KEGG   ENZYME: 2.3.3.20
Entry
EC 2.3.3.20                 Enzyme                                 
Name
acyl-CoA:acyl-CoA alkyltransferase;
oleA (gene name)
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
Sysname
acyl-CoA:acyl-CoA alkyltransferase [(2R)-2-alkyl-3-oxoalkanoate-forming]
Reaction(IUBMB)
2 an acyl-CoA + H2O = a (2R)-2-alkyl-3-oxoalkanoate + 2 CoA [RN:R11958]
Reaction(KEGG)
R11958
Substrate
acyl-CoA [CPD:C00040];
H2O [CPD:C00001]
Product
(2R)-2-alkyl-3-oxoalkanoate [CPD:C21651];
CoA [CPD:C00010]
Comment
The enzyme, found in certain bacterial species, catalyses a head-to-head non-decarboxylative Claisen condensation of two acyl-CoA molecules, resulting in formation of a 2-alkyl-3-oxoalkanoic acid. It is part of a pathway for the production of olefins.
History
EC 2.3.3.20 created 2018
Orthology
K22317  acyl-CoA:acyl-CoA alkyltransferase
Genes
KORAWR26_13240
KRDA3780_10770
XFAXF_1970
XFTPD_0832(fabH)
XFMXfasm12_1002
XFNXfasM23_0881
XFFXFLM_09840
XFLP303_04330
XFSD934_09805
XFHXFHB_05520
XTWAB672_06665
XCCXCC0212(fabH)
XCBXC_0222
XCAxcc-b100_0233(fabH1)
XCPXCR_4310
XCVXCV0239(fabH)
XAXXACM_0219(fabH)
XACXAC0233(fabH)
XCIXCAW_00631(fabH)
XCTJ151_00350
XCJJ158_00348
XCUJ159_00348
XCNJ169_00346
XCWJ162_00347
XCRJ163_00347
XCMJ164_00347
XCFJ172_00341
XFUXFF4834R_chr02040
XAOXAC29_01200
XOMXOO3978(XOO3978)
XOOXOO4209(fabH)
XOPPXO_03957
XOYAZ54_02895
XORXOC_0329
XOZBE73_22775
XALXALC_3073(fabH)
XSASB85_13790
XTNFD63_01095
XFRBER92_02120
XVEBJD12_13740
XPEBJD13_15885
XHRXJ27_16850
XGABI317_23615
XPHXppCFBP6546_10750(XppCFBP6546P_10750)
XVAC7V42_00990
XANAC801_00990
XARXB05_17850
XHYFZ025_08690
XCZEBN15_19085
XTHG4Q83_18930
XEUXSP_000235
XHDLMG31886_02510(oleA)
XPRMUG10_09155
XAGHEP73_00273
XDYNYR95_01310
XASHEP74_00266
SMLSmlt0205(fabH)
SMTSmal_0167
BUJBurJV3_0159
SMZSMD_0175(fabH)
SACZAOT14_35150(fabH_2)
STEKAXG53_15335
SRHBAY15_0298
SLMBIZ42_10285
STENCCR98_00900
STEMCLM74_00910
STESMG068_00765
SINCDAIF1_01790(fabH2)
SPAQSTNY_R02090
STEQICJ04_17665
SGENRKE57_00635
PSUPsesu_0121
PSUWWQ53_07310
PSDDSC_15465
PMEXH4W19_13895
PJPLAG73_18665
PDDMNQ95_05860
PWIMWN52_18420
LABLA76x_4702(fabH)
LAQGLA29479_5035(fabH)
LCPLC55x_0340(fabH)
LGULG3211_0363(fabH)
LEZGLE_5012
LEMLEN_4751
LMBC9I47_3102
LYTDWG18_14350
LUEDCD74_09650
LYJFKV23_15700
LSOLGOY17_18065
LSXH8B22_06720
LAREHIV01_014655
LHXLYSHEL_13640(fabH_3)
LCASLYSCAS_13640(fabH_3)
LCICINQ41_00510
LAVIINQ42_00510
LLZLYB30171_00193(oleA)
LAUXLA521A_36240
LYARDV84_08340
LUMCNR27_03310
LUSE5843_01140
LUGFPZ22_06765
THESFHQ07_09305
THEHG7079_01920
TCNH9L16_04265
TBVH9L17_09815
XBAC7S18_17845
PPRPBPRA1462(PD0832)
SONSO_1742(oleA)
SDNSden_1369
SFRSfri_1365
SAZSama_1182
SBLSbal_1550
SBMShew185_1546
SBNSbal195_1580
SBPSbal223_2800
SBTSbal678_1617
SBSSbal117_1657
SBBSbal175_2782
SLOShew_1713
SPCSputcn32_1445
SHPSput200_1458
SSESsed_1510
SPLSpea_2736
SHEShewmr4_2548
SHMShewmr7_2615
SHNShewana3_2715
SHWSputw3181_2654
SHLShal_2820
SWDSwoo_3159
SWPswp_3336
SVOSVI_3045
SHFCEQ32_07545
SJASJ2017_1515
SPSWSps_01977
SBJCF168_07305
SMAVCFF01_10795
SHEWCKQ84_00035
SALGBS332_15295
SLJEGC82_14500
SMAIEXU30_02230
SPOLFH971_12845
SBKSHEWBE_2081
SKHSTH12_00741(fabH_1)
SAESHBH39_06140
SLITJQC75_05795
SCAATUM17387_25580(oleA)
SPSHFM037_19450
SEURFM038_007245
SCYPJYB88_06030
SSEMJYB85_06325
SGLAFJ709_05990
SINVK8B83_10005
SXMMKD32_13225
SVMKDH10_001507
SHEJMZ182_06915
SSEHN7V09_09720
SCHKGII14_13330
SACHK0H61_11450
SAEGK0H80_08700
SDEOD0436_14500
SMESK0I73_07970
SHAOK0H81_11225
SZHK0H63_06425
SSPAK0I31_08845
SHNSK0J45_08675
SRHSK0I63_08795
SPSJK0I62_08430
SMAYK0H60_13705
SOGRA178_14660
CPSCPS_2153
COMCMT41_10385
PINPing_1997
PSYPCNPT3_05870
MYAMORIYA_1230
MOQHWV03_08495
SDESde_1517
TTUTERTU_4039
WMAWM2015_2413
WEZIC757_04060
GAIIMCC3135_24160(fabH_2)
MMEMarme_0184
SVASVA_3859
GEMGM21_2115
GEBGM18_2130
GURGura_2010
GEOGeob_3149(fabH-3)
GLOGlov_2269
TAMMGEAMG1_1449
GBMGbem_2102(fabH-3)
GBNGEOBRER4_19320(oleA)
GERKP004_09515
GSUBKP001_05680
GNTKP003_08920
GPLM1B72_11255
PPDPpro_3103
DESDSOUD_2646
DPSDP0741
DSFUWK_00960
DLMDPPLL_34380(fabH)
DPRDespr_2661
DEOCAY53_08355
DOGHP555_05650
DBKDGMP_33990(fabH_2)
DDUGF1_25110(fabH)
DOLDole_2008
DALDalk_0846
DATHRM2_23500(fabH1)
DTOTOL2_C24910
DOVDSCO28_48390
DWDDSCW_45700
DALKDSCA_44800
DMLDmul_23300
DLIdnl_18070
DMMdnm_089160
VINAKJ08_2414
SAMYDB32_004418
BBAEFRD01_17690
BMXBMS_1441
HAXBALOs_1694(fabH)
BSTOC0V70_08420
PSTISOO65_11660
MPAEK0O64_00515
RANTRHODO2019_13230
LXLKDY119_02263(oleA)
CMICMM_2155
CMHVO01_10025
CMSCMS1848(fabH)
CMCCMN_02122
CCAPAES38_10525
CZHH9X71_10920
CPHAFGI33_02330
CCAFFGD68_13245
MTSMTES_0535(fabH)
MCWA8L33_02690
MPALBO218_00785
MIHBJP65_04540
MLVCVS47_00572(fabH_1)
MWAE4K62_15615
MLZF6J85_14985
MCHNHCR76_03790
MICSC1N74_10460
MARKQUC20_10410
MINVT9R20_13445
RTXTI83_10145
RTCAPU90_06915
RTNA6122_2398
RIAC7V51_14960
RFSC1I64_12810
RTEGSU10_02650
ROEQ0F99_12215
CUMNI26_13040
CUBBJK06_11645
CUGC1N91_13455
CCITQPK07_13520
FRPAX769_07010
FSBGCM10025867_15420
CARTPA27867_0152
CRYB7495_00670
MALKMalAC0309_0667(fabH)
MDBOVN18_07375
MYLC3E77_02025
SALAESZ53_01605
SALDFVA74_09120
PLAPEAO79_05135
AGGC1N71_08995
AGROJSQ78_07900
MANTBHD05_11895
HEHL3i23_13840
FRNF1C15_06370
AGXAGREI_0630(oleA)
SUBTKPL76_12540
SUBALQ955_04745
NAEIGCM126_33360
ARRARUE_c21510
ARMART_1188
ARLAFL94_04870
AREAL755_14775
AAQAOC05_09350
ARWMB46_09735
ARYATC04_12980
ARQBWQ92_22600
ACRYAC20117_20155
ARTPE5206_10075
AAGINCTC2676_1_01687(fabH_2)
AJGKKR91_11270
ASUNKG104_12075
ASUFMNQ99_08605
ACAONF551_10355
AZHMUK71_10435
AGEGMUG94_11230
AKON9A08_10020
AZXN2K95_10370
AJRN2K98_11080
AAUAAur_1998
PNVJMY29_09445
ACHAchl_0446
PSNINIBR502771_13175
PDELJCQ34_11255
AAIAARI_10570(fabH)
GARAOZ07_05535
GCRGcLGCM259_0860(fabH_1)
GLUF0M17_05210
GPRJQN66_05310
GMINMP99_05695
GMYXH9_03550
GNCQQS42_05310
KRHKRH_10520
KPLKPaMU14_04555
KFVAS188_12300
KIIKocCE7_05295
KRSEQG70_07620
KODHBK84_05455
KVRCIB50_0002122(fabH_2)
MLUMlut_13230
MICKB1A86_00006570
MYUM8233_06340
MLYCJ228_004385
MPORKW076_07405
MTEUR3I42_04895
RMURMDY18_08260
RDNHMPREF0733_12127
RAJRA11412_2075
RTERIDM49_05050
RAMAIDM48_05225
RKRI6G21_10200
SATKSA2016_3971
NAEBHE16_01730
CIGE7744_06460
CMUAP8192_08570
PAEYKUF55_10275
BFABfae_17460
BRXBH708_04350
BRVCFK39_01165
BGGCFK41_08040
BRZCFK38_10140
BSAUDWV08_06130
BRRC1N80_10320
BKIM4486_03315
BRHANLU66_11210
BHHBra3105_01655
BHQBRM3_11055
DVADAD186_09740
DHMCYJ49_001230
HMMR3I40_05610
KSEKsed_07160
IVAIsova_0149
IDOI598_2610(fabH_3)
CPRTFIC82_010590
SKESked_36610
CELZE5225_13975
CEJGC089_14715
CDONKKR89_04000
CFENKG102_07185
CWNNP075_04160
CXIENP048_04180
SERJSGUI_1319
SERWFY030_02630
ORNDV701_15460
ORZFNH13_16505
OCPNF557_14275
BLYA2T55_16610
BLINBLSMQ_3613
BRIFDF13_04820
BLUTEW640_09550
BCAUI6G59_02565
BSPOL1F31_17235
DCOSAMEA4475696_0224(fabH_1)
GEZFE251_10290
GYUFE374_10110
RHALLQF10_10365
RSUALQF12_09160
MPHMLP_50950
MIKFOE78_05605
NMESH9L09_18010
NAQUENKNEFLB_01768(fabH_1)
NMLNamu_4240
NAKEH165_06740
NAKAH7F38_17575
GOBGobs_2463
MMARMODMU_2229
KRAKrad_1682
PHHAFB00_18775
PPELH6H00_20575
ACTYOG774_19165
MCRAID554_00395
VERHUT12_12065
AYMYM304_23870(fabH)
CAUCaur_3529
CHLChy400_3806
CAGCagg_0548
OTEOter_3278
OBGVerru16b_02927(fabH_2)
VBHCMV30_00900
OLEK0B96_08400
SLOMPXH66_08170
OBTOPIT5_15400
CAACaka_1901
RUFIK0V07_12825
PPHTGA004_15445
PUORZN69_13250
VBAIMCC26134_06600
RBARB12812(fabH)
PSLPsta_4249
PIRVN12_11405(fabH_3)
RULUC8_38840(fabH_2)
RMLFF011L_18030(fabH_2)
MFFMFFC18_26240(fabH_2)
ROLCA51_16720(fabH_2)
AHELQ31a_23000(fabH_2)
LCREPla8534_25300(fabH_2)
AAGGETAA8_27940(fabH_2)
BVOPan97_31620(fabH_3)
BREMPSR63_22630
RLCK227x_27120(fabH_2)
LPAVPLANPX_2250
AMUCPan181_33750(fabH_2)
PNDPla175_41990(fabH_2)
AMOBHG15A2_18100(fabH_1)
PLMPlim_3323
PEHSpb1_40820(fabH_3)
PBSPlabr_4721
PLSVT03_09575(fabH_1)
PLHVT85_06230(fabH_2)
FMRFuma_05660(fabHA)
GMRGmarT_00170(fabH_1)
GIMF1728_13865
GPNPan110_00170(fabH_1)
MRIMal4_58210(fabHA)
SDYNMal52_57220(fabH1)
PLONPla110_02840(fabH_2)
GESVT84_31330(pqsD)
GOGC1280_33730
GMSSOIL9_84900
TIMGMBLW1_07560
LRSPX52LOC_01177
FTJFTUN_1526
ULIETAA1_41110(pqsD)
TSPHKIH39_05450
IPAIsop_2005
SACISinac_3638
PBORBSF38_04652(fabH_2)
AGVOJF2_56780(fabH_2)
UAMUABAM_06727
LPROPQO03_09155
SCORJ3U87_32905
NLIG3M70_17265
NWTNSPWAT_1580(oleA)
LOBNEF87_003382
 » show all
Reference
1  [PMID:20418444]
  Authors
Sukovich DJ, Seffernick JL, Richman JE, Hunt KA, Gralnick JA, Wackett LP
  Title
Structure, function, and insights into the biosynthesis of a head-to-head hydrocarbon in Shewanella oneidensis strain MR-1.
  Journal
Appl Environ Microbiol 76:3842-9 (2010)
DOI:10.1128/AEM.00433-10
  Sequence
[son:SO_1742]
Reference
2  [PMID:21266575]
  Authors
Frias JA, Richman JE, Erickson JS, Wackett LP
  Title
Purification and characterization of OleA from Xanthomonas campestris and demonstration of a non-decarboxylative Claisen condensation reaction.
  Journal
J Biol Chem 286:10930-8 (2011)
DOI:10.1074/jbc.M110.216127
  Sequence
[xcc:XCC0212]
Reference
3  [PMID:22524624]
  Authors
Goblirsch BR, Frias JA, Wackett LP, Wilmot CM
  Title
Crystal structures of Xanthomonas campestris OleA reveal features that promote head-to-head condensation of two long-chain fatty acids.
  Journal
Biochemistry 51:4138-46 (2012)
DOI:10.1021/bi300386m
  Sequence
[xcc:XCC0212]
Reference
4  [PMID:27815501]
  Authors
Goblirsch BR, Jensen MR, Mohamed FA, Wackett LP, Wilmot CM
  Title
Substrate Trapping in Crystals of the Thiolase OleA Identifies Three Channels That Enable Long Chain Olefin Biosynthesis.
  Journal
J Biol Chem 291:26698-26706 (2016)
DOI:10.1074/jbc.M116.760892
  Sequence
[xcc:XCC0212]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.20
IUBMB Enzyme Nomenclature: 2.3.3.20
ExPASy - ENZYME nomenclature database: 2.3.3.20
BRENDA, the Enzyme Database: 2.3.3.20

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