
Enzymatic formation of homocitric acid, an intermediate in lysine biosynthesis.
  Journal
Biochem Biophys Res Commun 14:262-7 (1964)
DOI:10.1016/0006-291X(64)90446-2
Reference
2  [PMID:12095615]
  Authors
Wulandari AP, Miyazaki J, Kobashi N, Nishiyama M, Hoshino T, Yamane H.
  Title
Characterization of bacterial homocitrate synthase involved in lysine biosynthesis.
  Journal
FEBS Lett 522:35-40 (2002)
DOI:10.1016/S0014-5793(02)02877-6
Reference
3  [PMID:15362863]
  Authors
Andi B, West AH, Cook PF.
  Title
Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
  Journal
Biochemistry 43:11790-5 (2004)
DOI:10.1021/bi048766p
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.14
IUBMB Enzyme Nomenclature: 2.3.3.14
ExPASy - ENZYME nomenclature database: 2.3.3.14
BRENDA, the Enzyme Database: 2.3.3.14
CAS: 9075-60-9

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